The Library
1530 papers on microsampling and monitoring, each with a finding paraphrased to our standard and labelled in one vocabulary. Every entry links to a legitimate copy; nothing is copied from an abstract.
12 papers labelled “actigraphy”, newest first.
2026
A fully remote decentralised clinical trial in Danish adults with type 2 diabetes demonstrated operational feasibility with rapid recruitment, high retention (87 percent), and excellent adherence to continuous glucose monitoring (95 percent achieving ≥70 percent data coverage) and telemedicine visits (97 percent). Activity tracker adherence was poor (12 percent) due to technical issues, but remote safety monitoring was effective with no unexpected adverse events, supporting the viability of remote diabetes management.
Operational and Clinical Insights from a Fully Decentralized Clinical Study Evaluating Protocol Adherence, Participant Satisfaction, and Connected Device Data in Individuals with Type 2 Diabetes on Different Treatment Regimens — Nørgaard et al., Diabetes technology & therapeutics (paywalled)
- dct
- wearable
- rpm
- cgm
- actigraphy
2025
This study found that a decentralised approach using home-based sleep apnoea screening, heart rhythm monitoring and activity tracking in patients with atrial fibrillation is feasible, with high data completeness and low drop-out rates. The results support the use of patient-centric digital tools in decentralised trials for chronic cardiac conditions.
Feasibility of a decentralised trial of sleep apnoea screening in patients with atrial fibrillation — Hashiba et al., Danish medical journal (paywalled)
- dct
- wearable
- rpm
- digital-biomarker
- actigraphy
2025
In 50 cancer patients monitored at home with an Apple Watch for 28 days, a method that classified missing step data by gap duration and context produced the most reliable daily step estimates. Daily step counts on days with at least ten hours of wear time predicted time to first clinical event (p=0.068) and identified participants at lower hazard of mortality, with 83.3% accuracy for clinical event prediction, demonstrating that processed consumer wearable data can support remote monitoring in decentralised oncology trials.
Analysis Method of Real-World Digital Biomarkers for Clinical Impact in Cancer Patients — Oakley-Girvan et al., Digital biomarkers
- oncology
- dct
- wearable
- digital-biomarker
- actigraphy
2024
In a 14-day study of youth with neurodevelopmental conditions and chronic pain, multimodal in-home monitoring achieved good accelerometer wear compliance (77% wore devices for at least 7 days) and moderate survey engagement, but adherence to salivary cortisol sampling was low at 28% after excluding protocol violations and dry swabs. Families reported high overall satisfaction and willingness to participate again, highlighting that remote sampling protocols in pediatric populations require iterative tailoring to improve biospecimen collection adherence.
The Living Lab at Home: Feasibility and Acceptability of Multimodal In-Home Data Collection Among Youth Across the Developmental Spectrum — Boerner et al., Journal of developmental and behavioral pediatrics : JDBP
- saliva
- self-collection
- acceptability
- pediatric
- cortisol
- wearable
- actigraphy
- multimodal
2023
In this observational study of 14 female students, greater total daily energy expenditure and a later midpoint of sleep were associated with lower severity of several menstruation-related symptoms during the menstrual and luteal phases. These findings suggest that lifestyle factors such as physical activity and sleep timing may inform non-pharmacological management of menstrual symptoms, though larger studies are needed to confirm clinical utility.
Menstruation-related symptoms are associated with physical activity and midpoint of sleep: a pilot study — Masuda & Okada, Frontiers in global women's health
- fertility
- wearable
- digital-biomarker
- actigraphy
2023
Decentralised monitoring of people with type 2 diabetes using continuous glucose monitoring and a hybrid smartwatch was feasible, with high participant retention and successful collection of glucose, heart rate, activity, sleep and GPS data via a study app.
Exploring Decentralized Glucose and Behaviometric Monitoring of Persons with Type 2 Diabetes in the Setting of a Clinical Trial — Ali et al., Journal of diabetes science and technology (paywalled)
- dct
- wearable
- rpm
- cgm
- digital-biomarker
- actigraphy
2021
Self-collected saliva sampling in military technicians produced stable post-awakening cortisol parameters across two days, showing the expected rise thirty minutes after waking followed by recovery. Using actigraphy to verify compliance confirms that unsupervised saliva collection in free-living settings delivers reliable data for operational health surveillance of chronically stressed personnel.
Post-awakening Cortisol in Explosive Ordnance Disposal Technicians: A Replication Study in a Novel Population — Hernández et al., Military medicine (paywalled)
- saliva
- self-collection
- hormones
- cortisol
- actigraphy
- multimodal
2021
This study found that higher pre-sleep physiological stress, measured via self-collected saliva, was linked to increased cortical arousal during sleep and more consolidated rapid eye movement sleep in adolescents. The results support the use of decentralised sampling and in-home monitoring to investigate physiological interactions in natural sleep environments.
Presleep physiological stress is associated with a higher cortical arousal in sleep and more consolidated REM sleep — Pesonen et al., Stress (paywalled)
- saliva
- self-collection
- pediatric
- actigraphy
- multimodal
2020
Acutely concussed youth studied at home showed longer sleep latency and greater fatigue than controls, with altered overnight cortisol dynamics and lower bedtime melatonin; these home-based saliva and actigraphy measures highlight decentralised endpoints for acute concussion care.
Sleep and stress in the acute phase of concussion in youth — Maerlender et al., Sports medicine and health science
- saliva
- liquid
- self-collection
- pediatric
- hormones
- cortisol
- actigraphy
- multimodal
2020
In youth aged 8–16 years, first-waking saliva cortisol, IL-6 and IL-1β collected at home associate with prior-night actigraphy sleep metrics. Sleep quality confounds interpretation of salivary stress and immune biomarkers in decentralised paediatric microsampling, so protocols must account for it.
Bidirectional relationships between sleep and biomarkers of stress and immunity in youth — LaVoy et al., International journal of psychophysiology : official journal of the International Organization of Psychophysiology (paywalled)
- saliva
- self-collection
- pediatric
- cortisol
- biomarkers
- actigraphy
- multimodal
2019
Male fire and emergency service workers showed a lower cortisol awakening response and post-awakening cortisol levels the day after a night on-call with a call, likely due to noise, exertion and stress during callouts. This supports the use of decentralised saliva sampling to assess real-world physiological stress responses in working populations.
Salivary cortisol profiles of on-call from home fire and emergency service personnel — Hall et al., Stress (paywalled)
- saliva
- self-collection
- hormones
- cortisol
- actigraphy
- multimodal
2014
A US survey of 3,400 adults aged 62 to 90 collected up to 15 biomeasures at home, including saliva, dried blood spots and urine, with Salivette and Oragene among the devices used, which shows that several patient-centric sampling methods can run together in home-based research.
Continuity and innovation in the data collection protocols of the second Wave of the National Social Life, Health, and Aging Project — Jaszczak et al., The journals of gerontology. Series B, Psychological sciences and social sciences (paywalled)
- actigraphy
- multimodal
- blood
- dbs
- cortisol
- dna-genotek-oragene
- self-collection
- dried
- bd-microtainer
- hormones
- liquid
- urine
- saliva
- biomarkers
- genotyping
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