The Library
1530 papers on microsampling and monitoring, each with a finding paraphrased to our standard and labelled in one vocabulary. Every entry links to a legitimate copy; nothing is copied from an abstract.
40 papers labelled “rpm”, newest first.
2026
This proof-of-concept study demonstrated that patients with inflammatory bowel disease could successfully perform capillary blood microsampling at home with high analytical success rates, and a majority preferred this decentralised approach over hospital venous draws.
Implementation of a Capillary Blood Self-Sampling Technique at Home for Monitoring of Patients With IBD — Schuurman et al., Inflammatory bowel diseases
- acceptability
- multimodal
- blood
- rpm
- self-collection
- capillary
- liquid
2026
A fully remote decentralised clinical trial in Danish adults with type 2 diabetes demonstrated operational feasibility with rapid recruitment, high retention (87 percent), and excellent adherence to continuous glucose monitoring (95 percent achieving ≥70 percent data coverage) and telemedicine visits (97 percent). Activity tracker adherence was poor (12 percent) due to technical issues, but remote safety monitoring was effective with no unexpected adverse events, supporting the viability of remote diabetes management.
Operational and Clinical Insights from a Fully Decentralized Clinical Study Evaluating Protocol Adherence, Participant Satisfaction, and Connected Device Data in Individuals with Type 2 Diabetes on Different Treatment Regimens — Nørgaard et al., Diabetes technology & therapeutics (paywalled)
- dct
- wearable
- rpm
- cgm
- actigraphy
2026
Viloxazine extended release improved ADHD, depression and anxiety symptoms in adults with comorbid conditions during a 14-week decentralised trial. The study demonstrates that remote monitoring via televisit, mobile app and home devices can deliver real-world efficacy and safety data for psychiatric medications.
Viloxazine Extended Release in Adults With Attention-Deficit/Hyperactivity Disorder and Depression and/or Anxiety Symptoms: Results From a Decentralized, Open-Label, Phase 4 Trial — Adler et al., The Journal of clinical psychiatry (paywalled)
- dct
- rpm
2026
A proof-of-concept decentralised trial generated 169 support tickets over 17 months from 90% of sites, with device-related problems accounting for 46% of requests. Most issues were resolved within three days and required two to six exchanges, demonstrating that robust technical support infrastructure is essential for successful remote monitoring and wearable-based trial conduct.
Toward Effective Technology Support in DCTs: Insights from the Trials@Home Proof-of-Concept Trial RADIAL — Weitlaner et al., Journal of medical systems
- dct
- wearable
- rpm
2026
A hybrid decentralised clinical trial using wearable dosing-monitoring and remote adverse-event reporting in healthy adults achieved 100% adherence with only 2% missing data, maintained adverse-event detection sensitivity, and was rated less burdensome than conventional on-site visits. These findings support the feasibility and reliability of participant-centric remote monitoring in early-phase pharmacokinetic studies.
Pioneering a Hybrid Decentralized Clinical Trial in South Korea: Assessing Feasibility, Data Integrity, and Participant Perceptions — Kim et al., Clinical and translational science
- dct
- wearable
- rpm
2026
A direct-to-participant, multichannel recruitment strategy enrolled 34,244 older adults into a virtual trial testing an Apple Watch based heart health programme with electrocardiogram and irregular rhythm notification features, achieving broad geographic and gender diversity but under-representing non-White ethnic groups.
Direct-to-Participant Enrollment in a Virtual Trial: Lessons Learned From the Heartline Study — Hills et al., JACC. Advances
- dct
- wearable
- rpm
- digital-biomarker
2026
Home spirometry gave slightly lower percent-predicted FEV1 values than office measurements cross-sectionally, but the three-month change in lung function did not differ significantly between settings. This suggests home spirometry can reliably detect treatment effects, supporting its use as an endpoint for decentralised cystic fibrosis trials.
Home Spirometry as a Clinical Trial Endpoint in People with Cystic Fibrosis: Results of the OUTREACH Study — Rosenfeld et al., Annals of the American Thoracic Society (paywalled)
- dct
- rpm
- digital-biomarker
2025
This study validated a method combining quantitative dried blood spots with DNA methylation analysis to monitor B-cell counts remotely, achieving 100% sensitivity and specificity for a specific clinical threshold. This decentralised approach facilitates patient-centric therapeutic drug monitoring for anti-CD20 therapies by overcoming the logistical barriers of regular venous sampling.
Home-sampling of B cells using quantitative dried blood spots to enable tailored therapeutic re-dosing of anti-CD20 therapies — Tallantyre et al., Multiple sclerosis (paywalled)
- biologics
- multimodal
- blood
- rpm
- qdbs
- tdm
- self-collection
- dried
- validation
2025
A survey of 146 Brazilian infertility patients found that 88.3% were willing to perform ultrasounds at home provided image quality and diagnostic accuracy matched clinic-based examinations, and identified patients already familiar with assisted reproductive technology processes as the most suitable candidates for remote fertility monitoring.
Remote fertility care: Are patients prepared to forego physician proximity in favor of accessibility? — Collado et al., JBRA assisted reproduction
- acceptability
- fertility
- rpm
2025
The study found that acoustic speech features differed significantly between Android and iOS devices, with iOS recordings showing more periodic content but less high-frequency energy, while Android devices exhibited greater measurement variability. These platform-specific differences, coupled with participant experience challenges such as iOS users struggling with background noise checks, demonstrate that device choice and app instruction design materially affect data quality and trial outcomes in decentralised digital biomarker studies.
Comparing Phoneme Speech Recordings and Acoustic App Data Capture Experience for Android and iOS Mobile Device Users in the Large Decentralized AcRIS Study — Chappie et al., Journal of voice : official journal of the Voice Foundation (paywalled)
- dct
- rpm
- digital-biomarker
2025
A randomised trial of 47 participants using a mobile app integrated with remote patient monitoring devices achieved a 74% biomarker submission rate over four weeks, with system usability scores of 77–94 and acceptability exceeding benchmarks, showing the platform is feasible for remote data collection in decentralised clinical trials.
Evaluation of a remote biomarker capture system integrated with REDCap: A decentralized randomized trial — Dahne et al., Journal of clinical and translational science
- acceptability
- dct
- rpm
2025
This study found that a decentralised approach using home-based sleep apnoea screening, heart rhythm monitoring and activity tracking in patients with atrial fibrillation is feasible, with high data completeness and low drop-out rates. The results support the use of patient-centric digital tools in decentralised trials for chronic cardiac conditions.
Feasibility of a decentralised trial of sleep apnoea screening in patients with atrial fibrillation — Hashiba et al., Danish medical journal (paywalled)
- dct
- wearable
- rpm
- digital-biomarker
- actigraphy
2025
Self-scans with a smartphone-based home ultrasound device produced image quality and measurements of follicle count, endometrial thickness and oocyte yield that closely matched in-clinic sonography, with strong correlations and no difference in clinical decisions, supporting remote monitoring of ovarian stimulation.
Monitoring Ovarian Stimulation for Assisted Reproduction With Patient Self-Scans Using a Home Vaginal Ultrasound Device: A Single-Center Interventional, Prospective Study — Shufaro et al., Journal of medical Internet research
- fertility
- rpm
2025
Remote motor assessment achieved a 95 percent completion rate and high caregiver acceptability in children with Canavan disease. Good to excellent inter- and intra-rater reliability demonstrates that rigorous remote assessment protocols can be implemented in decentralised trials for rare pediatric conditions, reducing burden on families.
Feasibility, Acceptability, and Reliability of Remote Motor Assessment in Children With Canavan Disease — Kiefer et al., Pediatric neurology (paywalled)
- pediatric
- dct
- rpm
- digital-biomarker
2025
In a Phase 1 crossover study of etrasimod, self-collected blood microsamples yielded pharmacokinetic exposures comparable to conventional venous sampling, both with and without participant practice sessions. Continuous wearable sensors concurrently enabled real-time remote monitoring of safety vital signs and electrocardiograms, demonstrating the viability of hybrid decentralised designs in early-phase clinical trials.
Advancing Early Clinical Trials: The Transformative Potential of Decentralized Designs and Digital Technologies in Phase 1 Clinical Trial — Malhotra et al., Clinical pharmacology and therapeutics
- blood
- capillary
- self-collection
- venous-agreement
- dct
- wearable
- rpm
- digital-biomarker
- multimodal
2025
A fully decentralised trial of 9151 participants using a mobile app for daily voice capture found two machine learning algorithms met pre-specified success criteria for screening viral respiratory illness, with sensitivity increasing as symptoms increased while specificity remained consistent. This demonstrates voice-based digital biomarkers can identify infections remotely and validates bring-your-own-device trial designs.
Longitudinal voice monitoring in a decentralized Bring Your Own Device trial for respiratory illness detection — Santamaria et al., NPJ digital medicine
- dct
- rpm
- digital-biomarker
2025
A large decentralised trial investigating a wearable device for COVID-19 detection retained 80.4% of participants at six months and 68.5% until completion. Multivariable analysis identified vaccinated pensioners as a high-risk discontinuation group, and targeted telephone calls reduced their dropout rate to 11.4%, showing that personalised retention strategies can improve engagement in remote diagnostic studies.
Increasing Retention in a Large-Scale Decentralized Clinical Trial: Learnings From the COVID-RED Trial — Zwiers et al., Mayo Clinic proceedings. Digital health
- dct
- wearable
- rpm
2025
A programmatic architecture for remote decentralised clinical trials in atrial fibrillation successfully enrolled 513 participants across rural and metropolitan settings, with 89 percent retention at 12 months and sustained engagement with a smartphone-based adherence intervention. The approach reached diverse populations including 62 percent women and 44 percent with limited health literacy, demonstrating feasibility of patient-centric remote monitoring for cardiovascular research.
Augmenting Engagement in Decentralized Clinical Trials for Atrial Fibrillation: Development and Implementation of a Programmatic Architecture — Omole et al., JMIR cardio
- dct
- rpm
2025
Home-based ECG and blood pressure monitoring in 3,820 elderly hypertensive patients detected undiagnosed atrial fibrillation in 5.8 per cent over three months. The detection rate was not significantly associated with baseline blood pressure category, measurement frequency, or antihypertensive medication use, indicating that broad screening may be warranted regardless of blood pressure control.
Relationship Between Screening-Detected Atrial Fibrillation and Blood Pressure Levels in Elderly Hypertensive Patients: The OMRON Heart Study — Senoo et al., Thrombosis and haemostasis
- dct
- rpm
- digital-biomarker
2025
In this decentralised trial of 899 adults with asthma, participants using a digital self-management programme with wearable device integration showed a 4.6-point gain on the Asthma Control Test at 12 months relative to usual care. This provides evidence that remote digital interventions can achieve clinically significant improvements in asthma control without in-person visits.
A Digital Asthma Self-Management Program for Adults: A Randomized Clinical Trial — Silberman et al., JAMA network open
- dct
- wearable
- rpm
- digital-biomarker
2025
In a decentralised phase 1 trial, healthy adults used a clinical trial app to self-collect blood microsamples and vital signs at home, with 65 to 70 per cent successfully providing blood samples and most preferring self-collection over staff collection.
Conducting clinical trials with self-collection of pharmacokinetic samples: Experience from an exploratory, phase 1, open-label trial of centanafadine SR in healthy individuals — Ye et al., Contemporary clinical trials communications
- blood
- self-collection
- acceptability
- dct
- rpm
- multimodal
2025
Across perinatal care, wearable sensors and home-monitoring platforms support timely intervention, with remote monitoring linked to a 7 to 11 percent reduction in maternal mortality and preeclampsia incidence. In neonatal care, predictive digital monitoring such as the Heart Rate Observation system reduced mortality in very low-birth-weight infants by approximately 20 percent.
Integrating Artificial Intelligence into Perinatal Care Pathways: A Scoping Review of Reviews of Applications, Outcomes, and Equity — El Arab et al., Nursing reports
- fertility
- wearable
- rpm
2025
The RADIAL proof-of-concept trial demonstrated that a modular, multi-vendor technology package can operationalise decentralised clinical trials, but revealed significant challenges with Bring Your Own Device variability, immature device technologies, and clinical site infrastructure limitations. Investing in participant support infrastructure, automated multichannel notifications, and early cross-functional compliance planning enhanced participant engagement and streamlined governance, reducing burden.
Operationalizing Decentralized Clinical Trials: Technology Insights from the Trials@Home RADIAL Proof-of-Concept Trial — Hanke et al., Clinical pharmacology and therapeutics
- dct
- rpm
2024
A scoping review identified twelve studies comparing remote and in-person administration of the ALS Functional Rating Scale-Revised. While correlations between modes were high, the evidence remains insufficient to endorse remote clinician administration for high-quality data in decentralised ALS trials.
Remote-Use Applications of the Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised Clinical Outcome Assessment Tool: A Scoping Review — Bhushan et al., Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research (paywalled)
- dct
- rpm
2024
The survey of 80 clinical research stakeholders in India highlights the growing adoption of remote data capture, wearables, and digital biomarkers in decentralized clinical trials, driven by the COVID-19 pandemic, while also identifying key challenges that need to be addressed for wider implementation.
The role of remote data capture, wearables, and digital biomarkers in decentralized clinical trials — Chodankar et al., Perspectives in clinical research
- dct
- wearable
- rpm
- digital-biomarker
2024
A survey of eight biopharmaceutical companies, representing a third of the oncology market, revealed that remote monitoring adoption in oncology trials trails other therapeutic areas. Electronic diaries and digital clinical outcome assessments are the most deployed tools, while local physician network visits are least used; respondents expect adoption to rise by over 40% for most technologies within five years, with digital recruitment and local imaging prioritised for improving patient centricity.
Remote Monitoring and Data Collection for Decentralized Clinical Trials — Daly et al., JAMA network open
- dct
- rpm
2023
The authors developed and deployed a decentralised trial platform for a Phase 2 COVID-19 study that used home-based monitoring devices and mobile applications to collect health data remotely, enabling inclusion of participants from diverse socioeconomic backgrounds and rural settings. They created a Clinical-Trial-in-a-Box tool to standardise data collection across decentralised platforms, with lessons learned applicable to Long COVID research.
From a decentralized clinical trial to a decentralized and clinical-trial-in-a-box platform: Towards patient-centric and equitable trials — Dulko et al., Journal of clinical and translational science
- dct
- rpm
2023
Decentralised monitoring of people with type 2 diabetes using continuous glucose monitoring and a hybrid smartwatch was feasible, with high participant retention and successful collection of glucose, heart rate, activity, sleep and GPS data via a study app.
Exploring Decentralized Glucose and Behaviometric Monitoring of Persons with Type 2 Diabetes in the Setting of a Clinical Trial — Ali et al., Journal of diabetes science and technology (paywalled)
- dct
- wearable
- rpm
- cgm
- digital-biomarker
- actigraphy
2023
Remote smartphone cognitive testing using the ALLFTD Mobile App was feasible and acceptable for people with frontotemporal dementia and at-risk kindreds, supporting decentralised trials and improved access to research.
Feasibility and acceptability of remote smartphone cognitive testing in frontotemporal dementia research — Taylor et al., Alzheimer's & dementia
- dct
- rpm
- digital-biomarker
2022
Thirty-eight patients with rheumatic diseases showed high engagement with twice-daily smartphone symptom reporting (95% completion) and remote dried blood spot collection (84% returned samples, all viable for C-reactive protein analysis). Although symptoms varied considerably, clinically meaningful CRP changes were rare, confirming the feasibility of integrating microsampling with patient-generated health data in decentralised rheumatology research.
Remote sampling of biomarkers of inflammation with linked patient generated health data in patients with rheumatic and musculoskeletal diseases: an Ecological Momentary Assessment feasibility study — Druce et al., BMC musculoskeletal disorders
- blood
- dried
- dbs
- self-collection
- acceptability
- biomarkers
- rpm
- digital-biomarker
- multimodal
2022
In a large decentralised hypertension trial of 21,104 adults, nearly half used their own home blood pressure monitors for remote monitoring, but 18.7% of identifiable devices lacked validation against standardised protocols despite costing substantially less than validated models. This reveals a critical gap in device quality for decentralised trials relying on patient-owned equipment.
Home blood pressure monitors owned by participants in a large decentralised clinical trial in hypertension: the Treatment In Morning versus Evening (TIME) study — Anbarasan et al., Journal of human hypertension
- dct
- rpm
2022
Citation network and regulatory analysis shows that Internet of Medical Things technologies, particularly telemedicine and remote monitoring across neurology and psychology, are increasingly positioned for adoption in decentralised clinical trials under evolving regulatory frameworks.
Application of Internet of Medical/Health Things to Decentralized Clinical Trials: Development Status and Regulatory Considerations — Sato et al., Frontiers in medicine
- dct
- standards
- rpm
2022
An end-to-end remote digital protocol using the Current Health wearable and platform achieved rapid deployment and moderate adherence, capturing continuous pulse rate, respiratory rate, SpO2, skin temperature and step count alongside tablet-administered symptom surveys; vital signs remained within normal ranges and symptoms decreased over the 30-day period, demonstrating feasibility and clinical-grade signal quality for decentralised monitoring.
Deployment of an End-to-End Remote, Digitalized Clinical Study Protocol in COVID-19: Process Evaluation — Zahradka et al., JMIR formative research
- dct
- wearable
- rpm
- digital-biomarker
2022
Among 328 Chinese women with polycystic ovary syndrome, home testing identified obstructive sleep apnea in 40%, with higher body mass index and blood pressure in those affected. This shows decentralised sleep monitoring can uncover important comorbidities in patients attending fertility clinics.
Analysis of the proportion and clinical characteristics of obstructive sleep apnea in women with polycystic ovary syndrome — Yang et al., Sleep & breathing = Schlaf & Atmung (paywalled)
- fertility
- hormones
- rpm
2022
A six-month, fully decentralised trial in 100 atrial fibrillation patients using remote blood pressure and six-lead ECG sensors achieved 99% completion for device measurements and 91% for televisits, with oral anticoagulation adherence remaining stable at 96–97%. Rapid recruitment via social media (94 participants in 12 days) demonstrates that remote monitoring can sustain high engagement without clinic visits, supporting pandemic-proof trial designs.
Pandemic-proof recruitment and engagement in a fully decentralized trial in atrial fibrillation patients (DeTAP) — Sarraju et al., NPJ digital medicine
- dct
- wearable
- rpm
- digital-biomarker
2022
Most patients with motor neuron disease expressed a positive attitude towards remote monitoring and participating in decentralised clinical trials from home, with a majority finding the use of multiple digital devices acceptable for tracking respiratory function and muscle strength.
Patient perspectives on digital healthcare technology in care and clinical trials for motor neuron disease: an international survey — Helleman et al., Journal of neurology
- acceptability
- dct
- rpm
2021
The authors built a home-use ovulation detector that measures basal body temperature and cervical mucus pH, validated it in twenty women, and reported satisfactory performance for identifying fertility windows to aid both contraception and conception. This supports decentralised, patient-managed fertility monitoring integrated with smartphone e-health platforms.
Development of a Permanent Device for Fertility Period Detection by Basal Body Temperature and Analysis of the Cervical Mucus Potential of Hydrogen — Mansouri, Journal of medical signals and sensors
- fertility
- wearable
- rpm
- digital-biomarker
2021
The authors implemented a fully remote outpatient trial of hydroxychloroquine prophylaxis in 54 household COVID-19 contacts using self-collected saliva for SARS-CoV-2 RNA PCR testing and a smartphone-based six-lead ECG system for remote cardiac monitoring, with 42 participants completing the study and no serious treatment-related adverse events. The trial numbers were too small to assess prophylactic efficacy, but the experience demonstrates that decentralised enrolment, home diagnostic sampling and remote monitoring can be rapidly deployed in a community health system, while noting that lack of internet access excluded some potential participants.
The future is now: our experience starting a remote clinical trial during the beginning of the COVID-19 pandemic — Liu et al., Trials
- saliva
- self-collection
- dct
- serology
- rpm
- multimodal
2021
Smartphone photographs of atopic dermatitis lesions produced severity scores that correlated strongly with in-person clinical assessment (r=0.78) and were comparable to digital SLR camera images. The high inter-rater reliability among dermatologists supports remote photo-based scoring for decentralised trials and telehealth, reducing patient burden.
Remote Rating of Atopic Dermatitis Severity Using Photo-Based Assessments: Proof-of-Concept and Reliability Evaluation — Ali et al., JMIR formative research
- dct
- rpm
- digital-biomarker
2020
The study found reasonable agreement between finger-prick dried blood spot CRP measurements and venous reference assays in 100 rheumatoid arthritis patients, particularly at low to mid-range CRP values, and showed that weekly self-collected DBS CRP monitoring improved flare detection specificity to 72.7% compared with 54.5% for minimal sampling, supporting decentralised microsampling for remote arthritis management.
Assessment of a dried blood spot C-reactive protein method to identify disease flares in rheumatoid arthritis patients — D'Cruz et al., Scientific reports
- blood
- dried
- dbs
- self-collection
- validation
- venous-agreement
- rpm
- multimodal
Read from the corpus on .