The Library
1530 papers on microsampling and monitoring, each with a finding paraphrased to our standard and labelled in one vocabulary. Every entry links to a legitimate copy; nothing is copied from an abstract.
Papers 1–100 of 158 labelled “biomarkers”, newest first.
2026
DNA methylation markers in first-void urine effectively detect high-grade cervical lesions in HPV-positive women, with results similar to clinician-collected samples in those over 30. This enables reliable cervical cancer screening using self-collected urine, reducing the need for invasive follow-up procedures in decentralised settings.
Evaluating DNA methylation markers and extended HPV genotyping in first-void urine for detecting high-grade cervical lesions in HPV-positive women: a cross-sectional study — Tranberg et al., BMC medicine
- colli-pee
- first-void
- self-collection
- hpv
- urine
- biomarkers
- genotyping
2026
The analysis indicates that dried blood spots and volumetric absorptive microsampling enable minimally invasive monitoring of prohibited substances, with volumetric absorptive microsampling offering improved quantitative reliability over traditional dried spots.
Liquid Chromatographic Methods for Microsampling in Sports Drug Monitoring: Progress in DBS and VAMS — Zhang, Biomedical chromatography : BMC (paywalled)
- vams
- doping
- blood
- dbs
- dried
- steroids
- toxicology
- hormones
- validation
- biomarkers
2026
Researchers successfully validated an analytical method for measuring creatinine across plasma and volumetric absorptive microsampling devices, demonstrating strong correlation between conventional plasma and dried microsamples. This provides a reliable, patient-centric approach for monitoring kidney function remotely during transplant follow-up.
Surrogate-based LC-MS/MS quantification of endogenous creatinine in plasma, plasma-equivalent dried spots (qDPS), and volumetric absorptive microsampling (VAMS): an ICH M10-compliant bridging study — Kocur et al., European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences (paywalled)
- vams
- venous-agreement
- neoteryx-mitra
- blood
- dried
- validation
- biomarkers
2026
Volumetric absorptive microsampling showed better precision than dried blood spots and a metabolic profile closer to whole blood, with stable signalling lipids for 24 hours at room temperature but significant changes after one week unless stabilised, indicating feasibility for decentralised sampling with the need for storage strategies.
Volumetric absorptive microsampling for profiling of signaling lipids: a comparative analysis with whole blood and dried blood spots — Thangavelu et al., Analytical and bioanalytical chemistry
- vams
- volumetric
- blood
- dbs
- metabolome
- dried
- validation
- biomarkers
2026
Capillary dried blood spots, after haematocrit-dependent conversion, showed good agreement with plasma for 25-hydroxyvitamin D quantification, with 90 per cent of results within 20 per cent of plasma and substantial to almost perfect agreement in status classification, supporting reliable home self-collection for large-scale vitamin D monitoring.
Clinical validation of a DBS-based LC-MS/MS method for 25-hydroxyvitamin D: from lab sampling to home sampling — Heughebaert et al., Clinical chemistry and laboratory medicine (paywalled)
- venous-agreement
- blood
- dbs
- self-collection
- haematocrit
- dried
- capillary
- validation
- biomarkers
2026
The study found that testing for ASCL1/LHX8 DNA methylation in at-home collected first-void urine can detect most cervical cancers and high-grade precancers, supporting a fully molecular screening pathway without a clinical visit.
Clinical performance of ASCL1/LHX8 DNA methylation on first-void urine to screen for cervical cancer — Van Keer et al., Communications medicine
- colli-pee
- first-void
- self-collection
- hpv
- liquid-biopsy
- urine
- biomarkers
2026
An optimised VAMS workflow for blood proteomics increased protein identifications 4-fold in plasma and 2.1-fold in whole blood compared with liquid processing, with mean CVs below 11%, and whole blood showed greater robustness and storage stability at room temperature for up to 14 days. This enables reliable patient-centric microsampling for longitudinal biomarker studies.
Advancing Blood Proteome Analysis Past the Plasma Age: Mass Spectrometry of Whole Blood and Plasma Collected with Volumetric Absorptive Microsampling Devices — Karsten et al., Journal of proteome research (paywalled)
- vams
- neoteryx-mitra
- blood
- dried
- validation
- biomarkers
2026
The study found that capillary dried plasma spots correlated strongly with venous plasma for detecting the Alzheimer's disease biomarker p-tau217. This suggests that microsampling offers a viable, minimally invasive alternative to venipuncture for screening and monitoring Alzheimer's disease pathology.
A minimally invasive dried blood spot biomarker test for the detection of Alzheimer's disease pathology — Huber et al., Nature medicine
- blood
- dried
- capillary
- dbs
- venous-agreement
- biomarkers
2026
The study found that although participants preferred patient-centric microsampling devices for home use, the agreement with venous plasma for measuring CRP and cytokines was inconsistent, indicating that further validation is required before these methods replace standard venipuncture.
Limited agreement of cytokines and CRP through patient-centric microsampling compared to venipuncture in healthy adults — Tuttle et al., Bioanalysis (paywalled)
- dct
- venous-agreement
- acceptability
- blood
- dbs
- self-collection
- dried
- biomarkers
2026
This study used home self-collected saliva samples to successfully monitor cytokines and cortisol in mothers and infants, finding that a community singing intervention significantly reduced salivary interleukin-6 levels in mothers with postnatal depression.
Community singing intervention reduces maternal salivary cytokines and enhances maternal-infant cortisol synchrony in postnatal depression: biological findings from the SHAPER-PND trial — Kirkpatrick et al., Brain, behavior, and immunity (paywalled)
- dct
- cortisol
- self-collection
- pediatric
- hormones
- liquid
- saliva
- biomarkers
2026
In patients with type 2 diabetes and secondary polycythaemia, HbA1c-derived estimated mean plasma glucose showed a significant negative bias compared to structured home capillary blood glucose monitoring, whilst fructosamine served as a more reliable glycaemic marker.
Glycemic assessment in diabetic patients with secondary polycytheamia: limitations of HbA1c and the potential role of fructosamine-a prospective comparative study — Erarslan et al., Acta diabetologica (paywalled)
- blood
- haematocrit
- capillary
- liquid
- biomarkers
2026
The homeRNA capillary blood collection and stabilization platform successfully captured lipopolysaccharide-induced inflammatory gene expression profiles. These transcriptomic responses were comparable to those obtained from traditional venous blood samples stabilized with RNAlater or PAXgene, demonstrating the platform's suitability for remote transcriptomic monitoring.
From Home to Transcriptome: Comparing the Transcriptomic Profile of Induced Immune Response via Lipopolysaccharide Stimulation in homeRNA and Venous Blood — Brown et al., Analytical chemistry (paywalled)
- venous-agreement
- stabilised
- blood
- capillary
- liquid
- validation
- biomarkers
2026
A machine learning model called Remote Control was trained on 2685 blood samples to predict change due to instability, enabling accurate calibration of results to approximate the time zero value at collection. With calibration, unprocessed whole blood could be transported for up to 9 days under ambient conditions and temperatures between 3.4 and 47.4 degrees Celsius, achieving agreement with CLIA TEa between 98.1 and 100 per cent and expanding the catalog of tests available for at-home collection.
Prolonging Sample Stability with Machine Learning Expands the Catalog of Tests Available for Mail-In Capillary Blood Collected At-Home — O'Meara et al., Analytical chemistry (paywalled)
- dct
- blood
- self-collection
- capillary
- liquid
- validation
- biomarkers
2026
This study validated a dried blood spot method for tacrolimus monitoring and demonstrated agreement with venous whole blood measurements in kidney transplant recipients. It also found that dried blood spot analysis of the biomarker CXCL-10 was elevated in patients experiencing rejection or infection, supporting its use for decentralised monitoring.
Dried Blood Spot for CXCL-10 and Tacrolimus: Integrated Non-Invasive Monitoring to Guide Personalized Treatment in Adult Kidney Transplant Recipients — Millán et al., Pharmaceuticals
- venous-agreement
- blood
- dbs
- tdm
- dried
- immunosuppressants
- validation
- biomarkers
2026
Frequent dried blood spot sampling detected early changes in beta-cell function more effectively than mixed-meal tolerance tests or urine ratios, supporting its potential as a decentralised monitoring tool for clinical trials.
Serial Dried Blood Spot C-Peptide Sampling, but Not Urine C-Peptide-to-Creatinine Ratio, Detects Early Preservation of β-Cell Function in New-Onset Type 1 Diabetes: Experience From the USTEKID Trial — Dunseath et al., Diabetes care (paywalled)
- dct
- blood
- dbs
- dried
- pediatric
- urine
- biomarkers
2026
In a 20-person proof-of-concept pilot among veterans with HIV, remote self-collection of dried blood spots for phosphatidylethanol monitoring was feasible and acceptable, with high return and analysis rates and positive feedback; a small first step toward decentralised alcohol biomarker monitoring rather than proof of it.
Remote alcohol biomarker monitoring to promote drinking reductions among people with HIV: A proof-of-concept pilot study — Sheinfil et al., Journal of substance use and addiction treatment (paywalled)
- acceptability
- blood
- dbs
- self-collection
- dried
- biomarkers
2026
This developer study reports that a self-collection kit interfacing with a BD Microtainer produced RNA of sufficient quality and yield for transcriptomic analysis in a pilot group and a longitudinal rheumatology cohort. Most participants found the device easy to use, supporting its utility for decentralised blood sampling.
To the homeRNAmax: Developing an Improved Blood Self-Collection and Stabilization Platform for Remote Transcriptomic Studies — Eakman et al., Analytical chemistry (paywalled)
- dct
- blood
- self-collection
- bd-microtainer
- liquid
- validation
- biomarkers
2026
This review establishes that microsampling across blood, saliva, urine and stool matrices offers validated workflows and regulatory recognition for human biomonitoring comparable to conventional methods. It finds that these decentralised approaches enhance participant acceptability and enable screening in remote or low-resource settings.
Integrating Microsampling in Human Biomonitoring: Methodologies, Regulatory Frameworks, and Case Study Insights — Rajamani & Poongavanam, Critical reviews in analytical chemistry (paywalled)
- wearable
- acceptability
- multimodal
- sweat
- blood
- dbs
- standards
- dried
- serology
- colorectal
- pediatric
- stool
- urine
- validation
- saliva
- biomarkers
2026
Capillary finger-stick dried blood spots demonstrated strong analytical agreement with venous serum for prostate-specific antigen (R² = 0.987) and remained stable for 31 days across a wide temperature range. This less invasive microsampling approach enables at-home self-collection, supporting decentralised screening and tele-diagnostics for prostate cancer.
Accessible Prostate-Specific Antigen Testing through Finger-Stick Dried Blood Spots and Routine Laboratory Analyzers — van Vugt et al., The journal of applied laboratory medicine (paywalled)
- blood
- dried
- capillary
- dbs
- self-collection
- validation
- venous-agreement
- haematocrit
- biomarkers
2026
ALAS2 and CA1 mRNA were reliably quantified from venous-cellulose, capillary-cellulose and Tasso-M20 dried blood spots with strong linear agreement (r ≥ 0.96) and no bias for ALAS2. CA1 showed modest proportional bias of 9-22% only when Tasso-M20 was compared with cellulose cards in the rEPO cohort, but no significant differences in relative expression across matrices were observed at any timepoint. These findings support decentralised capillary sampling for longitudinal anti-doping monitoring.
Comparison of Dried Blood Spot Sampling Methods for RNA-Based Biomarker Measurement in Anti-Doping — Bejder et al., Drug testing and analysis
- blood
- dried
- capillary
- dbs
- validation
- venous-agreement
- doping
- biomarkers
2026
Low-volume blood collection devices enable frequent, longitudinal sampling at home with reduced invasiveness, thereby improving participant retention in patient-centric studies. This facilitates decentralised biomarker monitoring for tracking disease progression and understanding physiological responses to diet, medication and physical activity.
Low-volume collection devices for longitudinal biomarker monitoring in patient-centric sampling settings — Simon-Guth et al., Bioanalysis (paywalled)
- blood
- self-collection
- validation
- dct
- biomarkers
2026
In people at high risk of nasopharyngeal carcinoma, saliva showed decreased EBV load and increased EBV DNA methylation compared with controls, and a stepwise strategy that adds saliva testing to serum EBV antibodies improved triage efficiency.
Evaluation of Epstein-Barr virus DNA methylation and load in saliva in the management of individuals at high risk of nasopharyngeal carcinoma — Zheng et al., Biomarker research
- saliva
- biomarkers
2026
In a nationwide survey of 1047 Belgian adults, at-home VAMS achieved a 63% participation-to-analysis completion rate with 16% of samples excluded due to insufficient quality. While dietary intake suggested adequate thiamine consumption, 11% of participants had blood thiamine diphosphate concentrations below the reference threshold, showing the utility of remote microsampling for identifying true nutritional status.
Thiamine status in Belgian adults assessed by volumetric absorptive microsampling: a nation-wide cross-sectional survey — Heughebaert et al., The American journal of clinical nutrition (paywalled)
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- self-collection
- biomarkers
2026
Lower salivary lactoferrin concentrations were independently associated with positive brain amyloid PET imaging and with periodontal disease, suggesting saliva lactoferrin may have value as a non-invasive biomarker in cognitive impairment assessment.
Relationship between salivary lactoferrin level and brain amyloid load in periodontal and non-periodontal subjects — Gil-Montoya et al., Medicina oral, patologia oral y cirugia bucal
- saliva
- biomarkers
2026
Among 101 working-age women in Chicago, 70% returned at-home kits for capillary blood and saliva collection, demonstrating that patient-centric microsampling of stress biomarkers (cortisol and CRP) is feasible in diverse urban populations. This supports decentralised diagnostics for population health research.
A feasibility study exploring precarious employment and stress-related health among women — Oddo et al., BMC public health
- blood
- saliva
- capillary
- self-collection
- cortisol
- biomarkers
2026
Self-collected dried blood spots from 40 healthy participants arrived intact and yielded good-quality DNA, with most immune and epigenetic biomarkers remaining stable for up to six weeks at room temperature. The study confirms that minimally invasive dried blood and plasma spot sampling is feasible for scalable, longitudinal biomolecular surveillance in occupational health settings.
Dried blood spot-based monitoring of immune and epigenetic biomarkers in occupational exposure studies — De Ryck et al., Journal of exposure science & environmental epidemiology (paywalled)
- blood
- dried
- dbs
- self-collection
- validation
- acceptability
- biomarkers
2026
Untargeted metabolomic profiles from three blood microsampling devices aligned more closely with whole blood than with plasma, and all devices distinguished sex based on amino acids, lipids, and acylcarnitines. This validates that device choice can be tailored to the metabolites of interest for decentralised human biomonitoring.
An LC-MS untargeted metabolomic comparison between three blood microsampling devices, whole blood, and plasma — Avella et al., Metabolomics : Official journal of the Metabolomic Society
- blood
- dried
- vams
- neoteryx-mitra
- validation
- venous-agreement
- metabolome
- biomarkers
2026
A streamlined workflow quantified up to 10,000 protein groups and post-translational modifications from 20 microlitres of dried blood collected by volumetric absorptive microsampling, with mass spectrometry acquisition under two hours. The study established stability profiles and best practices for dried blood proteomics, supporting its feasibility for decentralised precision medicine and disease phenotyping.
Development and Validation of a Streamlined Workflow for Proteomic Analysis of Proteins and Post-translational Modifications from Dried Blood — Foster et al., Journal of proteome research (paywalled)
- blood
- dried
- vams
- validation
- biomarkers
- multi-omics
- multimodal
2026
PEth reference values for Belgium were derived from VAMS microsampling of 487 participants in a national survey, showing distinct biomarker distributions between the general population and higher‑alcohol‑consumption subgroups. This validates capillary blood collection as a practical method for decentralised alcohol monitoring and forensic assessment.
Reference values for the alcohol biomarker phosphatidylethanol (PEth) in the Belgian population: Insights from a nationwide microsampling study — Vandenbroucke et al., Drug and alcohol dependence reports
- blood
- dried
- vams
- neoteryx-mitra
- toxicology
- biomarkers
2025
Worked case studies of patient-centric sampling deployed in pharmaceutical drug development: how sponsors have implemented it, rather than whether it is possible.
Case Studies on the Use of Patient-centric Sampling for Clinical Studies in Pharmaceutical Drug Development — Patel et al., The AAPS Journal (paywalled)
- dct
- venous-agreement
- blood
- self-collection
- pediatric
- validation
- biomarkers
2025
Plasma lipidomes from self-collected upper-arm capillary blood were statistically indistinguishable from paired venous plasma, most classes at r=0.95–0.99, validating at-home capillary self-collection for lipidomics.
Comparison of capillary and venous plasma lipidomes: validation of self-collected blood for plasma lipidomics — Hameed et al., J. Lipid Research
- venous-agreement
- blood
- self-collection
- capillary
- liquid
- validation
- biomarkers
2025
The study found that VAMS devices exhibited elevated background metal concentrations that often matched or exceeded levels found in venous blood, complicating trace element analysis. Although a cleaning protocol reduced some background noise, persistent contamination limits the current efficacy of this microsampling method for environmental biomonitoring.
Evaluating the efficacy of the VAMS Mitra microsampler for whole blood trace element analysis — Ogunesan et al., Bioanalysis
- vams
- neoteryx-mitra
- blood
- dried
- validation
- biomarkers
2025
A comparison of three patient-centric dried blood microsampling devices, paper DBS, Mitra and Tasso-M20, found strong to excellent correlation with traditional venous plasma for measuring branched-chain amino acids and ketoacids. Participants reported high acceptability and expressed a strong willingness to use these devices for decentralised self-collection.
Quantitation of BCAA and BCKA in plasma and patient-centric dried blood microsamples in a clinical setting — Tierney et al., Bioanalysis
- vams
- venous-agreement
- acceptability
- neoteryx-mitra
- blood
- dbs
- metabolome
- dried
- validation
- biomarkers
2025
In 277 paediatric patients, capillary microsampling with the Microsemi CRP device found close agreement with venous testing for CRP, with a mean difference of -0.25 mg/dL and 95% limits of -2.1 to 1.6 mg/dL. WBC showed a bias of -18 × 100/μL, with 95% limits of -73 to 37 × 100/μL. This supports decentralised, patient-centric screening of febrile children.
Comparison between point-of-care testing from capillary samples and conventional laboratory testing from venous samples for white blood cells and C-reactive protein in a pediatric outpatient setting — Kuniyoshi et al., Journal of general and family medicine
- venous-agreement
- blood
- capillary
- pediatric
- biomarkers
2025
While 72 per cent of participants returned self-collected dried blood spot kits, only 46 per cent provided samples adequate for a full cardiometabolic profile, with insufficient blood volume cited as the primary difficulty.
Feasibility of self-administered dried blood spot collection for cardiometabolic profile analysis in a population-based sample of young adults — Livingstone et al., PloS one
- blood
- dried
- dbs
- self-collection
- acceptability
- biomarkers
2025
The paper summarises that volumetric finger-prick self-sampling is suitable for monitoring immunosuppressants and biomarkers after kidney transplantation, but successful implementation requires careful design of the entire workflow, including patient training and method validation. This matters because it provides a real-world framework for moving critical monitoring from the clinic to the patient's home.
Implementation of Volumetric Finger-Prick Self-Sampling for Therapeutic Drug Monitoring of Immunosuppressants After Kidney Transplantation: Lessons Learned From the Practice — Vethe et al., Therapeutic drug monitoring (paywalled)
- vams
- volumetric
- neoteryx-mitra
- blood
- tdm
- self-collection
- immunosuppressants
- validation
- biomarkers
2025
A study of 292 patients found that the slopes of home-collected stimulated dried blood spot C-peptide levels over six months predicted 12-month venous mixed-meal tolerance test results, P<0.001. This shows decentralised microsampling can monitor beta-cell function, though further validation is required to confirm its reliability and broader applicability.
Early Detection of β-Cell Decline Using Home Dried Blood Spot C-Peptide Levels in New-Onset Type 1 Diabetes — Hendriks et al., Diabetes care (paywalled)
- dct
- venous-agreement
- blood
- dbs
- self-collection
- dried
- pediatric
- biomarkers
2025
A validated offline SPE-LC-MS/MS method using the Mitra microsampling device successfully quantified tacrolimus, cyclosporine A, tryptophan, kynurenine, and creatinine simultaneously. The method met EMA and FDA criteria, showing agreement between capillary and venous sampling, which could facilitate decentralised therapeutic drug monitoring and transplant follow-up through patient self-collection.
An Offline SPE-LC-MS/MS Method for Simultaneous Quantification of Tacrolimus, Cyclosporine A, Kynurenine, Tryptophan, and Creatinine Using Volumetric Absorptive Microsampling Device Mitra — Nierychlewski et al., Therapeutic drug monitoring
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- tdm
- immunosuppressants
- biomarkers
2025
In an untargeted metabolomics study, microsampling devices, particularly the Mitra and Capitainer, yielded metabolic profiles comparable or superior to plasma in feature number and intensity, and in the precision and stability of some metabolites. This supports their potential for large-scale, decentralised metabolic profiling, though the captured metabolite profile was application-dependent.
LC-MS-Based Global Metabolic Profiles of Alternative Blood Specimens Collected by Microsampling — Thaitumu et al., Metabolites
- vams
- neoteryx-mitra
- blood
- dbs
- qdbs
- metabolome
- dried
- validation
- biomarkers
2025
Self-collected oral and stool samples revealed distinct microbiome compositions in patients with endometriosis compared to controls, with Fusobacterium enrichment specifically observed in oral samples from moderate to severe cases. These results support the feasibility of decentralised self-collection for non-invasive biomarker screening in reproductive health.
Oral, Vaginal, and Stool Microbial Signatures in Patients With Endometriosis as Potential Diagnostic Non-Invasive Biomarkers: A Prospective Cohort Study — Hicks et al., BJOG : an international journal of obstetrics and gynaecology
- self-collection
- microbiome
- fertility
- stool
- saliva
- biomarkers
2025
Cortisol dynamic range measured from participant-led saliva collection was feasible and associated with higher perceived stress and anxiety in African American women, suggesting saliva self-collection can serve as a decentralised biomarker of chronic stress.
A Community-Engaged Approach for Assessment of Cortisol Dynamic Range and Multilevel Chronic Stress in African Americans: FAITH! Heart Health+ Ancillary Study — Ortiz et al., Journal of participatory medicine
- cortisol
- self-collection
- hormones
- saliva
- biomarkers
2025
Circulating collagen X degradation product (CXM) remains stable in healthy adults regardless of age or sex. In patients with tibial or femoral shaft fractures, serum CXM correlates with established bone turnover markers, and finger prick collection makes it feasible for remote quantitative monitoring of fracture healing without repeated clinic visits.
Efficacy of biomarkers in the endochondral phase of fracture repair and healing in long bones: A clinical observational studys — Working et al., PLoS medicine
- blood
- capillary
- biomarkers
2025
This paper describes a handheld electrochemical sensor for vitamin C measurement in saliva and urine, showing a linear range from 0.2 to 200 µm and detection limit of 0.03 µm. The device demonstrated satisfactory accuracy and recovery in human samples, suggesting potential for affordable home-based testing of vitamin C status.
A Multi-Channel Handheld Diagnostic Device Based on Green Biomimetic Material for Point-of-Care Testing of Vitamin C in Human Fluids — Fu et al., Advanced healthcare materials (paywalled)
- saliva
- urine
- liquid
- self-collection
- biomarkers
2025
In 20 adults, CRP measured in urine and saliva strongly correlated with serum CRP (Spearman rho 0.886) and was significantly elevated in participants with systemic inflammation compared with controls, suggesting these noninvasive matrices could replace venipuncture for monitoring inflammatory status in remote or at-home settings.
Multimodal Noninvasive Assessment of C-Reactive Protein for Systemic Inflammation in Adults: Cross-Sectional Study — Shim et al., JMIR formative research
- saliva
- urine
- stool
- sweat
- venous-agreement
- acceptability
- biomarkers
2025
In 41 Black adults with heart failure, elevated xanthine oxidase activity from capillary blood collected with Mitra microsampling associated significantly with dyspnoea severity. This demonstrates that microsampling can capture clinically relevant inflammatory biomarkers linked to symptom burden in underserved populations, supporting its use in decentralised cardiovascular monitoring.
Inflammation markers associated with symptoms and neighborhood deprivation in black adults with heart failure — Butts et al., Heart & lung : the journal of critical care (paywalled)
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- biomarkers
2025
An LC-MS/MS assay using volumetric absorptive microsampling achieved 72.5% to 98.9% accuracy and under 8% precision for measuring circulating endocannabinoids and related lipid mediators. However, drying time significantly altered 2-AG and 2-OG concentrations, and marked differences were observed between whole blood and plasma measurements.
Spotlight on Endocannabinoids in Healthy Individuals Using Volumetric Absorptive Microsampling Combined with LC-MS/MS Analysis — Haroune et al., ACS omega
- blood
- dried
- vams
- neoteryx-mitra
- validation
- haematocrit
- biomarkers
2025
Targeted proteomic evaluation of a novel finger-prick dried plasma device demonstrated strong quantitative correlation with conventional plasma (R = 0.99) and precision under 10% CV for 80% of quantified peptides across healthy donors. Quantified targets also remained stable during room temperature storage for up to 232 days, supporting its use for decentralised biomarker monitoring.
Quantitative Assessment of a Novel Device Designed for Patient-centric Sampling of Dried Plasma Using Targeted Proteomics — Hober et al., Analytical chemistry
- blood
- dried
- capillary
- self-collection
- validation
- venous-agreement
- dct
- biomarkers
2025
Capillary blood collection using volumetric absorptive microsampling demonstrated equivalent quantification of principal colonic polyphenol metabolites compared with matched venous plasma across a six-hour period following barley biscuit consumption. The technique successfully captured the pharmacokinetic profiles over 48 hours, confirming VAMS as a reliable alternative to venepuncture for dietary biomarker monitoring.
Finger-prick blood sampling using volumetric absorptive microsampling (VAMS) method for monitoring the main (poly)phenolic metabolites in human blood after barley biscuit intake — Cortijo-Alfonso et al., Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- venous-agreement
- metabolome
- biomarkers
2025
A saliva-derived transcriptomic signature using support vector machine learning detected gastric cancer with an AUC of 0.87, sensitivity of 79% and specificity of 70%. Tissue-based gene expression models performed poorly when applied to saliva, indicating that saliva-specific biomarker panels are needed for effective non-invasive gastric cancer screening.
Saliva-derived transcriptomic signature for gastric cancer detection using machine learning and leveraging publicly available datasets — Lopes et al., Scientific reports
- saliva
- self-collection
- biomarkers
- liquid-biopsy
2025
An optimized 4D-lipidomics UHPLC-HRMS protocol using stable isotope internal standards enabled semi-quantitative profiling of 432 unique lipid features from 10 ̢L dried blood spot samples with high analytical reproducibility. The workflow demonstrates the viability of capillary blood microsampling for large-scale, remote population lipidomics and metabolic profiling.
Dried blood spot microsampling: A semi-quantitative 4D-lipidomics approach using ultrahigh-performance liquid chromatography - high-resolution mass spectrometry (UHPLC - HRMS) — Roberts et al., Talanta (paywalled)
- blood
- dried
- dbs
- self-collection
- validation
- metabolome
- biomarkers
2025
In 22 adults, capillary blood collection demonstrated strong correlation with venous sampling for 66 per cent of inflammatory proteins and moderate to strong correlation for 80 per cent overall, supporting its validity for proteomic measurement in decentralised trials.
Comparing Venous vs. Capillary Blood Collection Methods for Proteomic Measurement in Peripheral Blood — Ni Lochlainn et al., Proteomics. Clinical applications
- blood
- capillary
- validation
- venous-agreement
- dct
- biomarkers
2025
DNA methylation levels in self-collected cervicovaginal samples fell two years after treatment in patients who remained free of recurrent cervical cancer. This shows that home-collected urine and cervicovaginal specimens can be used to assess methylation markers for surveillance of cervical cancer recurrence.
Recurrent cervical cancer detection using DNA methylation markers in self-collected samples from home — Schaafsma et al., International journal of cancer
- urine
- self-collection
- hpv
- biomarkers
2025
This study developed a fluorescence probe for detecting histidine in saliva, demonstrating high sensitivity and specificity for cancer risk screening. The probe showed excellent recovery in real saliva samples and feasibility for point-of-care use in home or resource-limited settings.
Turn-on fluorescence sensing of histidine in body fluids: unveiling its oncogenic potential as a cancer risk biomarker — Indongo et al., The Analyst (paywalled)
- saliva
- liquid
- oncology
- biomarkers
2025
In women with endometriosis, longer individual exercise sessions were associated with lower levels of salivary c-reactive protein and estradiol, as well as reduced pain and fat mass. The results demonstrate the utility of timed, at-home saliva self-collection for assessing systemic biomarkers in reproductive health research.
Is exercise duration more important than intensity in endometriosis? — Hartmann et al., BMC women's health
- saliva
- self-collection
- fertility
- hormones
- cortisol
- biomarkers
2025
In an adolescent with cerebral palsy undergoing a home-based, remotely supervised sprint-intensity interval training intervention, dried blood spot testing demonstrated a 37.8% reduction in triglycerides and a 15.4% improvement in total cholesterol to HDL ratio. This illustrates how remote microsampling can support decentralized metabolic monitoring in pediatric disability rehabilitation.
Sprint-Intensity Arm Interval Training May Improve Cardiorespiratory Fitness and Cardiometabolic Health Among Children With Mobility Disabilities: Case Report — Dean et al., JMIR formative research
- blood
- dried
- dbs
- self-collection
- pediatric
- biomarkers
2025
The review identifies neurofilament light chain, brain-derived tau, glial fibrillary acidic protein and soluble TREM2 as fluid biomarkers that could monitor axonal damage and glial activation in hereditary spastic paraplegia. It proposes that dried blood spot collection enables minimally invasive longitudinal monitoring of these biomarkers, supporting patient-centred care models for this genetically heterogeneous neurodegenerative disease.
Fluid Biomarkers in Hereditary Spastic Paraplegia: A Narrative Review and Integrative Framework for Complex Neurodegenerative Mechanisms — Cipriano et al., Genes
- blood
- dried
- dbs
- self-collection
- validation
- biomarkers
2025
Volumetric dried blood spot microsampling enables retinol analysis with over 90% extraction efficiency from only 10 µL of blood, though α-tocopherol recovery ranges from 53 to 75% depending on filter paper. The method improves sample stability to 30 days at -80°C and reduces shipping volume more than a thousandfold, making micronutrient monitoring practical for decentralised settings.
Volumetric dried blood spot microsampling: A sustainable, patient-friendly, and practical approach for retinol and α-tocopherol analysis in a clinical setting — Suwanvecho et al., Methods (paywalled)
- blood
- dried
- dbs
- volumetric
- validation
- biomarkers
2025
A coffee-ring biosensor detected sepsis, COVID-19 and cancer proteins from self-collected saliva down to 3 pg/ml within 12 minutes, achieving sensitivity more than 100-fold higher than lateral flow assays. The system uses a smartphone camera and AI analysis, providing a rapid, affordable platform for decentralised protein diagnostics.
Plasmonic coffee-ring biosensing for AI-assisted point-of-care diagnostics — Behrouzi et al., Nature communications
- saliva
- self-collection
- serology
- biomarkers
2025
Growth differentiation factor 15 (GDF15) is significantly elevated in both plasma and saliva of patients with mitochondrial disease, and saliva GDF15 levels correlate with disease severity. This supports saliva as a patient-centric matrix for decentralised disease monitoring, potentially reducing the need for venous blood draws.
The mitochondrial disease biomarker GDF15 is dynamic, quantifiable in saliva, and correlates with disease severity — Huang et al., Molecular genetics and metabolism (paywalled)
- blood
- saliva
- biomarkers
2024
In 102 patients, Mitra and Capitainer microsamples gave urine albumin-to-creatinine ratios at 102% and 95% of the clinical analyser's, and both stayed within 98% to 103% after three weeks at room temperature, which supports either device for decentralised urine collection.
Patient-Centric Quantitative Microsampling for Accurate Determination of Urine Albumin to Creatinine Ratio (UACR) in a Clinical Setting — Löfgren et al., The journal of applied laboratory medicine (paywalled)
- dct
- volumetric
- neoteryx-mitra
- urine
- validation
- biomarkers
2024
Capillary blood self-collection yielded protein concentrations that matched venipuncture for only a minority of analytes, with 34 of 230 proteins showing acceptable correlation and low variability, while the remainder were more variable; this suggests capillary sampling can support decentralised proteomics for a subset of proteins but may not be universally interchangeable with venipuncture.
Capillary blood self-collection for high-throughput proteomics — El-Sabawi et al., Proteomics
- venous-agreement
- blood
- self-collection
- capillary
- liquid
- biomarkers
2024
This review found saliva comparable to blood and urine for detecting viral genetic material and antibodies, supporting patient-centric monitoring and decentralised surveillance. The authors state that standardised protocols and further validation are required for routine clinical use.
The Emergence of Saliva as a Diagnostic and Prognostic Tool for Viral Infections — Oliveira et al., Viruses
- blood
- self-collection
- serology
- hpv
- urine
- validation
- saliva
- biomarkers
2024
Microsampling enables less invasive, patient-centric self-collection of capillary blood for remote monitoring of metabolites and lipids, overcoming conventional venipuncture constraints. Recent device innovations address dried blood spot limitations, particularly haematocrit and volume variations, expanding decentralised applications in population health, drug discovery and multi-omics research.
Revolutionizing Blood Collection: Innovations, Applications, and the Potential of Microsampling Technologies for Monitoring Metabolites and Lipids — Bossi et al., Metabolites
- multimodal
- blood
- dbs
- metabolome
- self-collection
- haematocrit
- dried
- capillary
- validation
- biomarkers
- multi-omics
2024
This study of 82 children with concussion found that capillary blood collected with a Mitra device within 48 hours of injury could not identify protein markers that predict persistent posttraumatic headache at two weeks. The negative result highlights the need for novel biomarker discovery to enable risk stratification in paediatric concussion using decentralised sampling.
Capillary blood protein markers of posttraumatic headache in children after concussion — Fan et al., Journal of neurosurgery. Pediatrics (paywalled)
- blood
- capillary
- vams
- neoteryx-mitra
- pediatric
- biomarkers
2024
Using Saliva Children's Swabs to collect salivary alpha-amylase and cortisol was feasible in elderly nursing home residents with dementia, though active patient engagement remained necessary. However, an individualised music listening intervention showed no significant effect on these salivary stress markers.
Salivary cortisol and alpha-amylase as stress markers to evaluate an individualized music intervention for people with dementia: feasibility and pilot analyses — Hillebrand et al., BMC research notes
- saliva
- acceptability
- hormones
- cortisol
- biomarkers
2024
Adding polyethylene glycol to first-void urine before centrifugation markedly improved cell-free DNA recovery in the pellet, whereas low-speed centrifugation alone removed cellular DNA while keeping cell-free DNA in the supernatant. Pseudovirions pelleted reliably under all conditions, but the study revealed substantial variation between self-collected samples, highlighting the need for standardised protocols in decentralised HPV screening programmes.
Concentration strategies for spiked and naturally present biomarkers in non-invasively collected first-void urine — Téblick et al., European journal of medical research
- urine
- first-void
- hpv
- biomarkers
- liquid-biopsy
2024
Salivary tryptophan is significantly raised in HER2‑negative breast cancer and falls after tumour removal, correlating with aggressive disease features. This shows saliva can provide a non‑invasive metabolic marker for screening and monitoring breast cancer in decentralised settings.
Salivary Tryptophan as a Metabolic Marker of HER2-Negative Molecular Subtypes of Breast Cancer — Sarf et al., Metabolites
- saliva
- metabolome
- biomarkers
2024
Folate vitamer stability in dried blood microsamples was strongly dependent on temperature and time, with levels remaining within 85 to 115 per cent of baseline at -20°C and 4°C for up to two weeks in both VAMS and DBS, but only lasting three days at room temperature in VAMS and failing at 37°C. The authors conclude that decentralised sampling for folate status monitoring is feasible if transport temperature and duration are controlled, though pretreatment with stabilising agents and desiccant use offered only partial improvement at ambient temperature.
Is the stability of folates in dried blood microsamples sufficient to perform home-sampling studies? — Heughebaert & Stove, The Analyst (paywalled)
- blood
- dried
- vams
- dbs
- neoteryx-mitra
- self-collection
- validation
- biomarkers
2024
Low volume sampling devices showed good concordance with venous serum for measuring the pharmacodynamic biomarker sMAdCAM-1, but dried blood samples required substantial dilution to overcome buffer interference, which was mitigated by using a highly sensitive Simoa assay. The study demonstrates that while these devices have potential for decentralised clinical trials, careful validation is needed to address site-specific biases and assay sensitivity limitations.
Evaluation of low volume sampling devices for a pharmacodynamic biomarker analysis: Challenges and solutions — Yang et al., Journal of pharmaceutical and biomedical analysis (paywalled)
- blood
- liquid
- dried
- neoteryx-mitra
- validation
- venous-agreement
- dct
- biomarkers
2024
Salivary alpha-amylase activity rose from morning to afternoon across subjects and days, with no difference between two collection devices, and increased significantly after a simulated shoulder dystocia scenario alongside heart rate, supporting its use as a reliable stress marker when timing is considered.
Salivary alpha-amylase: A marker of stress in gynecological residents during a shoulder dystocia simulation scenario — Aita et al., PloS one
- saliva
- self-collection
- biomarkers
2024
Volumetric absorptive microsampling (VAMS) yielded superior classification of fibromyalgia and long COVID compared with dried blood spots when analysed by surface-enhanced Raman spectroscopy, delivering 100% accuracy, sensitivity and specificity with an area under the curve of 0.86. The method identified discriminatory metabolites from low-molecular-weight blood fractions, showing that VAMS can support decentralised metabolomic diagnostics for syndromes with overlapping clinical features.
Surface-Enhanced Raman Spectroscopy Combined with Multivariate Analysis for Fingerprinting Clinically Similar Fibromyalgia and Long COVID Syndromes — Nuguri et al., Biomedicines
- blood
- dried
- vams
- neoteryx-mitra
- metabolome
- biomarkers
2024
This review of 2022 to 2023 work surveys dried blood microsampling for targeted and untargeted metabolomic and lipidomic profiling, finding the approach viable across paediatric research, therapeutic drug monitoring, metabolite screening, biomarker discovery, sports supervision, clinical disorder studies and forensic toxicology. The authors note that dried blood spots and VAMS dominate the published literature over other volumetric formats, and argue that harmonising analytical methods would accelerate wider clinical adoption of microsampling as an alternative to conventional plasma or serum profiling.
Targeted and untargeted metabolomics and lipidomics in dried blood microsampling: Recent applications and perspectives — Couacault et al., Analytical science advances
- blood
- dried
- vams
- dbs
- validation
- pediatric
- tdm
- toxicology
- metabolome
- biomarkers
2024
Epstein-Barr virus DNA methylation in self-collected saliva and oropharyngeal swabs demonstrated superior diagnostic performance for nasopharyngeal carcinoma compared with oral swabs or mouthwash. Combining both sample types and two promoter methylation markers could optimise decentralised, patient-centric screening programmes.
Detection of Epstein‒Barr virus DNA methylation as tumor markers of nasopharyngeal carcinoma patients in saliva, oropharyngeal swab, oral swab, and mouthwash — Zheng et al., MedComm
- saliva
- self-collection
- biomarkers
- liquid-biopsy
2024
A graphene lab-on-a-chip device achieved high accuracy and precision for multiplex renal biomarker testing in serum and saliva, with sensitivities ranging from 89.0 to 99.7 per cent. Untrained volunteers produced results comparable to trained chemists, suggesting the device is suitable for patient-centric at-home diagnostics and could improve access to chronic kidney disease monitoring.
Noninvasive and Multiplex Self-Test of Kidney Disease Biomarkers with Graphene-Based Lab-on-a-Chip (G-LOC): Toward Digital Diagnostics in the Hands of Patients — Diforti et al., Analytical chemistry (paywalled)
- saliva
- self-collection
- validation
- acceptability
- biomarkers
2024
Sixty-nine metabolites in dried blood spots remained stable across storage temperatures of 4°C, 25°C and 40°C for 21 days, whereas seventy-eight metabolites showed instability, with phosphatidylcholines and triglycerides most affected. This demonstrates that storage conditions materially alter metabolite integrity, which is critical for biomarker selection and data quality in patient-centric, home-sampling protocols.
Evaluation of metabolite stability in dried blood spot stored at different temperatures and times — Cui et al., Scientific reports
- blood
- dried
- dbs
- metabolome
- biomarkers
2024
This literature review found that DNA methylation markers on self-collected urine or cervicovaginal swabs detected cervical intraepithelial neoplasia as well as cytology. The combination could improve screening uptake and reduce loss to follow-up, particularly in low- and middle-income countries, though more evidence is needed to identify the most efficacious methylation tests.
The current state of DNA methylation biomarkers in self-collected liquid biopsies for the early detection of cervical cancer: a literature review — Sumiec et al., Infectious agents and cancer
- urine
- self-collection
- validation
- hpv
- sti
- biomarkers
- liquid-biopsy
2024
Older adults achieved 98% adherence when self-collecting dried blood spots at home for inflammatory markers, with 97% of samples yielding valid results. Test-retest reliability was good (ICCs 0.70–0.76) and correlation with venous blood was strong (r=0.60–0.99), demonstrating that remote capillary sampling is a feasible and valid method for decentralised assessment of inflammation in older adults.
Remote dried blood spot collection for inflammatory markers in older adults is feasible, reliable, and valid — Reed et al., Brain, behavior, and immunity (paywalled)
- blood
- dried
- dbs
- self-collection
- validation
- venous-agreement
- acceptability
- biomarkers
2023
A UHPLC-HRMS assay quantified 25-hydroxyvitamin D2 and D3 from 20 µL Mitra VAMS samples with accuracy under 10% and precision under 11%, LOQ 5 ng/mL: sensitive enough to flag deficiency and simple enough for untrained self-collection, enabling year-round vitamin-D monitoring.
Quantification of 25-hydroxyvitamin D2 and D3 in Mitra devices (VAMS) by UHPLC-HRMS for regular vitamin D status monitoring — Tuma et al., J. Pharmaceutical and Biomedical Analysis (paywalled)
- vams
- neoteryx-mitra
- blood
- self-collection
- dried
- capillary
- validation
- biomarkers
2023
Capillary VAMS blood covered more of the metabolome than plasma, capturing intracellular red-cell metabolites, and correlated moderately-to-well with venous, Spearman 0.66; the honest caveats are higher finger-prick replicate variability and a need for −80 °C storage within six hours.
VAMS-based blood capillary sampling for mass-spectrometry-based human metabolomics studies — Volani et al., Metabolites
- vams
- venous-agreement
- blood
- metabolome
- dried
- capillary
- validation
- biomarkers
2023
TAP II capillary serum, both professionally collected and self-collected, correlated with venous serum at R > 0.9 for eight analytes including ALT, AST, cholesterol, HDL and triglycerides. Creatinine correlated acceptably but carried a consistent negative bias, and carbon dioxide, potassium and albumin did not reach acceptable agreement: the useful reading is that the panel has to be validated, not the device alone.
Maximizing microsampling: measurement of comprehensive metabolic and lipid panels using a novel capillary blood collection device — Collier et al., The Journal of Applied Laboratory Medicine (paywalled)
- venous-agreement
- blood
- self-collection
- capillary
- bd-microtainer
- liquid
- yourbio
- validation
- biomarkers
2023
Dried blood spot microsampling shows that paediatric lipid profiles vary significantly across three age groups, 0-10 days, 2-18 months and 3-13 years, with differences in 16 specific lipid species. The authors caution that paediatric ages remain under-mapped in DBS lipidomics and further investigation is required before establishing reference standards.
Lipid profile variability in children at different ages measured in dried blood spots — Ferreira et al., Molecular omics (paywalled)
- blood
- dbs
- metabolome
- dried
- pediatric
- biomarkers
2023
The study found that combining the Oragene saliva collector with the miRNeasy kit gave the most sensitive detection of seven saliva miRNAs, and that different collector-kit combinations can be selected to suit different study needs.
Obtaining miRNA from Saliva-Comparison of Sampling and Purification Methods — Urbizu et al., International journal of molecular sciences
- saliva
- liquid
- dna-genotek-oragene
- validation
- biomarkers
2023
Saliva offers a non-invasive specimen matrix for detecting both oral and systemic conditions at the point of care. Although home collection and diagnostic biosensors show strong clinical and economic utility, technical challenges remain in standardisation and device integration before widespread point-of-care adoption.
A Review on Saliva-Based Health Diagnostics: Biomarker Selection and Future Directions — Kumari et al., Biomedical materials & devices
- saliva
- self-collection
- validation
- biomarkers
2023
In a 16-donor validation study, prompt centrifugation of serum microsamples maintained analyte stability and preserved clinical chemistry and protein biomarker quality. This demonstrates that remote centrifugation with refrigerated shipping can lessen patient burden and broaden participation in decentralised clinical trials.
Decentralized clinical trial design using blood microsampling technology for serum bioanalysis — Lee et al., Bioanalysis (paywalled)
- blood
- liquid
- validation
- venous-agreement
- dct
- biomarkers
2023
Twenty dementia caregivers self-collected saliva at home while using a mobile yoga app for twelve weeks. Those who practised most showed decreased salivary cortisol and increased 1,5-anhydroglucitol, indicating that self-collected saliva can track stress responses to decentralised behavioural interventions.
Self-Administered Gentle Yoga and Yoga Breathing Intervention Improves Burden and Stress Biomarkers in Caregivers of Persons Living with Dementia — Balasubramanian et al., International journal of yoga therapy (paywalled)
- saliva
- self-collection
- cortisol
- biomarkers
2023
Volumetric absorptive microsampling (VAMS) of whole blood allows depletion of abundant red-cell proteins during processing, which improves detection of less abundant proteins from all blood compartments and yields deeper proteomic coverage than conventional plasma analysis alone.
Proteome Analysis of Whole Blood Collected by Volumetric Absorptive Microsampling — Molloy et al., Methods in molecular biology (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- biomarkers
2023
Mass spectrometry identified SARS-CoV-2 proteins in all self-collected saliva samples from people with COVID-19, while rRT-PCR detected viral RNA in only 57 per cent of the same samples, indicating that proteomic analysis may offer greater sensitivity for diagnosis and monitoring, especially in cases with low viral load.
Identification of SARS-CoV-2 biomarkers in saliva by transcriptomic and proteomics analysis — Marin et al., Clinical proteomics
- saliva
- self-collection
- serology
- biomarkers
2023
The analysis quantified 62 proteins with satisfactory analytical performance, and 48 proteins showed significant correlation between 2 µL plasma microsamples and dried blood spots, supporting the use of dried blood microsampling for home collection and predictive medicine in elderly patients.
New Perspectives of Multiplex Mass Spectrometry Blood Protein Quantification on Microsamples in Biological Monitoring of Elderly Patients — Vialaret et al., International journal of molecular sciences
- blood
- liquid
- dried
- dbs
- validation
- biomarkers
2023
The study optimised a UHPLC-MS/MS method to measure 11 lipids in 2.74 µL blood microsamples collected with hemaPEN® devices directly from athletes on a track. Five analytes, arachidonic acid, sphingosine, lactic acid, and two lysophosphatidylcholines, showed significant exercise-induced changes, demonstrating that capillary microsampling can reliably capture metabolic responses in decentralised settings without specialist staff.
A targeted UHPLC-MS/MS method to monitor lipidomic changes during a physical effort: Optimization and application to blood microsamples from athletes — Laurent et al., Journal of pharmaceutical and biomedical analysis (paywalled)
- blood
- capillary
- validation
- metabolome
- biomarkers
2023
This study of 184 individuals showed that home collection of dried blood spots and saliva can identify genetic polymorphisms linked to cardiac serum markers. Seven SNPs associated significantly with markers such as Apo B, LDL Direct, and hsCRP, while a polygenic risk score correlated strongly with NT-proBNP (r²=0.82, P=.03) and ox-LDL (r²=0.94, P=.005). These results indicate decentralised genetic sampling could enable early cardiovascular risk assessment and identify patients requiring closer serological monitoring.
Influence of genetic polymorphisms on serum biomarkers of cardiac health — Krishnamurthy et al., Medicine
- blood
- saliva
- dried
- dbs
- self-collection
- genotyping
- biomarkers
2023
In adults given EPA or DHA for 12 weeks, first-void urine analysed by MSI-CE-MS showed increased S-carboxypropylcysteamine and other candidate metabolites that correlated with the Omega-3 Index measured in erythrocytes, suggesting urine could support non-invasive monitoring of omega-3 status.
Urinary Metabolite Profiling to Non-Invasively Monitor the Omega-3 Index: An Exploratory Secondary Analysis of a Randomized Clinical Trial in Young Adults — MacIntyre et al., Metabolites
- urine
- first-void
- metabolome
- biomarkers
2023
A UHPLC-MS/MS method for measuring Fabry disease biomarkers in dried blood spots was validated using both conventional cards and Capitainer B devices. Capillary blood gave similar results to venous blood across a wide haematocrit range, supporting decentralised screening and longitudinal monitoring of patients.
Mass Spectrometry Analysis of Globotriaosylsphingosine and Its Analogues in Dried Blood Spots — Boutin et al., International journal of molecular sciences
- blood
- dried
- capillary
- dbs
- validation
- venous-agreement
- haematocrit
- biomarkers
2023
The authors developed a capillary microfluidic device that captures multiple blood biomarkers at collection and dries them on-chip, enabling safe shipment to centralised laboratories for multiplexed analysis. This patient-centric approach could support remote health monitoring and decentralised trials.
Microfluidic Device for Patient-Centric Multiplexed Assays with Readout in Centralized Laboratories — Hauser et al., Analytical chemistry
- blood
- dried
- capillary
- dct
- biomarkers
2023
The authors validated a UHPLC-MS/MS method for quantifying four ceramide species in 10 μL quantitative dried blood spots. Ceramides remained stable at room temperature, supporting remote self-collection, and concentrations were higher in fingertip whole blood than in plasma or serum, which is relevant for at-home monitoring of cardiovascular and metabolic disease risk.
Ceramides biomarkers determination in quantitative dried blood spots by UHPLC-MS/MS — Meikopoulos et al., Analytica chimica acta (paywalled)
- blood
- dried
- capillary
- qdbs
- validation
- metabolome
- biomarkers
2023
Capillary blood self-collection showed acceptable agreement with venous samples for vitamin D, C-reactive protein and alkaline phosphatase even after 36-hour delays, but calcium and phosphate levels were more affected by pre-analytical conditions. This supports decentralised serology and biomarker testing while highlighting analytes that need tighter pre-analytical control.
Concordance in COVID-19 serology, bone mineralization, and inflammatory analytes between venous and self-collected capillary blood samples exposed to various pre-analytical conditions — Hosseini et al., Annals of clinical biochemistry (paywalled)
- blood
- liquid
- capillary
- validation
- venous-agreement
- serology
- biomarkers
2023
The study describes a protocol for measuring the low-abundance cancer biomarker progastrin-releasing peptide in dried serum spots and volumetric absorptive microsampling devices, finding that VAMS yielded higher signal intensities than dried serum spots.
Microsampling in Targeted Mass Spectrometry-Based Protein Analysis of Low-Abundance Proteins — Ngo et al., Journal of visualized experiments : JoVE (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- biomarkers
2023
Targeted DNA methylation analysis accurately estimated relative and absolute leukocyte subset counts from dried capillary blood collected with Mitra devices, showing strong correlation with conventional venous blood methods (r=0.72–0.97). This enables self-sampling by finger prick, facilitating easier access to leukocyte testing for patients with haematological disorders.
Targeted DNA Methylation Analysis Facilitates Leukocyte Counts in Dried Blood Samples — Hubens et al., Clinical chemistry (paywalled)
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- venous-agreement
- biomarkers
2023
Self collected dried blood spots gave equivalent results to venous blood for lipids, HbA1c and C reactive protein, enabling similar classification of cardiovascular risk; self collection had lower response than nurse collection but similar demographic participation.
A randomised study of nurse collected venous blood and self-collected dried blood spots for the assessment of cardiovascular risk factors in the Understanding Society Innovation Panel — Kumari et al., Scientific reports
- blood
- dried
- dbs
- self-collection
- venous-agreement
- acceptability
- biomarkers
2023
First-void urine samples from 85 Austrian school children aged six to ten showed frequent low-level exposure to mycotoxins and phytoestrogens, with 22 percent exceeding the tolerable daily intake for deoxynivalenol and some facing possible health risks from ochratoxin A. The results support urine microsampling for decentralised exposome monitoring in paediatric populations.
The Austrian children's biomonitoring survey 2020 Part B: Mycotoxins, phytotoxins, phytoestrogens and food processing contaminants — Ayeni et al., Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (paywalled)
- urine
- first-void
- pediatric
- toxicology
- biomarkers
2023
Finger-stick capillary blood spotted onto filter paper and dried (DBS) provides C-reactive protein results that correlate excellently with venous plasma (R² = 0.986). The method correctly classified all 25 high cardiovascular-risk patients and 12 of 13 inflammation cases, with analyte stability demonstrated for 31 days, supporting its use for patient-centric at-home sampling in decentralised diagnostics and screening programmes.
Analysis of C-reactive protein from finger stick dried blood spot to predict high risk of cardiovascular disease — Schakelaar et al., Scientific reports
- blood
- dried
- capillary
- dbs
- self-collection
- validation
- venous-agreement
- haematocrit
- biomarkers
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