The Library
1530 papers on microsampling and monitoring, each with a finding paraphrased to our standard and labelled in one vocabulary. Every entry links to a legitimate copy; nothing is copied from an abstract.
Papers 1–100 of 541 labelled “dried”, newest first.
2026
In AML and CLL, 91% of VAMS venetoclax results fell within 20% of plasma after individualised haematocrit correction; in home sampling, 18 of 21 patients self-sampled independently and 76% of returned samples were analysable, which shows home microsampling is workable, though the authors ask for multicentre validation.
Clinical Validation of Venetoclax Volumetric Microsampling in Leukemia, with Whole-Blood-to-Plasma Conversion and Self-Microsampling Feasibility — Levens et al., Clinical Pharmacokinetics (paywalled)
- vams
- venous-agreement
- blood
- dbs
- tdm
- self-collection
- haematocrit
- dried
- oncology
- capillary
- validation
2026
Guidance on capillary-to-plasma conversion: method- and analyte-specific clinical validation with paired capillary–venous samples before reporting plasma-equivalent results.
To Convert or Not to Convert? Official IATDMCT Guideline on Converting Capillary-Blood Microsampling Concentrations to Plasma Concentrations — Boffel et al., Therapeutic Drug Monitoring (paywalled)
- venous-agreement
- blood
- tdm
- standards
- dried
- capillary
- validation
2026
The analysis indicates that dried blood spots and volumetric absorptive microsampling enable minimally invasive monitoring of prohibited substances, with volumetric absorptive microsampling offering improved quantitative reliability over traditional dried spots.
Liquid Chromatographic Methods for Microsampling in Sports Drug Monitoring: Progress in DBS and VAMS — Zhang, Biomedical chromatography : BMC (paywalled)
- vams
- doping
- blood
- dbs
- dried
- steroids
- toxicology
- hormones
- validation
- biomarkers
2026
At-home volumetric absorptive microsampling (VAMS) for anti-seizure medicines was feasible and reliable, with strong correlations to clinic VAMS and low bias for lacosamide, lamotrigine and levetiracetam; quantitative dried blood spot (qDBS) was a reliable alternative in the ambulatory setting, though older age reduced sampling quality.
Real-world evaluation of capillary microsampling for drug monitoring of anti-seizure medications — Cancellerini et al., Epilepsia (paywalled)
- vams
- venous-agreement
- acceptability
- blood
- qdbs
- tdm
- self-collection
- dried
- capillary
2026
Researchers successfully validated an analytical method for measuring creatinine across plasma and volumetric absorptive microsampling devices, demonstrating strong correlation between conventional plasma and dried microsamples. This provides a reliable, patient-centric approach for monitoring kidney function remotely during transplant follow-up.
Surrogate-based LC-MS/MS quantification of endogenous creatinine in plasma, plasma-equivalent dried spots (qDPS), and volumetric absorptive microsampling (VAMS): an ICH M10-compliant bridging study — Kocur et al., European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences (paywalled)
- vams
- venous-agreement
- neoteryx-mitra
- blood
- dried
- validation
- biomarkers
2026
In lung and renal transplant recipients, VAMS sampling with LC-MS/MS quantification of mycophenolic acid and tacrolimus showed good linearity and accuracy, and with a haematocrit-adjusted conversion formula achieved clinical agreement in most samples; tacrolimus did not require haematocrit correction. The approach is virtually painless and enables richer sampling for more accurate drug exposure estimates, supporting decentralised therapeutic drug monitoring.
Evaluation of hematocrit-adjusted conversion strategies for mycophenolic acid and tacrolimus monitoring using volumetric absorptive microsampling in lung and renal transplant recipients — Juan et al., Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
- blood
- dried
- vams
- neoteryx-mitra
- validation
- venous-agreement
- tdm
- immunosuppressants
- haematocrit
2026
This review found that volumetric microsampling devices, such as Mitra, HemaPEN, HemaXis DB10, and Tasso-M20, overcome haematocrit bias, whilst Telimmune plasma separation cards enable direct plasma collection without centrifugation. These technologies support patient-centric, decentralised sampling, though the authors note that clinical validation remains limited across different drugs and patient populations.
A Review of Blood-Based Microsampling Devices for Patient-Centered Application in Therapeutic Drug Monitoring — Huhn & Scherf-Clavel, Therapeutic drug monitoring (paywalled)
- vams
- volumetric
- acceptability
- neoteryx-mitra
- blood
- dbs
- tdm
- self-collection
- haematocrit
- dried
- capillary
- validation
2026
In 15 critically ill children with multiple organ dysfunction, a population pharmacokinetic model built on volumetric absorptive microsamples found that estimated glomerular filtration rate and age drove cefepime clearance and distribution; the authors take this as showing the method is workable for antimicrobial monitoring in this group.
Cefepime pharmacokinetics in critically ill children with multiple organ dysfunction syndrome using volumetric absorptive microsampling — Amajor et al., Antimicrobial agents and chemotherapy
- blood
- dried
- vams
- pediatric
- tdm
- antimicrobials
2026
Volumetric absorptive microsampling showed better precision than dried blood spots and a metabolic profile closer to whole blood, with stable signalling lipids for 24 hours at room temperature but significant changes after one week unless stabilised, indicating feasibility for decentralised sampling with the need for storage strategies.
Volumetric absorptive microsampling for profiling of signaling lipids: a comparative analysis with whole blood and dried blood spots — Thangavelu et al., Analytical and bioanalytical chemistry
- vams
- volumetric
- blood
- dbs
- metabolome
- dried
- validation
- biomarkers
2026
This study found that volumetric absorptive microsampling shows satisfactory agreement with venous plasma for monitoring several antiseizure medications in paediatric patients. However, a blood-to-plasma conversion factor was required to estimate plasma concentrations for clobazam and carbamazepine metabolites due to poor capillary-to-plasma interchangeability.
Volumetric Absorptive Microsampling (VAMS) for Therapeutic Drug Monitoring of Antiseizure Medications (ASMs) in Pediatric Patients — Simeoli et al., Pharmaceuticals (paywalled)
- blood
- dried
- vams
- validation
- venous-agreement
- pediatric
- tdm
2026
An LC-MS/MS method for tamoxifen and six metabolites in VAMS was developed and validated, with water prerinsing improving recoveries and poor room temperature stability but stability for at least 100 days at minus 80 degrees Celsius. Plasma to blood ratios were used to estimate plasma equivalent concentrations, and paired VAMS and plasma samples from ten breast cancer patients showed strong correlations and good agreement on Bland-Altman analysis, supporting reliable decentralised TDM.
Development and validation of an LC-MS/MS method for the comprehensive quantification of tamoxifen and its metabolites in volumetric absorptive microsampling: clinical application in breast cancer patients — Kuo et al., Analytical and bioanalytical chemistry (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- venous-agreement
- tdm
- oncology
2026
VAMS gave near‑quantitative recovery for cadmium and lead in human blood and correlated strongly with venous sampling, with pre‑cleaning improving correlation and lowering background lead, supporting its use for decentralised biomonitoring of these toxic elements.
Application of volumetric absorptive microsampling (VAMS) for the simultaneous determination of cadmium and lead in blood — Gutknecht et al., Environmental monitoring and assessment (paywalled)
- vams
- venous-agreement
- blood
- dried
- toxicology
- validation
2026
A post-mortem case study found that Mitra microsampling devices achieved comparable qualitative toxicological detection to conventional methods across blood, urine, bile, and vitreous humour, successfully identifying methamphetamine, opioids, and alpha-PHP. Whilst limited to a single case, this shows that microsampling is a viable alternative for qualitative screening when sample volumes are restricted.
Volumetric absorptive microsampling device for forensic Toxicologic screening: A case report as proof-of-concept — Magny et al., Forensic science international (paywalled)
- blood
- urine
- dried
- vams
- neoteryx-mitra
- toxicology
2026
This method validation for 15 cardiovascular drugs found that VAMS and Capitainer-B provided interchangeable patient results, although Capitainer-B showed higher matrix effects while VAMS exhibited stability losses for specific analytes after two weeks. The work confirms the suitability of these microsampling workflows for decentralised adherence monitoring but highlights the need for analyte-specific stability testing.
Capillary blood microsampling and LC-Orbitrap analysis for adherence monitoring of cardiovascular drugs: method development, cross-validation, and patient proof-of-concept using VAMS and Capitainer-B — Kretschmer et al., Talanta (paywalled)
- vams
- volumetric
- blood
- tdm
- dried
- capillary
- validation
2026
A liquid chromatography-tandem mass spectrometry method was successfully validated for measuring androstenedione, 17α-hydroxyprogesterone, and 11-ketotestosterone in dried blood samples collected via volumetric absorptive microsampling. The dried samples remained stable at room temperature for up to a week and after postal transit, and plasma concentrations could be reliably estimated from the microsamples when adjusting for haematocrit.
Analytical validation of a dried blood microsampling method to measure androstenedione, 17α‑hydroxyprogesterone, and 11‑ketotestosterone for congenital adrenal hyperplasia monitoring — De Baets et al., Talanta (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- venous-agreement
- pediatric
- hormones
- haematocrit
2026
Capillary dried blood spots, after haematocrit-dependent conversion, showed good agreement with plasma for 25-hydroxyvitamin D quantification, with 90 per cent of results within 20 per cent of plasma and substantial to almost perfect agreement in status classification, supporting reliable home self-collection for large-scale vitamin D monitoring.
Clinical validation of a DBS-based LC-MS/MS method for 25-hydroxyvitamin D: from lab sampling to home sampling — Heughebaert et al., Clinical chemistry and laboratory medicine (paywalled)
- venous-agreement
- blood
- dbs
- self-collection
- haematocrit
- dried
- capillary
- validation
- biomarkers
2026
For decentralised testing, a study found dry vaginal self-samples using Copan FLOQSwabs stored up to two weeks at room temperature maintain DNA quality. However, first-void urine collected with the Colli-Pee device may be less sensitive for HPV detection, showing lower positivity and higher cycle threshold values, median Ct 30 versus 27 for other samples.
Evaluation of the Quality and Suitability of Self-Collected Vaginal and Urine Samples for Human Papillomavirus Testing: A Prospective Matched Study — Chu et al., BJOG : an international journal of obstetrics and gynaecology
- colli-pee
- first-void
- sti
- self-collection
- dried
- hpv
- urine
- validation
2026
An optimised VAMS workflow for blood proteomics increased protein identifications 4-fold in plasma and 2.1-fold in whole blood compared with liquid processing, with mean CVs below 11%, and whole blood showed greater robustness and storage stability at room temperature for up to 14 days. This enables reliable patient-centric microsampling for longitudinal biomarker studies.
Advancing Blood Proteome Analysis Past the Plasma Age: Mass Spectrometry of Whole Blood and Plasma Collected with Volumetric Absorptive Microsampling Devices — Karsten et al., Journal of proteome research (paywalled)
- vams
- neoteryx-mitra
- blood
- dried
- validation
- biomarkers
2026
The study found that self-collection of dried blood spots and other samples using at-home kits was a useful and cost-effective method for screening a large cohort for sexually transmitted infections outside a clinic. This demonstrates the feasibility of decentralised, patient-centric sampling for population-level infectious disease surveillance.
Prevalence of chlamydial, gonococcal and syphilis positivity by anatomical site and sex via self-collected biospecimens using at-home testing kits among a large and diverse cohort of men and women enrolled in the MACS/WIHS Combined Cohort Study (MWCCS) in the USA — Mimiaga et al., Sexually transmitted infections (paywalled)
- blood
- sti
- dbs
- self-collection
- dried
- serology
- bd-microtainer
- urine
2026
The study found that capillary dried plasma spots correlated strongly with venous plasma for detecting the Alzheimer's disease biomarker p-tau217. This suggests that microsampling offers a viable, minimally invasive alternative to venipuncture for screening and monitoring Alzheimer's disease pathology.
A minimally invasive dried blood spot biomarker test for the detection of Alzheimer's disease pathology — Huber et al., Nature medicine
- blood
- dried
- capillary
- dbs
- venous-agreement
- biomarkers
2026
The study found that although participants preferred patient-centric microsampling devices for home use, the agreement with venous plasma for measuring CRP and cytokines was inconsistent, indicating that further validation is required before these methods replace standard venipuncture.
Limited agreement of cytokines and CRP through patient-centric microsampling compared to venipuncture in healthy adults — Tuttle et al., Bioanalysis (paywalled)
- dct
- venous-agreement
- acceptability
- blood
- dbs
- self-collection
- dried
- biomarkers
2026
This study found that self-collected vaginal dry swabs provided noninferior sensitivity for detecting high-grade cervical lesions compared to practitioner-collected samples, although specificity was lower.
Clinical Validation of the Roche cobas and cobas 4800 Human Papillomavirus Tests on Self-Collected Vaginal Dry Swabs versus Practitioner-Collected Cervical Specimens Using the VALHUDES Protocol — Hawkes et al., The Journal of molecular diagnostics : JMD (paywalled)
- sti
- self-collection
- dried
- hpv
- validation
2026
Dried urine strips demonstrated high diagnostic accuracy and stability for chlamydia and gonorrhea detection compared to standard urine samples. This method supports decentralised screening by allowing self-collection and ambient temperature transport without compromising sample integrity.
Development and evaluation of dried urine strip for genital chlamydia and gonorrhea testing — Gibbons et al., Journal of clinical microbiology
- sti
- self-collection
- dried
- urine
- validation
- genotyping
2026
The study found that self-collected dried saliva on FishburneTabs achieved 92% accuracy for viral RNA detection compared to standard liquid saliva samples. This method supports decentralised testing by enabling reliable sample storage and transport for upper respiratory infections.
Validation of Dried Saliva for Molecular Diagnostics — Mora et al., ACS measurement science au
- self-collection
- dried
- serology
- validation
- saliva
2026
The study validated a semi-quantitative protocol for Epstein-Barr virus serology using dried blood spots, demonstrating 98.8% sensitivity and 96.5% specificity compared to paired venous serum samples. The successful validation in a self-sampling cohort confirms the suitability of this patient-centric microsampling approach for large-scale seroprevalence studies and decentralised trials.
A dried blood spot protocol for high-throughput semi-quantitative analysis of Epstein-Barr Virus VCA IgG and EBNA IgG serologies based on the Roche Elecsys system — Rubio-Acero et al., Virology journal
- blood
- dried
- capillary
- dbs
- self-collection
- validation
- venous-agreement
- serology
2026
This study found that measuring thyroid-stimulating hormone via dried blood spots and a volumetric device showed high agreement with serum results, with classification accuracy exceeding 96 per cent. The volumetric approach demonstrated improved reproducibility and stability, supporting its use for decentralised thyroid function monitoring.
Adaptation of a routine immunoassay analyser for TSH measurement in dried blood spot and volumetric microsampling (Capitainer B50): evaluation for thyroid function testing in adults — Bornikowska et al., Practical laboratory medicine
- blood
- dried
- dbs
- volumetric
- validation
- venous-agreement
- hormones
2026
This study validated a dried blood spot method for tacrolimus monitoring and demonstrated agreement with venous whole blood measurements in kidney transplant recipients. It also found that dried blood spot analysis of the biomarker CXCL-10 was elevated in patients experiencing rejection or infection, supporting its use for decentralised monitoring.
Dried Blood Spot for CXCL-10 and Tacrolimus: Integrated Non-Invasive Monitoring to Guide Personalized Treatment in Adult Kidney Transplant Recipients — Millán et al., Pharmaceuticals
- venous-agreement
- blood
- dbs
- tdm
- dried
- immunosuppressants
- validation
- biomarkers
2026
Dried blood spot sampling achieved high agreement with serum for anti-Trypanosoma cruzi antibody detection, supporting its use in decentralised settings; however, samples collected on Cobas Plasma Separation Cards showed lower antibody index values than serum and Whatman cards, which may reduce sensitivity in low-titre specimens.
Comparison of Cobas Plasma Separation Cards and Whatman filter paper cards versus conventional serum samples for anti-Trypansoma cruzi antibody detection — Silgado et al., PLoS neglected tropical diseases (paywalled)
- blood
- dried
- dbs
- venous-agreement
- serology
2026
Frequent dried blood spot sampling detected early changes in beta-cell function more effectively than mixed-meal tolerance tests or urine ratios, supporting its potential as a decentralised monitoring tool for clinical trials.
Serial Dried Blood Spot C-Peptide Sampling, but Not Urine C-Peptide-to-Creatinine Ratio, Detects Early Preservation of β-Cell Function in New-Onset Type 1 Diabetes: Experience From the USTEKID Trial — Dunseath et al., Diabetes care (paywalled)
- dct
- blood
- dbs
- dried
- pediatric
- urine
- biomarkers
2026
In a 20-person proof-of-concept pilot among veterans with HIV, remote self-collection of dried blood spots for phosphatidylethanol monitoring was feasible and acceptable, with high return and analysis rates and positive feedback; a small first step toward decentralised alcohol biomarker monitoring rather than proof of it.
Remote alcohol biomarker monitoring to promote drinking reductions among people with HIV: A proof-of-concept pilot study — Sheinfil et al., Journal of substance use and addiction treatment (paywalled)
- acceptability
- blood
- dbs
- self-collection
- dried
- biomarkers
2026
Self-collected dried blood spot specimens for phenylketonuria monitoring showed very poor quality initially but improved substantially over a decade with training and education, reducing measurement error and the risk of incorrect clinical interpretation.
Improving self-collected dried blood spot specimens for phenylketonuria monitoring: a 10-year computer vision review of dried blood spot specimen quality — Flynn et al., Clinica chimica acta; international journal of clinical chemistry (paywalled)
- blood
- dbs
- self-collection
- dried
- validation
2026
In a pilot mixed-methods study of youth with HIV, mailed HemaSpot-HF kits enabled home-based dried blood spot collection that participants found feasible and acceptable, supporting remote viral load monitoring and a self-management model for decentralised care.
An Examination of Perceptions and Usage of Dried Blood Spot Biosampling Technology for HIV Viral Load Collection Among Youth with HIV — Gurung et al., AIDS and behavior (paywalled)
- blood
- dried
- dbs
- self-collection
- acceptability
- dct
- serology
2026
Enhanced visual and textual guidance significantly improved the quality of dried blood spots self-collected by children and adolescents, increasing the proportion of acceptable cards from 47.6% to 86.6%, which supports the feasibility of home sampling for therapeutic drug monitoring.
Optimizing Dried Blood Spot Sampling for Children and Adolescents With Autism Spectrum Disorder — Ringeling et al., Therapeutic drug monitoring
- blood
- dried
- dbs
- self-collection
- pediatric
- tdm
2026
The study found that quantitative dried blood spot sampling provided high clinical agreement for tacrolimus and creatinine monitoring, with patients rating the self-collection devices as user-friendly. These results support the feasibility of decentralised therapeutic drug monitoring for immunosuppressants.
Patient-centric capillary dried blood spot sampling for tacrolimus and creatinine monitoring in clinical practice — De Baets et al., Clinical chemistry and laboratory medicine (paywalled)
- blood
- dried
- capillary
- dbs
- qdbs
- self-collection
- venous-agreement
- acceptability
- tdm
- immunosuppressants
2026
This pilot study demonstrated that a fully remote web-based testing programme for sexually transmitted and blood-borne infections was feasible and acceptable overall, although participants encountered specific collection challenges with the dried blood spot component.
Comprehensive at-home sexually transmitted and blood borne infection (STBBI) testing program: A pilot study — Christensen et al., International journal of STD & AIDS
- blood
- urine
- dried
- dbs
- self-collection
- acceptability
- sti
2026
This study employed volumetric absorptive microsampling to collect blood samples from neonates, revealing that existing propofol pharmacokinetic models poorly predicted drug levels in this population. A newly developed meta-model provided accurate predictions, validating the use of patient-centric microsampling for therapeutic drug monitoring in preterm and term infants.
Systematic evaluation of propofol population pharmacokinetic models and development of a literature-supported new meta-model for critically ill preterm and term neonates — Rantanen et al., European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- pediatric
- tdm
2026
This study validated a method for monitoring mycophenolic acid in paediatric patients, demonstrating that quantitative dried plasma spots achieved close agreement with venous plasma. Quantitative dried blood spots showed significant haematocrit-related bias, making the plasma-based format more suitable for decentralised monitoring.
Matrix fidelity in microsampling: Plasma-first LC-MS/MS quantification of mycophenolic acid and MPAG — Kocur et al., Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (paywalled)
- venous-agreement
- blood
- qdbs
- tdm
- haematocrit
- dried
- pediatric
- immunosuppressants
- validation
2026
Capillary samples collected using dried blood spots and Mitra microsamplers showed strong agreement with venous plasma for quantifying IgG antibodies against most vaccine-preventable diseases. Sensitivity was high for the majority of pathogens, though the study noted that antibody stability declined at room temperature over time, favouring cold storage for longer durations.
Comparison of capillary microsampling and venous blood for multi-pathogen serosurveillance — Ombati et al., Scientific reports (paywalled)
- blood
- dried
- capillary
- vams
- dbs
- neoteryx-mitra
- validation
- venous-agreement
- serology
2026
Task sharing dried blood spot collection for HIV viral load testing with community lay cadres achieved high diagnostic agreement with healthcare worker collections and was highly acceptable to patients. This approach offers a viable strategy to overcome healthcare worker shortages and support decentralised viral load monitoring in resource-limited settings.
Feasibility and acceptability of task sharing collection of HIV viral load dried blood spot samples with community lay cadres: A cross-sectional diagnostic validation study in Zimbabwe — Prust et al., PLOS global public health
- acceptability
- blood
- dbs
- dried
- serology
- validation
2026
This review establishes that microsampling across blood, saliva, urine and stool matrices offers validated workflows and regulatory recognition for human biomonitoring comparable to conventional methods. It finds that these decentralised approaches enhance participant acceptability and enable screening in remote or low-resource settings.
Integrating Microsampling in Human Biomonitoring: Methodologies, Regulatory Frameworks, and Case Study Insights — Rajamani & Poongavanam, Critical reviews in analytical chemistry (paywalled)
- wearable
- acceptability
- multimodal
- sweat
- blood
- dbs
- standards
- dried
- serology
- colorectal
- pediatric
- stool
- urine
- validation
- saliva
- biomarkers
2026
Volumetric microsampling can enable patient-centred therapeutic drug monitoring with high patient preference and acceptable method validation for many drugs, but conversion from capillary to plasma and agreement with venous sampling varies by analyte and requires careful validation.
Volumetric Microsampling for Patient-Centric Therapeutic Drug Monitoring in Clinical Pharmacology: A Scoping Review — Tummala et al., Journal of clinical pharmacology (paywalled)
- volumetric
- venous-agreement
- acceptability
- blood
- tdm
- self-collection
- haematocrit
- dried
- capillary
- validation
2026
The study developed and validated a reliable HPLC-MS method for quantifying multiple tyrosine kinase inhibitors from VAMS microsamples of capillary blood, showing acceptable accuracy, precision, and 28-day stability at -21°C, with results comparable to venous plasma in 194 samples from patients with solid tumours. This enables therapeutic drug monitoring using microsamples in oncology practice.
HPLC-MS Quantification of Multiple Tyrosine Kinase Inhibitors in Patients with Solid Tumors: Method Validation and Clinical Application — Staudinger et al., Pharmaceutics (paywalled)
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- tdm
- oncology
2026
A validated two-step LC-MS/MS protocol can identify 91 prohibited doping agents from a single dried blood spot collected on either cellulose cards or volumetric absorptive microsampling devices. This demonstrates robust multi-analyte screening from capillary blood, supporting decentralised anti-doping programmes where venous sampling is impractical.
Dried Blood Spots for Doping Purpose-Two-Step Protocol for Analysis of Non-Threshold Substances and Anabolic Steroid Esters From One Spot/Pebble — Stojanovic et al., Biomedical chromatography : BMC (paywalled)
- blood
- dried
- capillary
- vams
- dbs
- validation
- doping
- toxicology
2026
Capillary finger-stick dried blood spots demonstrated strong analytical agreement with venous serum for prostate-specific antigen (R² = 0.987) and remained stable for 31 days across a wide temperature range. This less invasive microsampling approach enables at-home self-collection, supporting decentralised screening and tele-diagnostics for prostate cancer.
Accessible Prostate-Specific Antigen Testing through Finger-Stick Dried Blood Spots and Routine Laboratory Analyzers — van Vugt et al., The journal of applied laboratory medicine (paywalled)
- blood
- dried
- capillary
- dbs
- self-collection
- validation
- venous-agreement
- haematocrit
- biomarkers
2026
In a study of 46 perinatal nicotine users, dried blood spots and saliva were used weekly to measure reproductive hormones, finding that lower postpartum estradiol and greater peripartum declines in oxytocin were associated with increased nicotine craving and use. This demonstrates the feasibility of decentralised microsampling and remote surveys for longitudinal hormone tracking in vulnerable populations.
Exploring hormonal influences on nicotine craving and use across the perinatal period: A prospective longitudinal study — Allen et al., Drug and alcohol dependence reports (paywalled)
- blood
- dbs
- cortisol
- self-collection
- dried
- fertility
- hormones
- saliva
2026
This review highlights that microsampling techniques such as dried blood spots and volumetric absorptive microsampling offer superior alternatives to traditional sampling for the mass spectrometry detection of prohibited substances in anti-doping analysis. It provides guidance on selecting appropriate analytical methods and sample pretreatment strategies to ensure sensitive detection and reliable storage conditions.
Mass Spectrometry-Based Anti-Doping Analysis: A Critical Review of Emerging Analytical and Sample Pretreatment Strategies — Maykar et al., Critical reviews in analytical chemistry (paywalled)
- blood
- urine
- dried
- vams
- dbs
- validation
- doping
- toxicology
2026
The dried urine spot device showed strong agreement with liquid urine across three clinical chemistry analysers and stable performance across temperatures, enabling decentralised ambient collection for albumin-to-creatinine ratio.
Analysis of albumin-to-creatinine ratio on automated analysers using a microsampling card (Capitainer DIP70 card) for the collection of urine — Olausson et al., Clinical chemistry and laboratory medicine (paywalled)
- urine
- dried
- validation
2026
ALAS2 and CA1 mRNA were reliably quantified from venous-cellulose, capillary-cellulose and Tasso-M20 dried blood spots with strong linear agreement (r ≥ 0.96) and no bias for ALAS2. CA1 showed modest proportional bias of 9-22% only when Tasso-M20 was compared with cellulose cards in the rEPO cohort, but no significant differences in relative expression across matrices were observed at any timepoint. These findings support decentralised capillary sampling for longitudinal anti-doping monitoring.
Comparison of Dried Blood Spot Sampling Methods for RNA-Based Biomarker Measurement in Anti-Doping — Bejder et al., Drug testing and analysis
- blood
- dried
- capillary
- dbs
- validation
- venous-agreement
- doping
- biomarkers
2026
Saliva and dried saliva spot lamotrigine concentrations correlated strongly with plasma (R approximately 0.84 to 0.85), supporting saliva and DSS as needle-free alternatives for therapeutic drug monitoring.
Toward needle-free lamotrigine monitoring: Proof-of-concept for saliva and dried saliva spot analysis by LC-MS/MS - a short communication — Ďurčová et al., Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (paywalled)
- saliva
- dried
- validation
- venous-agreement
- tdm
2026
Among 8007 neonates screened using dried blood spots, the study identified prevalence rates for congenital hypothyroidism (1:2002), congenital adrenal hyperplasia (1:2002) and G6PD deficiency (1:900), with abnormal results confirmed by venous sampling. This demonstrates the practical utility of microsampling for decentralised newborn screening and subsequent clinical management.
Birth Prevalence of Endocrine-Metabolic Disorders Detected by Newborn Screening Test in Pune (India) Population — Narawade et al., Indian journal of clinical biochemistry : IJCB (paywalled)
- blood
- dried
- dbs
- pediatric
- hormones
2026
Statewide mail-based serosurveys using dried blood spot cards showed high spike antibody positivity and rising neutralising antibodies over time, with no differences by socio-demographic factors, supporting the feasibility of decentralised self-sampling for population infection surveillance.
Population-based serosurveys for SARS-CoV-2 transmission 2021-2022, Massachusetts USA — Cramer et al., Vaccine (paywalled)
- blood
- dried
- dbs
- self-collection
- serology
2026
Capillary blood collected by volumetric absorptive microsampling gave a shorter detection window than urine for a stimulant, helping to distinguish recent from earlier use, and more reliable detection of long-acting diuretics that bind red cells. This shows microsampling can improve interpretation in drug-monitoring programmes where urinary data alone may be ambiguous.
Stressing the limits of capillary blood in anti-doping analysis: perspectives on alkylamine-like stimulants and carbonic anhydrase II inhibitors in result management — da Costa Nunes et al., Frontiers in sports and active living
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- doping
- toxicology
2026
In a nationwide survey of 1047 Belgian adults, at-home VAMS achieved a 63% participation-to-analysis completion rate with 16% of samples excluded due to insufficient quality. While dietary intake suggested adequate thiamine consumption, 11% of participants had blood thiamine diphosphate concentrations below the reference threshold, showing the utility of remote microsampling for identifying true nutritional status.
Thiamine status in Belgian adults assessed by volumetric absorptive microsampling: a nation-wide cross-sectional survey — Heughebaert et al., The American journal of clinical nutrition (paywalled)
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- self-collection
- biomarkers
2026
The authors validated VAMS for lumateperone therapeutic drug monitoring and confirmed its stability, which supports decentralised, patient-centric antipsychotic therapy through low-volume blood collection.
Volumetric absorptive microsampling for lumateperone analysis: method validation and stability evaluation — Milandri et al., Analytical and bioanalytical chemistry
- blood
- dried
- vams
- neoteryx-mitra
- validation
- tdm
2026
The authors developed and optimised a dual LC-MS workflow for non-targeted metabolomics from blood microsamples, comprising a 15-minute HILIC-MS method for polar metabolites and an RPLC-MS method for mid- to non-polar compounds. A 20% water/80% methanol extraction with rehydration offered a practical compromise that detected numerous metabolite features across amino acid, acylcarnitine and bile acid pathways, enabling decentralised metabolomic analysis.
RPLC- and HILIC-based non-targeted metabolomics workflow for blood microsamples — Couacault & Witting, Metabolomics : Official journal of the Metabolomic Society
- blood
- dried
- vams
- neoteryx-mitra
- validation
- metabolome
2026
The study found that dried blood microsampling using DBS and VAMS improves the detection of unstable drugs in post-mortem blood compared to conventional tubes, with some substances showing better stability on microsamples. This supports the use of microsampling in forensic settings where sample degradation affects diagnostic accuracy.
Use of blood micro-samples in forensic thanatology — Bertrand-Ndoye et al., Forensic science international (paywalled)
- blood
- dried
- vams
- dbs
- toxicology
2026
Analysis of dried blood spots from 813 newborns demonstrated that extremely preterm infants have markedly elevated corticosterone and 17-hydroxyprogesterone, with the latter showing the strongest inverse correlation with gestational age, indicating these precursors better reflect adrenal immaturity than cortisol alone. This validates DBS as a practical tool for guiding postnatal steroid therapy in preterm infants by helping clinicians distinguish physiological adrenal immaturity from true insufficiency.
Elevation of corticosterone and 17OH progesterone in extremely preterm infants and clinical implications — Kessel et al., Pediatric research
- blood
- dried
- dbs
- pediatric
- hormones
- cortisol
2026
Dried blood spot collection proved feasible during parabolic flight, with seventeen of twenty volunteers successfully providing samples for caffeine pharmacokinetic profiling. The method yielded stable metabolic ratios between ground and weightless conditions, and participants reported high satisfaction, suggesting DBS could support therapeutic drug monitoring in remote or extreme environments such as long-term spaceflight.
Feasibility of dried blood spot collection for caffeine pharmacokinetic studies in microgravity: Insights from parabolic flight campaigns — Derobertmasure et al., British journal of clinical pharmacology
- blood
- dried
- dbs
- self-collection
- acceptability
- tdm
- genotyping
2026
Capillary whole blood collected and dried on the OneDraw device gave robust PFAS measurements with low limits of quantification, and levels of ten PFAS correlated strongly with matched venous plasma levels in 133 veterans, enabling remote sampling without clinical infrastructure.
Use of a capillary blood collection device to monitor exposure to per- and polyfluoroalkyl substances (PFAS) in Veterans living in proximity to potential sources of environmental contamination — Havens et al., Journal of exposure science & environmental epidemiology (paywalled)
- blood
- dried
- capillary
- validation
- venous-agreement
2026
The study found that coached dried blood spot collection was feasible for remote biobehavioural assessment of CTRA gene expression among Black women activists, with usable data from 28 of 29 participants at baseline and 27 at follow-up. Within-person increases in activist identity and search for meaning were associated with more favourable CTRA gene expression changes, though mean CTRA did not shift across the group over the two-month period.
The paradox of action: Trajectories in distress, meaning, and gene regulation following self-directed activist engagement among Black women — Geyton & Cole, SSM. Mental health
- blood
- dried
- dbs
- self-collection
- dct
2026
Self-collected dried blood spots from 40 healthy participants arrived intact and yielded good-quality DNA, with most immune and epigenetic biomarkers remaining stable for up to six weeks at room temperature. The study confirms that minimally invasive dried blood and plasma spot sampling is feasible for scalable, longitudinal biomolecular surveillance in occupational health settings.
Dried blood spot-based monitoring of immune and epigenetic biomarkers in occupational exposure studies — De Ryck et al., Journal of exposure science & environmental epidemiology (paywalled)
- blood
- dried
- dbs
- self-collection
- validation
- acceptability
- biomarkers
2026
Finger-stick dried blood spots produce creatinine measurements that correlate strongly with venous plasma (R² = 0.97), with 91% sensitivity and 96% specificity for detecting reduced eGFR. Creatinine stays stable in dried spots for up to one month at refrigerated or frozen temperatures, supporting accurate home-based kidney function screening, patient follow-up, and medication management.
Creatinine measurement from finger stick dried blood spots with a routine chemistry analyzer for estimation of GFR — van Dam et al., Clinical chemistry and laboratory medicine (paywalled)
- blood
- dried
- capillary
- dbs
- self-collection
- validation
- venous-agreement
- haematocrit
2026
Dried blood spot screening of 3210 neonates in an Eastern Indian province found 10.2% had an inherited disorder, most commonly partial biotinidase deficiency (4.5%) and G6PD deficiency (2.7%), with no sex difference except higher 17-OHP in males; the findings justify national newborn screening to reach all communities.
Newborn screening in an Eastern Indian province: prevalence and trends from a burgeoning newborn screening unit — Saharia et al., Journal of tropical pediatrics (paywalled)
- blood
- dried
- dbs
- pediatric
2026
This study demonstrated that a fully remote genome sequencing study using self-collected dried blood spots and buccal swabs is feasible for individuals with Prader-Willi syndrome, with all participants completing the study and reporting the process was easy despite being lengthy. The design successfully returned actionable genetic findings, including those related to blood clot formation, to participants.
Study design with responsible return of results for a fully remote genome sequencing study in individuals with Prader-Willi syndrome — Vrana-Diaz et al., Genetics in medicine open
- blood
- saliva
- dried
- dbs
- self-collection
- acceptability
- dct
- genotyping
2026
This scoping review identified 15 distinct technologies for measuring HbA1c from capillary blood, with point-of-care devices requiring only 2 to 10 µL and delivering results within minutes. However, diagnostic accuracy varied widely between studies and devices, and most evidence comes from high-income countries, indicating gaps in validation for low- and middle-income settings where decentralised screening is most needed.
HbA1c measurement using capillary blood in epidemiological studies: a scoping review of technologies and approaches — Breternitz et al., BMC endocrine disorders (paywalled)
- blood
- dried
- capillary
- dbs
- self-collection
- validation
2026
Home DBS sampling gave testosterone results that agreed well with venous blood in men on intramuscular testosterone undecanoate, but showed falsely high values in those using topical gel, likely from skin contamination. Patients preferred home collection for its convenience, suggesting DBS is viable for decentralised monitoring of injectable testosterone if patients are taught proper technique.
From venipuncture to self-sampling dried blood spots: a shift in monitoring testosterone levels — Olthof et al., Clinical chemistry and laboratory medicine (paywalled)
- blood
- dried
- capillary
- dbs
- self-collection
- validation
- venous-agreement
- acceptability
- fertility
- hormones
- tdm
2026
The TaqPath kit performed well for HIV drug resistance testing from dried blood spots in samples with high viral loads, meeting WHO criteria for sensitivity and mutation detection, but showed reduced sensitivity at lower viral loads below 5000 copies/mL. This supports the use of DBS for decentralised HIV monitoring in resource-limited settings, though caution is needed when viral load is low.
Evaluation of the Applied Biosystems™ TaqPath™ Seq HIV-1 Genotyping Kit for HIV-1 drug resistance testing from dried blood spot specimens — Okafor et al., Journal of virological methods (paywalled)
- blood
- dried
- dbs
- validation
- serology
2026
Among 1242 asymptomatic children in a remote Congolese district, dried blood spot sampling identified 53% as Plasmodium falciparum-positive. No validated artemisinin-resistance mutations were found, but a lumefantrine-susceptibility marker was present in 15% of samples, demonstrating that community-based microsampling can generate actionable resistance surveillance data to guide decentralised malaria treatment strategies.
Prevalence of antimalarial drug resistance markers and factors associated with Plasmodium falciparum infection in asymptomatic children prior to rectal artesunate implementation in Kapolowe Health District, Democratic Republic of the Congo — Luzolo Khote et al., Malaria journal (paywalled)
- blood
- dried
- dbs
- pediatric
- serology
2026
The study validated an LC-MS/MS method for eight antiepileptic drugs and two metabolites in dried blood spot and VAMS formats, with satisfactory analytical performance and stability, and was the first to include the oxcarbazepine metabolite DHCB. In 80 paired patient samples, microsampling concentrations showed promising correlation with plasma, supporting decentralised therapeutic drug monitoring of antiepileptic treatment.
Development and application of an LC-MS/MS method for 8 antiepileptic drugs and 2 metabolites using microsampling techniques (DBS and VAMS) — Cobo-Golpe et al., Journal of analytical toxicology
- blood
- dried
- vams
- dbs
- neoteryx-mitra
- validation
- venous-agreement
- tdm
- haematocrit
2026
Untargeted metabolomic profiles from three blood microsampling devices aligned more closely with whole blood than with plasma, and all devices distinguished sex based on amino acids, lipids, and acylcarnitines. This validates that device choice can be tailored to the metabolites of interest for decentralised human biomonitoring.
An LC-MS untargeted metabolomic comparison between three blood microsampling devices, whole blood, and plasma — Avella et al., Metabolomics : Official journal of the Metabolomic Society
- blood
- dried
- vams
- neoteryx-mitra
- validation
- venous-agreement
- metabolome
- biomarkers
2026
This narrative review surveys remote biospecimen collection products for sexual health research, including dried blood spots and volumetric absorptive microsampling, and concludes that successful implementation needs a multidisciplinary, participant-centred team with sufficient time allocated to the complexities of collection procedures and processes.
A Narrative Review of Remote Biospecimen Collection Product and Implementation Considerations for Sexual Health Clinical Research — Horvath et al., AIDS and behavior (paywalled)
- blood
- dried
- vams
- dbs
- self-collection
- validation
- dct
- serology
- sti
2026
A streamlined workflow quantified up to 10,000 protein groups and post-translational modifications from 20 microlitres of dried blood collected by volumetric absorptive microsampling, with mass spectrometry acquisition under two hours. The study established stability profiles and best practices for dried blood proteomics, supporting its feasibility for decentralised precision medicine and disease phenotyping.
Development and Validation of a Streamlined Workflow for Proteomic Analysis of Proteins and Post-translational Modifications from Dried Blood — Foster et al., Journal of proteome research (paywalled)
- blood
- dried
- vams
- validation
- biomarkers
- multi-omics
- multimodal
2026
PEth reference values for Belgium were derived from VAMS microsampling of 487 participants in a national survey, showing distinct biomarker distributions between the general population and higher‑alcohol‑consumption subgroups. This validates capillary blood collection as a practical method for decentralised alcohol monitoring and forensic assessment.
Reference values for the alcohol biomarker phosphatidylethanol (PEth) in the Belgian population: Insights from a nationwide microsampling study — Vandenbroucke et al., Drug and alcohol dependence reports
- blood
- dried
- vams
- neoteryx-mitra
- toxicology
- biomarkers
2026
The study developed and validated a rapid LC-MS/MS method for quantifying cefazolin in capillary whole blood collected via VAMS, plasma, and plasma ultrafiltrate, showing robust performance across matrices and successful application in a pediatric pilot cohort for therapeutic drug monitoring.
Rapid, robust LC-MS/MS quantification of cefazolin in whole blood microsamples, plasma, and plasma ultrafiltrate: Analytical method validation and preliminary clinical application in pediatric population — Kocur et al., Clinica chimica acta; international journal of clinical chemistry (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- pediatric
- tdm
- antimicrobials
2026
This study demonstrates that a commercial conductive vial electromembrane extraction device can reliably isolate basic pharmaceuticals from whole blood collected on volumetric absorptive microsampling tips, showing superior reproducibility and reduced matrix effects compared to conventional treatment.
Volumetric absorptive microsampling and conductive vial electromembrane extraction for the analysis of pharmaceuticals in whole blood — Reguli et al., Talanta (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- tdm
- haematocrit
2026
In matched clinical samples from rheumatoid arthritis, VAMS and DBS showed strong agreement for methotrexate polyglutamates (slopes 0.95-1.07; bias within -4.21% to 0.36%; SRCC ≥ 0.969), with up to 100% of total MTXPG results within ±20% limits; capillary microsampling agreed closely with whole blood but differed from red blood cells, indicating matrix-specific differences that must be accounted for when interpreting against RBC-based reference values.
Multi-Matrix LC-MS/MS Validation of Methotrexate Polyglutamates: Comparison of VAMS, DBS, and Conventional Blood Sampling in Rheumatoid Arthritis — Kocur et al., International journal of molecular sciences
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- venous-agreement
- tdm
- immunosuppressants
2026
A UPLC-MS/MS method for linezolid and metabolites in oral fluid and VAMS capillary blood satisfied ICH M10 validation requirements. Linezolid concentrations correlated strongly with venous plasma in both matrices, offering a non‑invasive option for therapeutic drug monitoring, whereas metabolites were systematically underestimated in VAMS and seldom detectable in oral fluid, restricting metabolite measurement.
Simultaneous quantification of linezolid and its metabolites (PNU-142300 and PNU-142586) in oral fluid and capillary blood by UPLC-MS/MS: method validation and clinical application using non-invasive sampling techniques — González-Berdullas et al., Journal of translational medicine (paywalled)
- blood
- saliva
- dried
- capillary
- vams
- validation
- venous-agreement
- tdm
- antimicrobials
- haematocrit
2025
A head-to-head pharmacokinetic comparison of conventional venous sampling against patient-centric microsampling: exactly the bridging study regulators now expect before microsampled data supports an endpoint.
A Pharmacokinetic Study of Zavegepant Nasal Spray in Healthy Adults Comparing Conventional Venous Blood Sampling With Patient-Centric Microsampling — Shahin et al., Clinical and Translational Science
- dct
- venous-agreement
- blood
- dried
- capillary
- liquid
- validation
2025
A phase 1 trial designed around participant self-collection of pharmacokinetic samples at home, with video training and pre-assembled kits: evidence that the model is a training and logistics package, not only a device.
At-Home Self-Collection of Pharmacokinetic Data: Design and Results From a Phase 1 Open-Label Feasibility Trial — Raoufinia et al., Clinical Pharmacology in Drug Development
- dct
- neoteryx-mitra
- blood
- tdm
- self-collection
- dried
2025
A systematic review found mixed economic evidence for microsampling in therapeutic drug monitoring; one study reported no cost reduction with DBS home-sampling, €688 versus €676, whilst another predicted savings up to 61%. The authors caution that more work is required to assess costs alongside clinical outcomes and optimise logistics for decentralised implementation.
The economic evidence for microsampling to support therapeutic drug monitoring: A systematic review — Carland et al., British Journal of Clinical Pharmacology (paywalled)
- vams
- blood
- economics
- dbs
- tdm
- self-collection
- dried
- antimicrobials
- pediatric
- immunosuppressants
- validation
2025
A review of 39 studies found that dried blood spot and volumetric absorptive microsampling show promising results for therapeutic drug monitoring of oral targeted anticancer drugs. The authors state that external validation remains crucial to confirm reliability, citing haematocrit effects and sample stability as key challenges.
Advancing Therapeutic Drug Monitoring for Oral Targeted Anticancer Drugs: From Hospital-Based Towards Home-Sampling — Meertens et al., Biomedical Chromatography
- vams
- blood
- dbs
- tdm
- self-collection
- haematocrit
- dried
- oncology
- validation
2025
A multi-targeted procedure covered 237 prohibited substances across 11 WADA classes in dried urine spots, with environmental-stability testing for refrigeration-free transport.
LC-HRMS screening for 11 classes of prohibited substances in dried urine spots for doping control — Mazzarino et al., Analytical and Bioanalytical Chemistry (paywalled)
- neoteryx-mitra
- doping
- dried
- toxicology
- urine
- validation
2025
This study validated a method for measuring the alcohol biomarker phosphatidylethanol using two volumetric absorptive microsampling devices, finding that the Mitra device met all validation criteria and agreed with venous sampling. The Capitainer device was deemed suitable but showed reduced accuracy at higher concentrations, with a small proportional negative bias compared to venous results.
A validated method for capillary phosphatidylethanol 16:0/18:1 quantification with two different 10-µl volumetric absorptive microsample devices in the same setup — Andreassen et al., Journal of analytical toxicology (paywalled)
- vams
- venous-agreement
- neoteryx-mitra
- blood
- dbs
- dried
- toxicology
- capillary
- validation
2025
A comparison of blood microsampling found that after 35 days, PFAS recovery changed by over 10% for five analytes using the Neoteryx hemaPEN and four using Whatman 903, but zero using the Neoteryx Mitra. The Mitra retained 45 of 49 PFAS within 70-130% recovery, showing its high stability for decentralised biomonitoring without contamination risks.
Comparison of microsampling for PFAS blood analysis: Enabling cheap high-resolution biomonitoring — Partington et al., Analytica chimica acta (paywalled)
- vams
- neoteryx-mitra
- blood
- dbs
- self-collection
- dried
- capillary
- validation
2025
The study found that VAMS devices exhibited elevated background metal concentrations that often matched or exceeded levels found in venous blood, complicating trace element analysis. Although a cleaning protocol reduced some background noise, persistent contamination limits the current efficacy of this microsampling method for environmental biomonitoring.
Evaluating the efficacy of the VAMS Mitra microsampler for whole blood trace element analysis — Ogunesan et al., Bioanalysis
- vams
- neoteryx-mitra
- blood
- dried
- validation
- biomarkers
2025
Dried saliva collected with the Mitra device correlated strongly with wet saliva but poorly with plasma unbound and total concentrations, indicating it is not a reliable substitute for plasma in routine therapeutic drug monitoring of mycophenolic acid and its glucuronide metabolite. Capillary blood collected via VAMS remains a promising alternative for long term monitoring in paediatric patients.
Volumetric Absorptive Microsampling of Saliva for Pharmacokinetic Evaluation of Mycophenolic Acid and Its Glucuronide Metabolite in Pediatric Renal Transplant Recipients: Bioanalytical Method Validation and Clinical Feasibility Evaluation — Kocur et al., Pharmaceuticals
- blood
- saliva
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- pediatric
- tdm
- immunosuppressants
2025
The study found very strong correlation between venous blood collection and capillary VAMS using Mitra devices for detecting SARS-CoV-2 spike antibodies, with samples remaining stable at room temperature for several months. This enables reliable at-home, patient-centric serological testing for large-scale community surveillance and vaccine studies.
Validation of at-home blood sampling for large scale, cost effective serological analysis for anti-viral antibody responses — Mayer et al., Journal of immunological methods (paywalled)
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- self-collection
- validation
- venous-agreement
- serology
2025
This study compared four dried blood spot devices for glucocorticoid detection, finding that the Mitra VAMS device offered the best combination of analytical recovery and user usability, whilst the HemaXis DB10 showed the least bias compared to whole blood.
Analytical and usability comparison of microsampling dried blood spot devices for glucocorticoid detection in sports using ultra-high-performance liquid chromatography-tandem mass spectrometry — Chen et al., Analytica chimica acta (paywalled)
- vams
- acceptability
- neoteryx-mitra
- doping
- blood
- dbs
- haematocrit
- dried
- toxicology
- hormones
- validation
2025
The study found a dried blood spot method for ustekinumab was linear from 3 to 12 mg/L with inter-day accuracy of 90.1 to 106%, enabling reliable capillary blood measurement for remote monitoring; the authors note the single-centre design.
Development, Validation and Application of the Dried Blood Spot Analysis Method for the Determination of Ustekinumab in Patients with Inflammatory Bowel Disease — Mingas et al., Pharmaceuticals
- blood
- dried
- capillary
- dbs
- validation
- tdm
- biologics
2025
Capillary dried blood spots yielded reference ranges for testosterone, androstenedione, 17α hydroxyprogesterone and progesterone in healthy premenopausal women, with lower concentrations in users of systemic hormonal contraceptives and cycle-related variation for 17OHP and P4. These ranges enable screening for disorders of sex development using less invasive microsampling.
Evaluation of reference ranges of four circulating sex steroids from dried blood spots in women aged 18-40 years — Wang et al., The Journal of steroid biochemistry and molecular biology (paywalled)
- blood
- dbs
- dried
- capillary
- fertility
- hormones
2025
The study validated a method for measuring cystic fibrosis drugs in dried blood spots, showing statistical equivalence to plasma concentrations, which supports their use as a less invasive alternative for therapeutic drug monitoring. It also found higher drug levels in nasal swabs, indicating localised accumulation at the disease site, which could inform more personalised treatment.
Development and application of a multimatrix LC-MS/MS method for quantifying elexacaftor-tezacaftor-ivacaftor: Expanding therapeutic drug monitoring in cystic fibrosis from systemic circulation to airways and sweat — Mucci et al., Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (paywalled)
- venous-agreement
- sweat
- blood
- dbs
- qdbs
- tdm
- dried
- pediatric
- validation
2025
Validated on 40 adults, leptin measured from finger-prick dried blood spots agreed closely with matched serum and stayed stable at ambient and raised temperatures for 72 hours; the authors present it as a route into groups such as children that venepuncture has kept out of leptin research.
Validation of an Enzyme-Linked Immunosorbent Assay for Measuring Leptin, a Key Metabolic Hormone, in Dried Blood Spot Samples — Kim et al., American journal of human biology : the official journal of the Human Biology Council
- blood
- dried
- dbs
- validation
- venous-agreement
- hormones
2025
The study found that capillary microtube samples showed perfect correlation, R 1.00, and narrow limits of agreement with venous blood for IgG monitoring, making them a viable alternative. Dried blood spots showed only moderate correlation, R 0.77, and broad limits of agreement, which the authors state makes them unsuitable for routine diagnostics.
Comparison of capillary dried blood spot and capillary microtubes with venous immunoglobulin G levels for routine diagnostics — Boland et al., Clinical biochemistry (paywalled)
- venous-agreement
- blood
- dbs
- dried
- capillary
- liquid
- validation
2025
The HematoCARD cartridge autonomously collects duplicate 10 microlitre dried blood spot samples from a single finger prick and shows good analytical performance for monitoring adalimumab, with accuracy between 91 and 111 per cent, linearity R squared 0.99 and coefficient of variation at or above 0.94 compared with serum reference and commercial DBS microsampling methods.
HematoCARD: A Volumetric Duplicate Dried Blood Spot Collection Cartridge Validated for Therapeutic Drug Monitoring — Van Hileghem et al., Analytical chemistry (paywalled)
- volumetric
- biologics
- blood
- dbs
- tdm
- haematocrit
- dried
- capillary
- validation
2025
A quantitative dried blood spot method using only 10 µL of blood successfully quantified six azole antimycotics and showed samples were stable under conditions simulating postal mailing. A formula to convert dried spot results to plasma values was derived, though the authors note this is an in vitro validation and clinical studies are required for translation to patient care.
Simultaneous Quantification of Azole Antimycotics in Quantitative Dried Blood Spots: A Step Toward Home Sampling for Therapeutic Drug Monitoring — Li et al., Therapeutic drug monitoring (paywalled)
- blood
- dried
- dbs
- qdbs
- self-collection
- validation
- tdm
- antimicrobials
2025
The study determined that using self-collected dried blood spots alongside online surveys was a feasible and acceptable method for remote pre-exposure prophylaxis adherence monitoring, with 64% of participants returning at least one blood specimen.
Remote pre-exposure prophylaxis adherence monitoring among young, Black men who have sex with men: a feasibility and acceptability pilot study — Jones et al., Current psychology (paywalled)
- dct
- acceptability
- blood
- dbs
- tdm
- self-collection
- dried
2025
This study validated a method for quantifying fluconazole using the Mitra device, demonstrating sufficient accuracy and precision for therapeutic drug monitoring in paediatric patients.
Determination of Fluconazole in Children in Small Blood Volumes Using Volumetric Absorptive Microsampling (VAMS) and Isocratic High-Performance Liquid Chromatography-Ultraviolet (HPLC-UV) Detection — Zimbelmann et al., Pharmaceutics
- blood
- dried
- vams
- neoteryx-mitra
- validation
- pediatric
- tdm
- antimicrobials
2025
A comparison of three patient-centric dried blood microsampling devices, paper DBS, Mitra and Tasso-M20, found strong to excellent correlation with traditional venous plasma for measuring branched-chain amino acids and ketoacids. Participants reported high acceptability and expressed a strong willingness to use these devices for decentralised self-collection.
Quantitation of BCAA and BCKA in plasma and patient-centric dried blood microsamples in a clinical setting — Tierney et al., Bioanalysis
- vams
- venous-agreement
- acceptability
- neoteryx-mitra
- blood
- dbs
- metabolome
- dried
- validation
- biomarkers
2025
The study found volumetric absorptive microsampling showed high agreement between capillary and venous concentrations, with 94% of dasatinib and 95% of imatinib samples meeting the 20% acceptance criterion. VAMS is viable for imatinib monitoring and may allow longitudinal follow-up for dasatinib; however, VAMS results for imatinib, but not dasatinib, could be converted to plasma concentrations using prior ratios.
Toward Clinical Implementation of a Volumetric Absorptive Microsampling-Based Method for Dasatinib and Imatinib Therapeutic Drug Monitoring — Verougstraete et al., Therapeutic drug monitoring (paywalled)
- blood
- dried
- capillary
- vams
- validation
- venous-agreement
- tdm
- oncology
2025
While 72 per cent of participants returned self-collected dried blood spot kits, only 46 per cent provided samples adequate for a full cardiometabolic profile, with insufficient blood volume cited as the primary difficulty.
Feasibility of self-administered dried blood spot collection for cardiometabolic profile analysis in a population-based sample of young adults — Livingstone et al., PloS one
- blood
- dried
- dbs
- self-collection
- acceptability
- biomarkers
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