The Library
1530 papers on microsampling and monitoring, each with a finding paraphrased to our standard and labelled in one vocabulary. Every entry links to a legitimate copy; nothing is copied from an abstract.
Papers 601–700 of 1530, newest first.
2024
In young elite footballers with regular cycles, salivary progesterone correlated strongly with capillary blood concentrations, offering a non‑invasive way to track ovarian function. A luteal‑phase saliva progesterone threshold of 50 pg/ml and a 1.5‑fold rise over follicular baseline showed good accuracy for confirming ovulation against serum criteria.
The use of saliva and blood progesterone to profile the menstrual cycles of youth professional football players — Ferrer et al., Frontiers in sports and active living
- blood
- saliva
- capillary
- validation
- fertility
- hormones
2024
This literature review found that DNA methylation markers on self-collected urine or cervicovaginal swabs detected cervical intraepithelial neoplasia as well as cytology. The combination could improve screening uptake and reduce loss to follow-up, particularly in low- and middle-income countries, though more evidence is needed to identify the most efficacious methylation tests.
The current state of DNA methylation biomarkers in self-collected liquid biopsies for the early detection of cervical cancer: a literature review — Sumiec et al., Infectious agents and cancer
- urine
- self-collection
- validation
- hpv
- sti
- biomarkers
- liquid-biopsy
2024
Fifty-eight matched capillary and venous blood samples collected under official doping control conditions demonstrated excellent laboratory agreement for complete blood count parameters (except platelets) after temperature-monitored air shipment. This validates micro capillary collection as a virtually painless, athlete-friendly alternative to venipuncture for the Athlete Biological Passport, supporting its use in decentralised diagnostics.
Application of micro capillary blood sampling in an anti-doping setting — Lewis et al., Drug testing and analysis (paywalled)
- blood
- capillary
- validation
- venous-agreement
- doping
2024
Self-collected dried blood spots were used to assess HIV status at 12 months in 1168 participants. Integration of sexual and reproductive health services increased linkage to HIV prevention care within 60 days (adjusted odds ratio 1·68) compared with standard referral, whereas peer support had no effect.
Effectiveness of integrating HIV prevention within sexual reproductive health services with or without peer support among adolescents and young adults in rural KwaZulu-Natal, South Africa (Isisekelo Sempilo): 2 × 2 factorial, open-label, randomised controlled trial — Shahmanesh et al., The lancet. HIV (paywalled)
- blood
- dried
- dbs
- self-collection
- dct
- serology
- sti
2024
The authors validated an LC-MS/MS method for quantifying 18 endogenous steroids and metabolites in 30 μL dried blood VAMS samples from 20 healthy volunteers. Steroids remained stable for up to 100 days across storage temperatures from room temperature to -80 °C and through three freeze-thaw cycles, suggesting VAMS is reliable for doping control and clinical hormone monitoring outside traditional settings.
LC-MS/MS measurement of endogenous steroid hormones and phase II metabolites in blood volumetric absorptive microsampling (VAMS) for doping control purposes — Ponzetto et al., Clinica chimica acta; international journal of clinical chemistry (paywalled)
- blood
- dried
- vams
- validation
- hormones
- doping
- toxicology
2024
Self-collected dried blood spots showed high specificity and acceptable sensitivity for detecting islet antibodies compared to serum samples, and participants preferred this method over venous blood draw for its ease and reduced pain.
Feasibility and Validity of In-Home Self-Collected Capillary Blood Spot Screening for Type 1 Diabetes Risk — Sing et al., Diabetes technology & therapeutics (paywalled)
- blood
- capillary
- dbs
- self-collection
- validation
- venous-agreement
- acceptability
2024
In 30 adult solid organ transplant recipients, capillary blood self-collected using the Tasso+ device showed 91% concordance with venous samples for detecting CMV DNAemia above the limit of detection, with excellent quantitative correlation (Spearman R² = 0.99). Most participants preferred self-collection over venipuncture, suggesting the device could enable decentralised viral monitoring, though sensitivity was lower (95% at 308 IU/mL).
Evaluation of the Tasso+ blood self-collection device for quantitation of plasma cytomegalovirus (CMV) DNAemia in adult solid organ transplant recipients (SOTr) — Phan et al., Microbiology spectrum
- blood
- liquid
- capillary
- self-collection
- validation
- venous-agreement
- acceptability
- serology
2024
Older adults achieved 98% adherence when self-collecting dried blood spots at home for inflammatory markers, with 97% of samples yielding valid results. Test-retest reliability was good (ICCs 0.70–0.76) and correlation with venous blood was strong (r=0.60–0.99), demonstrating that remote capillary sampling is a feasible and valid method for decentralised assessment of inflammation in older adults.
Remote dried blood spot collection for inflammatory markers in older adults is feasible, reliable, and valid — Reed et al., Brain, behavior, and immunity (paywalled)
- blood
- dried
- dbs
- self-collection
- validation
- venous-agreement
- acceptability
- biomarkers
2024
Interviews with European health technology assessment representatives showed that while decentralised clinical trial models offer real-world relevance and reduced recall bias, concerns persist regarding data quality when trial participants manage data collection independently.
Opportunities and Challenges for Decentralized Clinical Trial Approaches: European Health Technology Assessment Perspective — de Jong et al., Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research (paywalled)
- dct
- economics
2024
This analysis of regulatory guidance and 4,874 registered trials found that decentralised clinical trials have grown annually, especially after 2020, with most involving simple behavioural and technological interventions rather than drug studies. Both the FDA and EMA emphasised patient safety and data integrity as the two axes for assessing decentralised elements, and the trial landscape aligned with these recommendations by predominantly using low-risk, previously approved oral drugs.
The landscape of decentralized clinical trials (DCTs): focusing on the FDA and EMA guidance — Park et al., Translational and clinical pharmacology
- dct
2024
A systematic review of 70 studies found that 94.7% of accuracy studies reported comparable sensitivity and specificity between self-sampling and clinician collection for HPV detection, with patient acceptability ranging from 84.2% to 100% for devices including Colli-Pee. This evidence endorses decentralised cervical screening to improve uptake.
Comparison of diagnostic accuracy and acceptability of self-sampling devices for human Papillomavirus detection: A systematic review — Aimagambetova et al., Preventive medicine reports
- urine
- first-void
- colli-pee
- self-collection
- validation
- acceptability
- hpv
2024
Brief spontaneous speech analysis using machine learning can accurately identify individuals with Alzheimer's dementia and mild cognitive impairment and predict performance across attention, memory, executive function, language and visuospatial domains, supporting its use for remote screening and disease monitoring.
Unveiling the sound of the cognitive status: Machine Learning-based speech analysis in the Alzheimer's disease spectrum — García-Gutiérrez et al., Alzheimer's research & therapy
- dct
- digital-biomarker
2024
A survey of eight biopharmaceutical companies, representing a third of the oncology market, revealed that remote monitoring adoption in oncology trials trails other therapeutic areas. Electronic diaries and digital clinical outcome assessments are the most deployed tools, while local physician network visits are least used; respondents expect adoption to rise by over 40% for most technologies within five years, with digital recruitment and local imaging prioritised for improving patient centricity.
Remote Monitoring and Data Collection for Decentralized Clinical Trials — Daly et al., JAMA network open
- dct
- rpm
2024
Adolescents collecting blood microsamples at home achieved varying success rates across six devices, with Minicollect tubes performing poorest. The confirmation that visual inspection alone was insufficient, by analytical variability, underscores the need for robust quality assessment before deploying any device in decentralised trials.
Self-Sampling by Adolescents at Home: Assessment of the Feasibility to Successfully Collect Blood Microsamples by Inexperienced Individuals — Boffel et al., The AAPS journal (paywalled)
- blood
- liquid
- dried
- capillary
- vams
- dbs
- neoteryx-mitra
- self-collection
- acceptability
- pediatric
- dct
2024
First-void urine collected with the Colli-pee device detected high-grade cervical precancer with 90.3% sensitivity, substantially better than the 73.4% sensitivity of standard-pot urine, and was acceptable to colposcopy attendees. The device achieved 92% relative sensitivity compared with clinician-collected cervical samples, showing promise for decentralised HPV screening.
Urine high-risk human papillomavirus testing as an alternative to routine cervical screening: A comparative diagnostic accuracy study of two urine collection devices using a randomised study design trial — Davies et al., BJOG : an international journal of obstetrics and gynaecology (paywalled)
- urine
- first-void
- colli-pee
- self-collection
- acceptability
- hpv
- sti
2024
The novel lateral flow assay demonstrated excellent clinical sensitivity and specificity for detecting Neisseria gonorrhoeae in first-void urine and vaginal swabs, meeting the target product profile for a rapid point-of-care test. This decentralised diagnostic tool could optimise clinical management and reduce unnecessary antibiotic use in primary care settings lacking laboratory infrastructure.
Novel lateral flow assay for point-of-care detection of Neisseria gonorrhoeae infection in syndromic management settings: a cross-sectional performance evaluation — Peters et al., Lancet
- urine
- first-void
- validation
- sti
2023
An expected net present value model found that decentralised clinical trials in phases II and III increase drug value by an average of $20 million, yielding a seven-fold return on investment. However, the authors caution that larger datasets and broader operational coverage are needed to validate these findings.
Assessing the Financial Value of Decentralized Clinical Trials — DiMasi et al., Therapeutic Innovation & Regulatory Science
- dct
- economics
2023
A systematic review of 13 decentralised studies: 11 reported recruitment success with approaches departing from site-based methods, and 7 reported success retaining participants. The recruitment finding largely reflects remote outreach rather than remote sampling specifically.
Methods and perceptions of success for patient recruitment in decentralized clinical studies — Miyata et al., Journal of Clinical and Translational Science
- dct
- acceptability
2023
A study of 50 paediatric renal transplant recipients found that a validated VAMS LC-MS/MS method for tacrolimus showed high correlation with the reference method over 0.5–60 ng/mL, with minimal haematocrit effect.
Therapeutic Drug Monitoring of Tacrolimus Based on VAMS in Renal Transplant Pediatric Recipients — LC-MS/MS Method, Hematocrit Effect, and Clinical Application — Kocur et al., Pharmaceutics
- vams
- neoteryx-mitra
- blood
- tdm
- haematocrit
- dried
- capillary
- pediatric
- immunosuppressants
- validation
2023
VAMS microsampling found no significant difference from venous blood for tacrolimus in paediatric patients; samples were stable for 14 days, with average difference between paired at-home samples of 0.12 ± 0.94 ng/mL.
VAMS and parallel-reaction-monitoring mass spectrometry for tacrolimus trough measurements at home in paediatric heart-transplant patients — Zhao et al., J. Mass Spectrometry and Advances in the Clinical Lab
- vams
- venous-agreement
- acceptability
- blood
- dbs
- tdm
- self-collection
- dried
- capillary
- pediatric
- immunosuppressants
- validation
2023
A structured review: many VAMS assays are analytically validated and can substitute for venous sampling for well-characterised analytes, though clinical-validation depth varies.
Analytical and Clinical Validation of Assays for VAMS of Drugs in Different Blood Matrices: A Literature Review — Nugraha et al., Molecules
- vams
- venous-agreement
- blood
- tdm
- dried
- immunosuppressants
- validation
2023
VAMS matched serum for the kinase inhibitors nilotinib, cabozantinib, dabrafenib and ruxolitinib, r 0.94–0.97, with serum reliably predictable for the first three, and 93% of at-home samples were collected correctly: at-home VAMS shown feasible for routine cancer-drug monitoring.
Clinical validation and feasibility of VAMS for monitoring of nilotinib, cabozantinib, dabrafenib, trametinib and ruxolitinib — Zimmermann et al., J. Pharmaceutical and Biomedical Analysis (paywalled)
- vams
- venous-agreement
- acceptability
- blood
- tdm
- self-collection
- haematocrit
- dried
- oncology
- capillary
- validation
2023
In children, VAMS and dried plasma spot voriconazole, posaconazole and isavuconazole correlated with fresh plasma, Spearman 0.82–0.94, and stayed stable at room temperature for at least 14 days: refrigeration-free antifungal TDM in paediatrics.
VAMS and dried plasma spot for antifungal triazole agents (voriconazole, posaconazole, isavuconazole) in pediatric patients by LC-MS/MS — Simeoli et al., J. Pharmaceutical and Biomedical Analysis (paywalled)
- vams
- neoteryx-mitra
- blood
- tdm
- dried
- antimicrobials
- pediatric
2023
A UHPLC-HRMS assay quantified 25-hydroxyvitamin D2 and D3 from 20 µL Mitra VAMS samples with accuracy under 10% and precision under 11%, LOQ 5 ng/mL: sensitive enough to flag deficiency and simple enough for untrained self-collection, enabling year-round vitamin-D monitoring.
Quantification of 25-hydroxyvitamin D2 and D3 in Mitra devices (VAMS) by UHPLC-HRMS for regular vitamin D status monitoring — Tuma et al., J. Pharmaceutical and Biomedical Analysis (paywalled)
- vams
- neoteryx-mitra
- blood
- self-collection
- dried
- capillary
- validation
- biomarkers
2023
Capillary VAMS blood covered more of the metabolome than plasma, capturing intracellular red-cell metabolites, and correlated moderately-to-well with venous, Spearman 0.66; the honest caveats are higher finger-prick replicate variability and a need for −80 °C storage within six hours.
VAMS-based blood capillary sampling for mass-spectrometry-based human metabolomics studies — Volani et al., Metabolites
- vams
- venous-agreement
- blood
- metabolome
- dried
- capillary
- validation
- biomarkers
2023
Dried urine spots with automated extraction detected over 95% of the drugs found in paired liquid urine by LC-Q-TOF.
Application of dried urine spots for non-targeted quadrupole time-of-flight drug screening — Stöth et al., J. Analytical Toxicology (paywalled)
- urine
- dried
- toxicology
2023
Across 18 saliva samples, mouthwash collection gave higher alpha diversity than passive drooling on both Illumina and Nanopore platforms, and three preservation methods performed alike; mouthwash and simple collection are convenient decentralised options, provided a study keeps one collection method for all participants to avoid confounding.
Factors influencing oral microbiome analysis: from saliva sampling to sequencing platforms — Bang et al., Scientific Reports
- stabilised
- microbiome
- liquid
- validation
- saliva
2023
During ACTH stimulation, salivary cortisol correlated only weakly with serum and gave modest accuracy: saliva does not reliably replace serum cortisol for adrenal insufficiency. A concrete limit.
Reliability of Salivary versus Serum Cortisol for Diagnosing Adrenal Insufficiency in Children — Ciancia et al., Children
- venous-agreement
- blood
- cortisol
- pediatric
- hormones
- liquid
- validation
- saliva
2023
TAP II capillary serum, both professionally collected and self-collected, correlated with venous serum at R > 0.9 for eight analytes including ALT, AST, cholesterol, HDL and triglycerides. Creatinine correlated acceptably but carried a consistent negative bias, and carbon dioxide, potassium and albumin did not reach acceptable agreement: the useful reading is that the panel has to be validated, not the device alone.
Maximizing microsampling: measurement of comprehensive metabolic and lipid panels using a novel capillary blood collection device — Collier et al., The Journal of Applied Laboratory Medicine (paywalled)
- venous-agreement
- blood
- self-collection
- capillary
- bd-microtainer
- liquid
- yourbio
- validation
- biomarkers
2023
Fingerstick blood self-collected into BD Microtainer tubes and posted at ambient temperature for 24 h agreed acceptably with paired serum for 11 of 12 analytes, HbA1c, lipids, creatinine, urea, urate, liver enzymes and total protein, with only AST falling outside limits.
Capillary blood stability and analytical accuracy of 12 analytes stored in Microtainers — Fontaine & Saez, Practical Laboratory Medicine
- blood
- liquid
- capillary
- bd-microtainer
- self-collection
- venous-agreement
- validation
2023
This review evaluates established and emerging capillary blood sampling techniques, comparing factors such as wound geometry and patient comfort, and identifies microneedles as a promising option for paediatric care because they can obtain samples virtually painlessly.
Minimally invasive capillary blood sampling methods — Hoffman et al., Expert review of medical devices (paywalled)
- blood
- capillary
- validation
- acceptability
- pediatric
2023
Using the Oragene Discovery 500 series for decentralised saliva collection in 524 African American adolescents, this study found that positive neighbourhood conditions relate to fewer behavioural difficulties, despite genetic risk. The authors note that most gene-environment studies of behaviour use European ancestry samples, limiting generalisability to African American youth.
Genetic Risk, Neighborhood Characteristics, and Behavioral Difficulties Among African American Adolescents Living in Very Low-Income Neighborhoods — Sterrett-Hong et al., Research on child and adolescent psychopathology (paywalled)
- dna-genotek-oragene
- pediatric
- saliva
- genotyping
2023
In 28 healthy adults, alectinib concentrations from capillary microsamples were generally similar to venous ones, which supports the method for therapeutic drug monitoring; the study tested a paediatric-friendly suspension, and the authors point to children, for whom venepuncture is difficult, as the intended use.
Relative bioavailability and food effect study of an oral suspension of alectinib in healthy volunteers using venipuncture and capillary microsampling — Liu et al., Clinical and translational science
- blood
- capillary
- venous-agreement
- pediatric
- tdm
- oncology
2023
The study compared two stool collection devices and found that GutAlive maintained bacterial viability and DNA integrity over time, preserving the original microbiome composition and diversity, which supports its use for decentralised self-collection in microbiome diagnostics.
GutAlive<sup>®</sup> enables DNA-based microbiome analysis without disrupting the original composition and diversity — Montero et al., Frontiers in microbiology
- stabilised
- self-collection
- microbiome
- stool
2023
Using patient-centric saliva microsampling with the Oragene kit, the study found a low overall prevalence, 13%, of the OPRM1 118G allele in a Western Saudi population, with a significantly higher frequency in females, 21%, than males, 5%. The authors note the findings are specific to this population and may not be generalisable.
Allele frequency and genotype distribution of the opioid receptor μ-1 (OPRM1) A118G polymorphism in the Western Saudi population — Bagher & Hareeri, Journal of applied biomedicine (paywalled)
- saliva
- dna-genotek-oragene
- genotyping
2023
Dried blood spot microsampling shows that paediatric lipid profiles vary significantly across three age groups, 0-10 days, 2-18 months and 3-13 years, with differences in 16 specific lipid species. The authors caution that paediatric ages remain under-mapped in DBS lipidomics and further investigation is required before establishing reference standards.
Lipid profile variability in children at different ages measured in dried blood spots — Ferreira et al., Molecular omics (paywalled)
- blood
- dbs
- metabolome
- dried
- pediatric
- biomarkers
2023
A new method using a direct mercury analyser allows for precise total mercury measurement in dried blood spot samples while controlling for sample volume. This approach facilitates minimally invasive capillary blood collection, making it highly suitable for human biomonitoring studies in vulnerable populations such as children.
A simple method for direct mercury analysis in dried blood spots (DBS) samples for human biomonitoring studies — González-Rubio et al., Environment international (paywalled)
- blood
- dried
- dbs
- validation
- pediatric
- toxicology
2023
A validated LC-MS/MS method successfully quantified vincristine in paediatric patient-centric whole blood collected via VAMS microsampling, spanning 1 to 50 ng/mL with intra- and inter-accuracy and precision within ±10.3% and ≤7.3%. Whole blood concentrations showed a non-linear relationship to plasma concentrations, which was described by a saturable binding model.
A sensitive liquid chromatographic-mass spectrometry method for the quantification of vincristine in whole blood collected with volumetric absorptive microsampling — van et al., Journal of pharmaceutical and biomedical analysis (paywalled)
- blood
- vams
- validation
- pediatric
- tdm
- oncology
2023
Stool from two volunteers showed different microbiome profiles between the outer cortex and the inner core, and homogenising then stabilising at 4°C for 24 hours preserved diversity better than fresh or frozen processing; a possible route to home stool collection, though only two people were sampled.
Accelerating Gut Microbiome Research with Robust Sample Collection — Zreloff et al., Research & reviews. Journal of microbiology and biotechnology
- stool
- stabilised
- microbiome
2023
A study of 50 paediatric renal transplant recipients found that a UHPLC-MS/MS method successfully quantified mycophenolic acid in VAMS microsampling samples over a 0.10-15 µg/mL range. However, converting microsampling results to plasma equivalents using haematocrit-based regression is required for clinical interpretation, supporting patient-centric decentralised monitoring.
Therapeutic drug monitoring of mycophenolic acid (MPA) using volumetric absorptive microsampling (VAMS) in pediatric renal transplant recipients: ultra-high-performance liquid chromatography-tandem mass spectrometry analytical method development, cross-validation, and clinical application — Kocur et al., Pharmacological reports : PR
- vams
- venous-agreement
- blood
- tdm
- haematocrit
- dried
- capillary
- pediatric
- immunosuppressants
- validation
2023
Over three years after HPV vaccination in 58 women, HPV-specific IgG was detected in 84% to 100% of first-void urine samples against 98% to 100% of serum samples, and the two correlated strongly; the authors support self-collected urine for follow-up of vaccine-induced immunity, with the caveat that only women were studied.
Follow-up of humoral immune response after HPV vaccination using first-void urine: A longitudinal cohort study — Téblick et al., Journal of medical virology (paywalled)
- dct
- colli-pee
- first-void
- serology
- hpv
- urine
2023
Self-collection of capillary blood using a topper and paediatric tube was successful for most patients under 70 and showed excellent agreement with venous sampling for PSA measurement, supporting its use for decentralised patient monitoring.
Self-sampling of blood using a topper and pediatric tubes; a prospective feasibility study for PSA analysis using 120 prostate cancer patients — van et al., Clinical chemistry and laboratory medicine (paywalled)
- venous-agreement
- blood
- self-collection
- oncology
- capillary
- liquid
2023
In 26 participants, capillary self-collection with Tasso-SST showed no qualitative discrepancies from venous phlebotomy for SARS-CoV-2 antibody results, and quantitative levels correlated strongly, total Ig Spearman rho 0.72 and IgG 0.85; within the limits of so small a study, this supports at-home collection for serosurveillance.
Comparison of capillary blood self-collection using the Tasso-SST device with venous phlebotomy for anti-SARS-CoV-2 antibody measurement — King et al., Journal of immunological methods (paywalled)
- venous-agreement
- blood
- self-collection
- serology
- capillary
- liquid
2023
A study of 37 kidney transplant recipients found Capitainer and Mitra microsampling feasible for decentralised monitoring. Capitainer showed consistent sampling success, 92%-96%, and higher analytical accuracy than Mitra, 52%-88% success. Proportions within ±15% of venous reference for creatinine and haemoglobin were 92%-100% and 93%-100% for Capitainer, versus 79%-96% and 67%-92% for Mitra, despite small cohorts.
Clinical performance of volumetric finger-prick sampling for the monitoring of tacrolimus, creatinine and haemoglobin in kidney transplant recipients — Vethe et al., British journal of clinical pharmacology (paywalled)
- blood
- capillary
- qdbs
- volumetric
- neoteryx-mitra
- self-collection
- validation
- venous-agreement
- tdm
- immunosuppressants
2023
The study found that combining the Oragene saliva collector with the miRNeasy kit gave the most sensitive detection of seven saliva miRNAs, and that different collector-kit combinations can be selected to suit different study needs.
Obtaining miRNA from Saliva-Comparison of Sampling and Purification Methods — Urbizu et al., International journal of molecular sciences
- saliva
- liquid
- dna-genotek-oragene
- validation
- biomarkers
2023
The study found that the Oragene OG-600 receptacle provided the highest concentration of salivary DNA, including short fragments suitable for analysis, and successfully detected HPV DNA from patient saliva. This matters for decentralised sampling as it supports the use of a standardised, self-collection device for non-invasive cancer biomarker detection.
Isolation of salivary cell-free DNA for cancer detection — Brooks et al., PloS one
- dna-genotek-oragene
- hpv
- liquid-biopsy
- liquid
- saliva
- genotyping
2023
The Tasso+ capillary blood collection device showed substantial to almost perfect concordance with standard venipuncture for measuring abnormal liver function tests including ALT, ALP, AST and total bilirubin, and patient feedback indicated a very favourable experience, supporting its use for more frequent and convenient testing outside the clinic.
Standard Venipuncture vs a Capillary Blood Collection Device for the Prospective Determination of Abnormal Liver Chemistry — Wickremsinhe et al., The journal of applied laboratory medicine (paywalled)
- blood
- capillary
- validation
- venous-agreement
- acceptability
2023
Saliva offers a non-invasive specimen matrix for detecting both oral and systemic conditions at the point of care. Although home collection and diagnostic biosensors show strong clinical and economic utility, technical challenges remain in standardisation and device integration before widespread point-of-care adoption.
A Review on Saliva-Based Health Diagnostics: Biomarker Selection and Future Directions — Kumari et al., Biomedical materials & devices
- saliva
- self-collection
- validation
- biomarkers
2023
In a national probability survey of Croatian emerging adults, chlamydia prevalence was 2.5% in women and 1.0% in men, with low prior testing rates and gaps in knowledge; self-collected urine testing proved feasible and supports decentralised STI screening strategies.
Knowledge about and prevalence of Chlamydia trachomatis in a population-based sample of emerging Croatian adults — Bozicevic et al., PloS one
- urine
- self-collection
- sti
2023
In a survey of 88 young people assigned female at birth, 69% preferred at-home self-collection for gonorrhoea and chlamydia screening, and lower educational attainment was associated with reduced preference, suggesting that at-home sampling is broadly acceptable but may need tailored support to address educational and other social determinants.
At-Home Self-Collection of Urine or Vaginal Samples for Gonorrhea and Chlamydia Screening Among Young People Who Were Assigned Female at Birth — Chongsuwat & Cody, AJPM focus
- urine
- self-collection
- acceptability
- sti
2023
In sixteen workers observed during the COVID-19 pandemic, those working from home had higher waking and lower nocturnal melatonin, and higher oxytocin, than office-based colleagues, while cortisol and s-IgA rhythms were unchanged. The study shows that self-collected saliva samples can detect how remote work alters stress-related biomarkers, supporting decentralised occupational-health monitoring.
Differences in the diurnal variation of salivary stress biomarkers during the coronavirus (COVID-19) pandemic between telecommuters and office workers — Hasebe et al., Neuro endocrinology letters (paywalled)
- saliva
- self-collection
- hormones
- cortisol
2023
Saliva self-collection for SARS-CoV-2 RNA detection showed 81.5% sensitivity and 76.4% specificity against nasopharyngeal swabs in 153 patients. Performance was highest four to seven days after symptom onset, supporting saliva as a viable decentralised diagnostic specimen during the first week of illness.
Use of saliva as an alternative diagnostic method for diagnosis of COVID-19 — Ganie et al., IJID regions
- saliva
- self-collection
- validation
- serology
2023
Toddler saliva cortisol fell from an initial rise back to low levels over three months, matching parents' and caregivers' reports of an easy start when parents were present followed by demanding first weeks of separation and then improved well-being; this concordance supports using self-collected saliva cortisol as a pragmatic, patient-centric biomarker of adaptation during the transition to childcare.
Do toddlers' levels of cortisol and the perceptions of parents and professional caregivers tell the same story about transition from home to childcare? A mixed method study — Drugli et al., Frontiers in psychology
- saliva
- pediatric
- hormones
- cortisol
2023
This multisite diagnostic accuracy study evaluated pooling strategies for detecting Chlamydia trachomatis and Neisseria gonorrhoeae using self-collected first-void urine and clinician-collected swabs from 437 men who have sex with men. Both ex-ante and ex-post pooling approaches showed high sensitivity and specificity compared with single-specimen testing, with ex-post pooling achieving 100% sensitivity for gonorrhoea, supporting decentralised screening programmes.
Using pooled urogenital, anorectal and oropharyngeal specimens to detect <i>Chlamydia trachomatis</i> and <i>Neisseria gonorrhoeae</i> among men who have sex with men in China: a multisite diagnostic accuracy study — Jiang et al., BMJ open
- urine
- first-void
- self-collection
- validation
- sti
2023
In a review of 91 human adenovirus-associated urethritis cases, dysuria occurred in 84% and meatitis in 34% of patients, with adenovirus type D being the most common subtype identified in first-void urine and urethral smears. Multiplex PCR screening for adenovirus in non-gonococcal urethritis can help establish accurate diagnoses and avoid unnecessary treatments.
Adenovirus-Associated Urethritis, a Not So Uncommon Entity. A Review of 91 Cases — Idigoras et al., Sexually transmitted diseases (paywalled)
- urine
- first-void
- serology
- sti
2023
The COVID-OUT trial showed a fully decentralised, multicentre randomised trial could be completed with only 1.4% loss to follow-up using electronic consent, prepackaged investigational product, and remote outcome confirmation. This demonstrates decentralised trials can achieve high retention without in-person contact, directly informing decentralised diagnostic study design.
Strategies used for the COVID-OUT decentralized trial of outpatient treatment of SARS-CoV-2 — Avula et al., Journal of clinical and translational science
- dct
2023
In a 16-donor validation study, prompt centrifugation of serum microsamples maintained analyte stability and preserved clinical chemistry and protein biomarker quality. This demonstrates that remote centrifugation with refrigerated shipping can lessen patient burden and broaden participation in decentralised clinical trials.
Decentralized clinical trial design using blood microsampling technology for serum bioanalysis — Lee et al., Bioanalysis (paywalled)
- blood
- liquid
- validation
- venous-agreement
- dct
- biomarkers
2023
Antigen rapid diagnostic tests using saliva, nasal and nasopharyngeal samples showed 60% sensitivity and 98% specificity against RT-qPCR in 609 patients with suspected COVID-19. The high specificity and moderate concordance support their role as a decentralised, patient-centric triage tool to identify likely infectious individuals and guide public health measures.
Rapid antigen test as a tool for the identification of SARS-CoV-2 infection and its potential as a self-testing device — Filgueiras et al., Revista da Sociedade Brasileira de Medicina Tropical
- saliva
- self-collection
- validation
- serology
2023
Twenty dementia caregivers self-collected saliva at home while using a mobile yoga app for twelve weeks. Those who practised most showed decreased salivary cortisol and increased 1,5-anhydroglucitol, indicating that self-collected saliva can track stress responses to decentralised behavioural interventions.
Self-Administered Gentle Yoga and Yoga Breathing Intervention Improves Burden and Stress Biomarkers in Caregivers of Persons Living with Dementia — Balasubramanian et al., International journal of yoga therapy (paywalled)
- saliva
- self-collection
- cortisol
- biomarkers
2023
In 880 people who self-collected three saliva samples at home, more than half in each cohort were cortisol awakening non-responders. No association was found between cortisol awakening response and trait resilience, but age, sex, weekday collection and awakening time significantly affected results, revealing compliance challenges for decentralised hormone monitoring.
The relationship between cortisol awakening response and trait resilience in two patient cohorts and one population-based cohort — Linnemann et al., The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry (paywalled)
- saliva
- self-collection
- hormones
- cortisol
2023
Dried blood spot eluates showed high agreement with serum for SARS-CoV-2 IgG against Spike and Nucleocapsid (r≈0.96; qualitative φ≈0.98–1.0) and remained stable after 6–8 hours of storage, supporting use of capillary DBS for serosurveys and decentralised testing.
Dried blood spot eluates are suitable for testing of SARS-CoV-2 IgG antibodies targeting Spike protein 1 and Nucleocapsid protein — Guttmann et al., Biochemistry and biophysics reports
- blood
- dried
- capillary
- self-collection
- validation
- venous-agreement
- serology
2023
A remote protocol combining daily surveys with weekly self-collected dried blood spots achieved a 92% study completion rate and high acceptability among reproductive-age women smokers, with 87% of participants collecting most samples and the same proportion extremely willing to repeat the study. This feasibility demonstrates that decentralised microsampling can support longitudinal research on hormonal contraceptive effects and smoking behaviour.
Feasibility of remotely assessing hormonal contraceptive use and smoking-related symptomatology: Evidence from a preliminary prospective cohort study — Medvescek & Allen, Drug and alcohol dependence reports (paywalled)
- blood
- dried
- dbs
- self-collection
- acceptability
- fertility
- hormones
- dct
2023
Volumetric absorptive microsampling of whole blood did not provide a reliable basis for calculating meropenem plasma concentrations in critically ill children, so a validated low volume plasma method was required for paediatric therapeutic drug monitoring.
Developing a Method for Quantifying Meropenem in Children-Volumetric Adsorptive Microsampling Versus Plasma Sampling — Ramadan et al., Therapeutic drug monitoring (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- venous-agreement
- pediatric
- tdm
- antimicrobials
2023
Volumetric absorptive microsampling (VAMS) of whole blood allows depletion of abundant red-cell proteins during processing, which improves detection of less abundant proteins from all blood compartments and yields deeper proteomic coverage than conventional plasma analysis alone.
Proteome Analysis of Whole Blood Collected by Volumetric Absorptive Microsampling — Molloy et al., Methods in molecular biology (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- biomarkers
2023
Quantitative at-home urine monitors clearly demarcated luteal phase transitions, luteinisation, progestation, and luteolysis, and identified anovulation across three clinical scenarios. This proof-of-concept suggests self-collected urine hormone measurements could help women target fertility interventions without clinic visits.
Using Quantitative Hormonal Fertility Monitors to Evaluate the Luteal Phase: Proof of Concept Case Study — Bouchard, Medicina
- urine
- self-collection
- fertility
- hormones
2023
Fertility patients commonly use direct-to-consumer ovulation prediction methods, yet reproductive endocrinologists rate the utility of these tests substantially lower than patients do. This discordance highlights the need for better patient education and guidelines to inform self-collection and interpretation of fertility biomarkers in decentralised care.
Direct-to-consumer fertility testing: utilization and perceived utility among fertility patients and reproductive endocrinologists — Peipert et al., Reproductive biomedicine online (paywalled)
- self-collection
- acceptability
- fertility
- hormones
2023
Lead can be measured accurately in dried blood spots by ICP-MS only when matrix-matched calibrators are used; aqueous calibrators perform poorly. The three methods evaluated showed strong agreement with whole blood analysis and offer a robust option for decentralised lead screening in children, though the recognised limitations of dried blood spots remain.
Matrix-matched calibrators are necessary for robust and high-quality dried blood spots lead screening assays by inductively coupled plasma-mass spectrometry — Franco et al., Journal of mass spectrometry and advances in the clinical lab
- blood
- dried
- dbs
- validation
- venous-agreement
- pediatric
- toxicology
2023
Self-collected first-void urine showed substantial agreement with clinician-collected cervical samples for high-risk HPV detection in 54 women with confirmed cervical precancer or cancer, with a Cohen's kappa of 0.70 and 86 per cent overall agreement, supporting urine self-sampling as a potential alternative for cervical cancer screening where pelvic examination is not feasible or acceptable.
Study to Determine Concordance between High-Risk Human Papilloma Virus DNA Detection in Self Collected First Voided Urine Samples and Health-Care Worker Collected Cervical Samples in a Subset of Women with Proven Histopathological Precancerous and Cancerous Lesions of the Cervix — Purwar et al., Journal of mid-life health
- urine
- first-void
- self-collection
- validation
- hpv
- sti
2023
The review found that self-collected saliva samples had much lower sensitivity for SARS-CoV-2 rapid antigen tests compared to healthcare worker-collected nasal or nasopharyngeal samples, while specificity remained high across all strategies. This matters for decentralised diagnostics because it highlights that both sample type and collector significantly impact test accuracy in self-testing scenarios, informing protocol design for remote screening programmes.
Performance of different rapid antigen testing strategies for SARS-CoV-2: A living rapid review — Shaver et al., European journal of clinical investigation (paywalled)
- saliva
- self-collection
- validation
2023
Mass spectrometry identified SARS-CoV-2 proteins in all self-collected saliva samples from people with COVID-19, while rRT-PCR detected viral RNA in only 57 per cent of the same samples, indicating that proteomic analysis may offer greater sensitivity for diagnosis and monitoring, especially in cases with low viral load.
Identification of SARS-CoV-2 biomarkers in saliva by transcriptomic and proteomics analysis — Marin et al., Clinical proteomics
- saliva
- self-collection
- serology
- biomarkers
2023
In unmedicated major depressive disorder, prefrontal and anterior cingulate 5-HT4 receptor binding positively associated with cortisol awakening response; eight weeks of antidepressant treatment did not alter cortisol awakening response and pretreatment cortisol awakening response did not predict outcome.
Stress Hormone Dynamics Are Coupled to Brain Serotonin 4 Receptor Availability in Unmedicated Patients With Major Depressive Disorder: A NeuroPharm Study — Vulpius et al., The international journal of neuropsychopharmacology
- saliva
- self-collection
- hormones
- cortisol
2023
The authors validated a simultaneous LC-MS/MS assay for hydroxychloroquine, its metabolites, and azithromycin from self-collected dried blood spots. Requiring only ten microlitres of blood and achieving a sensitivity of one nanogram per millilitre, the method enabled remote therapeutic drug monitoring in more than two thousand specimens during the COVID-19 pandemic.
Simultaneous LC-MS/MS method for the quantitation of Azithromycin, Hydroxychloroquine and its metabolites in SARS-CoV-2(-/ +) populations using dried blood spots — Chhonker et al., Scientific reports
- blood
- dried
- dbs
- self-collection
- validation
- tdm
2023
Capillary finger-stick dried blood spots yielded TSH measurements that agreed strongly with venous plasma (R² 0.988) and correctly identified hypothyroidism and hypothyrotropinemia in most cases. The analyte remained stable for at least four days between -20°C and +30°C, indicating potential for at-home collection in thyroid diagnostics and monitoring.
A Preliminary Analysis of Thyrotropin Measurement from Finger Stick Dried Blood Spot with an Automated High-Throughput Immunoassay Analyzer — Schakelaar et al., Thyroid : official journal of the American Thyroid Association (paywalled)
- blood
- dried
- capillary
- dbs
- self-collection
- validation
- venous-agreement
- hormones
- haematocrit
2023
In term newborns, measuring thyroid-stimulating hormone from dried blood spots before 72 hours of life is as accurate as later sampling and enables treatment of positive cases around 6 days instead of 8.5 days, without increasing false positives; however, home sampling delays laboratory receipt and yields more unusable samples than hospital sampling.
Thyrotropin Screening of Newborns: Before or After 72 Hours of Life? Before Discharge or at Home? — Boros et al., Thyroid : official journal of the American Thyroid Association (paywalled)
- blood
- dried
- dbs
- self-collection
- pediatric
- hormones
2023
The analysis quantified 62 proteins with satisfactory analytical performance, and 48 proteins showed significant correlation between 2 µL plasma microsamples and dried blood spots, supporting the use of dried blood microsampling for home collection and predictive medicine in elderly patients.
New Perspectives of Multiplex Mass Spectrometry Blood Protein Quantification on Microsamples in Biological Monitoring of Elderly Patients — Vialaret et al., International journal of molecular sciences
- blood
- liquid
- dried
- dbs
- validation
- biomarkers
2023
This study used first-void urine samples to detect mutations associated with antibiotic resistance in gonorrhoea, showing high prevalence of ciprofloxacin resistance and low prevalence of azithromycin resistance. Molecular testing on urine samples enables decentralised, non-invasive screening for drug-resistant infections.
Prevalence of mutations associated with macrolide and fluoroquinolone resistance in Neisseria gonorrhoeae with Allplex NG-DR Assay (Seegene) in a tertiary hospital from Madrid, Spain — Maldonado-Barrueco et al., Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia
- urine
- first-void
- sti
2023
The study found that serum concentrations of lacosamide and levetiracetam can be accurately estimated from dried capillary blood samples using simple ratio conversion, with high agreement to measured serum levels, supporting their use in decentralised therapeutic drug monitoring. For lamotrigine, the method is acceptable at low to medium concentrations but less reliable at higher levels, indicating a need for cautious interpretation in clinical practice.
Validation of Conversion Factors for Therapeutic Drug Monitoring of Lacosamide, Lamotrigine, and Levetiracetam in Dried Capillary Blood — Hagemann et al., Therapeutic drug monitoring (paywalled)
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- venous-agreement
- tdm
2023
In healthy Chinese adults a single oral dose of padsevonil showed rapid absorption and a favourable safety profile. VAMS dried blood concentrations of padsevonil and its metabolites were generally lower than plasma but were comparable at some time points by Passing‑Bablok regression, indicating that VAMS is promising for therapeutic drug monitoring of this novel antiepileptic drug and warrants further validation.
Pharmacokinetics and safety of Padsevonil in healthy Chinese subjects and comparison of two sampling methods for Padsevonil quantification — Li et al., European review for medical and pharmacological sciences (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- venous-agreement
- tdm
2023
The study optimised a UHPLC-MS/MS method to measure 11 lipids in 2.74 µL blood microsamples collected with hemaPEN® devices directly from athletes on a track. Five analytes, arachidonic acid, sphingosine, lactic acid, and two lysophosphatidylcholines, showed significant exercise-induced changes, demonstrating that capillary microsampling can reliably capture metabolic responses in decentralised settings without specialist staff.
A targeted UHPLC-MS/MS method to monitor lipidomic changes during a physical effort: Optimization and application to blood microsamples from athletes — Laurent et al., Journal of pharmaceutical and biomedical analysis (paywalled)
- blood
- capillary
- validation
- metabolome
- biomarkers
2023
In this observational study of 14 female students, greater total daily energy expenditure and a later midpoint of sleep were associated with lower severity of several menstruation-related symptoms during the menstrual and luteal phases. These findings suggest that lifestyle factors such as physical activity and sleep timing may inform non-pharmacological management of menstrual symptoms, though larger studies are needed to confirm clinical utility.
Menstruation-related symptoms are associated with physical activity and midpoint of sleep: a pilot study — Masuda & Okada, Frontiers in global women's health
- fertility
- wearable
- digital-biomarker
- actigraphy
2023
Daily remote urine hormone monitoring of LH and PdG, together with age and cycle start day, can identify menstrual cycle phase and day with 95% confidence; this supports precise, patient-centric cycle tracking outside clinic settings.
Using Hormone Data and Age to Pinpoint Cycle Day within the Menstrual Cycle — Hills et al., Medicina (paywalled)
- urine
- fertility
- hormones
2023
An intensive protocol combining daily at-home saliva collection for ovarian hormones with smartphone-based ecological momentary assessment achieved 85% compliance in 50 female smokers, revealing substantial within- and between-subject heterogeneity in hormone levels, anxiety and nicotine craving. This demonstrates feasibility of decentralised, patient-centric data collection for studying complex comorbidities.
Methodological approach for an integrated female-specific study of anxiety and smoking comorbidity — Farris et al., Frontiers in psychiatry
- saliva
- self-collection
- fertility
- hormones
- digital-biomarker
- multimodal
2023
Canadian dentists self-collected monthly saliva samples over one year during COVID-19. Salivary cortisol levels showed a modest positive association with national COVID-19 case counts, while dentistry-specific anxiety peaked during waves but general anxiety declined, demonstrating feasibility of longitudinal stress monitoring through decentralised sampling.
Salivary Cortisol and Anxiety in Canadian Dentists over 1 Year of COVID-19 — Kolbe et al., Journal of dental research
- saliva
- self-collection
- hormones
- cortisol
2023
Among 667 men who have sex with men who self-collected saliva at home, experiences of sexual behaviour stigma, particularly gossip by healthcare providers, were associated with elevated evening and average daily cortisol. This demonstrates that decentralised saliva microsampling can capture physiological stress responses in hard-to-reach populations, enabling remote psychosocial monitoring.
Predicting salivary cortisol and sexual behavior stigma among MSM in the American Men's Internet Survey 2019 — Dibble et al., Scientific reports
- saliva
- self-collection
- hormones
- cortisol
2023
Nine studies of non-pharmacological interventions in hospitalised children demonstrated reduced anxiety and distress when outcomes were confirmed by salivary cortisol, supporting saliva as an objective stress biomarker in paediatric settings. The authors concluded that higher-quality studies are needed to strengthen the evidence base for saliva cortisol as a reliable anxiety measurement tool.
Investigating Non-Pharmacological Stress Reduction Interventions in Pediatric Patients Confirmed with Salivary Cortisol Levels: A Systematic Review — Grigoropoulou et al., Pediatric reports
- saliva
- pediatric
- cortisol
2023
Capillary blood collected in microtubes yielded HbA1c results that agreed closely with venous sampling, while dried blood spots showed markedly poorer agreement. High patient acceptability and willingness to repeat suggest microtubes are a viable option for decentralised diabetes monitoring.
Home monitoring of haemoglobin A<sub>1c</sub> in diabetes: A systematic review and narrative synthesis on accuracy, reliability and patient acceptability — Colley et al., Diabetic medicine : a journal of the British Diabetic Association (paywalled)
- blood
- liquid
- capillary
- dbs
- self-collection
- validation
- venous-agreement
- acceptability
2023
Self-collected capillary blood produces serum creatinine results comparable to venous blood, and the analyte remains stable in unspun capillary samples stored at ambient temperature for three days. This supports the use of capillary microsampling for kidney function monitoring in patient-centric, decentralised settings.
Comparability and Stability of Serum Creatinine Concentration in Capillary and Venous Blood — Woolley et al., British journal of biomedical science
- blood
- liquid
- capillary
- validation
- venous-agreement
2023
Internet-based self-sampling of dried blood spots for HIV total nucleic acid testing was feasible, with a 95% qualification rate and good confidentiality, and it complemented sentinel surveillance.
A novel internet sampling for HIV surveillance: feasibility of self-sampling and preparation of DBS for delivery detection of HIV total nucleic acid and complementarity to sentinel surveillance — Su et al., BMC infectious diseases
- blood
- dried
- dbs
- self-collection
- serology
- sti
2023
This study of 184 individuals showed that home collection of dried blood spots and saliva can identify genetic polymorphisms linked to cardiac serum markers. Seven SNPs associated significantly with markers such as Apo B, LDL Direct, and hsCRP, while a polygenic risk score correlated strongly with NT-proBNP (r²=0.82, P=.03) and ox-LDL (r²=0.94, P=.005). These results indicate decentralised genetic sampling could enable early cardiovascular risk assessment and identify patients requiring closer serological monitoring.
Influence of genetic polymorphisms on serum biomarkers of cardiac health — Krishnamurthy et al., Medicine
- blood
- saliva
- dried
- dbs
- self-collection
- genotyping
- biomarkers
2023
In 1070 young adults, dried blood spot eluates correlated strongly with serum for anti-spike IgGAM and total IgG, IgA and IgM; labDBS achieved 82.0% sensitivity and 98.2% specificity and ssDBS 86.1% sensitivity and 96.7% specificity versus serum, with minimal difference between self and investigator collection.
Validation of dried blood spot sampling for detecting SARS-CoV-2 antibodies and total immunoglobulins in a large cohort of asymptomatic young adults — Ferentinos et al., Journal of immunological methods
- blood
- dried
- dbs
- self-collection
- validation
- venous-agreement
- serology
2023
Self-collection of dried blood spots in the home was feasible for healthy youth, with 82% consenting to provide a sample in the lab and 75% of those willing to self-collect at home, and DNA extraction quality was high across demographic groups.
At-home dried blood spot (DBS) collection to increase population heterogeneity representation in pediatric research: An ECHO study — Green et al., Frontiers in pediatrics
- blood
- dried
- dbs
- self-collection
- pediatric
2023
Dried blood spot sampling shows moderate agreement with plasma for therapeutic drug monitoring across evaluated drugs, and home based DBS achieves high yield and adherence with patient preference around three quarters; DBS is a reliable and feasible option for decentralised TDM but needs careful design and evaluation before use.
Reliability and feasibility of home-based dried blood spot in therapeutic drug monitoring: a systematic review and meta-analysis — Xiaoyong et al., European journal of clinical pharmacology (paywalled)
- blood
- dried
- dbs
- self-collection
- validation
- venous-agreement
- acceptability
- tdm
2023
Urine sampling with the Colli-Pee device revealed a substantial burden of high-risk HPV infection among unvaccinated Thai schoolgirls, with prevalence increasing from 8.6% in grade 10 to 12.4% in grade 12, demonstrating the feasibility of decentralised screening to guide immunisation policy.
Prevalence of HPV infection among Thai schoolgirls in the north-eastern provinces in 2018: implications for HPV immunization policy — Vongpunsawad et al., IJID regions
- urine
- first-void
- colli-pee
- serology
- hpv
2023
In adults given EPA or DHA for 12 weeks, first-void urine analysed by MSI-CE-MS showed increased S-carboxypropylcysteamine and other candidate metabolites that correlated with the Omega-3 Index measured in erythrocytes, suggesting urine could support non-invasive monitoring of omega-3 status.
Urinary Metabolite Profiling to Non-Invasively Monitor the Omega-3 Index: An Exploratory Secondary Analysis of a Randomized Clinical Trial in Young Adults — MacIntyre et al., Metabolites
- urine
- first-void
- metabolome
- biomarkers
2023
A VAMS method using Mitra devices for whole blood lead quantification showed no significant difference compared with the centre's routine method, supporting VAMS as a practical alternative for blood lead and other trace element analyses.
Method development for the quantification of lead levels in whole blood sampled on Mitra<sup>®</sup> with VAMS<sup>®</sup> tips by inductively coupled plasma-MS/MS — Breton et al., Bioanalysis (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- venous-agreement
- toxicology
2023
Capillary blood collected with the Mitra® device showed correlation with venous samples for paclitaxel therapeutic drug monitoring, but wide confidence intervals suggest the methods may not be interchangeable. While plasma and whole blood concentrations were more closely aligned, the variability raises questions about using self-collected capillary samples for dose individualisation without further validation.
Paclitaxel and Therapeutic Drug Monitoring with Microsampling in Clinical Practice — Radovanovic et al., Pharmaceuticals
- blood
- liquid
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- venous-agreement
- tdm
- oncology
2023
The authors developed and validated a workflow that couples Mitra volumetric absorptive microsampling with hybridisation LC-MS/MS to quantify the antisense oligonucleotide fomivirsen in human blood. Quantitative recovery was achieved irrespective of haematocrit level or sample age, and the method demonstrated sensitivity, linearity, precision, accuracy, and four-month stability, supporting its use for therapeutic drug monitoring of biologic candidates in decentralised trials.
Volumetric absorptive microsampling coupled with hybridization LC-MS/MS for quantitation of antisense oligonucleotides — Chen et al., Bioanalysis (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- haematocrit
2023
Patient-collected dried blood spot specimens for phenylketonuria monitoring showed significant quality variability across ten UK laboratories, with rejection rates rising from a median of 4.0% under existing local criteria to 21.9% under proposed national guidelines, most commonly because spots were too small or multi-spotted. The authors estimate that accepting poor-quality specimens could lead to approximately 12,410 incorrect results annually in England, and recommend ongoing training for patients and carers to prevent distress from higher rejection rates.
Cross-sectional audit assessing the quality of dried bloodspot specimens received by UK metabolic biochemistry laboratories for the biochemical monitoring of individuals with Phenylketonuria — Hogg et al., Annals of clinical biochemistry (paywalled)
- blood
- dried
- dbs
- self-collection
2023
The study found that minimally invasive self-sampling at home was acceptable to most families, with saliva and hand sampling well tolerated across all ages and nasal sampling mainly accepted by adults and children over five. This supports the use of decentralised, patient-centric microsampling for long-term community surveillance of microbiota.
Assessing the use of minimally invasive self-sampling at home for long-term monitoring of the microbiota within UK families — Nikolaou et al., Scientific reports
- saliva
- self-collection
- acceptability
- pediatric
- microbiome
2023
At-home urine oestrone-3-glucuronide measured with the Mira Fertility Tracker during gonadotropin stimulation correlated well with paired serum oestradiol (r = 0.761) and predicted mature oocyte yield to a similar degree, suggesting that patient-centric oestrogen monitoring could reduce reliance on clinic-based venous draws during fertility treatment.
At-home urine estrone-3-glucuronide quantification predicts oocyte retrieval outcomes comparably with serum estradiol — Nakhuda et al., F&S reports
- urine
- first-void
- self-collection
- venous-agreement
- fertility
- hormones
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