The Library
1530 papers on microsampling and monitoring, each with a finding paraphrased to our standard and labelled in one vocabulary. Every entry links to a legitimate copy; nothing is copied from an abstract.
32 papers labelled “colli-pee”, newest first.
2026
DNA methylation markers in first-void urine effectively detect high-grade cervical lesions in HPV-positive women, with results similar to clinician-collected samples in those over 30. This enables reliable cervical cancer screening using self-collected urine, reducing the need for invasive follow-up procedures in decentralised settings.
Evaluating DNA methylation markers and extended HPV genotyping in first-void urine for detecting high-grade cervical lesions in HPV-positive women: a cross-sectional study — Tranberg et al., BMC medicine
- colli-pee
- first-void
- self-collection
- hpv
- urine
- biomarkers
- genotyping
2026
Urinary HPV testing using first-void urine collected with the Colli-Pee device showed substantial agreement with clinician-collected cervico-vaginal sampling and near-equivalent negative predictive value, supporting its use as a clinically credible non-invasive entry point for cervical screening in settings where low participation rather than analytical performance is the principal barrier.
Agreement and Diagnostic Performance of Urinary HPV Testing Versus Clinician-Collected Cervico-Vaginal Sampling: A Prospective Cross-Sectional Study in a Romanian Cohort — Nati et al., Medical sciences (paywalled)
- urine
- first-void
- colli-pee
- hpv
- sti
2026
This meta-analysis found that self-collected urine samples for HPV testing had lower sensitivity for detecting high-grade lesions compared to physician-collected cervical specimens. The use of a first-void collection device such as Colli-Pee was associated with marginally higher sensitivity than general urine sampling.
Accuracy of HPV Testing Using Self-collected Urine Compared With Physician-collected Cervical Specimen for HSIL or Worse — Chen et al., Journal of lower genital tract disease (paywalled)
- urine
- first-void
- colli-pee
- self-collection
- validation
- hpv
- sti
2026
This randomised sub-study found return rates of 10.4% for Colli-Pee, 10.1% for FLOQSwabs and 7.4% for Evalyn-Brush. All devices yielded sufficient DNA with low invalid rates, but the authors noted the study was limited by low overall participation.
Comparison of three different hpv self-sampling tools - a subanalysis of the prospective, randomized hannover self-collection study — Hempel et al., Archives of gynecology and obstetrics
- urine
- first-void
- colli-pee
- self-collection
- acceptability
- hpv
- sti
2026
For decentralised testing, a study found dry vaginal self-samples using Copan FLOQSwabs stored up to two weeks at room temperature maintain DNA quality. However, first-void urine collected with the Colli-Pee device may be less sensitive for HPV detection, showing lower positivity and higher cycle threshold values, median Ct 30 versus 27 for other samples.
Evaluation of the Quality and Suitability of Self-Collected Vaginal and Urine Samples for Human Papillomavirus Testing: A Prospective Matched Study — Chu et al., BJOG : an international journal of obstetrics and gynaecology
- colli-pee
- first-void
- sti
- self-collection
- dried
- hpv
- urine
- validation
2026
The study found that testing for ASCL1/LHX8 DNA methylation in at-home collected first-void urine can detect most cervical cancers and high-grade precancers, supporting a fully molecular screening pathway without a clinical visit.
Clinical performance of ASCL1/LHX8 DNA methylation on first-void urine to screen for cervical cancer — Van Keer et al., Communications medicine
- colli-pee
- first-void
- self-collection
- hpv
- liquid-biopsy
- urine
- biomarkers
2025
In 498 women living with HIV, self-collected first-void urine and vaginal samples showed 78% high-risk HPV prevalence and good genotype concordance, kappa 0.64-0.78. Participants preferred the Colli-Pee device over the Evalyn Brush, supporting decentralised, patient-centric screening feasibility.
Feasibility of First-Void Urinary and Vaginal Self-Sampling for High-Risk Human Papillomavirus Testing Among Women Living With Human Immunodeficiency Virus in Guinea-Bissau-A Multicenter Cross-Sectional Study — Madsen et al., Journal of medical virology
- colli-pee
- acceptability
- first-void
- sti
- self-collection
- hpv
- urine
2025
Urine self-sampling for HPV showed non-inferior specificity to cervical samples, 85.19%, and found 96% of high-grade lesions. While acceptable, a survey of 1382 participants found 41.6% preferred conventional screening, showing the importance of offering choice in a decentralised, patient-centric programme.
Urine human papillomavirus testing for cervical screening in a UK general screening population: a diagnostic test accuracy study — Davies et al., The British journal of general practice : the journal of the Royal College of General Practitioners
- urine
- first-void
- colli-pee
- self-collection
- acceptability
- hpv
- sti
2025
The EUROArray HPV test achieved similar sensitivity and specificity for CIN2+ detection using first-void urine and vaginal self-samples compared with clinician-collected cervical samples, supporting the use of self-collection for cervical screening.
EUROArray HPV test accuracy for cervical precancer in self- vs. clinician-collected samples using the VALHUDES protocol — van et al., Gynecologic oncology (paywalled)
- urine
- first-void
- colli-pee
- self-collection
- validation
- hpv
2025
This study found that the HarmoniaHPV assay on first-void urine collected via Colli-Pee and vaginal self-samples showed a relative sensitivity of 0.95 for detecting CIN2+ compared to cervical samples. The VenusHPV assay showed similar accuracy but required cut-off optimisation, supporting decentralised HPV screening.
Accuracy of Liferiver HarmoniaHPV and VenusHPV Assays on Urine and Vaginal Self-Samples — Latsuzbaia et al., Journal of medical virology
- colli-pee
- first-void
- self-collection
- hpv
- urine
- validation
2025
In a Belgian colposcopy referral cohort, a study found that 66.6% of women preferred home-based first-void urine self-sampling over physician-taken samples, and 96.6% found the Colli-Pee UCM FV-5010 device easy to use. This supports patient-centric, decentralised screening, though results are limited to this specific referral population.
Home-based urinary HPV self-sampling for the detection of cervical cancer precursor lesions: attitudes and preferences from Belgian females participating in the CASUS study — Hendrickx et al., Archives of public health = Archives belges de sante publique
- colli-pee
- acceptability
- first-void
- self-collection
- hpv
- liquid-biopsy
- liquid
- urine
2025
Using the Novosanis Colli-Pee Small Volumes device, this study found that self-collected first-void urine had slightly lower sensitivity for detecting high-grade cervical intraepithelial neoplasia than cervical samples, CIN2+ ratio 0.91, 95% CI 0.83-0.99, with comparable specificity. This patient-centric, decentralised approach offers a feasible screening alternative despite a marginal reduction in sensitivity.
Clinical and Analytical Evaluation of the Abbott Alinity m HR HPV Assay in a New Generation First-Void Urine Collector — Van Keer et al., Journal of medical virology (paywalled)
- urine
- first-void
- colli-pee
- self-collection
- validation
- hpv
2025
The study validated the Allplex HPV28 assay for use with first-void urine samples collected using a Colli-Pee device, finding good agreement with a reference method and that it works without pre-centrifugation. This provides a reliable, non-invasive option for HPV screening and vaccine monitoring, which is important for increasing participation in decentralised settings.
Optimization and analytical validation of the Allplex HPV28 genotyping assay for use in first-void urine samples — Bell et al., Journal of clinical microbiology
- colli-pee
- first-void
- sti
- hpv
- urine
- validation
- genotyping
2025
A Danish study found that first-void urine testing using the 10-mL Colli-Pee device had similar sensitivity to cervical sampling for detecting CIN2+, ratio 0.97, and CIN3+, ratio 0.95, though specificity was lower. This patient-centric, decentralised microsampling method shows promise, but further clinical accuracy and acceptability data in under-screened populations are needed before implementation.
High-risk human papillomavirus testing in first-void urine as a novel and non-invasive cervical cancer screening modality-a Danish diagnostic test accuracy study — Tranberg et al., BMC medicine
- urine
- first-void
- colli-pee
- validation
- hpv
2024
An independent VALHUDES evaluation found HPV screening on Colli-Pee first-void urine detected high-grade cervical lesions with sensitivity comparable to clinician-collected cervical samples, reinforcing urine self-sampling for cervical screening.
Clinical Performance of the OncoPredict HPV Screening Assay on Self-Collected Vaginal and Urine Specimens (VALHUDES) — Giubbi et al., J. Medical Virology
- colli-pee
- first-void
- self-collection
- hpv
- liquid
- urine
- validation
2024
The OncoPredict HPV Quantitative Typing assay achieved clinical sensitivity ratios of 0.99 for urine and 1.00 for vaginal self-samples versus clinician-collected cervical samples for detecting CIN2+, and after cut-off optimisation showed similar accuracy on self-collected and cervical specimens, supporting decentralised cervical screening through urine self-collection with Colli-Pee.
Clinical accuracy of OncoPredict HPV Quantitative Typing (QT) assay on self-samples — Latsuzbaia et al., Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology (paywalled)
- urine
- first-void
- colli-pee
- self-collection
- validation
- hpv
- sti
2024
Self-collected first-void urine using the Colli-Pee device detected high-risk HPV with 96.7 per cent concordance compared with clinician-collected cervical swabs in 240 women, with a Cohen's kappa of 0.87, indicating strong agreement and supporting urine self-collection as an acceptable approach for HPV screening.
Comparable detection of HPV using real-time PCR in paired cervical samples and concentrated first-stream urine collected with Colli-Pee device — Nilyanimit et al., Diagnostic microbiology and infectious disease
- urine
- first-void
- colli-pee
- self-collection
- validation
- hpv
2024
A systematic review of 70 studies found that 94.7% of accuracy studies reported comparable sensitivity and specificity between self-sampling and clinician collection for HPV detection, with patient acceptability ranging from 84.2% to 100% for devices including Colli-Pee. This evidence endorses decentralised cervical screening to improve uptake.
Comparison of diagnostic accuracy and acceptability of self-sampling devices for human Papillomavirus detection: A systematic review — Aimagambetova et al., Preventive medicine reports
- urine
- first-void
- colli-pee
- self-collection
- validation
- acceptability
- hpv
2024
First-void urine collected with the Colli-pee device detected high-grade cervical precancer with 90.3% sensitivity, substantially better than the 73.4% sensitivity of standard-pot urine, and was acceptable to colposcopy attendees. The device achieved 92% relative sensitivity compared with clinician-collected cervical samples, showing promise for decentralised HPV screening.
Urine high-risk human papillomavirus testing as an alternative to routine cervical screening: A comparative diagnostic accuracy study of two urine collection devices using a randomised study design trial — Davies et al., BJOG : an international journal of obstetrics and gynaecology (paywalled)
- urine
- first-void
- colli-pee
- self-collection
- acceptability
- hpv
- sti
2023
Over three years after HPV vaccination in 58 women, HPV-specific IgG was detected in 84% to 100% of first-void urine samples against 98% to 100% of serum samples, and the two correlated strongly; the authors support self-collected urine for follow-up of vaccine-induced immunity, with the caveat that only women were studied.
Follow-up of humoral immune response after HPV vaccination using first-void urine: A longitudinal cohort study — Téblick et al., Journal of medical virology (paywalled)
- dct
- colli-pee
- first-void
- serology
- hpv
- urine
2023
Urine sampling with the Colli-Pee device revealed a substantial burden of high-risk HPV infection among unvaccinated Thai schoolgirls, with prevalence increasing from 8.6% in grade 10 to 12.4% in grade 12, demonstrating the feasibility of decentralised screening to guide immunisation policy.
Prevalence of HPV infection among Thai schoolgirls in the north-eastern provinces in 2018: implications for HPV immunization policy — Vongpunsawad et al., IJID regions
- urine
- first-void
- colli-pee
- serology
- hpv
2023
In a colposcopy referral population, the Alinity m HR HPV assay showed similar sensitivity for CIN2+ on home-collected first-void urine and vaginal self-samples compared with clinician-collected cervical samples, with comparable specificity for first-void urine and variable specificity across vaginal devices; adjusting signal thresholds improved assay accuracy across all self-sample types.
Clinical Accuracy of Alinity m HR HPV Assay on Self- versus Clinician-Taken Samples Using the VALHUDES Protocol — Latsuzbaia et al., The Journal of molecular diagnostics : JMD (paywalled)
- urine
- first-void
- colli-pee
- self-collection
- validation
- hpv
2022
Home-collected first-void urine testing for high-risk HPV showed sensitivity equivalent to clinician-collected cervical samples for detecting CIN2+ and CIN3, but with marginally lower specificity. This supports urine self-sampling as a viable decentralised screening method to improve coverage among unscreened women.
Analytical and clinical performance of extended HPV genotyping with BD Onclarity HPV Assay in home-collected first-void urine: A diagnostic test accuracy study — Van Keer et al., Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology (paywalled)
- urine
- first-void
- colli-pee
- self-collection
- validation
- hpv
2021
In first-void urine collected with Colli-Pee, the extraction method influenced HPV and human DNA yield more than the collected volume did: standardising processing matters at least as much as standardising volume.
Impact of Collection Volume and DNA Extraction Method on the Detection of Biomarkers and HPV DNA in First-Void Urine — Téblick et al., Molecules
- colli-pee
- first-void
- self-collection
- hpv
- liquid-biopsy
- liquid
- urine
- biomarkers
2021
High-risk HPV testing on first-void urine self-collected with Colli-Pee was about as sensitive, relative sensitivity 0.95, and specific for CIN2+ as clinician-taken cervical samples, supporting standardised first-void urine as a valid screening matrix.
Clinical and analytical evaluation of high-risk HPV testing on Colli-Pee first-void urine using the VALHUDES protocol — Van Keer et al., Gynecologic Oncology (paywalled)
- colli-pee
- first-void
- self-collection
- hpv
- liquid
- urine
- validation
2021
Among 515 women, 93% believed HPV self-sampling could improve screening uptake and 95% found instructions clear and felt confident, yet 41% still preferred clinician collection and 9-19% found it unpleasant. This shows urine-based screening with Colli-Pee is well accepted but not universally preferred, a crucial insight for patient-centric decentralised programmes.
Cervical cancer screening using HPV tests on self-samples: attitudes and preferences of women participating in the VALHUDES study — De Pauw et al., Archives of public health = Archives belges de sante publique
- urine
- first-void
- colli-pee
- self-collection
- acceptability
- hpv
- sti
2021
Two dry vaginal self-sampling devices and a first-void urine collector detected over 90% of high-grade cervical lesions (CIN 3+) and all invasive cancers, with sensitivity comparable to clinician-taken smears. Participants found the devices easy to use and self-sampling was well accepted, which could improve uptake of cervical screening.
CoCoss-Trial: Concurrent Comparison of Self-Sampling Devices for HPV-Detection — Ertik et al., International journal of environmental research and public health
- urine
- first-void
- colli-pee
- self-collection
- acceptability
- hpv
- sti
2019
At-home first-void urine self-collection with Colli-Pee was feasible, well accepted, and gave chlamydia/gonorrhoea detection comparable to routine clinic-based urine, supporting home first-void sampling for populations needing frequent STI testing.
Evaluation of Colli-Pee first-void urine self-sampling at home versus clinic-based collection for sexually transmitted infections in MSM — De Baetselier et al., BMJ Open
- colli-pee
- acceptability
- first-void
- sti
- self-collection
- liquid
- urine
2019
In women with HPV, first-void urine collected with the Colli-Pee device had higher HPV DNA concentrations than urine collected with a standard cup, although this advantage disappeared at high HPV DNA loads. Timing of collection (morning versus later) did not affect HPV DNA copies.
Human papillomavirus detection in urine: Effect of a first-void urine collection device and timing of collection — Pattyn et al., Journal of virological methods (paywalled)
- urine
- first-void
- colli-pee
- self-collection
- validation
- hpv
- sti
2019
The Colli-Pee device achieved very good to almost perfect agreement with clinic collected urine for chlamydia, gonorrhoea and mycoplasma testing, and participants found it feasible and convenient for home sampling, supporting its use for frequent STI screening in at-risk groups.
Evaluation of the 'Colli-Pee', a first-void urine collection device for self-sampling at home for the detection of sexually transmitted infections, versus a routine clinic-based urine collection in a one-to-one comparison study design: efficacy and acceptability among MSM in Belgium — De Baetselier et al., BMJ open
- urine
- first-void
- colli-pee
- self-collection
- acceptability
- sti
2018
First-void urine collected with a dedicated device showed good agreement with cervical samples for detecting HPV DNA and viral load, and was strongly preferred by patients over clinician collection, supporting its use for decentralised screening.
Human papillomavirus genotype and viral load agreement between paired first-void urine and clinician-collected cervical samples — Van Keer et al., European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
- urine
- first-void
- colli-pee
- self-collection
- acceptability
- hpv
2017
First-void urine self-collected with the Colli-Pee device detected high-risk HPV with sensitivity for CIN2+ comparable to clinician-taken smears and brush-based self-samples. This supports urine as a viable matrix for decentralised, patient-centric cervical cancer screening.
HPV testing in first-void urine provides sensitivity for CIN2+ detection comparable with a smear taken by a clinician or a brush-based self-sample: cross-sectional data from a triage population — Leeman et al., BJOG : an international journal of obstetrics and gynaecology (paywalled)
- urine
- first-void
- colli-pee
- self-collection
- validation
- hpv
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