The Library
1530 papers on microsampling and monitoring, each with a finding paraphrased to our standard and labelled in one vocabulary. Every entry links to a legitimate copy; nothing is copied from an abstract.
Papers 1–100 of 733 labelled “blood”, newest first.
2026
In AML and CLL, 91% of VAMS venetoclax results fell within 20% of plasma after individualised haematocrit correction; in home sampling, 18 of 21 patients self-sampled independently and 76% of returned samples were analysable, which shows home microsampling is workable, though the authors ask for multicentre validation.
Clinical Validation of Venetoclax Volumetric Microsampling in Leukemia, with Whole-Blood-to-Plasma Conversion and Self-Microsampling Feasibility — Levens et al., Clinical Pharmacokinetics (paywalled)
- vams
- venous-agreement
- blood
- dbs
- tdm
- self-collection
- haematocrit
- dried
- oncology
- capillary
- validation
2026
Guidance on capillary-to-plasma conversion: method- and analyte-specific clinical validation with paired capillary–venous samples before reporting plasma-equivalent results.
To Convert or Not to Convert? Official IATDMCT Guideline on Converting Capillary-Blood Microsampling Concentrations to Plasma Concentrations — Boffel et al., Therapeutic Drug Monitoring (paywalled)
- venous-agreement
- blood
- tdm
- standards
- dried
- capillary
- validation
2026
In four crew members, capillary volumetric absorptive microsampling caught altered acetaminophen pharmacokinetics in flight: Cmax rose to 43,300 ng/mL from 9,110 before flight and clearance fell to 3,890 mL/h from 16,200, pointing to toxicity risk at standard dosing; four people only, but a case for microsampling where no clinic can reach.
Volumetric Absorptive Microsampling During Spaceflight for Analysis of Acetaminophen Pharmacokinetics in Whole Blood — Mampre et al., Journal of clinical pharmacology
- blood
- capillary
- vams
- tdm
- dct
2026
The analysis indicates that dried blood spots and volumetric absorptive microsampling enable minimally invasive monitoring of prohibited substances, with volumetric absorptive microsampling offering improved quantitative reliability over traditional dried spots.
Liquid Chromatographic Methods for Microsampling in Sports Drug Monitoring: Progress in DBS and VAMS — Zhang, Biomedical chromatography : BMC (paywalled)
- vams
- doping
- blood
- dbs
- dried
- steroids
- toxicology
- hormones
- validation
- biomarkers
2026
At-home volumetric absorptive microsampling (VAMS) for anti-seizure medicines was feasible and reliable, with strong correlations to clinic VAMS and low bias for lacosamide, lamotrigine and levetiracetam; quantitative dried blood spot (qDBS) was a reliable alternative in the ambulatory setting, though older age reduced sampling quality.
Real-world evaluation of capillary microsampling for drug monitoring of anti-seizure medications — Cancellerini et al., Epilepsia (paywalled)
- vams
- venous-agreement
- acceptability
- blood
- qdbs
- tdm
- self-collection
- dried
- capillary
2026
Researchers successfully validated an analytical method for measuring creatinine across plasma and volumetric absorptive microsampling devices, demonstrating strong correlation between conventional plasma and dried microsamples. This provides a reliable, patient-centric approach for monitoring kidney function remotely during transplant follow-up.
Surrogate-based LC-MS/MS quantification of endogenous creatinine in plasma, plasma-equivalent dried spots (qDPS), and volumetric absorptive microsampling (VAMS): an ICH M10-compliant bridging study — Kocur et al., European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences (paywalled)
- vams
- venous-agreement
- neoteryx-mitra
- blood
- dried
- validation
- biomarkers
2026
In lung and renal transplant recipients, VAMS sampling with LC-MS/MS quantification of mycophenolic acid and tacrolimus showed good linearity and accuracy, and with a haematocrit-adjusted conversion formula achieved clinical agreement in most samples; tacrolimus did not require haematocrit correction. The approach is virtually painless and enables richer sampling for more accurate drug exposure estimates, supporting decentralised therapeutic drug monitoring.
Evaluation of hematocrit-adjusted conversion strategies for mycophenolic acid and tacrolimus monitoring using volumetric absorptive microsampling in lung and renal transplant recipients — Juan et al., Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
- blood
- dried
- vams
- neoteryx-mitra
- validation
- venous-agreement
- tdm
- immunosuppressants
- haematocrit
2026
This review found that volumetric microsampling devices, such as Mitra, HemaPEN, HemaXis DB10, and Tasso-M20, overcome haematocrit bias, whilst Telimmune plasma separation cards enable direct plasma collection without centrifugation. These technologies support patient-centric, decentralised sampling, though the authors note that clinical validation remains limited across different drugs and patient populations.
A Review of Blood-Based Microsampling Devices for Patient-Centered Application in Therapeutic Drug Monitoring — Huhn & Scherf-Clavel, Therapeutic drug monitoring (paywalled)
- vams
- volumetric
- acceptability
- neoteryx-mitra
- blood
- dbs
- tdm
- self-collection
- haematocrit
- dried
- capillary
- validation
2026
In 15 critically ill children with multiple organ dysfunction, a population pharmacokinetic model built on volumetric absorptive microsamples found that estimated glomerular filtration rate and age drove cefepime clearance and distribution; the authors take this as showing the method is workable for antimicrobial monitoring in this group.
Cefepime pharmacokinetics in critically ill children with multiple organ dysfunction syndrome using volumetric absorptive microsampling — Amajor et al., Antimicrobial agents and chemotherapy
- blood
- dried
- vams
- pediatric
- tdm
- antimicrobials
2026
Volumetric absorptive microsampling showed better precision than dried blood spots and a metabolic profile closer to whole blood, with stable signalling lipids for 24 hours at room temperature but significant changes after one week unless stabilised, indicating feasibility for decentralised sampling with the need for storage strategies.
Volumetric absorptive microsampling for profiling of signaling lipids: a comparative analysis with whole blood and dried blood spots — Thangavelu et al., Analytical and bioanalytical chemistry
- vams
- volumetric
- blood
- dbs
- metabolome
- dried
- validation
- biomarkers
2026
This study found that volumetric absorptive microsampling shows satisfactory agreement with venous plasma for monitoring several antiseizure medications in paediatric patients. However, a blood-to-plasma conversion factor was required to estimate plasma concentrations for clobazam and carbamazepine metabolites due to poor capillary-to-plasma interchangeability.
Volumetric Absorptive Microsampling (VAMS) for Therapeutic Drug Monitoring of Antiseizure Medications (ASMs) in Pediatric Patients — Simeoli et al., Pharmaceuticals (paywalled)
- blood
- dried
- vams
- validation
- venous-agreement
- pediatric
- tdm
2026
An LC-MS/MS method for tamoxifen and six metabolites in VAMS was developed and validated, with water prerinsing improving recoveries and poor room temperature stability but stability for at least 100 days at minus 80 degrees Celsius. Plasma to blood ratios were used to estimate plasma equivalent concentrations, and paired VAMS and plasma samples from ten breast cancer patients showed strong correlations and good agreement on Bland-Altman analysis, supporting reliable decentralised TDM.
Development and validation of an LC-MS/MS method for the comprehensive quantification of tamoxifen and its metabolites in volumetric absorptive microsampling: clinical application in breast cancer patients — Kuo et al., Analytical and bioanalytical chemistry (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- venous-agreement
- tdm
- oncology
2026
VAMS gave near‑quantitative recovery for cadmium and lead in human blood and correlated strongly with venous sampling, with pre‑cleaning improving correlation and lowering background lead, supporting its use for decentralised biomonitoring of these toxic elements.
Application of volumetric absorptive microsampling (VAMS) for the simultaneous determination of cadmium and lead in blood — Gutknecht et al., Environmental monitoring and assessment (paywalled)
- vams
- venous-agreement
- blood
- dried
- toxicology
- validation
2026
A post-mortem case study found that Mitra microsampling devices achieved comparable qualitative toxicological detection to conventional methods across blood, urine, bile, and vitreous humour, successfully identifying methamphetamine, opioids, and alpha-PHP. Whilst limited to a single case, this shows that microsampling is a viable alternative for qualitative screening when sample volumes are restricted.
Volumetric absorptive microsampling device for forensic Toxicologic screening: A case report as proof-of-concept — Magny et al., Forensic science international (paywalled)
- blood
- urine
- dried
- vams
- neoteryx-mitra
- toxicology
2026
In 480 adults, capillary specimens from fingertip lancets or the TAP Micro Select device gave clinically comparable results to venous samples for 16 of 18 routine chemistry analytes; potassium and chloride were not interchangeable, and fingertip collection showed more haemolysis, both points to weigh before decentralised microsampling of routine chemistry.
Venous-capillary blood agreement for routine chemistry analytes: effects of collection site and sample matrix — Deza et al., Clinical chemistry and laboratory medicine (paywalled)
- venous-agreement
- blood
- capillary
- yourbio
- validation
2026
This method validation for 15 cardiovascular drugs found that VAMS and Capitainer-B provided interchangeable patient results, although Capitainer-B showed higher matrix effects while VAMS exhibited stability losses for specific analytes after two weeks. The work confirms the suitability of these microsampling workflows for decentralised adherence monitoring but highlights the need for analyte-specific stability testing.
Capillary blood microsampling and LC-Orbitrap analysis for adherence monitoring of cardiovascular drugs: method development, cross-validation, and patient proof-of-concept using VAMS and Capitainer-B — Kretschmer et al., Talanta (paywalled)
- vams
- volumetric
- blood
- tdm
- dried
- capillary
- validation
2026
A liquid chromatography-tandem mass spectrometry method was successfully validated for measuring androstenedione, 17α-hydroxyprogesterone, and 11-ketotestosterone in dried blood samples collected via volumetric absorptive microsampling. The dried samples remained stable at room temperature for up to a week and after postal transit, and plasma concentrations could be reliably estimated from the microsamples when adjusting for haematocrit.
Analytical validation of a dried blood microsampling method to measure androstenedione, 17α‑hydroxyprogesterone, and 11‑ketotestosterone for congenital adrenal hyperplasia monitoring — De Baets et al., Talanta (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- venous-agreement
- pediatric
- hormones
- haematocrit
2026
Capillary dried blood spots, after haematocrit-dependent conversion, showed good agreement with plasma for 25-hydroxyvitamin D quantification, with 90 per cent of results within 20 per cent of plasma and substantial to almost perfect agreement in status classification, supporting reliable home self-collection for large-scale vitamin D monitoring.
Clinical validation of a DBS-based LC-MS/MS method for 25-hydroxyvitamin D: from lab sampling to home sampling — Heughebaert et al., Clinical chemistry and laboratory medicine (paywalled)
- venous-agreement
- blood
- dbs
- self-collection
- haematocrit
- dried
- capillary
- validation
- biomarkers
2026
An optimised VAMS workflow for blood proteomics increased protein identifications 4-fold in plasma and 2.1-fold in whole blood compared with liquid processing, with mean CVs below 11%, and whole blood showed greater robustness and storage stability at room temperature for up to 14 days. This enables reliable patient-centric microsampling for longitudinal biomarker studies.
Advancing Blood Proteome Analysis Past the Plasma Age: Mass Spectrometry of Whole Blood and Plasma Collected with Volumetric Absorptive Microsampling Devices — Karsten et al., Journal of proteome research (paywalled)
- vams
- neoteryx-mitra
- blood
- dried
- validation
- biomarkers
2026
The study found that self-collection of dried blood spots and other samples using at-home kits was a useful and cost-effective method for screening a large cohort for sexually transmitted infections outside a clinic. This demonstrates the feasibility of decentralised, patient-centric sampling for population-level infectious disease surveillance.
Prevalence of chlamydial, gonococcal and syphilis positivity by anatomical site and sex via self-collected biospecimens using at-home testing kits among a large and diverse cohort of men and women enrolled in the MACS/WIHS Combined Cohort Study (MWCCS) in the USA — Mimiaga et al., Sexually transmitted infections (paywalled)
- blood
- sti
- dbs
- self-collection
- dried
- serology
- bd-microtainer
- urine
2026
The study found that capillary dried plasma spots correlated strongly with venous plasma for detecting the Alzheimer's disease biomarker p-tau217. This suggests that microsampling offers a viable, minimally invasive alternative to venipuncture for screening and monitoring Alzheimer's disease pathology.
A minimally invasive dried blood spot biomarker test for the detection of Alzheimer's disease pathology — Huber et al., Nature medicine
- blood
- dried
- capillary
- dbs
- venous-agreement
- biomarkers
2026
The study found that although participants preferred patient-centric microsampling devices for home use, the agreement with venous plasma for measuring CRP and cytokines was inconsistent, indicating that further validation is required before these methods replace standard venipuncture.
Limited agreement of cytokines and CRP through patient-centric microsampling compared to venipuncture in healthy adults — Tuttle et al., Bioanalysis (paywalled)
- dct
- venous-agreement
- acceptability
- blood
- dbs
- self-collection
- dried
- biomarkers
2026
This retrospective analysis of over 600,000 online postal self-sampling orders found that whilst return rates for urine samples were moderate to high, the return of processable blood samples was significantly lower and varied by age and deprivation level.
Factors associated with the online postal self-sampling testing cascade in England, 2022: a retrospective observational study of routinely collected service-level healthcare data — Gibbs et al., Sexually transmitted infections (paywalled)
- blood
- sti
- self-collection
- serology
- urine
2026
Self-collected vaginal samples demonstrated comparable sensitivity to clinician-collected specimens for detecting high-grade squamous intraepithelial lesions, whereas urine and menstrual blood samples showed lower sensitivity despite moderate concordance for human papillomavirus detection.
HPV Detection in Clinician-Collected, Self-Collected Vagina, Urine, and Menstrual Blood Samples — Ho et al., Journal of lower genital tract disease (paywalled)
- blood
- urine
- self-collection
- hpv
- sti
2026
Self-collected salivary progesterone and the ratio of estradiol to progesterone showed strong agreement with serum levels, supporting the use of saliva as a noninvasive matrix for monitoring the menstrual cycle.
Salivary estradiol and progesterone across the menstrual cycle: Association and agreement with serum concentrations — Goldenstein et al., Physiological reports
- venous-agreement
- blood
- self-collection
- fertility
- hormones
- saliva
2026
This study validated a lateral flow fluorescence assay using quantum dots for saliva and europium nanoparticles for serum to detect cortisol within physiological ranges. The test operates in 15 minutes with a handheld reader, supporting point-of-care and at-home monitoring without a cold chain.
Ultrasensitive de novo Protein Sandwich Lateral flow Fluorescence Assay for Cortisol in Saliva and Serum using Quantum dots and Europium Nanoparticles — Bruno et al., Journal of fluorescence (paywalled)
- blood
- saliva
- liquid
- self-collection
- validation
- hormones
- cortisol
2026
In patients with type 2 diabetes and secondary polycythaemia, HbA1c-derived estimated mean plasma glucose showed a significant negative bias compared to structured home capillary blood glucose monitoring, whilst fructosamine served as a more reliable glycaemic marker.
Glycemic assessment in diabetic patients with secondary polycytheamia: limitations of HbA1c and the potential role of fructosamine-a prospective comparative study — Erarslan et al., Acta diabetologica (paywalled)
- blood
- haematocrit
- capillary
- liquid
- biomarkers
2026
The homeRNA capillary blood collection and stabilization platform successfully captured lipopolysaccharide-induced inflammatory gene expression profiles. These transcriptomic responses were comparable to those obtained from traditional venous blood samples stabilized with RNAlater or PAXgene, demonstrating the platform's suitability for remote transcriptomic monitoring.
From Home to Transcriptome: Comparing the Transcriptomic Profile of Induced Immune Response via Lipopolysaccharide Stimulation in homeRNA and Venous Blood — Brown et al., Analytical chemistry (paywalled)
- venous-agreement
- stabilised
- blood
- capillary
- liquid
- validation
- biomarkers
2026
The study validated a semi-quantitative protocol for Epstein-Barr virus serology using dried blood spots, demonstrating 98.8% sensitivity and 96.5% specificity compared to paired venous serum samples. The successful validation in a self-sampling cohort confirms the suitability of this patient-centric microsampling approach for large-scale seroprevalence studies and decentralised trials.
A dried blood spot protocol for high-throughput semi-quantitative analysis of Epstein-Barr Virus VCA IgG and EBNA IgG serologies based on the Roche Elecsys system — Rubio-Acero et al., Virology journal
- blood
- dried
- capillary
- dbs
- self-collection
- validation
- venous-agreement
- serology
2026
In pregnant women at high risk of gestational diabetes, the GTT@home capillary glucose device showed a small positive bias of 0.16 mmol/L versus venous laboratory OGTT, with 79.8 per cent of results in the lowest surveillance risk zone and diagnostic classification agreement in 54 of 61 cases, suggesting it could support home OGTT in pregnancy.
Use of the GTT@home Oral Glucose Tolerance Test Kit in Gestational Diabetes Mellitus: Performance Evaluation Study — Dunseath et al., JMIR diabetes
- blood
- liquid
- capillary
- validation
- venous-agreement
2026
The POC haemoglobin device showed moderate correlation with laboratory values but was not accurate enough for routine monitoring; however, it had a high negative predictive value at the 7 g/dL threshold, meaning it can reliably rule out severe anaemia and may help avoid unnecessary transfusions and hospital visits if confirmed in larger studies.
The Use of Point-of-Care Hemoglobin Measurements in an Elderly Population with Hematological Disorders and Anemia — Appel et al., Hematology reports
- blood
- liquid
- capillary
- venous-agreement
2026
A machine learning model called Remote Control was trained on 2685 blood samples to predict change due to instability, enabling accurate calibration of results to approximate the time zero value at collection. With calibration, unprocessed whole blood could be transported for up to 9 days under ambient conditions and temperatures between 3.4 and 47.4 degrees Celsius, achieving agreement with CLIA TEa between 98.1 and 100 per cent and expanding the catalog of tests available for at-home collection.
Prolonging Sample Stability with Machine Learning Expands the Catalog of Tests Available for Mail-In Capillary Blood Collected At-Home — O'Meara et al., Analytical chemistry (paywalled)
- dct
- blood
- self-collection
- capillary
- liquid
- validation
- biomarkers
2026
This proof-of-concept study demonstrated that patients with inflammatory bowel disease could successfully perform capillary blood microsampling at home with high analytical success rates, and a majority preferred this decentralised approach over hospital venous draws.
Implementation of a Capillary Blood Self-Sampling Technique at Home for Monitoring of Patients With IBD — Schuurman et al., Inflammatory bowel diseases
- acceptability
- multimodal
- blood
- rpm
- self-collection
- capillary
- liquid
2026
The True Dose TD-EPI kit demonstrated strong analytical agreement with venous blood for epirubicin monitoring, and the capillary samples remained stable for 72 hours at ambient temperature.
Method-Comparison Validation of a Novel Capillary Blood Collection Kit, True Dose<sup>®</sup> TD-EPI, for Therapeutic Drug Monitoring of Epirubicin — De Chiara et al., Pharmaceuticals
- venous-agreement
- stabilised
- blood
- tdm
- oncology
- capillary
- liquid
- validation
2026
This UK consensus opinion outlines how clinical laboratories can validate self-collected capillary blood sampling against venous reference standards to achieve accreditation and facilitate the shift towards community-based patient care.
UK recommendations for the validation and adoption of capillary blood testing within the routine clinical laboratory: Consensus opinion from the LabMed patient-centred testing and sampling (PaCTS) group — Woolley et al., Annals of clinical biochemistry (paywalled)
- venous-agreement
- blood
- standards
- self-collection
- capillary
- liquid
- validation
2026
Capillary blood samples collected by staff or self-collected by participants showed strong correlation and clinically acceptable agreement with venipuncture for influenza haemagglutination inhibition titers. The small differences observed were not clinically meaningful, and adequate sample volume was achieved in most attempts, supporting the feasibility of decentralised serological testing.
Comparison of influenza hemagglutination inhibition titers from capillary blood versus venipuncture — Rick et al., Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology (paywalled)
- blood
- liquid
- capillary
- self-collection
- validation
- venous-agreement
- serology
2026
This study found strong concordance between capillary samples collected via the Tasso device and standard venous draws for VirScan serology, indicating that self-collected samples are a practical alternative for decentralised research. The authors advise against interchanging these collection methods within a single longitudinal study to avoid introducing technical variability.
Assessing VirScan serosurvey epitope profiling variability between in-clinic venous blood draw and capillary blood self-sampling device — Sircy et al., Microbiology spectrum
- dct
- venous-agreement
- blood
- self-collection
- serology
- capillary
- liquid
2026
Self-collected capillary blood samples posted by standard mail showed high concordance with couriered venous samples for HbA1c, creatinine and lipid parameters, supporting their use for remote monitoring in diabetes management and screening.
Concordance of HbA1c, creatinine, LDL cholesterol, HDL cholesterol, and total cholesterol between venous and self-collected capillary blood samples sent by mail — Hoffmeister et al., Journal of diabetes investigation
- venous-agreement
- blood
- self-collection
- capillary
- liquid
- validation
2026
This study found that measuring thyroid-stimulating hormone via dried blood spots and a volumetric device showed high agreement with serum results, with classification accuracy exceeding 96 per cent. The volumetric approach demonstrated improved reproducibility and stability, supporting its use for decentralised thyroid function monitoring.
Adaptation of a routine immunoassay analyser for TSH measurement in dried blood spot and volumetric microsampling (Capitainer B50): evaluation for thyroid function testing in adults — Bornikowska et al., Practical laboratory medicine
- blood
- dried
- dbs
- volumetric
- validation
- venous-agreement
- hormones
2026
This study validated a dried blood spot method for tacrolimus monitoring and demonstrated agreement with venous whole blood measurements in kidney transplant recipients. It also found that dried blood spot analysis of the biomarker CXCL-10 was elevated in patients experiencing rejection or infection, supporting its use for decentralised monitoring.
Dried Blood Spot for CXCL-10 and Tacrolimus: Integrated Non-Invasive Monitoring to Guide Personalized Treatment in Adult Kidney Transplant Recipients — Millán et al., Pharmaceuticals
- venous-agreement
- blood
- dbs
- tdm
- dried
- immunosuppressants
- validation
- biomarkers
2026
Dried blood spot sampling achieved high agreement with serum for anti-Trypanosoma cruzi antibody detection, supporting its use in decentralised settings; however, samples collected on Cobas Plasma Separation Cards showed lower antibody index values than serum and Whatman cards, which may reduce sensitivity in low-titre specimens.
Comparison of Cobas Plasma Separation Cards and Whatman filter paper cards versus conventional serum samples for anti-Trypansoma cruzi antibody detection — Silgado et al., PLoS neglected tropical diseases (paywalled)
- blood
- dried
- dbs
- venous-agreement
- serology
2026
Frequent dried blood spot sampling detected early changes in beta-cell function more effectively than mixed-meal tolerance tests or urine ratios, supporting its potential as a decentralised monitoring tool for clinical trials.
Serial Dried Blood Spot C-Peptide Sampling, but Not Urine C-Peptide-to-Creatinine Ratio, Detects Early Preservation of β-Cell Function in New-Onset Type 1 Diabetes: Experience From the USTEKID Trial — Dunseath et al., Diabetes care (paywalled)
- dct
- blood
- dbs
- dried
- pediatric
- urine
- biomarkers
2026
In a 20-person proof-of-concept pilot among veterans with HIV, remote self-collection of dried blood spots for phosphatidylethanol monitoring was feasible and acceptable, with high return and analysis rates and positive feedback; a small first step toward decentralised alcohol biomarker monitoring rather than proof of it.
Remote alcohol biomarker monitoring to promote drinking reductions among people with HIV: A proof-of-concept pilot study — Sheinfil et al., Journal of substance use and addiction treatment (paywalled)
- acceptability
- blood
- dbs
- self-collection
- dried
- biomarkers
2026
Self-collected dried blood spot specimens for phenylketonuria monitoring showed very poor quality initially but improved substantially over a decade with training and education, reducing measurement error and the risk of incorrect clinical interpretation.
Improving self-collected dried blood spot specimens for phenylketonuria monitoring: a 10-year computer vision review of dried blood spot specimen quality — Flynn et al., Clinica chimica acta; international journal of clinical chemistry (paywalled)
- blood
- dbs
- self-collection
- dried
- validation
2026
In a pilot mixed-methods study of youth with HIV, mailed HemaSpot-HF kits enabled home-based dried blood spot collection that participants found feasible and acceptable, supporting remote viral load monitoring and a self-management model for decentralised care.
An Examination of Perceptions and Usage of Dried Blood Spot Biosampling Technology for HIV Viral Load Collection Among Youth with HIV — Gurung et al., AIDS and behavior (paywalled)
- blood
- dried
- dbs
- self-collection
- acceptability
- dct
- serology
2026
Enhanced visual and textual guidance significantly improved the quality of dried blood spots self-collected by children and adolescents, increasing the proportion of acceptable cards from 47.6% to 86.6%, which supports the feasibility of home sampling for therapeutic drug monitoring.
Optimizing Dried Blood Spot Sampling for Children and Adolescents With Autism Spectrum Disorder — Ringeling et al., Therapeutic drug monitoring
- blood
- dried
- dbs
- self-collection
- pediatric
- tdm
2026
The study found that quantitative dried blood spot sampling provided high clinical agreement for tacrolimus and creatinine monitoring, with patients rating the self-collection devices as user-friendly. These results support the feasibility of decentralised therapeutic drug monitoring for immunosuppressants.
Patient-centric capillary dried blood spot sampling for tacrolimus and creatinine monitoring in clinical practice — De Baets et al., Clinical chemistry and laboratory medicine (paywalled)
- blood
- dried
- capillary
- dbs
- qdbs
- self-collection
- venous-agreement
- acceptability
- tdm
- immunosuppressants
2026
This pilot study demonstrated that a fully remote web-based testing programme for sexually transmitted and blood-borne infections was feasible and acceptable overall, although participants encountered specific collection challenges with the dried blood spot component.
Comprehensive at-home sexually transmitted and blood borne infection (STBBI) testing program: A pilot study — Christensen et al., International journal of STD & AIDS
- blood
- urine
- dried
- dbs
- self-collection
- acceptability
- sti
2026
Although most kidney transplant recipients successfully collected capillary blood samples at home, haemolysis and transport conditions affected analyte stability. Agreement with venous sampling was acceptable for haemoglobin and creatinine, but potassium and haematocrit exceeded total allowable error limits.
At-home blood collection for clinical chemistry analyses in a kidney transplant population: a feasibility study — Hoekstra et al., Clinical chemistry and laboratory medicine (paywalled)
- blood
- liquid
- capillary
- bd-microtainer
- self-collection
- validation
- venous-agreement
2026
This developer study reports that a self-collection kit interfacing with a BD Microtainer produced RNA of sufficient quality and yield for transcriptomic analysis in a pilot group and a longitudinal rheumatology cohort. Most participants found the device easy to use, supporting its utility for decentralised blood sampling.
To the homeRNAmax: Developing an Improved Blood Self-Collection and Stabilization Platform for Remote Transcriptomic Studies — Eakman et al., Analytical chemistry (paywalled)
- dct
- blood
- self-collection
- bd-microtainer
- liquid
- validation
- biomarkers
2026
This study employed volumetric absorptive microsampling to collect blood samples from neonates, revealing that existing propofol pharmacokinetic models poorly predicted drug levels in this population. A newly developed meta-model provided accurate predictions, validating the use of patient-centric microsampling for therapeutic drug monitoring in preterm and term infants.
Systematic evaluation of propofol population pharmacokinetic models and development of a literature-supported new meta-model for critically ill preterm and term neonates — Rantanen et al., European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- pediatric
- tdm
2026
This study validated a method for monitoring mycophenolic acid in paediatric patients, demonstrating that quantitative dried plasma spots achieved close agreement with venous plasma. Quantitative dried blood spots showed significant haematocrit-related bias, making the plasma-based format more suitable for decentralised monitoring.
Matrix fidelity in microsampling: Plasma-first LC-MS/MS quantification of mycophenolic acid and MPAG — Kocur et al., Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (paywalled)
- venous-agreement
- blood
- qdbs
- tdm
- haematocrit
- dried
- pediatric
- immunosuppressants
- validation
2026
Capillary samples collected using dried blood spots and Mitra microsamplers showed strong agreement with venous plasma for quantifying IgG antibodies against most vaccine-preventable diseases. Sensitivity was high for the majority of pathogens, though the study noted that antibody stability declined at room temperature over time, favouring cold storage for longer durations.
Comparison of capillary microsampling and venous blood for multi-pathogen serosurveillance — Ombati et al., Scientific reports (paywalled)
- blood
- dried
- capillary
- vams
- dbs
- neoteryx-mitra
- validation
- venous-agreement
- serology
2026
Task sharing dried blood spot collection for HIV viral load testing with community lay cadres achieved high diagnostic agreement with healthcare worker collections and was highly acceptable to patients. This approach offers a viable strategy to overcome healthcare worker shortages and support decentralised viral load monitoring in resource-limited settings.
Feasibility and acceptability of task sharing collection of HIV viral load dried blood spot samples with community lay cadres: A cross-sectional diagnostic validation study in Zimbabwe — Prust et al., PLOS global public health
- acceptability
- blood
- dbs
- dried
- serology
- validation
2026
This review establishes that microsampling across blood, saliva, urine and stool matrices offers validated workflows and regulatory recognition for human biomonitoring comparable to conventional methods. It finds that these decentralised approaches enhance participant acceptability and enable screening in remote or low-resource settings.
Integrating Microsampling in Human Biomonitoring: Methodologies, Regulatory Frameworks, and Case Study Insights — Rajamani & Poongavanam, Critical reviews in analytical chemistry (paywalled)
- wearable
- acceptability
- multimodal
- sweat
- blood
- dbs
- standards
- dried
- serology
- colorectal
- pediatric
- stool
- urine
- validation
- saliva
- biomarkers
2026
Volumetric microsampling can enable patient-centred therapeutic drug monitoring with high patient preference and acceptable method validation for many drugs, but conversion from capillary to plasma and agreement with venous sampling varies by analyte and requires careful validation.
Volumetric Microsampling for Patient-Centric Therapeutic Drug Monitoring in Clinical Pharmacology: A Scoping Review — Tummala et al., Journal of clinical pharmacology (paywalled)
- volumetric
- venous-agreement
- acceptability
- blood
- tdm
- self-collection
- haematocrit
- dried
- capillary
- validation
2026
In a large study using self-collected capillary blood, current vaping and smoking were independently associated with lower levels of anti-Müllerian hormone, a marker of ovarian reserve. This demonstrates the utility of decentralised capillary sampling for large-scale epidemiological research on reproductive health.
E-cigarette use (vaping) and cigarette smoking are associated with reduced markers of ovarian reserve: a cross-sectional study of 16,087 women — Getreu et al., BMC women's health (paywalled)
- blood
- self-collection
- capillary
- fertility
- hormones
2026
Capillary fingerstick sampling showed high correlation and agreement with venous sampling for serum AMH but with proportional bias, so it may improve access to testing yet should not be considered fully interchangeable without further validation.
Comparison of serum anti-Müllerian hormone concentrations measured in capillary fingerstick and venous samples from Korean reproductive-aged women — Lavadia et al., Clinical and experimental reproductive medicine (paywalled)
- blood
- capillary
- validation
- venous-agreement
- acceptability
- fertility
- hormones
2026
Fingerstick capillary sampling showed strong agreement with venous sampling for mycophenolic acid, tacrolimus and cyclosporine A, with acceptable bias and improved agreement for mycophenolic acid after haematocrit correction. This minimally invasive approach may reduce procedural burden and support outpatient or home based therapeutic drug monitoring in children.
Minimally Invasive Therapeutic Drug Monitoring of Immunosuppressants in Children with Kidney Diseases: Validation of Fingerstick Sampling Using LC-MS/MS — Ishii et al., Pharmaceuticals
- venous-agreement
- blood
- tdm
- haematocrit
- capillary
- pediatric
- immunosuppressants
- validation
2026
This study validated a method requiring only 10 microlitres of serum and found high agreement between fingerstick capillary samples and venous serum for monitoring twelve antibiotics. The results suggest capillary serum sampling is a feasible, minimally invasive alternative that avoids the haematocrit effect associated with whole blood microsampling.
Feasibility verification of fingerstick capillary microsampling replacing venipuncture for therapeutic drug monitoring of 12 antibiotics using a rapid LC-MS/MS assay — Chen et al., Talanta (paywalled)
- blood
- liquid
- capillary
- validation
- venous-agreement
- pediatric
- tdm
- antimicrobials
2026
The study developed and validated a reliable HPLC-MS method for quantifying multiple tyrosine kinase inhibitors from VAMS microsamples of capillary blood, showing acceptable accuracy, precision, and 28-day stability at -21°C, with results comparable to venous plasma in 194 samples from patients with solid tumours. This enables therapeutic drug monitoring using microsamples in oncology practice.
HPLC-MS Quantification of Multiple Tyrosine Kinase Inhibitors in Patients with Solid Tumors: Method Validation and Clinical Application — Staudinger et al., Pharmaceutics (paywalled)
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- tdm
- oncology
2026
A validated two-step LC-MS/MS protocol can identify 91 prohibited doping agents from a single dried blood spot collected on either cellulose cards or volumetric absorptive microsampling devices. This demonstrates robust multi-analyte screening from capillary blood, supporting decentralised anti-doping programmes where venous sampling is impractical.
Dried Blood Spots for Doping Purpose-Two-Step Protocol for Analysis of Non-Threshold Substances and Anabolic Steroid Esters From One Spot/Pebble — Stojanovic et al., Biomedical chromatography : BMC (paywalled)
- blood
- dried
- capillary
- vams
- dbs
- validation
- doping
- toxicology
2026
Capillary finger-stick dried blood spots demonstrated strong analytical agreement with venous serum for prostate-specific antigen (R² = 0.987) and remained stable for 31 days across a wide temperature range. This less invasive microsampling approach enables at-home self-collection, supporting decentralised screening and tele-diagnostics for prostate cancer.
Accessible Prostate-Specific Antigen Testing through Finger-Stick Dried Blood Spots and Routine Laboratory Analyzers — van Vugt et al., The journal of applied laboratory medicine (paywalled)
- blood
- dried
- capillary
- dbs
- self-collection
- validation
- venous-agreement
- haematocrit
- biomarkers
2026
In a study of 46 perinatal nicotine users, dried blood spots and saliva were used weekly to measure reproductive hormones, finding that lower postpartum estradiol and greater peripartum declines in oxytocin were associated with increased nicotine craving and use. This demonstrates the feasibility of decentralised microsampling and remote surveys for longitudinal hormone tracking in vulnerable populations.
Exploring hormonal influences on nicotine craving and use across the perinatal period: A prospective longitudinal study — Allen et al., Drug and alcohol dependence reports (paywalled)
- blood
- dbs
- cortisol
- self-collection
- dried
- fertility
- hormones
- saliva
2026
This review highlights that microsampling techniques such as dried blood spots and volumetric absorptive microsampling offer superior alternatives to traditional sampling for the mass spectrometry detection of prohibited substances in anti-doping analysis. It provides guidance on selecting appropriate analytical methods and sample pretreatment strategies to ensure sensitive detection and reliable storage conditions.
Mass Spectrometry-Based Anti-Doping Analysis: A Critical Review of Emerging Analytical and Sample Pretreatment Strategies — Maykar et al., Critical reviews in analytical chemistry (paywalled)
- blood
- urine
- dried
- vams
- dbs
- validation
- doping
- toxicology
2026
Capillary blood collected with Tasso+ devices demonstrated strong agreement with venous blood for primary Athlete Biological Passport markers (haemoglobin, reticulocytes, OFF-score, ABPS) with correlations ≥0.9, though platelet count showed poor concordance. Despite 44 of 209 samples failing pre-analytical checks mainly due to coagulation, high athlete acceptance and minimal pain support capillary sampling as a less invasive, viable alternative for decentralised anti-doping controls.
Capillary Blood as a Potential New Matrix for the Athlete Biological Passport: A Field-Based Comparison Study — Requena-Tutusaus et al., Medicine and science in sports and exercise (paywalled)
- blood
- liquid
- capillary
- validation
- venous-agreement
- acceptability
- doping
2026
ALAS2 and CA1 mRNA were reliably quantified from venous-cellulose, capillary-cellulose and Tasso-M20 dried blood spots with strong linear agreement (r ≥ 0.96) and no bias for ALAS2. CA1 showed modest proportional bias of 9-22% only when Tasso-M20 was compared with cellulose cards in the rEPO cohort, but no significant differences in relative expression across matrices were observed at any timepoint. These findings support decentralised capillary sampling for longitudinal anti-doping monitoring.
Comparison of Dried Blood Spot Sampling Methods for RNA-Based Biomarker Measurement in Anti-Doping — Bejder et al., Drug testing and analysis
- blood
- dried
- capillary
- dbs
- validation
- venous-agreement
- doping
- biomarkers
2026
In a cohort of 62 participants evaluating home self-collection with the TassoPlus device, 38 returned samples, with 29% excluded due to insufficient plasma volume below 200 ΔL. Although viral load measurements in adequate samples correlated well with conventional testing (r = 0.800), the high failure rate and missed detection in low-volume viremic samples indicate that further technical refinements are necessary before clinical adoption.
Feasibility and reliability of decentralized HIV-1 viral load monitoring on self-sampled blood — Mendes de Leon et al., PloS one
- blood
- liquid
- capillary
- self-collection
- validation
- venous-agreement
- acceptability
- serology
2026
In a feasibility randomised controlled trial with 28 adults aged 65 years, 62% successfully self-collected finger-prick capillary blood samples for influenza antibody and vitamin D measurement. While overall study procedures were acceptable, the capillary sampling method requires refinement before wider deployment in decentralised diagnostics for older adults.
PROTECTIVE-D-a feasibility randomised controlled trial examining the effect of a positive mood intervention and vitamin D supplementation on the immunological responses to influenza vaccination in older adults — Royal et al., Pilot and feasibility studies (paywalled)
- blood
- capillary
- self-collection
- acceptability
- dct
2026
Among 8007 neonates screened using dried blood spots, the study identified prevalence rates for congenital hypothyroidism (1:2002), congenital adrenal hyperplasia (1:2002) and G6PD deficiency (1:900), with abnormal results confirmed by venous sampling. This demonstrates the practical utility of microsampling for decentralised newborn screening and subsequent clinical management.
Birth Prevalence of Endocrine-Metabolic Disorders Detected by Newborn Screening Test in Pune (India) Population — Narawade et al., Indian journal of clinical biochemistry : IJCB (paywalled)
- blood
- dried
- dbs
- pediatric
- hormones
2026
Menstrual blood offers a noninvasive, patient-centric matrix for detecting endometriosis, cervical cancer, and hormonal disorders through self-collected samples. Wearable in-pad biosensors enabling real-time monitoring and long-term tracking could transform fertility evaluation and early disease detection, though standardisation and large-scale validation remain critical gaps.
Beyond waste: menstrual blood as a powerful diagnostic tool for women's health — Shafiq et al., Annals of medicine and surgery
- blood
- self-collection
- fertility
- hormones
- wearable
- multimodal
2026
In female shift workers, 0.3 mg melatonin reduced climacteric symptoms by 15.8% compared with placebo and improved sleep quality on days off by 35.33%, with no shift interaction; home blood sampling enabled measurement of LH, FSH, estradiol and progesterone.
Low-Dose Melatonin, Climacteric Symptoms and Sleep in Female Shift Workers: A Randomized Controlled Trial — Saraiva et al., Journal of pineal research
- blood
- fertility
- hormones
2026
Low-volume blood collection devices enable frequent, longitudinal sampling at home with reduced invasiveness, thereby improving participant retention in patient-centric studies. This facilitates decentralised biomarker monitoring for tracking disease progression and understanding physiological responses to diet, medication and physical activity.
Low-volume collection devices for longitudinal biomarker monitoring in patient-centric sampling settings — Simon-Guth et al., Bioanalysis (paywalled)
- blood
- self-collection
- validation
- dct
- biomarkers
2026
A female participant using the Tasso+ capillary self-blood collection device developed a gaping lesion at the application site that required surgical treatment and left a permanent scar, highlighting an unexpected safety issue and the need for further safety evaluation of self-administered blood collection systems.
Unexpected scarring following use of capillary self-blood collection device: A case report and discussion of device design — Müller et al., The journal of vascular access
- blood
- capillary
- self-collection
2026
A liquid-phase microsampling method using 2.8 µL of whole blood demonstrated strong correlation with conventional venous sampling for immunosuppressant monitoring in renal transplant recipients. This approach enables patient-centric therapeutic drug monitoring, reducing burden and supporting implementation in home-based, paediatric, and telemedicine settings.
Clinical Application of Microvolume LC-MS/MS for Therapeutic Drug Monitoring of Immunosuppressants in Solid-Organ Transplant Recipients — Iwami et al., Journal of clinical medicine
- blood
- liquid
- validation
- venous-agreement
- tdm
- immunosuppressants
- haematocrit
2026
Statewide mail-based serosurveys using dried blood spot cards showed high spike antibody positivity and rising neutralising antibodies over time, with no differences by socio-demographic factors, supporting the feasibility of decentralised self-sampling for population infection surveillance.
Population-based serosurveys for SARS-CoV-2 transmission 2021-2022, Massachusetts USA — Cramer et al., Vaccine (paywalled)
- blood
- dried
- dbs
- self-collection
- serology
2026
Capillary blood collected by volumetric absorptive microsampling gave a shorter detection window than urine for a stimulant, helping to distinguish recent from earlier use, and more reliable detection of long-acting diuretics that bind red cells. This shows microsampling can improve interpretation in drug-monitoring programmes where urinary data alone may be ambiguous.
Stressing the limits of capillary blood in anti-doping analysis: perspectives on alkylamine-like stimulants and carbonic anhydrase II inhibitors in result management — da Costa Nunes et al., Frontiers in sports and active living
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- doping
- toxicology
2026
In a nationwide survey of 1047 Belgian adults, at-home VAMS achieved a 63% participation-to-analysis completion rate with 16% of samples excluded due to insufficient quality. While dietary intake suggested adequate thiamine consumption, 11% of participants had blood thiamine diphosphate concentrations below the reference threshold, showing the utility of remote microsampling for identifying true nutritional status.
Thiamine status in Belgian adults assessed by volumetric absorptive microsampling: a nation-wide cross-sectional survey — Heughebaert et al., The American journal of clinical nutrition (paywalled)
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- self-collection
- biomarkers
2026
The authors validated VAMS for lumateperone therapeutic drug monitoring and confirmed its stability, which supports decentralised, patient-centric antipsychotic therapy through low-volume blood collection.
Volumetric absorptive microsampling for lumateperone analysis: method validation and stability evaluation — Milandri et al., Analytical and bioanalytical chemistry
- blood
- dried
- vams
- neoteryx-mitra
- validation
- tdm
2026
The authors developed and optimised a dual LC-MS workflow for non-targeted metabolomics from blood microsamples, comprising a 15-minute HILIC-MS method for polar metabolites and an RPLC-MS method for mid- to non-polar compounds. A 20% water/80% methanol extraction with rehydration offered a practical compromise that detected numerous metabolite features across amino acid, acylcarnitine and bile acid pathways, enabling decentralised metabolomic analysis.
RPLC- and HILIC-based non-targeted metabolomics workflow for blood microsamples — Couacault & Witting, Metabolomics : Official journal of the Metabolomic Society
- blood
- dried
- vams
- neoteryx-mitra
- validation
- metabolome
2026
The study found that dried blood microsampling using DBS and VAMS improves the detection of unstable drugs in post-mortem blood compared to conventional tubes, with some substances showing better stability on microsamples. This supports the use of microsampling in forensic settings where sample degradation affects diagnostic accuracy.
Use of blood micro-samples in forensic thanatology — Bertrand-Ndoye et al., Forensic science international (paywalled)
- blood
- dried
- vams
- dbs
- toxicology
2026
Analysis of dried blood spots from 813 newborns demonstrated that extremely preterm infants have markedly elevated corticosterone and 17-hydroxyprogesterone, with the latter showing the strongest inverse correlation with gestational age, indicating these precursors better reflect adrenal immaturity than cortisol alone. This validates DBS as a practical tool for guiding postnatal steroid therapy in preterm infants by helping clinicians distinguish physiological adrenal immaturity from true insufficiency.
Elevation of corticosterone and 17OH progesterone in extremely preterm infants and clinical implications — Kessel et al., Pediatric research
- blood
- dried
- dbs
- pediatric
- hormones
- cortisol
2026
In adults with type 1 diabetes, Dexcom G7 and FreeStyle Libre 3 showed high accuracy during physical activity, whereas the Simplera system was less accurate; this matters for selecting devices in decentralised monitoring.
Performance of three simultaneously used rtCGM systems around a physically active weekend camp in adults with type 1 diabetes: A prospective lab and real-world study — Sanfilippo et al., Diabetes, obesity & metabolism
- blood
- capillary
- wearable
- cgm
- multimodal
2026
Dried blood spot collection proved feasible during parabolic flight, with seventeen of twenty volunteers successfully providing samples for caffeine pharmacokinetic profiling. The method yielded stable metabolic ratios between ground and weightless conditions, and participants reported high satisfaction, suggesting DBS could support therapeutic drug monitoring in remote or extreme environments such as long-term spaceflight.
Feasibility of dried blood spot collection for caffeine pharmacokinetic studies in microgravity: Insights from parabolic flight campaigns — Derobertmasure et al., British journal of clinical pharmacology
- blood
- dried
- dbs
- self-collection
- acceptability
- tdm
- genotyping
2026
Among 101 working-age women in Chicago, 70% returned at-home kits for capillary blood and saliva collection, demonstrating that patient-centric microsampling of stress biomarkers (cortisol and CRP) is feasible in diverse urban populations. This supports decentralised diagnostics for population health research.
A feasibility study exploring precarious employment and stress-related health among women — Oddo et al., BMC public health
- blood
- saliva
- capillary
- self-collection
- cortisol
- biomarkers
2026
Capillary whole blood collected and dried on the OneDraw device gave robust PFAS measurements with low limits of quantification, and levels of ten PFAS correlated strongly with matched venous plasma levels in 133 veterans, enabling remote sampling without clinical infrastructure.
Use of a capillary blood collection device to monitor exposure to per- and polyfluoroalkyl substances (PFAS) in Veterans living in proximity to potential sources of environmental contamination — Havens et al., Journal of exposure science & environmental epidemiology (paywalled)
- blood
- dried
- capillary
- validation
- venous-agreement
2026
Capillary blood obtained using an at-home collection device matched venous blood closely in immune cell composition and phenotype. Although shipping affected myeloid cells, T cell numbers, subsets, and phenotypes stayed stable, which supports the practicality of remote immune monitoring.
An at-home blood collection device for remote immune monitoring by high-parameter flow cytometry — Konecny et al., JCI insight
- blood
- liquid
- capillary
- validation
- venous-agreement
2026
The study found that coached dried blood spot collection was feasible for remote biobehavioural assessment of CTRA gene expression among Black women activists, with usable data from 28 of 29 participants at baseline and 27 at follow-up. Within-person increases in activist identity and search for meaning were associated with more favourable CTRA gene expression changes, though mean CTRA did not shift across the group over the two-month period.
The paradox of action: Trajectories in distress, meaning, and gene regulation following self-directed activist engagement among Black women — Geyton & Cole, SSM. Mental health
- blood
- dried
- dbs
- self-collection
- dct
2026
Self-collected dried blood spots from 40 healthy participants arrived intact and yielded good-quality DNA, with most immune and epigenetic biomarkers remaining stable for up to six weeks at room temperature. The study confirms that minimally invasive dried blood and plasma spot sampling is feasible for scalable, longitudinal biomolecular surveillance in occupational health settings.
Dried blood spot-based monitoring of immune and epigenetic biomarkers in occupational exposure studies — De Ryck et al., Journal of exposure science & environmental epidemiology (paywalled)
- blood
- dried
- dbs
- self-collection
- validation
- acceptability
- biomarkers
2026
Finger-stick dried blood spots produce creatinine measurements that correlate strongly with venous plasma (R² = 0.97), with 91% sensitivity and 96% specificity for detecting reduced eGFR. Creatinine stays stable in dried spots for up to one month at refrigerated or frozen temperatures, supporting accurate home-based kidney function screening, patient follow-up, and medication management.
Creatinine measurement from finger stick dried blood spots with a routine chemistry analyzer for estimation of GFR — van Dam et al., Clinical chemistry and laboratory medicine (paywalled)
- blood
- dried
- capillary
- dbs
- self-collection
- validation
- venous-agreement
- haematocrit
2026
Dried blood spot screening of 3210 neonates in an Eastern Indian province found 10.2% had an inherited disorder, most commonly partial biotinidase deficiency (4.5%) and G6PD deficiency (2.7%), with no sex difference except higher 17-OHP in males; the findings justify national newborn screening to reach all communities.
Newborn screening in an Eastern Indian province: prevalence and trends from a burgeoning newborn screening unit — Saharia et al., Journal of tropical pediatrics (paywalled)
- blood
- dried
- dbs
- pediatric
2026
This study demonstrated that a fully remote genome sequencing study using self-collected dried blood spots and buccal swabs is feasible for individuals with Prader-Willi syndrome, with all participants completing the study and reporting the process was easy despite being lengthy. The design successfully returned actionable genetic findings, including those related to blood clot formation, to participants.
Study design with responsible return of results for a fully remote genome sequencing study in individuals with Prader-Willi syndrome — Vrana-Diaz et al., Genetics in medicine open
- blood
- saliva
- dried
- dbs
- self-collection
- acceptability
- dct
- genotyping
2026
This scoping review identified 15 distinct technologies for measuring HbA1c from capillary blood, with point-of-care devices requiring only 2 to 10 µL and delivering results within minutes. However, diagnostic accuracy varied widely between studies and devices, and most evidence comes from high-income countries, indicating gaps in validation for low- and middle-income settings where decentralised screening is most needed.
HbA1c measurement using capillary blood in epidemiological studies: a scoping review of technologies and approaches — Breternitz et al., BMC endocrine disorders (paywalled)
- blood
- dried
- capillary
- dbs
- self-collection
- validation
2026
Home DBS sampling gave testosterone results that agreed well with venous blood in men on intramuscular testosterone undecanoate, but showed falsely high values in those using topical gel, likely from skin contamination. Patients preferred home collection for its convenience, suggesting DBS is viable for decentralised monitoring of injectable testosterone if patients are taught proper technique.
From venipuncture to self-sampling dried blood spots: a shift in monitoring testosterone levels — Olthof et al., Clinical chemistry and laboratory medicine (paywalled)
- blood
- dried
- capillary
- dbs
- self-collection
- validation
- venous-agreement
- acceptability
- fertility
- hormones
- tdm
2026
The TaqPath kit performed well for HIV drug resistance testing from dried blood spots in samples with high viral loads, meeting WHO criteria for sensitivity and mutation detection, but showed reduced sensitivity at lower viral loads below 5000 copies/mL. This supports the use of DBS for decentralised HIV monitoring in resource-limited settings, though caution is needed when viral load is low.
Evaluation of the Applied Biosystems™ TaqPath™ Seq HIV-1 Genotyping Kit for HIV-1 drug resistance testing from dried blood spot specimens — Okafor et al., Journal of virological methods (paywalled)
- blood
- dried
- dbs
- validation
- serology
2026
Among 1242 asymptomatic children in a remote Congolese district, dried blood spot sampling identified 53% as Plasmodium falciparum-positive. No validated artemisinin-resistance mutations were found, but a lumefantrine-susceptibility marker was present in 15% of samples, demonstrating that community-based microsampling can generate actionable resistance surveillance data to guide decentralised malaria treatment strategies.
Prevalence of antimalarial drug resistance markers and factors associated with Plasmodium falciparum infection in asymptomatic children prior to rectal artesunate implementation in Kapolowe Health District, Democratic Republic of the Congo — Luzolo Khote et al., Malaria journal (paywalled)
- blood
- dried
- dbs
- pediatric
- serology
2026
The study validated an LC-MS/MS method for eight antiepileptic drugs and two metabolites in dried blood spot and VAMS formats, with satisfactory analytical performance and stability, and was the first to include the oxcarbazepine metabolite DHCB. In 80 paired patient samples, microsampling concentrations showed promising correlation with plasma, supporting decentralised therapeutic drug monitoring of antiepileptic treatment.
Development and application of an LC-MS/MS method for 8 antiepileptic drugs and 2 metabolites using microsampling techniques (DBS and VAMS) — Cobo-Golpe et al., Journal of analytical toxicology
- blood
- dried
- vams
- dbs
- neoteryx-mitra
- validation
- venous-agreement
- tdm
- haematocrit
2026
Untargeted metabolomic profiles from three blood microsampling devices aligned more closely with whole blood than with plasma, and all devices distinguished sex based on amino acids, lipids, and acylcarnitines. This validates that device choice can be tailored to the metabolites of interest for decentralised human biomonitoring.
An LC-MS untargeted metabolomic comparison between three blood microsampling devices, whole blood, and plasma — Avella et al., Metabolomics : Official journal of the Metabolomic Society
- blood
- dried
- vams
- neoteryx-mitra
- validation
- venous-agreement
- metabolome
- biomarkers
2026
This narrative review surveys remote biospecimen collection products for sexual health research, including dried blood spots and volumetric absorptive microsampling, and concludes that successful implementation needs a multidisciplinary, participant-centred team with sufficient time allocated to the complexities of collection procedures and processes.
A Narrative Review of Remote Biospecimen Collection Product and Implementation Considerations for Sexual Health Clinical Research — Horvath et al., AIDS and behavior (paywalled)
- blood
- dried
- vams
- dbs
- self-collection
- validation
- dct
- serology
- sti
2026
A streamlined workflow quantified up to 10,000 protein groups and post-translational modifications from 20 microlitres of dried blood collected by volumetric absorptive microsampling, with mass spectrometry acquisition under two hours. The study established stability profiles and best practices for dried blood proteomics, supporting its feasibility for decentralised precision medicine and disease phenotyping.
Development and Validation of a Streamlined Workflow for Proteomic Analysis of Proteins and Post-translational Modifications from Dried Blood — Foster et al., Journal of proteome research (paywalled)
- blood
- dried
- vams
- validation
- biomarkers
- multi-omics
- multimodal
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