The Library
1530 papers on microsampling and monitoring, each with a finding paraphrased to our standard and labelled in one vocabulary. Every entry links to a legitimate copy; nothing is copied from an abstract.
14 papers labelled “liquid-biopsy”, newest first.
2026
The study found that testing for ASCL1/LHX8 DNA methylation in at-home collected first-void urine can detect most cervical cancers and high-grade precancers, supporting a fully molecular screening pathway without a clinical visit.
Clinical performance of ASCL1/LHX8 DNA methylation on first-void urine to screen for cervical cancer — Van Keer et al., Communications medicine
- colli-pee
- first-void
- self-collection
- hpv
- liquid-biopsy
- urine
- biomarkers
2026
Salivary HPV DNA testing achieved 91.7% sensitivity and 100% specificity against oropharyngeal swab in patients with oral cavity cancer, demonstrating potential for non-invasive self-collection screening programmes and long-term monitoring of HPV-driven disease.
Application of a Saliva-Based Liquid Biopsy for the Detection of HPV in Patients With Oral Cavity Squamous Cell Carcinoma (OCSCC) — Bulfoni et al., Head & neck
- saliva
- self-collection
- validation
- hpv
- liquid-biopsy
2025
In a Belgian colposcopy referral cohort, a study found that 66.6% of women preferred home-based first-void urine self-sampling over physician-taken samples, and 96.6% found the Colli-Pee UCM FV-5010 device easy to use. This supports patient-centric, decentralised screening, though results are limited to this specific referral population.
Home-based urinary HPV self-sampling for the detection of cervical cancer precursor lesions: attitudes and preferences from Belgian females participating in the CASUS study — Hendrickx et al., Archives of public health = Archives belges de sante publique
- colli-pee
- acceptability
- first-void
- self-collection
- hpv
- liquid-biopsy
- liquid
- urine
2025
This review summarises how emerging HPV detection methods including CRISPR/Cas systems, droplet digital PCR and isothermal amplification, combined with self-collected vaginal swabs and liquid biopsy from urine or blood, could improve screening acceptability and enable point-of-care testing compared with conventional approaches that require invasive sampling and centralised laboratory infrastructure.
Evolving HPV diagnostics: current practice and future frontiers — Shi et al., Frontiers in cellular and infection microbiology
- urine
- self-collection
- validation
- hpv
- sti
- liquid-biopsy
2025
A saliva-derived transcriptomic signature using support vector machine learning detected gastric cancer with an AUC of 0.87, sensitivity of 79% and specificity of 70%. Tissue-based gene expression models performed poorly when applied to saliva, indicating that saliva-specific biomarker panels are needed for effective non-invasive gastric cancer screening.
Saliva-derived transcriptomic signature for gastric cancer detection using machine learning and leveraging publicly available datasets — Lopes et al., Scientific reports
- saliva
- self-collection
- biomarkers
- liquid-biopsy
2024
Adding polyethylene glycol to first-void urine before centrifugation markedly improved cell-free DNA recovery in the pellet, whereas low-speed centrifugation alone removed cellular DNA while keeping cell-free DNA in the supernatant. Pseudovirions pelleted reliably under all conditions, but the study revealed substantial variation between self-collected samples, highlighting the need for standardised protocols in decentralised HPV screening programmes.
Concentration strategies for spiked and naturally present biomarkers in non-invasively collected first-void urine — Téblick et al., European journal of medical research
- urine
- first-void
- hpv
- biomarkers
- liquid-biopsy
2024
Epstein-Barr virus DNA methylation in self-collected saliva and oropharyngeal swabs demonstrated superior diagnostic performance for nasopharyngeal carcinoma compared with oral swabs or mouthwash. Combining both sample types and two promoter methylation markers could optimise decentralised, patient-centric screening programmes.
Detection of Epstein‒Barr virus DNA methylation as tumor markers of nasopharyngeal carcinoma patients in saliva, oropharyngeal swab, oral swab, and mouthwash — Zheng et al., MedComm
- saliva
- self-collection
- biomarkers
- liquid-biopsy
2024
This literature review found that DNA methylation markers on self-collected urine or cervicovaginal swabs detected cervical intraepithelial neoplasia as well as cytology. The combination could improve screening uptake and reduce loss to follow-up, particularly in low- and middle-income countries, though more evidence is needed to identify the most efficacious methylation tests.
The current state of DNA methylation biomarkers in self-collected liquid biopsies for the early detection of cervical cancer: a literature review — Sumiec et al., Infectious agents and cancer
- urine
- self-collection
- validation
- hpv
- sti
- biomarkers
- liquid-biopsy
2023
The study found that the Oragene OG-600 receptacle provided the highest concentration of salivary DNA, including short fragments suitable for analysis, and successfully detected HPV DNA from patient saliva. This matters for decentralised sampling as it supports the use of a standardised, self-collection device for non-invasive cancer biomarker detection.
Isolation of salivary cell-free DNA for cancer detection — Brooks et al., PloS one
- dna-genotek-oragene
- hpv
- liquid-biopsy
- liquid
- saliva
- genotyping
2023
Profiling EBV DNA methylation in self-collected saliva distinguished nasopharyngeal carcinoma from controls with 90% sensitivity and 100% specificity by capture sequencing; a q-PCR assay targeting one CpG site achieved 78% sensitivity and 100% specificity. The methylation density fell after therapy and rose with recurrence, confirming that decentralised salivary screening can support both diagnosis and disease monitoring.
Saliva biopsy: Detecting the difference of EBV DNA methylation in the diagnosis of nasopharyngeal carcinoma — Zheng et al., International journal of cancer (paywalled)
- saliva
- self-collection
- validation
- oncology
- biomarkers
- liquid-biopsy
2023
A prospective study of 1384 individuals developed an 18-small RNA signature (miLung) for lung cancer detection, achieving an area under the curve of 0.86 in discovery and 0.83 in validation cohorts. Diagnostic performance increased with tumour stage, and dried blood spot collection suggests feasibility for home self-collection.
Early Detection of Lung Cancer Using Small RNAs — Sikosek et al., Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer (paywalled)
- blood
- dried
- dbs
- self-collection
- biomarkers
- liquid-biopsy
2021
In first-void urine collected with Colli-Pee, the extraction method influenced HPV and human DNA yield more than the collected volume did: standardising processing matters at least as much as standardising volume.
Impact of Collection Volume and DNA Extraction Method on the Detection of Biomarkers and HPV DNA in First-Void Urine — Téblick et al., Molecules
- colli-pee
- first-void
- self-collection
- hpv
- liquid-biopsy
- liquid
- urine
- biomarkers
2020
Vaccine-induced HPV antibodies from cervicovaginal secretions were detectable in first-void urine and correlated with serum levels, so one self-collected urine sample can monitor both HPV infection and immunogenicity without a blood draw; the authors see promise for decentralised follow-up after vaccination.
Non-invasive Assessment of Vaccine-Induced HPV Antibodies via First-Void Urine — Pattyn et al., Frontiers in Immunology
- first-void
- sti
- serology
- hpv
- liquid-biopsy
- liquid
- urine
- biomarkers
2017
The review concludes that first-void urine is a feasible source for molecular biomarkers, such as host and viral gene methylation, to triage high-risk HPV infections, offering a non-invasive and preferred method for women that may improve screening adherence.
First-void urine: A potential biomarker source for triage of high-risk human papillomavirus infected women — Van Keer et al., European journal of obstetrics, gynecology, and reproductive biology (paywalled)
- urine
- first-void
- self-collection
- validation
- hpv
- biomarkers
- liquid-biopsy
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