The Library
1530 papers on microsampling and monitoring, each with a finding paraphrased to our standard and labelled in one vocabulary. Every entry links to a legitimate copy; nothing is copied from an abstract.
Papers 501–600 of 1530, newest first.
2024
Self-collected urine samples detected high-risk HPV DNA in 25.5 per cent of women and 8 per cent of men by qPCR, while oral gargle samples detected HPV in 7 per cent of women and 5 per cent of men. With good diagnostic accuracy against Pap smear, qPCR on self-collected specimens offers a viable decentralised approach to HPV screening in remote populations.
Evaluating different samples & techniques for hr-HPV DNA genotyping to improve the efficiency of risk profiling for oral & cervical cancers in Sikkim, India — Gupta et al., The Indian journal of medical research
- saliva
- urine
- self-collection
- validation
- genotyping
- hpv
- sti
2024
SalivaDirect offers a simpler, faster RNA extraction protocol for SARS-CoV-2 detection from self-collected saliva samples, demonstrating good diagnostic performance and enabling large-scale testing in resource-limited settings without trained healthcare professionals.
SalivaDirect: an alternative to a conventional RNA extraction protocol for molecular detection of SARS-CoV-2 in a clinical setting — Uddin et al., Microbiology spectrum
- saliva
- self-collection
- validation
- serology
2024
Healthy postpartum women exhibited a blunted cortisol awakening response and lower evening cortisol than non-perinatal controls when samples were self-collected at home. This suggests reduced CAR may reflect healthy adjustment to motherhood, demonstrating the feasibility of patient-centric saliva microsampling for perinatal mental health monitoring.
The cortisol awakening response is blunted in healthy women early postpartum — Høgh et al., Psychoneuroendocrinology (paywalled)
- saliva
- self-collection
- hormones
- cortisol
2024
Using Saliva Children's Swabs to collect salivary alpha-amylase and cortisol was feasible in elderly nursing home residents with dementia, though active patient engagement remained necessary. However, an individualised music listening intervention showed no significant effect on these salivary stress markers.
Salivary cortisol and alpha-amylase as stress markers to evaluate an individualized music intervention for people with dementia: feasibility and pilot analyses — Hillebrand et al., BMC research notes
- saliva
- acceptability
- hormones
- cortisol
- biomarkers
2024
A do‑it‑yourself incubator enabling LAMP amplification of SARS‑CoV‑2 RNA from self‑collected saliva achieved 100 per cent sensitivity and 87 per cent selectivity in a proof‑of‑concept deployment to more than 15 homes, offering a simple, low cost route to decentralised molecular diagnostics.
Self-Diagnosis of SARS-CoV-2 from Saliva Samples at Home: Isothermal Amplification Enabled by Do-It-Yourself Portable Incubators and Laminated Poly-ethyl Sulfonate Membranes — Bravo-González et al., Diagnostics
- saliva
- self-collection
2024
A short fasting test initiated overnight at home and completed in an outpatient setting diagnosed insulinoma in 11 of 12 patients within 24 hours (91.7% sensitivity). This decentralised approach avoids prolonged inpatient monitoring while maintaining diagnostic accuracy.
Short fasting test as a reliable and effective tool to diagnose insulinoma — Mikovic et al., Endocrine
- blood
- liquid
- capillary
- venous-agreement
- hormones
2024
The study found low SARS-CoV-2 seropositivity in unvaccinated children and young adults in British Columbia, with higher rates in South Asian participants and young infants. Many infections were undetected, highlighting the value of patient-centric microsampling for more accurate, decentralised surveillance.
Factors associated with SARS-CoV-2 infection in unvaccinated children and young adults — Silverberg et al., BMC infectious diseases
- blood
- dried
- dbs
- acceptability
- pediatric
- serology
2024
The review found dried blood spot sampling correlates strongly with plasma for HIV-1 viral load and offers simplified collection, transport and storage without cold-chain. This could expand access to monitoring in resource-limited settings and improve clinical outcomes through earlier detection of treatment failure.
Revolutionizing HIV-1 Viral Load Monitoring in India: The Potential of Dried Blood Spot Analysis for Expanding Access and Improving Care — Chandane Tak et al., Healthcare
- blood
- dried
- dbs
- validation
- venous-agreement
- serology
2024
A statewide remote seroprevalence study using at-home dried blood spot kits achieved a 71.6% sample return rate from registered households, with success dependent on integrated data systems, responsive participant support, and strong health department partnerships. This demonstrates feasibility of large-scale decentralised microsampling for public health surveillance.
CalScope: methodology and lessons learned for conducting a remote statewide SARS-CoV-2 seroprevalence study in California using an at-home dried blood spot collection kit and online survey — Lim et al., BMC medical research methodology
- blood
- dried
- dbs
- self-collection
- dct
- serology
2024
First-void urine IgG remained stable for at least 14 days at room temperature when stored with conservation medium. Amicon filtration with Melon Gel purification enriched HPV16-specific IgG that correlated strongly with serum levels, supporting non-invasive disease monitoring and vaccine impact assessment.
Stability, enrichment, and quantification of total and HPV16-specific IgG present in first-void urine — Téblick et al., Scientific reports
- urine
- first-void
- validation
- serology
- hpv
2024
Microsampling with Mitra® devices correlated strongly with venous plasma for capecitabine therapeutic drug monitoring (r=0.97), but yielded consistently lower concentrations. Patients preferred this method and reported minimal pain, suggesting it is suitable for patient-centric oncology drug monitoring in decentralised settings.
Comparison of capecitabine concentrations determined by microsampling versus plasma concentrations for therapeutic drug monitoring: a pilot study — Shafiei et al., The Journal of pharmacy and pharmacology (paywalled)
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- venous-agreement
- acceptability
- tdm
- oncology
2024
The authors validated a VAMS method for ivermectin therapeutic drug monitoring in whole blood, achieving a lower limit of quantification of 1 ng/mL and a linear range of 1–150 ng/mL. By eliminating haematocrit effects that limit dried blood spots, the method supports accurate decentralised sampling for antiparasitic therapy.
Development and validation of ivermectin quantification method in volumetric absorptive microsampling using liquid chromatography-tandem mass spectrometry — Harahap et al., Heliyon
- blood
- dried
- vams
- neoteryx-mitra
- validation
- tdm
- antimicrobials
2024
An LC-MS/MS method for warfarin in VAMS samples was validated to FDA 2022 standards, showing linearity from 5–500 ng/mL. Analysis of 25 patients on warfarin therapy yielded concentrations of 6.05–431.39 ng/mL, confirming that self-collected VAMS can reliably support anticoagulation monitoring in decentralised settings.
Determination of warfarin in volumetric absorptive microsampling by liquid chromatography-tandem mass spectrometry — Harahap et al., Heliyon
- blood
- dried
- vams
- neoteryx-mitra
- validation
- tdm
2024
The LC-MS/MS method using VAMS quantified doxorubicin and its metabolite doxorubicinol with linear ranges 8-200 and 3-100 ng/mL and LLOQs of 8 and 3 ng/mL; patient levels ranged 9.47-87.84 ng/mL for doxorubicin and 4.24-54.02 ng/mL for doxorubicinol, enabling TDM with cumulative doses 47.93-346.09 mg/m2 and an estimated cardiomyopathy risk under 4%.
Doxorubicin, doxorubicinol, cardiotoxicity, breast cancer, volumetric absorptive microsampling, LC-MS/MS — Chairunnisa et al., Pakistan journal of biological sciences : PJBS (paywalled)
- blood
- dried
- vams
- tdm
- oncology
2024
The study developed and validated an ICP-MS/MS method for trace elements in whole blood collected on VAMS and found that most targeted elements gave accurate and reproducible results compared with a reference method, indicating that VAMS could become an alternative to venipuncture for blood sampling in trace elements analysis.
Validation of Mitra<sup>®</sup> VAMS<sup>®</sup> as a blood collection technique for trace elements analysis using ICP-MS/MS — Breton et al., Bioanalysis (paywalled)
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- venous-agreement
2024
The authors validated a UPLC-PDA assay for ceftazidime in 10 microlitre dried blood spots collected with the Capitainer device from neonatal patients, achieving accuracy of 90.1 to 104.8 per cent and precision within 11.7 per cent coefficient of variation across a quantification range of 0.5 to 200 micrograms per millilitre, and confirmed the method worked on clinical neonatal samples. This supports microsampling-based therapeutic drug monitoring of an antimicrobial in a vulnerable population where conventional venous blood draws are difficult.
Development and validation of a UPLC-PDA method for quantifying ceftazidime in dried blood spots — Lv et al., Journal of pharmaceutical and biomedical analysis (paywalled)
- blood
- dried
- capillary
- dbs
- validation
- pediatric
- tdm
- antimicrobials
2024
An analytical method using Capitainer B devices collecting 10 microlitres of capillary blood was successfully validated for the quantitative determination of 25 PFAS using UHPLC-MS/MS. The method demonstrated high recovery above 80% and met precision and accuracy criteria across the validated range of 2 to 100 ng/mL.
Development and validation of the UHPLC-MS/MS method for the quantitative determination of 25 PFAS in dried blood spots — Galletto et al., Analytical and bioanalytical chemistry
- blood
- dried
- capillary
- dbs
- qdbs
- validation
- toxicology
2024
Plasma separation cards showed high specificity (99.3%) but moderate sensitivity (87.5%) against EDTA-plasma for HIV-1 viral load monitoring at a 1,000 copies/ml threshold in a South African cohort. Despite favourable usability among healthcare workers, laboratory-reported technical difficulties must be addressed to enable reliable decentralised scale-up in resource-constrained settings.
Assessment of the performance of the plasma separation card for HIV-1 viral load monitoring in South Africa — Chimoyi et al., Journal of clinical microbiology
- blood
- dried
- capillary
- validation
- venous-agreement
- acceptability
- pediatric
- serology
2024
A dried urine spot method for measuring 14 amino acids was validated using filter paper and mass spectrometry, offering a stable alternative to liquid urine that supports patient self-collection and remote analysis.
Dried urine spot (DUS) applied for sampling prior to the accurate HILIC-MS/MS determination of 14 amino acids — Meikopoulos et al., Talanta (paywalled)
- urine
- dried
- validation
- dct
2024
A modified Delphi consensus panel developed 40 pragmatic recommendations to guide the delivery of decentralised clinical trials for dementia risk-reduction medications. The guidance outlines necessary safety balances, dispensing protocols, outcome assessments, and remote data collection methods.
Decentralized clinical trials for medications to reduce the risk of dementia: Consensus report and guidance — Howard et al., Alzheimer's & dementia : the journal of the Alzheimer's Association
- dct
- standards
2024
In a Vietnamese HIV PrEP cohort, self-collected urine, rectal and pharyngeal specimens tested with the Alinity m STI Assay showed a 10.9% prevalence of Mycoplasma genitalium, highest in rectal sites, and 71% of infections were asymptomatic. This supports decentralised, patient-collected sampling for STI screening to identify asymptomatic infections and guide pathogen directed therapy.
Mycoplasma genitalium Infections Among Participants in an HIV Pre-exposure Prophylaxis Program in Hanoi, Vietnam — Nguyen et al., Sexually transmitted diseases (paywalled)
- urine
- self-collection
- sti
2024
Fourteen of 15 under-screened women said they would be more likely to participate in cervical screening if they could self-collect samples, indicating that self-sampling could improve uptake among those who rarely or never attend screening.
Experiences and Perceptions of Cervical Cancer Screening Using Self-Sampling among Under-Screened Women in Flanders — Buelens et al., Healthcare
- urine
- self-collection
- acceptability
- hpv
2024
Self-directed STI testing kits were requested by some people who use drugs but few were returned, indicating the approach is acceptable yet highlighting logistical and behavioural barriers that need targeted support to realise decentralised testing.
Evaluation of self-directed specimen collection for chlamydia and gonorrhea testing among people who use drugs — Scheidell et al., International journal of STD & AIDS (paywalled)
- urine
- self-collection
- sti
2024
The study found improved salivary DHEA levels and reduced anxiety and loneliness in older adults after a 12-week digital music and movement intervention, showing that decentralised, patient-centric saliva sampling can support biological and psychosocial monitoring in care homes.
Digital music and movement intervention to improve health and wellbeing in older adults in care homes: a pilot mixed methods study — De Nys et al., BMC geriatrics
- saliva
- hormones
- cortisol
2024
The study developed a curcumin-embedded paper sensor for bilirubin detection in saliva, coupled with an IoT-enabled hand-held reader. Clinical testing in 18 jaundiced infants demonstrated good correlation with reference methods for both salivary and blood bilirubin, indicating utility for decentralised neonatal jaundice monitoring.
Spicy Recipe for At-Home Diagnostics: Smart Salivary Sensors for Point-of-Care Diagnosis of Jaundice — Golmohammadi et al., ACS sensors (paywalled)
- saliva
- self-collection
- validation
- pediatric
2024
In confirmed COVID-19 patients, direct RT-PCR on self-collected raw saliva detected all cases (100% sensitivity) with 94.3% concordance to nasopharyngeal swabs. Guanidine-based and guanidine-free inactivators reduced sensitivity to 65.9% and 82.9% respectively. Raw saliva offers a reliable patient-centric alternative for decentralised SARS-CoV-2 testing without sample treatment.
Diagnostic accuracy of direct reverse transcription-polymerase chain reaction using guanidine-based and guanidine-free inactivators for SARS-CoV-2 detection in saliva samples — Katsuno et al., Journal of virological methods (paywalled)
- saliva
- self-collection
- validation
- serology
2024
A community survey of 1699 Tanzanian children using dried blood spots found 17.4% had residual antibiotics, with half of those exposed having no reported use, showing microsampling can reveal hidden antibiotic exposure for stewardship programmes.
Prevalence and predictors of residual antibiotics in children's blood in community settings in Tanzania — Lotto et al., Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases (paywalled)
- blood
- dried
- dbs
- pediatric
- antimicrobials
2024
Adding polyethylene glycol to first-void urine before centrifugation markedly improved cell-free DNA recovery in the pellet, whereas low-speed centrifugation alone removed cellular DNA while keeping cell-free DNA in the supernatant. Pseudovirions pelleted reliably under all conditions, but the study revealed substantial variation between self-collected samples, highlighting the need for standardised protocols in decentralised HPV screening programmes.
Concentration strategies for spiked and naturally present biomarkers in non-invasively collected first-void urine — Téblick et al., European journal of medical research
- urine
- first-void
- hpv
- biomarkers
- liquid-biopsy
2024
When patiromer is taken three hours after tacrolimus, it does not alter tacrolimus exposure in kidney transplant recipients. The study also shows that self-collected capillary blood samples using volumetric absorptive microsampling (VAMS) can reliably measure tacrolimus concentrations, which simplifies pharmacokinetic studies and enables decentralised therapeutic drug monitoring.
Patiromer Does Not Alter Tacrolimus Pharmacokinetics in Kidney Transplant Recipients When Administered Three Hours Post-Tacrolimus — Drevland et al., Transplantation direct
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- self-collection
- tdm
- immunosuppressants
- dct
2024
Salivary tryptophan is significantly raised in HER2‑negative breast cancer and falls after tumour removal, correlating with aggressive disease features. This shows saliva can provide a non‑invasive metabolic marker for screening and monitoring breast cancer in decentralised settings.
Salivary Tryptophan as a Metabolic Marker of HER2-Negative Molecular Subtypes of Breast Cancer — Sarf et al., Metabolites
- saliva
- metabolome
- biomarkers
2024
Microsampling enables home-based specimen collection for drug development and clinical trials, reducing patient burden and expanding enrolment diversity, but requires bridging studies to ensure data comparability with conventional methods and faces analytical challenges that LC-MS strategies aim to address.
Enhancing drug development and clinical studies with patient-centric sampling using microsampling techniques: Opportunities, challenges, and insights into liquid chromatography-mass spectrometry strategies — Chen et al., Journal of mass spectrometry : JMS (paywalled)
- validation
- dct
- standards
2024
A fully remote phase II trial in major depressive disorder was terminated early due to poor recruitment but demonstrated feasibility with a 97.7% completion rate and 88% positive patient experience, highlighting the need to optimise eligibility criteria and recruitment strategies for future decentralised interventional studies.
Safety of BI 1358894 in patients with major depressive disorder: Results and learnings from a phase II randomized decentralized clinical trial — Reist et al., Clinical and translational science
- dct
2024
The article identifies enhanced accessibility, participant diversity and research efficacy as benefits of decentralised clinical trials in asthma, while noting concerns around regulatory compliance and data privacy. It concludes that mHealth-enabled decentralised studies are a feasible step toward improving equity in allergy and immunology research.
Enhancing asthma research and improving health equity through decentralized clinical trials (DCTs) and mHealth technology — Hunt et al., The Journal of asthma : official journal of the Association for the Care of Asthma (paywalled)
- dct
2024
Urinary HPV testing offers comparable detection to cervical samples and high patient acceptability, making it a viable noninvasive option for decentralised cervical cancer screening and vaccine surveillance. However, the absence of standardised protocols for sample collection and processing currently limits its widespread clinical adoption.
A review of urinary HPV testing for cervical cancer management and HPV vaccine surveillance: rationale, strategies, and limitations — Cheng et al., European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (paywalled)
- urine
- self-collection
- validation
- acceptability
- hpv
- sti
2024
The review found that saliva and nasal samples generally have lower sensitivity than nasopharyngeal samples for detecting SARS-CoV-2, though performance varies with operator expertise and collection protocol; this supports careful selection of sampling site and method to optimise accuracy in decentralised diagnostics.
The effect of sample site and collection procedure on identification of SARS-CoV-2 infection — Davenport et al., The Cochrane database of systematic reviews
- saliva
- self-collection
- validation
2024
Maltreated adolescents exhibited persistently flattened cortisol diurnal rhythms when saliva was collected at home, showing that decentralised, patient-centric microsampling across laboratory, home, and school settings can reveal neurobiological adaptations to chronic stress. This supports saliva self-collection as a feasible method for monitoring HPA axis dysfunction in vulnerable youth.
Cortisol's diurnal rhythm indexes the neurobiological impact of child adversity in adolescence — Shirtcliff et al., Biological psychology (paywalled)
- saliva
- self-collection
- pediatric
- hormones
- cortisol
2024
The authors demonstrated that saliva is a viable specimen for SARS-CoV-2 detection and developed an open-source, extraction-free RT-PCR protocol (SalivaDirect) that uses readily available reagents. This approach, which gained FDA Emergency Use Authorisation and scaled to over 200 laboratories performing more than 6.5 million tests, establishes a decentralised model that reduces logistical barriers and enables frequent, self-collected testing for pandemic response.
Scalable solutions for global health: the SalivaDirect model — Wyllie et al., Frontiers in cellular and infection microbiology
- saliva
- self-collection
- validation
- serology
2024
LiFT, a low-cost yarn-based sensor, measured lithium in saliva and urine with FDA-required accuracy, achieving a detection limit of 0.97 µM and a sodium-corrected linear range to 0.5 mM. By transmitting results to patients' smartphones for sharing with clinicians, the device supports at-home therapeutic drug monitoring to minimise lithium toxicity in bipolar disorder.
LiFT (a Lithium Fiber-Based Test): An At-Home Companion Diagnostics for a Safer Lithium Therapy in Bipolar Disorder — Amirghasemi et al., Advanced healthcare materials (paywalled)
- saliva
- urine
- self-collection
- tdm
2024
The bivalent HPV vaccine showed 100 percent effectiveness against vaccine types 16 and 18 seven years post-vaccination in Thai schoolgirls, but only 32.8 percent effectiveness against other high-risk types, indicating limited cross-protection. The study used first-void urine self-collection for HPV DNA detection, demonstrating a scalable, non-invasive approach for vaccine effectiveness monitoring in decentralised settings.
Effectiveness of HPV vaccine as part of national immunization program for preventing HPV infection in Thai schoolgirls after seven years post-vaccination — Nilyanimit et al., Human vaccines & immunotherapeutics
- urine
- first-void
- hpv
2024
Folate vitamer stability in dried blood microsamples was strongly dependent on temperature and time, with levels remaining within 85 to 115 per cent of baseline at -20°C and 4°C for up to two weeks in both VAMS and DBS, but only lasting three days at room temperature in VAMS and failing at 37°C. The authors conclude that decentralised sampling for folate status monitoring is feasible if transport temperature and duration are controlled, though pretreatment with stabilising agents and desiccant use offered only partial improvement at ambient temperature.
Is the stability of folates in dried blood microsamples sufficient to perform home-sampling studies? — Heughebaert & Stove, The Analyst (paywalled)
- blood
- dried
- vams
- dbs
- neoteryx-mitra
- self-collection
- validation
- biomarkers
2024
The study developed and validated LC-MS/MS methods for ganciclovir in serum, dried serum spots, and VAMS-Mitra devices. In 80 pediatric renal transplant recipients, VAMS showed interchangeability with serum samples while extending stability to at least 49 days at room temperature, making decentralised therapeutic drug monitoring more feasible for transplant patients.
Assessment of Dried Serum Spots (DSS) and Volumetric-Absorptive Microsampling (VAMS) Techniques in Therapeutic Drug Monitoring of (Val)Ganciclovir-Comparative Study in Analytical and Clinical Practice — Kocur et al., International journal of molecular sciences
- blood
- dried
- vams
- neoteryx-mitra
- validation
- pediatric
- tdm
- antimicrobials
2024
An online service that mailed saliva self-sampling kits to 4623 GBMSM and trans women achieved a 67.5% return rate, detected 2.45% HIV prevalence with 100% linkage to care, and was recommended by 98% of participants, proving feasibility for decentralised screening.
An Online HIV Self-Sampling Strategy for Gay, Bisexual and Other Men Who Have Sex with Men and Trans Women in Spain — Martínez-Riveros et al., Journal of community health
- saliva
- self-collection
- acceptability
- serology
- sti
2024
The Tasso+ device, which uses a vacuum to collect capillary blood from the upper arm, gathered an average of 536 microlitres of whole blood from 47 men who have sex with men using PrEP, with 91% of samples sufficient for HIV testing and 89% for syphilis testing. Acceptability was high, with 87% expressing a positive attitude and 77% willing to use the device again for home self-sampling.
Using an Innovative Method for Self-Collection of Capillary Blood for HIV and Syphilis Testing Among Men Who Have Sex With Men Who Use Pre-exposure Prophylaxis in the Netherlands; Limburg4zero — Goense et al., Sexually transmitted diseases (paywalled)
- blood
- liquid
- capillary
- self-collection
- validation
- acceptability
- serology
- sti
2024
BATURA is a fully decentralised, phase 3b, randomised, double blind study comparing as needed albuterol budesonide with albuterol alone in mild asthma, with all visits conducted virtually and study medication shipped to participants; medication use is captured by a digital sensor and the primary endpoint is time to first severe asthma exacerbation, enabling assessment of efficacy while reducing participant burden and improving access.
A Fully Decentralized Randomized Controlled Study of As-Needed Albuterol-Budesonide Fixed-Dose Inhaler in Mild Asthma: The BATURA Study Design — LaForce et al., Journal of asthma and allergy
- dct
- digital-biomarker
2024
Capillary blood collection using liquid and dried microsampling devices yielded pharmacokinetic profiles comparable to venous sampling for two monoclonal antibodies and a small molecule, whereas haematocrit correction was necessary for dried formats and bridging was ineffective for hydroxychloroquine. The findings demonstrate the bioanalytical feasibility and patient acceptability of remote microsampling tools for pharmacokinetic evaluations in decentralised clinical trials.
Evaluation of Patient-Centric Sample Collection Technologies for Pharmacokinetic Assessment of Large and Small Molecules — Mandlekar et al., Clinical pharmacology and therapeutics (paywalled)
- blood
- liquid
- dried
- capillary
- neoteryx-mitra
- validation
- venous-agreement
- acceptability
- tdm
- biologics
- dct
- haematocrit
2024
Low volume sampling devices showed good concordance with venous serum for measuring the pharmacodynamic biomarker sMAdCAM-1, but dried blood samples required substantial dilution to overcome buffer interference, which was mitigated by using a highly sensitive Simoa assay. The study demonstrates that while these devices have potential for decentralised clinical trials, careful validation is needed to address site-specific biases and assay sensitivity limitations.
Evaluation of low volume sampling devices for a pharmacodynamic biomarker analysis: Challenges and solutions — Yang et al., Journal of pharmaceutical and biomedical analysis (paywalled)
- blood
- liquid
- dried
- neoteryx-mitra
- validation
- venous-agreement
- dct
- biomarkers
2024
This decentralised clinical trial demonstrated that home-delivered meals tailored to laboratory findings significantly stabilised serum phosphorus levels and improved nutritional status in haemodialysis patients.
Adaptive Nutrition Intervention Stabilizes Serum Phosphorus Levels in Hemodialysis Patients: A Multicenter Decentralized Clinical Trial Using Real-World Data — Chung et al., Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation (paywalled)
- blood
- dct
2024
Salivary alpha-amylase activity rose from morning to afternoon across subjects and days, with no difference between two collection devices, and increased significantly after a simulated shoulder dystocia scenario alongside heart rate, supporting its use as a reliable stress marker when timing is considered.
Salivary alpha-amylase: A marker of stress in gynecological residents during a shoulder dystocia simulation scenario — Aita et al., PloS one
- saliva
- self-collection
- biomarkers
2024
Self-collected dried blood spots analysed on the Roche Elecsys platform gave quantitative anti-spike antibody results that agreed closely with paired venous samples, with sensitivity 96.63% and specificity 97.81% and a conversion formula across 0.018 to 250 U/mL, enabling accurate tracking of titre changes in longitudinal cohorts after vaccination.
A Dried Blood Spot protocol for high-throughput quantitative analysis of SARS-CoV-2 RBD serology based on the Roche Elecsys system — Castelletti et al., Microbiology spectrum
- blood
- dried
- dbs
- self-collection
- validation
- venous-agreement
- serology
2024
Steroid hormones in dried blood spots remained within 15% of baseline for up to 14 days at 37C, and for up to 6 months at -20C, 4C and room temperature, with specific exceptions for androstenedione, 17-OHP, cortisone and cortisol. These findings support the use of DBS for decentralised hormone monitoring by defining storage limits that preserve analyte integrity during transit and storage.
Stability of steroid hormones in dried blood spots (DBS) — Olthof et al., Clinical chemistry and laboratory medicine (paywalled)
- blood
- dried
- dbs
- self-collection
- validation
- hormones
2024
First-void urine testing detected HPV with 87% sensitivity and 89% specificity, and participants reported feeling comfortable with this self-collection method. This approach could improve uptake of cervical cancer screening in decentralised settings.
The Impact of Urine-Sample HPV Testing on the Effectiveness of Screening for Cervical Cancer: An Umbrella Review — Miazga et al., Cancers
- urine
- first-void
- self-collection
- validation
- acceptability
- hpv
2024
A validated LC-MS method quantified multiple antibiotics from a single volumetric absorptive microsample, with stability up to 90 days for most analytes and minimal haematocrit effect except vancomycin, enabling pharmacokinetic and pharmacodynamic studies in decentralised settings.
Bioanalysis of six antibiotics from volumetric microsamples: a new tool for precision dosing in critically ill children — Takyi-Williams et al., Bioanalysis (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- pediatric
- tdm
- antimicrobials
- haematocrit
2024
The study validated an LC-HRMS method for measuring breast cancer drugs in plasma, urine, VAMS and oral fluid, showing that all matrices except oral fluid for certain drugs can support decentralised therapeutic drug monitoring. VAMS and oral fluid faced practical challenges in collection due to patient conditions, but the method enables patient-centric monitoring with dried blood and other self-collected samples.
Towards clinical adherence monitoring of oral endocrine breast cancer therapies by LC-HRMS-method development, validation, comparison of four sample matrices, and proof of concept — Jacobs et al., Analytical and bioanalytical chemistry
- blood
- saliva
- urine
- dried
- vams
- neoteryx-mitra
- validation
- tdm
- oncology
2024
Portable mid‑infrared spectroscopy combined with chemometrics classified fibromyalgia and other rheumatologic syndromes from dried blood collected by volumetric absorptive microsampling with 84% accuracy, 83% sensitivity and 85% specificity; spectral regions linked to amide bands and amino acids acted as discriminatory features, offering a point‑of‑care screening tool for decentralised diagnostics.
Portable Mid-Infrared Spectroscopy Combined with Chemometrics to Diagnose Fibromyalgia and Other Rheumatologic Syndromes Using Rapid Volumetric Absorptive Microsampling — Nuguri et al., Molecules
- blood
- dried
- vams
- neoteryx-mitra
2024
The authors validated an LC-HRMS/MS assay for steroids and thyroid hormones in 30 microlitres of capillary blood collected with Neoteryx Mitra VAMS devices, demonstrating storage stability of over 28 days frozen and 14 days at room temperature. Using authentic samples from 50 healthy active adults, the method showed adequate sensitivity to detect the reduced hormone concentrations seen in relative energy deficiency in sport, supporting self-collected VAMS as a practical tool for regular hormone monitoring in athletes.
Development of an LC-HRMS/MS Method for Quantifying Steroids and Thyroid Hormones in Capillary Blood: A Potential Tool for Assessing Relative Energy Deficiency in Sport (RED-S) — Tuma et al., Metabolites
- blood
- dried
- vams
- neoteryx-mitra
- validation
- hormones
2024
Flexibility of location and time were the most motivating factors for people with type 2 diabetes to participate in decentralised clinical trials. Digital infrastructure, literacy, home visits, personal interaction, and healthcare professional relationships could be either enablers or barriers depending on individual preferences, suggesting these must be addressed in trial design.
What motivates people with type 2 diabetes mellitus to participate in clinical trials from home? — Kopanz et al., Clinical and translational science
- acceptability
- dct
2024
Self-sampled multi-anatomic site testing for CT/NG in community MSM uncovered a substantial burden of undiagnosed infection, with 21% positivity overall and higher yields from rectal and pharyngeal swabs than urine, indicating that decentralised self-sampling can complement clinic-based screening.
Self-sampled multi-anatomic site testing for uncovering the community burden of undiagnosed Chlamydia trachomatis and Neisseria gonorrhoeae infection in men who have sex with men — Wong et al., Infection (paywalled)
- urine
- self-collection
- sti
2024
The saliva-STAT platform uses a battery-powered handheld instrument and a low-cost cassette to perform a fully automated nucleic acid amplification test on directly dispensed saliva, detecting SARS-CoV-2 at 0.2 copies per microlitre. This enables accurate, decentralised testing in walk-in and mobile clinics and at home, and can be adapted for other respiratory viruses.
Saliva-STAT: Sample-to-answer saliva test for COVID-19 — Boegner et al., Sensors and actuators. B, Chemical (paywalled)
- saliva
- self-collection
2024
This study found that dried blood spot samples stored at room temperature for four years correlated highly with serum measurements for testosterone and androstenedione, indicating that hematocrit adjustment may be unnecessary for serial monitoring in home-based self-sampling.
Dried blood spot sampling of testosterone microdosing in healthy females — Desai et al., The Journal of steroid biochemistry and molecular biology (paywalled)
- blood
- dried
- capillary
- dbs
- self-collection
- validation
- venous-agreement
- fertility
- hormones
- haematocrit
2024
The study found that DBS testing showed high specificity for HIV, HBV and HCV and perfect sensitivity for HIV and HBV, but lower sensitivity for syphilis and HCV, with creatinine measurements slightly higher than venous samples. Despite challenges in sample adequacy, DBS was acceptable to participants and could support decentralised STI and renal monitoring in men who have sex with men.
Use of Home-Based Self-Collected Dried Blood Spots to Test for Syphilis, Human Immunodeficiency Virus, Hepatitis C and B Virus Infections and Measuring Creatinine Concentration — Nieuwenburg et al., Sexually transmitted diseases
- blood
- dried
- dbs
- self-collection
- venous-agreement
- acceptability
- serology
- sti
2024
The study found that HPV16-specific neutralizing antibodies can be reliably detected in first-void urine samples, with strong correlation to serum levels, supporting the use of this virtually painless, self-collected sample for monitoring immune response in a decentralised setting.
HPV-specific antibodies in female genital tract secretions captured via first-void urine retain their neutralizing capacity — Téblick et al., Human vaccines & immunotherapeutics
- urine
- first-void
- serology
- hpv
2024
An on-line SPE-LC-MS method using 10 microlitre capillary blood samples collected on VAMS tips achieved lower limits of quantitation of 0.03 micromolar for methotrexate and 7-OH-MTX and 0.05 micromolar for DAMPA, with acceptable accuracy and precision. A plasma-to-whole-blood correlation factor of 0.46 was observed, supporting low-volume pediatric drug monitoring.
Development and validation of a bioanalytical method for the quantification of methotrexate from serum and capillary blood using volumetric absorptive microsampling (VAMS) and on-line solid phase extraction (SPE) LC-MS — Opitz et al., Journal of chromatography. A (paywalled)
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- pediatric
- tdm
- oncology
2024
The study validated a VAMS-based method for measuring cenobamate in capillary blood, showing high precision accuracy and stability at room temperature for up to 15 days. Cenobamate levels in VAMS samples agreed with those in venous plasma, supporting its use in decentralised therapeutic drug monitoring for epilepsy patients.
A VAMS-based LC-MS/MS method for precise cenobamate quantification in epilepsy (patients) — Pigliasco et al., Epilepsia open
- blood
- dried
- vams
- validation
- venous-agreement
- tdm
2024
An LC-MS/MS method for seven antiepileptic drugs was validated using dried blood and dried plasma spots, showing acceptable precision and accuracy. Samples remained stable for seven days at ambient temperature and 40°C, with good correlation to wet plasma concentrations, supporting decentralised therapeutic drug monitoring with self-collection and room-temperature transport.
Simultaneous monitoring of seven antiepileptic drugs by dried blood spot and dried plasma spot sampling: method validation and clinical application of a LC-MS/MS-based technique — Cao et al., Journal of pharmaceutical and biomedical analysis (paywalled)
- blood
- dried
- dbs
- validation
- venous-agreement
- tdm
2024
Routine clinic-based cervical sampling generated 3670 g CO2e per sample, whereas vaginal self-sampling produced 423 g CO2e and first-void urine collection produced 570 g CO2e. Decentralised self-collection approaches substantially lowered emissions by eliminating primary care clinic visits.
A comparison of the carbon footprint of alternative sampling approaches for cervical screening in the UK: A descriptive study — Whittaker et al., BJOG : an international journal of obstetrics and gynaecology (paywalled)
- urine
- first-void
- self-collection
- economics
- hpv
- sti
2024
Self-collected saliva without additives showed comparable diagnostic performance to nasopharyngeal swabs for SARS-CoV-2 detection, with 87.6% sensitivity and 99.6% specificity. The sample remained stable for 72 hours and was deemed acceptable by both patients and staff, supporting its use in decentralised, patient-centric screening programmes.
Diagnostic performance, stability, and acceptability of self-collected saliva without additives for SARS-CoV-2 molecular diagnosis — Marín-Echeverri et al., European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (paywalled)
- saliva
- self-collection
- validation
- acceptability
- serology
2024
A validated high-throughput LC-MS/MS assay for piperaquine from dried blood spots achieved 54-72% recovery with <9% relative standard deviation and a quantification limit of 3 ng/mL, enabling detection for 4-8 weeks post-dose. The method showed minimal haematocrit interference and is suitable for therapeutic drug monitoring of antimalarial treatment in resource-limited settings and pediatric populations.
A high-throughput LC-MS/MS assay for piperaquine from dried blood spots: Improving malaria treatment in resource-limited settings — Blessborn et al., Journal of mass spectrometry and advances in the clinical lab
- blood
- dried
- capillary
- dbs
- validation
- tdm
- antimicrobials
- haematocrit
2024
This pilot study of 15 subjects demonstrated that dried fecal spots on quantitative DBS devices yielded bile acid profiles equivalent to frozen samples after four months of ambient storage and shipping. This validates a decentralised stool microsampling method that could enable patient home testing and expand screening in rural or resource-limited settings.
Repurposing dried blood spot device technology to examine bile acid profiles in human dried fecal spot samples — Engevik et al., American journal of physiology. Gastrointestinal and liver physiology (paywalled)
- stool
- dried
- qdbs
- self-collection
- validation
- metabolome
2024
The OncoPredict HPV Quantitative Typing assay achieved clinical sensitivity ratios of 0.99 for urine and 1.00 for vaginal self-samples versus clinician-collected cervical samples for detecting CIN2+, and after cut-off optimisation showed similar accuracy on self-collected and cervical specimens, supporting decentralised cervical screening through urine self-collection with Colli-Pee.
Clinical accuracy of OncoPredict HPV Quantitative Typing (QT) assay on self-samples — Latsuzbaia et al., Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology (paywalled)
- urine
- first-void
- colli-pee
- self-collection
- validation
- hpv
- sti
2024
Self-collected first-void urine using the Colli-Pee device detected high-risk HPV with 96.7 per cent concordance compared with clinician-collected cervical swabs in 240 women, with a Cohen's kappa of 0.87, indicating strong agreement and supporting urine self-collection as an acceptable approach for HPV screening.
Comparable detection of HPV using real-time PCR in paired cervical samples and concentrated first-stream urine collected with Colli-Pee device — Nilyanimit et al., Diagnostic microbiology and infectious disease
- urine
- first-void
- colli-pee
- self-collection
- validation
- hpv
2024
Volumetric absorptive microsampling (VAMS) yielded superior classification of fibromyalgia and long COVID compared with dried blood spots when analysed by surface-enhanced Raman spectroscopy, delivering 100% accuracy, sensitivity and specificity with an area under the curve of 0.86. The method identified discriminatory metabolites from low-molecular-weight blood fractions, showing that VAMS can support decentralised metabolomic diagnostics for syndromes with overlapping clinical features.
Surface-Enhanced Raman Spectroscopy Combined with Multivariate Analysis for Fingerprinting Clinically Similar Fibromyalgia and Long COVID Syndromes — Nuguri et al., Biomedicines
- blood
- dried
- vams
- neoteryx-mitra
- metabolome
- biomarkers
2024
This review of 2022 to 2023 work surveys dried blood microsampling for targeted and untargeted metabolomic and lipidomic profiling, finding the approach viable across paediatric research, therapeutic drug monitoring, metabolite screening, biomarker discovery, sports supervision, clinical disorder studies and forensic toxicology. The authors note that dried blood spots and VAMS dominate the published literature over other volumetric formats, and argue that harmonising analytical methods would accelerate wider clinical adoption of microsampling as an alternative to conventional plasma or serum profiling.
Targeted and untargeted metabolomics and lipidomics in dried blood microsampling: Recent applications and perspectives — Couacault et al., Analytical science advances
- blood
- dried
- vams
- dbs
- validation
- pediatric
- tdm
- toxicology
- metabolome
- biomarkers
2024
The study found that higher cumulative doses and more treatment cycles of nab-paclitaxel, along with older age, are linked to increased frequency and severity of peripheral neuropathy in pancreatic cancer patients. VAMS was shown to be a feasible, minimally invasive alternative to venous sampling for monitoring drug levels, supporting its use in patient-centric, decentralised care.
Factors affecting peripheral neuropathy induced by nanoparticle albumin-bound paclitaxel in patients with pancreatic cancer — Kang et al., British journal of clinical pharmacology
- blood
- dried
- vams
- neoteryx-mitra
- tdm
- oncology
2024
This review of remote HbA1c testing via capillary blood microsampling finds that both dried and liquid formats can produce results comparable to venous sampling when collection, stability and extraction are properly validated. It matters because self-collected microsamples could enable decentralised diabetes monitoring and telemedicine, but heterogeneity in study designs and methods must be resolved before reliable implementation.
Remote HbA<sub>1c</sub> testing via microsampling: fit for purpose? — Verougstraete et al., Clinical chemistry and laboratory medicine (paywalled)
- blood
- liquid
- dried
- capillary
- self-collection
- validation
- venous-agreement
- acceptability
2024
The authors validated a dried blood spot method for simultaneous measurement of vancomycin and creatinine with a 5.2-minute run time, demonstrating linear ranges suitable for therapeutic drug monitoring. This supports home-based sampling to reduce the burden of clinic visits for patients requiring vancomycin monitoring.
Dried blood spot analysis for the quantification of vancomycin and creatinine using liquid chromatography - tandem mass spectrometry: Method development and validation — Bahmany et al., Clinica chimica acta; international journal of clinical chemistry (paywalled)
- blood
- dried
- dbs
- validation
- tdm
- antimicrobials
2024
The Xpert CT/NG assay showed high specificity and moderate-to-high sensitivity for chlamydia and gonorrhoea in urine and rectal specimens, though pharyngeal sensitivity was lower. High acceptability among men who have sex with men and rapid turnaround support its use for decentralised STI screening with immediate treatment initiation.
Clinic-based evaluation of the dual Xpert CT/NG assay on the GeneXpert System for screening for extragenital chlamydial and gonococcal infections amongst men who have sex with men — Cordioli et al., BMC infectious diseases
- urine
- first-void
- validation
- acceptability
- sti
2024
This study validated a method for measuring six oral anticancer drugs and their metabolites in 10 μL dried whole blood collected by VAMS. The method remained stable for 14 days at room temperature during shipping and up to nine months when frozen, supporting its use for decentralised therapeutic drug monitoring and reducing the need for clinic visits.
Analytical Validation of a Volumetric Absorptive Microsampling Method for Therapeutic Drug Monitoring of the Oral Targeted Anticancer Agents, Abiraterone, Alectinib, Cabozantinib, Imatinib, Olaparib, and Sunitinib, and Metabolites — Meertens et al., Therapeutic drug monitoring (paywalled)
- blood
- dried
- vams
- validation
- tdm
- oncology
2024
In a qualitative study of 100 service users, online postal self-sampling for STIs was valued for privacy and for overcoming barriers such as limited clinic appointments, although blood self-sampling proved challenging for most participants. Users favoured retaining clinic access for broader sexual health support, indicating that decentralised testing works best as part of a hybrid model rather than a complete replacement.
How does online postal self-sampling (OPSS) shape access to testing for sexually transmitted infections (STIs)? A qualitative study of service users — Spence et al., BMC public health
- blood
- self-collection
- acceptability
- sti
2024
Among 105 women with grade 1 cervical intraepithelial neoplasia followed for a median 20 months, 29.3% experienced disease progression or persistence, which was significantly predicted by HPV positivity in physician- and self-collected samples. In 59 women with grade 2 disease followed for a median 12 months, half showed progression or persistence, but HPV status from physician-, self-, or urine-collected samples did not predict outcomes. Self-collection may enable decentralised risk stratification for CIN 1 surveillance.
Human papillomavirus self-sampling and urine-sampling tests and the management and short-term outcomes of cervical intraepithelial neoplasia: A prospective observational study — Matsuura et al., The journal of obstetrics and gynaecology research (paywalled)
- urine
- self-collection
- hpv
- sti
2024
The study developed a one-pot duplex RT-LAMP assay for saliva that detects SARS-CoV-2 down to 100 copies per microlitre within 30 minutes without RNA extraction, using human 18S ribosomal RNA as an internal amplification control. In 30 clinical saliva samples the assay achieved 95 per cent sensitivity, 100 per cent specificity and 96 per cent accuracy, supporting reliable at-home and point-of-care molecular diagnostics.
Development of an integrated sample amplification control for salivary point-of-care pathogen testing — Sritong et al., Analytica chimica acta (paywalled)
- saliva
- self-collection
- validation
2024
In 60 healthy young adults who self-collected saliva, habitual coffee consumption at low, moderate or high intake did not significantly alter morning or evening levels of salivary cortisol or alpha amylase under non-stressful conditions. This suggests that for decentralised diagnostics, coffee drinking is unlikely to confound salivary hormone results, supporting the validity of self-collection for cortisol and stress biomarker monitoring.
[Effects of coffee consumption on salivary cortisol and alpha amylase in young adults] — Alejandro Juárez & Celia, Revista cientifica odontologica
- saliva
- self-collection
- hormones
- cortisol
2024
Self-collected saliva for SARS-CoV-2 RT-PCR showed high sensitivity and specificity with an overall agreement of 84% compared with nasopharyngeal swabs, supporting its use as a viable diagnostic option where laboratory facilities are limited.
MOLECULAR DETECTION PROTOCOL OF SARS-COV-2 THROUGH SELF-COLLECTED SALIVA SPECIMENS VERSUS NASOPHARYNGEAL SWABS — Abderezak et al., African journal of infectious diseases
- saliva
- self-collection
- validation
- pediatric
- serology
2024
Self-collected unpreserved saliva samples gave SARS-CoV-2 detection that was only slightly less accurate than nasopharyngeal swabs, offering a more convenient patient-centric alternative for COVID-19 surveillance and potentially increasing testing in decentralised settings.
Evaluation of Self-collected Saliva Samples Without Viral Transport Media for SARS-CoV-2 Testing via RT-PCR and Comparison of Amplicon Sequences Against Commonly Used Primers in Diagnostic Assays — Ramos et al., Military medicine (paywalled)
- saliva
- liquid
- self-collection
- validation
- serology
2024
Self-collected saliva samples for SARS-CoV-2 testing yielded higher viral loads than nasal or urine specimens and showed moderate agreement (kappa 0.52) with nasal swabs. A colourimetric LAMP assay achieved 90% concordance with RT-PCR, offering a rapid alternative deployable in clinics, workplaces, and homes for decentralised surveillance.
Evaluation of self-collected nasal, urine, and saliva samples for molecular detection of SARS-CoV-2 using an EUA approved RT-PCR assay and a laboratory developed LAMP SARS-CoV-2 test — Purcell-Wiltz et al., Immunity, inflammation and disease
- saliva
- urine
- self-collection
- validation
- serology
2024
Self-collection of saliva for cortisol awakening response research at home was experienced as arduous, with participants reporting apprehension, cognitive burden, and disruption to sleep and morning routines. Difficulty identifying the moment of awakening affected sample timing, though habituation reduced these effects over repeated days, indicating that clear protocols are needed to improve ecological validity in decentralised hormone monitoring.
<b>Experiences of participating in cortisol awakening response research:</b> <i>"I was more conscious</i> <i>than usual, I wanted to get it right</i> <i>"</i> — Ramachandran et al., Comprehensive psychoneuroendocrinology
- saliva
- self-collection
- acceptability
- hormones
- cortisol
2024
Two cases of sexually acquired reactive arthritis secondary to Chlamydia trachomatis were diagnosed by PCR on first-void urine. This demonstrates that urine-based molecular testing can identify the infectious trigger in reactive arthritis, supporting decentralised STI screening and subsequent rheumatology referral.
Chronic sexually acquired reactive arthritis secondary to Chlamydiatrachomatis — Basu et al., Indian journal of medical microbiology (paywalled)
- urine
- first-void
- sti
2024
Three freeze-thaw cycles, Virkon disinfectant, and air drying on Mitra microsamplers for two hours each inactivated Trypanosoma cruzi in spiked blood, while FTA C cards failed. These validated methods permit safe removal of infectious samples from containment facilities for storage and analysis, supporting decentralised diagnostics.
Validation of Trypanosoma cruzi inactivation techniques for laboratory use — MacLean et al., PloS one
- blood
- dried
- vams
- neoteryx-mitra
- validation
- serology
2024
Epstein-Barr virus DNA methylation in self-collected saliva and oropharyngeal swabs demonstrated superior diagnostic performance for nasopharyngeal carcinoma compared with oral swabs or mouthwash. Combining both sample types and two promoter methylation markers could optimise decentralised, patient-centric screening programmes.
Detection of Epstein‒Barr virus DNA methylation as tumor markers of nasopharyngeal carcinoma patients in saliva, oropharyngeal swab, oral swab, and mouthwash — Zheng et al., MedComm
- saliva
- self-collection
- biomarkers
- liquid-biopsy
2024
Dried blood microsamplers (Mitra) and dried blood spots maintained metabolite stability comparable to plasma at minus 80 degrees Celsius, and both dried formats remained stable at minus 20 degrees Celsius while plasma showed reduced stability. At refrigerated temperature, Mitra microsampler profiles were more stable than plasma or dried blood spots, particularly for lipids, suggesting capillary blood microsampling could support sample collection outside clinical settings where ultra-cold storage is unavailable.
Effects of storage temperature and time on metabolite profiles measured in dried blood spots, dried blood microsamplers, and plasma — Petrick et al., The Science of the total environment (paywalled)
- blood
- dried
- capillary
- vams
- dbs
- neoteryx-mitra
- validation
- metabolome
2024
Filtered protein precipitation was the most effective extraction method for 75 per- and polyfluoroalkyl substances from dried blood spots collected with a capillary microsampler, recovering 72 analytes within 70–130% with limits of detection from 0.05 to 0.34 ng/mL. The method detected 16 PFAS in self-collected human samples, demonstrating feasibility for large-scale biomonitoring studies using minimally invasive sampling.
Validating blood microsampling for per- and polyfluoroalkyl substances quantification in whole blood — Partington et al., Journal of chromatography. A (paywalled)
- blood
- dried
- capillary
- dbs
- validation
- toxicology
2024
Among 1,423 people who use drugs across 21 community centres, a decentralised care programme using dried blood spot testing achieved a 93% cure rate in those who completed hepatitis C therapy and were monitored. Over 90% of participants accepted the decentralised screening and treatment approach, showing patient-centric microsampling can improve healthcare access for stigmatised populations.
Implementing a new HCV model of care for people who use drugs — Herranz Mochales et al., JHEP reports : innovation in hepatology
- blood
- dried
- dbs
- acceptability
- dct
- serology
2024
The survey of 80 clinical research stakeholders in India highlights the growing adoption of remote data capture, wearables, and digital biomarkers in decentralized clinical trials, driven by the COVID-19 pandemic, while also identifying key challenges that need to be addressed for wider implementation.
The role of remote data capture, wearables, and digital biomarkers in decentralized clinical trials — Chodankar et al., Perspectives in clinical research
- dct
- wearable
- rpm
- digital-biomarker
2024
The authors propose applying the ICH E9(R1) estimand framework to decentralised clinical trials to systematically evaluate each decentralisation component. This approach reveals how off-site data collection changes the scientific questions being addressed, exposing both new opportunities and hidden assumptions that affect trial validity.
Decentralized Clinical Trials: Scientific Considerations Through the Lens of the Estimand Framework — Izem et al., Therapeutic innovation & regulatory science (paywalled)
- dct
2024
High-risk HPV prevalence was 34.3% among HIV-positive women in Ugandan ART clinics, with non-16/18 genotypes predominating; self-collected vaginal sampling is feasible and supports integrating cervical screening into HIV care.
Prevalence of genital high-risk human papillomavirus infections and associated factors among women living with human immunodeficiency virus in Uganda — Nakigozi et al., BMC cancer
- self-collection
- hpv
- sti
2024
Molecular point-of-care testing on self-collected urine proved feasible and achieved high linkage to treatment among street-based female sex workers in Madrid, with an overall STI prevalence of 66 per cent and a strong association between recent drug use and STI infection.
On-site testing and treatment of sexually transmitted infections among female sex workers using molecular point-of-care testing integrated into harm reduction services in Madrid, Spain — Valencia et al., The International journal on drug policy (paywalled)
- urine
- self-collection
- sti
2024
A graphene lab-on-a-chip device achieved high accuracy and precision for multiplex renal biomarker testing in serum and saliva, with sensitivities ranging from 89.0 to 99.7 per cent. Untrained volunteers produced results comparable to trained chemists, suggesting the device is suitable for patient-centric at-home diagnostics and could improve access to chronic kidney disease monitoring.
Noninvasive and Multiplex Self-Test of Kidney Disease Biomarkers with Graphene-Based Lab-on-a-Chip (G-LOC): Toward Digital Diagnostics in the Hands of Patients — Diforti et al., Analytical chemistry (paywalled)
- saliva
- self-collection
- validation
- acceptability
- biomarkers
2024
Capillary dried blood spots collected during professional triathlon competitions detected endogenous erythropoietin in all 111 athletes using Tasso-M20 devices, even when matching urine samples were negative. Mitra VAMS devices also sensitively detected recombinant EPO micro-doses and the EPO c.577del variant, confirming that microsampling provides a viable complementary matrix for decentralised doping analysis.
Dried blood spots for erythropoietin analysis: Detection of micro-doses, EPO c.577del variant and comparison with in-competition matching urine samples — Heiland et al., Drug testing and analysis (paywalled)
- blood
- dried
- capillary
- vams
- dbs
- neoteryx-mitra
- validation
- doping
2024
Most women were confident using vaginal self-sampling kits and trusted the results, with 71 percent preferring self-sampling over clinician-collected tests for future screening. However, preferences varied by ethnicity and prior screening status, and a significant minority preferred urine-based tests, suggesting that offering choice between sampling methods will improve uptake in decentralised cervical screening programmes.
Experiences of Self-Sampling and Future Screening Preferences in Non-Attenders Who Returned an HPV Vaginal Self-Sample in the YouScreen Study: Findings From a Cross-Sectional Questionnaire — Drysdale et al., Health expectations : an international journal of public participation in health care and health policy
- self-collection
- acceptability
- hpv
2024
Dried blood spots stored at ambient temperature for up to 15 years retained sufficient DNA quantity and integrity for some genomic applications, but were of limited use for viral pathogen research, especially RNA viruses. This suggests DBS can support decentralised genomics but may not be reliable for RNA virus diagnostics without additional stabilisation.
Nucleic acid degradation after long-term dried blood spot storage — Li et al., Molecular ecology resources
- blood
- dried
- dbs
2024
Sixty-nine metabolites in dried blood spots remained stable across storage temperatures of 4°C, 25°C and 40°C for 21 days, whereas seventy-eight metabolites showed instability, with phosphatidylcholines and triglycerides most affected. This demonstrates that storage conditions materially alter metabolite integrity, which is critical for biomarker selection and data quality in patient-centric, home-sampling protocols.
Evaluation of metabolite stability in dried blood spot stored at different temperatures and times — Cui et al., Scientific reports
- blood
- dried
- dbs
- metabolome
- biomarkers
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