The Library
1530 papers on microsampling and monitoring, each with a finding paraphrased to our standard and labelled in one vocabulary. Every entry links to a legitimate copy; nothing is copied from an abstract.
Papers 401–500 of 1530, newest first.
2025
The hrHPV ReadyMix qPCR Kit detected high-risk HPV DNA in self-collected urine with 80.9% sensitivity and 100% specificity when compared to cervical swabs. Urine testing identified a similar HPV prevalence (6.28%) to cervical swabs (6.62%), suggesting this non-invasive method could expand cervical cancer screening programmes in low-resource settings.
Urinary detection of high-risk HPV DNA to enhance cervical cancer screening in developing countries — Intan et al., Microbiology spectrum
- urine
- self-collection
- validation
- genotyping
- hpv
- sti
2025
Urine-based HPV testing showed broad variability in diagnostic performance, with sensitivity ranging from 44.8 to 98.6 per cent and specificity from 61 to 100 per cent against cervical specimens. High patient acceptability was reported, yet standardisation is needed before this self-collection approach can be approved for decentralised cervical cancer screening.
A Narrative Review of Urine-Based Human Papillomavirus Screening: Performance, Challenges, and Opportunities to Expand Access in the United States — Yang et al., Sexually transmitted diseases (paywalled)
- urine
- self-collection
- validation
- acceptability
- hpv
- sti
2025
Urinary HPV testing showed lower sensitivity than cervical sampling for detecting CIN2+ (79% versus 93%) but higher specificity (58% versus 50%), and participants favoured urine self-collection. The authors conclude that while urine sampling may complement screening in resource-limited or culturally conservative settings, its suboptimal performance and absence of standardised protocols preclude its use for general population screening.
Pooled performance of urinary human papillomavirus (HPV) testing for the presence of cervical HPV — Ye et al., Cancer (paywalled)
- urine
- self-collection
- validation
- acceptability
- hpv
- sti
2025
Self-collected first-void urine from male partners of women diagnosed with Chlamydia trachomatis achieved an 84.1% return rate and detected infection in 43.9% of returned specimens, with the highest partner positivity of 53.5% in women aged 16 to 25 years, indicating that targeted partner notification and self-sampling can identify prevalent infection in this demographic.
Evaluation of chlamydia trachomatis prevalence in male sexual partners: a hospital-based cross-sectional study in Shaoxing, China — Guan et al., Sexually transmitted infections (paywalled)
- urine
- self-collection
- sti
2025
Self-collected urine and vaginal samples for hrHPV and CIN2+ detection showed high diagnostic accuracy and acceptability compared with clinician sampling, supporting their use as viable alternatives that could improve screening accessibility and compliance in decentralised settings.
Feasibility and acceptability of human papillomavirus self-sampling compared with clinician sampling in urban areas of western China: a cross-sectional survey — Xue et al., Frontiers in public health
- urine
- self-collection
- acceptability
- hpv
- sti
2025
Only 24% of participants completed this two-cycle feasibility study of AI-interpreted salivary ferning for ovulation prediction in females with irregular cycles, with 44% withdrawing citing cycle irregularity, pregnancy, or time constraints. The authors concluded that decentralised fertility trials must streamline procedures and provide ovulatory health education to improve retention and reduce burden before smartphone-based diagnostics can be scaled for this population.
Digitally Enabled AI-Interpreted Salivary Ferning-Based Ovulation Prediction: Feasibility Study — Peebles et al., Journal of medical Internet research
- saliva
- self-collection
- acceptability
- fertility
- hormones
2025
Among children of parents with bipolar disorder, saliva samples collected at home over two days showed that improvements in family organisation during a six-month prevention programme were associated with adaptive changes in hypothalamic-pituitary-adrenal axis activity, including elevated cortisol awakening response and steeper diurnal slope. These results indicate that decentralised saliva collection can capture clinically meaningful neuroendocrine responses to psychosocial interventions in at-risk paediatric populations.
Hypothalamic-pituitary-adrenal axis function in the offspring of parents with bipolar disorder and the impact of the family environment: A pilot study of the Reducing Unwanted Stress in the Home (RUSH) prevention program — Ping et al., Psychoneuroendocrinology (paywalled)
- saliva
- self-collection
- pediatric
- hormones
- cortisol
2025
The Ovul portable device, which analyses dried saliva crystallisation patterns to detect the fertile window, achieved 97.4% sensitivity and 97.6% accuracy in women with idiopathic infertility, outperforming urine test strips while both methods maintained 100% specificity against folliculometry. This supports its use as a decentralised, patient‑centric tool for home fertility monitoring that could reduce costs and improve convenience.
Effectiveness of using ferning of the dried saliva crystallization to determine the fertile window in women with idiopathic infertility — Kolomiichenko et al., Wiadomosci lekarskie (paywalled)
- saliva
- dried
- self-collection
- fertility
- hormones
2025
This study developed a fluorescence probe for detecting histidine in saliva, demonstrating high sensitivity and specificity for cancer risk screening. The probe showed excellent recovery in real saliva samples and feasibility for point-of-care use in home or resource-limited settings.
Turn-on fluorescence sensing of histidine in body fluids: unveiling its oncogenic potential as a cancer risk biomarker — Indongo et al., The Analyst (paywalled)
- saliva
- liquid
- oncology
- biomarkers
2025
In 404 symptomatic patients, self-collected nasal swabs and saliva showed almost perfect agreement with healthcare-collected nasopharyngeal swabs for detecting SARS-CoV-2 and influenza A RNA. Performance and reproducibility were favourable, and collection without viral transport media offers practical advantages for decentralised screening.
Evaluation of alternative clinical samples for the detection of SARS-CoV-2 and influenza virus by automated multiplex RT-PCR — Özarslan et al., Journal of infection in developing countries (paywalled)
- saliva
- self-collection
- validation
- serology
2025
In women with endometriosis, longer individual exercise sessions were associated with lower levels of salivary c-reactive protein and estradiol, as well as reduced pain and fat mass. The results demonstrate the utility of timed, at-home saliva self-collection for assessing systemic biomarkers in reproductive health research.
Is exercise duration more important than intensity in endometriosis? — Hartmann et al., BMC women's health
- saliva
- self-collection
- fertility
- hormones
- cortisol
- biomarkers
2025
Salivary concentrations of 17OH-progesterone, androstenedione, dehydroepiandrosterone, testosterone and progesterone showed strong positive correlations with serum in both prepubertal and pubertal children with congenital adrenal hyperplasia, supporting saliva as a minimally invasive alternative to venipuncture for diagnosis and therapy monitoring.
[Salivary steroid profile investigation by high performance liquid chromatography-tandem mass spectrometry in children with congenital adrenal hyperplasia] — Tiulpakov et al., Problemy endokrinologii
- blood
- saliva
- venous-agreement
- pediatric
- hormones
2025
In adults, cleaning the fingertip with an alcohol swab did not significantly change capillary glucose readings compared with handwashing, whether the alcohol was left wet or allowed to dry completely. This supports the continued safe use of alcohol swabs before capillary glucose testing in clinical and home settings.
Effect of Alcohol Swab on Blood Glucose Readings Using a Glucometer: A Quasi-Experimental Study — Al-Aithan et al., Cureus
- blood
- liquid
- capillary
- validation
2025
In an adolescent with cerebral palsy undergoing a home-based, remotely supervised sprint-intensity interval training intervention, dried blood spot testing demonstrated a 37.8% reduction in triglycerides and a 15.4% improvement in total cholesterol to HDL ratio. This illustrates how remote microsampling can support decentralized metabolic monitoring in pediatric disability rehabilitation.
Sprint-Intensity Arm Interval Training May Improve Cardiorespiratory Fitness and Cardiometabolic Health Among Children With Mobility Disabilities: Case Report — Dean et al., JMIR formative research
- blood
- dried
- dbs
- self-collection
- pediatric
- biomarkers
2025
The review identifies neurofilament light chain, brain-derived tau, glial fibrillary acidic protein and soluble TREM2 as fluid biomarkers that could monitor axonal damage and glial activation in hereditary spastic paraplegia. It proposes that dried blood spot collection enables minimally invasive longitudinal monitoring of these biomarkers, supporting patient-centred care models for this genetically heterogeneous neurodegenerative disease.
Fluid Biomarkers in Hereditary Spastic Paraplegia: A Narrative Review and Integrative Framework for Complex Neurodegenerative Mechanisms — Cipriano et al., Genes
- blood
- dried
- dbs
- self-collection
- validation
- biomarkers
2025
Volumetric dried blood spot microsampling enables retinol analysis with over 90% extraction efficiency from only 10 µL of blood, though α-tocopherol recovery ranges from 53 to 75% depending on filter paper. The method improves sample stability to 30 days at -80°C and reduces shipping volume more than a thousandfold, making micronutrient monitoring practical for decentralised settings.
Volumetric dried blood spot microsampling: A sustainable, patient-friendly, and practical approach for retinol and α-tocopherol analysis in a clinical setting — Suwanvecho et al., Methods (paywalled)
- blood
- dried
- dbs
- volumetric
- validation
- biomarkers
2025
A new model using sex, age and body surface area most accurately predicted one-day creatinine excretion in Japanese schoolchildren, outperforming eleven existing methods; this improves decentralised assessment of chemical exposure and dietary nutrient intake from first-void urine.
Prediction of one-day creatinine excretion in Japanese schoolchildren based on anthropometric measurements — Kato et al., Environmental health and preventive medicine
- urine
- first-void
- validation
- pediatric
2025
Gargling was less sensitive than throat swabbing for detecting pharyngeal gonorrhoea (85.9% versus 97.2%), though patients preferred gargle samples. This suggests gargle samples can be used as an alternative specimen in decentralised STI screening but with reduced sensitivity compared to throat swabs.
Pharyngeal gonococcal infection and the sensitivity of oral gargle samples in comparison to self-collected throat swabs for the detection of N. gonorrhoeae in persons in Tyrol, Austria — Kitchen et al., Infection (paywalled)
- urine
- first-void
- self-collection
- sti
2025
The SHERLOCK assay detected Mycoplasma genitalium in first-void urine with a limit of detection of 10 copies per reaction and achieved 91.4% overall agreement with the cobas TV/MG PCR test (positive agreement 79.6%, negative agreement 100%), supporting its potential as a rapid point-of-care test for MG.
Development and clinical evaluation of a novel SHERLOCK test for <i>Mycoplasma genitalium</i> — Omachi et al., Microbiology spectrum
- urine
- first-void
- validation
- sti
2025
First-void urine self-collection achieved almost perfect agreement with clinician-collected cervical samples for high-risk HPV detection (prevalence-adjusted kappa 0.95 for HPV16). The method showed comparable sensitivity and specificity ratios for identifying cervical intraepithelial neoplasia grade two or worse, supporting its use as a decentralised screening alternative.
A United States study of self-collected urine vs clinician-collected cervical sample for HPV and cervical intraepithelial neoplasia grade two or worse detection: Cross-sectional agreement and diagnostic accuracy study — Young et al., Preventive medicine reports
- urine
- first-void
- self-collection
- validation
- hpv
- sti
2025
The study found that levels of an acrylamide metabolite in first-void urine were significantly and inversely associated with testosterone, puberty stage and facial hair growth in boys aged 13 to 14, but not in girls, suggesting that acrylamide exposure may disrupt pubertal development in males through effects on testosterone.
Acrylamide exposure, sex hormones, and pubertal status in Japanese adolescents — Nagata et al., International journal of environmental health research (paywalled)
- urine
- first-void
- pediatric
- hormones
- toxicology
2025
Urine-based HPV testing demonstrated 74% sensitivity and 52% specificity for detecting CIN2+, with performance improving when first-void collection and PCR-based assays were used. Although less sensitive than clinician-collected cervical samples, urine testing was preferred by over 90% of women, indicating potential as a complementary screening strategy to improve uptake.
- urine
- first-void
- self-collection
- validation
- acceptability
- hpv
- sti
2025
A randomised trial of 13,061 under-screened French women found that mailing vaginal or first-void urine self-sampling kits for HPV testing increased participation in cervical cancer screening to 23.5 to 23.6 per cent, compared with 12.9 per cent for conventional physician invitation letters. This demonstrates that decentralised, patient-centric screening can substantially improve population coverage.
Mailing Vaginal or Urine Self-Sampling Kits versus Conventional Invitation Letters: A Randomized Trial to Assess the Effect on Cervical Cancer Screening Attendance — Lefeuvre et al., Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
- urine
- first-void
- self-collection
- hpv
2025
Researchers validated a UHPLC-MS/MS assay for citrinin in capillary blood collected with Neoteryx Mitra VAMS devices, plus feces and urine, achieving quantification limits of 0.05 ng/mL. The study derived human toxicokinetic parameters from 48-hour sample collection after a single oral dose, demonstrating that microsampling enables robust population-level exposure assessment for mycotoxins.
Derivation of Human Toxicokinetic Parameters and Chemical-Specific Adjustment Factor of Citrinin Through a Human Intervention Trial and Hierarchical Bayesian Population Modeling — Visintin et al., Toxins
- blood
- urine
- stool
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- toxicology
2025
The study develops and validates a dried blood microsampling method for oxylipin analysis in newborn blood using UPLC-MS/MS, showing that small-volume, minimally invasive capillary blood collection is feasible and suitable for unstable, low-abundant analytes, enabling practical decentralised sampling in vulnerable populations.
Assessment of dried blood micro-sampling methods for oxylipin analysis in newborn blood using UPLC-MS/MS — Albiach-Delgado et al., Analytica chimica acta (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- pediatric
2025
In 55 patients, four approaches to convert dried capillary blood concentrations to plasma equivalents were evaluated. All methods except haematocrit-based conversion yielded acceptable analytical and clinical agreement for paracetamol and metabolites, supporting the reliability of capillary microsampling for decentralised therapeutic drug monitoring.
Comparative Evaluation of Approaches to Convert Microsampled Capillary Blood Concentrations to Plasma Concentrations: Paracetamol and Metabolites as a Case Study — Boffel et al., The AAPS journal (paywalled)
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- venous-agreement
- dct
- haematocrit
2025
This feasibility study demonstrated that a surrogate matrix solution enables accurate quantitation of a monoclonal antibody from dried blood samples collected via VAMS or Tasso-M20 devices. The method resolves challenges related to daily calibrator preparation and sample dilution for ligand binding assays used in pharmacokinetic studies.
The Use of Surrogate Matrix for Calibrators in the Analysis of Dried Blood Samples - A Feasibility Study — Lee et al., The AAPS journal (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- biologics
2025
Capillary volumetric absorptive microsampling showed significant differences in absolute antibiotic concentrations compared to venous plasma, yet it reliably tracked the pharmacokinetic profiles of amoxicillin, metronidazole, and azithromycin over time. The approach was well accepted by both participants and clinicians, indicating its feasibility for less invasive therapeutic drug monitoring in periodontal clinical trials.
A comparison between venous blood sampling and capillary volumetric absorptive microsampling for antibiotics levels monitoring in individuals with and without periodontal disease — Lazaridi et al., Clinical oral investigations
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- venous-agreement
- acceptability
- tdm
- antimicrobials
2025
All five at-home urine ovulation predictor kits demonstrated high accuracy (92–97%) when compared with blood LH levels, though sensitivity varied widely from 38% to 77% with Clinical Guard the lowest. Patient experience was comparable across kits, though Clinical Guard was slightly less favoured for future use.
Similar accuracy and patient experience with different one-step ovulation predictor kits — Vanderhoff et al., Fertility and sterility (paywalled)
- blood
- urine
- self-collection
- validation
- venous-agreement
- acceptability
- fertility
- hormones
2025
Capillary blood collected with a Tasso+ device showed excellent agreement with venous serum for testosterone, the testosterone/androstenedione ratio, and luteinising hormone in 20 adults tracked over six weeks. The biomarkers remained stable when capillary samples were stored at room temperature, suggesting capillary microsampling could enable decentralised, patient-centric collection for the Athlete Biological Passport without cold-chain logistics.
Is blood blood? Comparing quantitation of endogenous steroids and luteinizing hormone in concurrently collected venous serum and Tasso+ SST capillary serum samples — Goodrum et al., Drug testing and analysis (paywalled)
- blood
- capillary
- validation
- venous-agreement
- hormones
- doping
2025
A coffee-ring biosensor detected sepsis, COVID-19 and cancer proteins from self-collected saliva down to 3 pg/ml within 12 minutes, achieving sensitivity more than 100-fold higher than lateral flow assays. The system uses a smartphone camera and AI analysis, providing a rapid, affordable platform for decentralised protein diagnostics.
Plasmonic coffee-ring biosensing for AI-assisted point-of-care diagnostics — Behrouzi et al., Nature communications
- saliva
- self-collection
- serology
- biomarkers
2025
Growth differentiation factor 15 (GDF15) is significantly elevated in both plasma and saliva of patients with mitochondrial disease, and saliva GDF15 levels correlate with disease severity. This supports saliva as a patient-centric matrix for decentralised disease monitoring, potentially reducing the need for venous blood draws.
The mitochondrial disease biomarker GDF15 is dynamic, quantifiable in saliva, and correlates with disease severity — Huang et al., Molecular genetics and metabolism (paywalled)
- blood
- saliva
- biomarkers
2025
Capillary finger-stick blood showed excellent comparability with venous samples for 30 of 33 routine chemistry analytes against total allowable error criteria, and met CLIA 2024 proficiency testing limits for all but glucose. This validates capillary sampling as a clinically acceptable alternative for most routine tests, benefiting patients with needle phobia and enabling remote sampling.
Comparison of capillary finger stick and venous blood sampling for 34 routine chemistry analytes: potential for in hospital and remote blood sampling — Doeleman et al., Clinical chemistry and laboratory medicine (paywalled)
- blood
- liquid
- capillary
- validation
- venous-agreement
2025
Whole-genome sequencing of dried blood spots from 1,000 newborns identified 16 infants with high-chance results, most missed by standard screening. The 13-day turnaround and high parental acceptability show a feasible, scalable model for decentralised genomic screening.
Feasibility, acceptability and clinical outcomes of the BabyScreen+ genomic newborn screening study — Lunke et al., Nature medicine
- blood
- dried
- dbs
- acceptability
- pediatric
- genotyping
2025
In a fully virtual decentralised trial of 2516 participants with mild asthma, as-needed albuterol-budesonide cut the risk of severe exacerbation by 47 per cent compared with albuterol alone (hazard ratio 0.53). The trial shows that decentralised designs can deliver robust event-driven outcomes for respiratory disease without traditional site visits.
As-Needed Albuterol-Budesonide in Mild Asthma — LaForce et al., The New England journal of medicine (paywalled)
- dct
2025
The authors observe that self-sampling devices for capillary blood are gaining traction as a patient-preferred alternative to venous collection, with one centre reporting a 15 percent reduction in laboratory test volumes when local collection was offered. They argue that successful integration into total laboratory automation requires addressing cost, transport regulations and sample volume adequacy while ensuring robust device design and seamless workflow compatibility.
Blood self-sampling devices: innovation, interpretation and implementation in total lab automation — Poland & Cobbaert, Clinical chemistry and laboratory medicine (paywalled)
- blood
- liquid
- capillary
- self-collection
- acceptability
2024
At-home capillary microsampling carried pharmacokinetic sampling across the Paxlovid phase II/III programme, with fewer than 3% of more than 800 samples unusable, and the resulting data supported the Emergency Use Authorization and subsequent FDA approval: remotely collected samples accepted in a registrational filing.
Patient Centric Microsampling to Support Paxlovid Clinical Development: Bridging and Implementation — Wan et al., Clinical Pharmacology & Therapeutics (paywalled)
- dct
- volumetric
- venous-agreement
- blood
- self-collection
- dried
- capillary
- validation
2024
Head-to-head clinical validation of two VAMS devices for tacrolimus and mycophenolic acid, with roughly 86–88% of samples within ±20% of venous.
Clinical validation of two volumetric absorptive microsampling devices to support home-based therapeutic drug monitoring of immunosuppression — Leino et al., British Journal of Clinical Pharmacology (paywalled)
- vams
- venous-agreement
- acceptability
- neoteryx-mitra
- blood
- tdm
- self-collection
- dried
- immunosuppressants
- validation
2024
DBS achieved 100% sensitivity, 99% specificity and ~97% concordance versus paired serum: the strength of the classic card for ratio/threshold serology.
Using Dried Blood Spots to Quantitatively Detect Anti-SARS-CoV-2 IgG Antibodies by ELISA: A Validation Study — Ylade et al., American J. Tropical Medicine and Hygiene
- blood
- dbs
- dried
- serology
- validation
2024
Confirms urine is the second-most-applied VAMS matrix in forensics, collecting a consistent volume regardless of viscosity and enabling room-temperature storage and shipping.
Volumetric Absorptive Microsampling in Toxicology — Review, Toxics
- vams
- volumetric
- blood
- dried
- toxicology
- urine
- validation
- saliva
2024
An analysis of 88 individuals aged 7 to 18 years found that stimulated saliva collection detected disease-associated microbiome taxa that unstimulated sampling missed. The authors note that sampling protocols must be standardised before results can be compared across decentralised studies.
Saliva sampling method influences oral microbiome composition and taxa associated with oral diseases — Roca et al., PLoS ONE
- microbiome
- pediatric
- liquid
- validation
- saliva
2024
In 91 children and adults, capillary C-peptide taken with the TAP device matched venous sampling with 100% sensitivity and specificity for a clinically relevant level, 200 pmol/L or above, with r = 0.996. 63% preferred it to a needle against 7% who preferred the needle, and same-day bruising was 5.5% versus 34.8% after a venous draw.
Transdermal blood sampling for C-peptide is a minimally invasive, reliable alternative to venous sampling in children and adults with type 1 diabetes — Besser et al., Diabetes Care
- blood
- liquid
- yourbio
- capillary
- pediatric
- venous-agreement
- acceptability
- validation
2024
In at-home and trial settings, a wet capillary device reliably collected a median ~450 µL with a 4.4% failure rate; 88% of adults preferred self-collection over venipuncture, with lower pain.
Feasibility, acceptability and safety of a device for self-collecting capillary blood in clinical trials — Dasari et al., PLOS ONE
- acceptability
- blood
- self-collection
- capillary
- pediatric
- liquid
- validation
2024
An independent VALHUDES evaluation found HPV screening on Colli-Pee first-void urine detected high-grade cervical lesions with sensitivity comparable to clinician-collected cervical samples, reinforcing urine self-sampling for cervical screening.
Clinical Performance of the OncoPredict HPV Screening Assay on Self-Collected Vaginal and Urine Specimens (VALHUDES) — Giubbi et al., J. Medical Virology
- colli-pee
- first-void
- self-collection
- hpv
- liquid
- urine
- validation
2024
This study compared two preservatives for stool samples and found that OMNIgene GUT OMR-200 produced less variation in metagenomic taxonomic data across different storage temperatures, supporting its use in decentralised field studies. The authors recommend absolute quantification to address bias in microbial measurements.
Quantifying bias introduced by sample collection in relative and absolute microbiome measurements — Maghini et al., Nature biotechnology (paywalled)
- stool
- stabilised
- dna-genotek-omnigene
- microbiome
2024
In children, stool preserved in OMNIgene-GUT kept its microbial community structure better than unpreserved stool, with alpha and beta diversity similar to direct freezing, which supports the kit for decentralised stool collection from children.
Omnigene-Gut<sup>tm</sup> ensures fecal microbiome stability in the pediatric population — Hoogendijk et al., AMB Express
- dct
- stabilised
- dna-genotek-omnigene
- microbiome
- pediatric
- stool
- validation
2024
A study of 301 adults with epilepsy providing 464 measurements found that patient-centric capillary VAMS microsampling showed good agreement with plasma for seven of 13 antiseizure medicines, such as carbamazepine and levetiracetam. However, systematic differences remained for valproate, primidone, topiramate, and zonisamide, meaning decentralised monitoring is feasible for most but some drugs need further evaluation.
Fingerprick volumetric absorptive microsampling for therapeutic drug monitoring of antiseizure medications: Reliability and real-life feasibility in epilepsy patients — Cancellerini et al., Journal of pharmaceutical and biomedical analysis (paywalled)
- vams
- venous-agreement
- blood
- tdm
- self-collection
- dried
- capillary
2024
Self-collected rectal and pharyngeal specimens showed high agreement and diagnostic accuracy compared to clinician-taken samples for detecting Chlamydia trachomatis and Neisseria gonorrhoeae. The approach was highly acceptable to participants, the majority of whom preferred self-sampling to clinician-sampling.
Performance and acceptability of self-collected specimens for diagnosis of rectal and pharyngeal Chlamydia trachomatis and Neisseria gonorrhoeae infections among men who have sex with men in China: a randomized controlled trial — Jiang et al., BMC infectious diseases
- acceptability
- first-void
- sti
- self-collection
- urine
2024
The study found excellent agreement between hCG levels measured in remotely collected capillary blood and standard venous samples, with a near-perfect correlation. This demonstrates that remote self-collection is a feasible and acceptable alternative for serial pregnancy monitoring, reducing the need for clinic visits.
Proof-of-concept study: Remote capillary blood collection for hCG analysis in early pregnancy — Joyce et al., European journal of obstetrics, gynecology, and reproductive biology (paywalled)
- venous-agreement
- acceptability
- blood
- self-collection
- capillary
- fertility
- hormones
- liquid
2024
Plasma total carbon dioxide concentrations were significantly lower in BD Microtainers compared to standard vacutainers, with reductions driven by low sample volume and transport delays rather than brief air exposure. These findings indicate that microtainers must be filled completely and analysed rapidly to maintain accuracy for this analyte.
Impact of blood volume, air exposure duration, transport duration, and testing delay on plasma total carbon dioxide in simulated open collections using microtainers — Reid et al., Clinical biochemistry (paywalled)
- blood
- liquid
- capillary
- bd-microtainer
- validation
2024
In a cross-sectional study of 90 adolescents, 94 per cent provided at least one salivary sample and 89 per cent supplied a stool sample, with high adherence to study instructions, indicating that self-collection of these biospecimens is feasible and acceptable in this age group.
Engaging adolescents in research: Home self-collection of biological samples and health questionnaires — Leung et al., Research in nursing & health (paywalled)
- acceptability
- self-collection
- microbiome
- pediatric
- stool
- saliva
2024
A validated LC-MS/MS assay successfully measured 13 steroid hormones and two synthetic steroids in saliva, requiring only 50 microlitres, or down to 2 to 5 microlitres for nine analytes. This shows saliva's viability for non-invasive, patient-centric microsampling and decentralised monitoring in paediatric, neonatal and adult populations.
An LC-MS/MS assay for simultaneous determination of 13 steroid hormones and two synthetic steroids in saliva: potential utility for paediatric population and beyond — Dahl et al., Scandinavian journal of clinical and laboratory investigation (paywalled)
- cortisol
- self-collection
- steroids
- pediatric
- hormones
- liquid
- validation
- saliva
2024
In 102 patients, Mitra and Capitainer microsamples gave urine albumin-to-creatinine ratios at 102% and 95% of the clinical analyser's, and both stayed within 98% to 103% after three weeks at room temperature, which supports either device for decentralised urine collection.
Patient-Centric Quantitative Microsampling for Accurate Determination of Urine Albumin to Creatinine Ratio (UACR) in a Clinical Setting — Löfgren et al., The journal of applied laboratory medicine (paywalled)
- dct
- volumetric
- neoteryx-mitra
- urine
- validation
- biomarkers
2024
A decentralised trial in Singapore found 97% participant retention and high sample collection rates. Participants reported convenience and safety, while reduced travel lowered environmental impact compared to traditional trials.
Decentralized clinical trials are better for the participants and for the planet: the case study of a double-blind randomized controlled trial in Singapore (PROMOTE study) — Fries et al., Frontiers in public health
- dct
- acceptability
2024
A review of 18 studies found that microsampling techniques, including dried blood spot sampling and volumetric absorptive microsampling, are validated for antipsychotic monitoring. Although most studies have shortcomings limiting generalisability, microsampling is recommended for clozapine and is a promising, virtually painless option to support decentralised, patient-centric care.
Microsampling Techniques Suitable for Therapeutic Drug Monitoring of Antipsychotics — Geers et al., Journal of clinical psychopharmacology (paywalled)
- vams
- blood
- dbs
- tdm
- dried
- validation
2024
A pilot RCT found home self-sampling tools substantially increased screening uptake for colorectal cancer, 75% vs 13%, and cervical cancer, 79% vs 8%, versus standard reminders among underserved patients, with abnormal findings in a quarter of returned tests. The study was limited by small sample size and short follow-up.
Self-sampling tools to increase cancer screening among underserved patients: a pilot randomized controlled trial — Moss et al., JNCI cancer spectrum
- stool
- self-collection
- colorectal
- hpv
2024
The study validated a VAMS-based LC-MS/MS method for measuring sirolimus levels, showing it was clinically equivalent to the standard whole blood method and suitable for therapeutic drug monitoring in paediatric transplant patients, supporting the use of decentralised microsampling for this purpose.
Personalization of pharmacotherapy with sirolimus based on volumetric absorptive microsampling (VAMS) in pediatric renal transplant recipients-from LC-MS/MS method validation to clinical application — Kocur et al., Pharmacological reports : PR
- vams
- venous-agreement
- neoteryx-mitra
- blood
- tdm
- haematocrit
- dried
- capillary
- pediatric
- immunosuppressants
- validation
2024
The study developed and validated LC-MS/MS methods for ciclosporin in whole blood and volumetric absorptive microsampling across 1-2000 ng/mL, meeting international bioanalytical criteria, and confirmed interchangeability with clinical samples and external proficiency testing, supporting decentralised microsampling for therapeutic drug monitoring in children.
A novel approach to therapeutic drug monitoring of Ciclosporin in pediatric renal transplant recipients using volumetric absorptive microsampling (VAMS) - Teaching old dog new tricks — Kocur et al., Clinica chimica acta; international journal of clinical chemistry (paywalled)
- vams
- blood
- tdm
- pediatric
- immunosuppressants
- validation
2024
A study of 152 women found that HbA1c and reproductive hormone levels from menstrual blood collected via a modified pad highly correlated with venous blood, supporting its use as a decentralised surrogate, though interassay variability was noted.
Concordance of hemoglobin A1c and reproductive hormone levels in menstrual and venous blood — Naseri et al., F&S reports
- blood
- dried
- dbs
- venous-agreement
- fertility
- hormones
2024
This study evaluated the repeatability of a point-of-care G6PD test using capillary blood collected via fingerprick and BD Microtainers, finding that modified sample application methods reduced variability in laboratory and field settings.
Field assessment of the operating procedures of a semi-quantitative G6PD Biosensor to improve repeatability of routine testing — Sadhewa et al., PloS one
- blood
- liquid
- capillary
- bd-microtainer
- validation
2024
Self-collected oral sponge sampling found high accuracy for HPV DNA detection in oral cancer patients, with 100% specificity, 85.7% sensitivity and an AUC of 0.93, compared to oral rinse. The authors note larger cohorts are required to confirm performance.
Human Papilloma Virus (HPV) Detection in Oral Rinse vs. Oral Sponge: A Preliminary Accuracy Report in Oral Cancer Patients — Panzarella et al., Cancers
- self-collection
- hpv
- liquid
- saliva
- genotyping
2024
Capillary sampling gave TSH and FT4 results that closely matched venous values, with Spearman correlations of 0.99 and 0.97 respectively. This supports using small capillary samples for remote thyroid function testing.
Determination of Capillary Blood TSH and Free Thyroxine Levels Using Digital Immunoassay — Suzuki et al., Journal of the Endocrine Society
- venous-agreement
- blood
- capillary
- hormones
- yourbio
2024
Capillary serum collected with Tasso-SST and Tasso+ devices correlated with venous plasma at r = 0.98 for abrocitinib and its three metabolites, and exposure met bioequivalence criteria; the authors present this as the basis for using Tasso devices in future paediatric studies of abrocitinib.
Patient-centric microsampling for abrocitinib pharmacokinetics: multiple-analytes assay bridging using Tasso device — Tripathy et al., Bioanalysis
- blood
- capillary
- venous-agreement
- pediatric
- tdm
2024
Patterned DBS cards meter reproducible volumes of dried blood across a range of haematocrits, allowing accurate white blood cell counts by qPCR that match HemoCue measurements. This enables reliable at-home sampling for populations without easy access to clinical facilities.
Hematocrit-Independent Sampling Enables White Blood Cell Counts from Patterned Dried Blood Spot Cards — Tierney et al., Analytical chemistry (paywalled)
- blood
- dbs
- self-collection
- haematocrit
- dried
- validation
2024
Capillary sampling for carcinoembryonic antigen showed near perfect agreement with venous results and was preferred by most participants, supporting reliable home based collection that could reduce hospital visits.
Feasibility, reliability and satisfaction of (automated) capillary carcinoembryonic antigen measurements for future home-based blood sampling: the prospective CASA-I study — Voigt et al., Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland (paywalled)
- venous-agreement
- acceptability
- blood
- self-collection
- oncology
- colorectal
- capillary
- yourbio
2024
A study found that stool stabilised in 95% ethanol or OMNImet•GUT and OMNIgene•GUT kits maintained metabolome and microbiome profiles comparable to flash freezing for up to seven days at room temperature. Non-stabilised samples showed temperature-dependent changes in bile and short-chain fatty acids, supporting decentralised, patient-centric ambient collection.
Comparative Metabolomics and Microbiome Analysis of Ethanol versus OMNImet/gene•GUT Fecal Stabilization — Isokääntä et al., Analytical chemistry
- stool
- stabilised
- dna-genotek-omnigene
- microbiome
- metabolome
2024
Capillary blood self-collection yielded protein concentrations that matched venipuncture for only a minority of analytes, with 34 of 230 proteins showing acceptable correlation and low variability, while the remainder were more variable; this suggests capillary sampling can support decentralised proteomics for a subset of proteins but may not be universally interchangeable with venipuncture.
Capillary blood self-collection for high-throughput proteomics — El-Sabawi et al., Proteomics
- venous-agreement
- blood
- self-collection
- capillary
- liquid
- biomarkers
2024
Capillary finger prick sampling at home showed close agreement with venous sampling for measuring infliximab, vedolizumab and CRP, with no systematic bias and high patient tolerability and practicality, supporting decentralised monitoring of biologic therapy in IBD.
Clinical Validation of a Capillary Blood Home-Based Self-Sampling Technique for Monitoring of Infliximab, Vedolizumab, and C-Reactive Protein Concentrations in Patients With Inflammatory Bowel Disease — Otten et al., Inflammatory bowel diseases
- blood
- liquid
- capillary
- self-collection
- venous-agreement
- acceptability
- tdm
- biologics
2024
This review found saliva comparable to blood and urine for detecting viral genetic material and antibodies, supporting patient-centric monitoring and decentralised surveillance. The authors state that standardised protocols and further validation are required for routine clinical use.
The Emergence of Saliva as a Diagnostic and Prognostic Tool for Viral Infections — Oliveira et al., Viruses
- blood
- self-collection
- serology
- hpv
- urine
- validation
- saliva
- biomarkers
2024
Using the Oragene saliva device, this study identified elevated CYP2C8 allele frequencies in a Saudi paediatric cohort compared to other Asian populations, suggesting potential variability in ibuprofen metabolism and drug response.
Pediatric pharmacogenetics: profiling CYP2C8 polymorphisms at King Abdulaziz University Dental Clinic — Bagher et al., Drug metabolism and personalized therapy (paywalled)
- saliva
- dna-genotek-oragene
- pediatric
- genotyping
2024
Primary caregivers of children with metabolic disorders found at-home dried blood spot collection acceptable after training, which could enable more timely and cost-effective monitoring. This supports the feasibility of decentralised, patient-centric sampling for long-term condition management.
Acceptability of dried blood spot collection by primary caregivers of Filipino patients with maple syrup urine disease (MSUD) and phenylketonuria (PKU) — Merencilla et al., Journal of community genetics (paywalled)
- acceptability
- blood
- dbs
- self-collection
- dried
- pediatric
2024
This retrospective case series found that a protocol combining home-based urinary hormone testing with a smartphone application supported fertility management and family planning without unintended pregnancies. The findings suggest that integrating self-collected urinary data with digital tools offers a viable decentralised approach for ovulation prediction.
Helping Patients to Predict and Confirm Ovulation with the Use of Combined Urinary Hormonal and Smartphone Technology: A Proof-of-Concept Retrospective Descriptive Case Series — Leiva & Ecochard, Seminars in reproductive medicine
- multimodal
- self-collection
- fertility
- hormones
- urine
2024
Microsampling enables less invasive, patient-centric self-collection of capillary blood for remote monitoring of metabolites and lipids, overcoming conventional venipuncture constraints. Recent device innovations address dried blood spot limitations, particularly haematocrit and volume variations, expanding decentralised applications in population health, drug discovery and multi-omics research.
Revolutionizing Blood Collection: Innovations, Applications, and the Potential of Microsampling Technologies for Monitoring Metabolites and Lipids — Bossi et al., Metabolites
- multimodal
- blood
- dbs
- metabolome
- self-collection
- haematocrit
- dried
- capillary
- validation
- biomarkers
- multi-omics
2024
The review highlights that decentralized clinical trials can improve inclusivity and efficiency by overcoming geographical and logistical barriers through remote digital technologies, though challenges remain regarding data security, privacy, and regulatory standardisation.
The value of decentralized clinical trials: Inclusion, accessibility, and innovation — Jean-Louis & Seixas, Science (paywalled)
- dct
2024
This study of 82 children with concussion found that capillary blood collected with a Mitra device within 48 hours of injury could not identify protein markers that predict persistent posttraumatic headache at two weeks. The negative result highlights the need for novel biomarker discovery to enable risk stratification in paediatric concussion using decentralised sampling.
Capillary blood protein markers of posttraumatic headache in children after concussion — Fan et al., Journal of neurosurgery. Pediatrics (paywalled)
- blood
- capillary
- vams
- neoteryx-mitra
- pediatric
- biomarkers
2024
Decentralised recruitment channels generated 97.5% of enrolments, were cost effective, and met timelines, with 82.6% retention at six months, showing that decentralised strategies are feasible and conducive to achieving enrolment targets.
Recruitment, Retention, and Participant Diversity in the Context of a Heart Failure Self-Care Digital Intervention Decentralized Clinical Trial — West et al., AMIA ... Annual Symposium proceedings. AMIA Symposium (paywalled)
- dct
2024
A national steering committee developed twelve standard operating procedures and a supervision plan to guide decentralised cancer clinical trials in New Zealand with an equity focus. This patient-centred approach allows patients to stay in their local areas with their support networks, improving trial accessibility.
Process of development of decentralised clinical trial methodology for cancer clinical trials in Aotearoa New Zealand — Lawrence et al., The New Zealand medical journal (paywalled)
- dct
2024
Preliminary data from the HOT4PrEP trial show 67% of participants offered home-based PrEP monitoring chose to self-collect blood and STI samples at home, and 82% of these successfully returned kits. This demonstrates feasibility and acceptability of decentralised microsampling for HIV prevention, which may improve PrEP retention and expand clinical capacity.
Implementation and Evaluation of a Home-Based Pre-Exposure Prophylaxis Monitoring Option: Protocol for a Randomized Controlled Trial — Cannon et al., JMIR research protocols
- blood
- self-collection
- acceptability
- dct
- sti
2024
In subfertile women, urinary microbiota profiles correlated strongly with vaginal profiles but contained fewer species, indicating that vaginal sampling is preferable for predicting fertility treatment outcomes.
Clinical Applicability of Microbiota Sampling in a Subfertile Population: Urine versus Vagina — Koedooder et al., Microorganisms
- urine
- self-collection
- fertility
- microbiome
2024
The study found that distance to the study institution was a significant barrier to enrollment in a prehabilitation trial for advanced ovarian cancer patients, with fewer enrolled patients living 200 miles or more away compared to those not enrolled, supporting the need for decentralised clinical trials.
An Argument for Decentralized Clinical Trials in Gynecologic Oncology — Mokshagundam et al., O&G open
- oncology
- dct
2024
Decentralised clinical trials conducted in home environments shift substantial logistical and procedural responsibilities onto caregivers of cancer patients. Addressing digital literacy barriers, sample handling workflows, and inadequate support is essential to prevent excessive caregiver burden during remote trial execution.
Decentralized Clinical Trials at Home: Commentary on Caregivers' Burden — Bolajoko et al., Cancer control : journal of the Moffitt Cancer Center
- oncology
- dct
2024
Transgender women in Uganda initially anxious about point-of-care urine tenofovir testing for PrEP adherence monitoring found it acceptable after counselling, though test interpretation caused confusion as two lines indicated non-adherence rather than positivity as with HIV self-tests. Some participants avoided clinic visits to prevent detection of non-adherence, a behaviour termed 'white coat dosing', highlighting the need for tailored adherence strategies in this population.
Urine tenofovir testing for real-time PrEP adherence feedback: a qualitative study involving transgender women in Uganda — Mujugira et al., Journal of the International AIDS Society
- urine
- self-collection
- acceptability
- tdm
2024
Among 195 men who have sex with men in Shenzhen, self-reported sexual positioning proved unreliable for guiding chlamydia and gonorrhoea screening. Urine testing alone would have missed 69.2 per cent of rectal chlamydia and 85.7 per cent of rectal gonorrhoea infections even in participants who reported exclusively insertive anal sex, demonstrating that self-collected rectal swabs are essential for comprehensive decentralised STI screening programmes.
Using Self-Reported Sexual Positioning as an Indicator for Rectal Chlamydia and Gonorrhea Screening Among Men Who Have Sex With Men in China: A Missed Opportunity — Weng et al., Sexually transmitted diseases (paywalled)
- urine
- self-collection
- sti
2024
This randomised trial found that peer-delivered HIV self-testing and sexually transmitted infection self-sampling did not improve oral pre-exposure prophylaxis adherence among transgender women in Uganda compared to standard care. Adherence was monitored using dried blood spots and urine, which showed a strong correlation in tenofovir detection.
Peer-Delivered HIV Self-Testing, Sexually Transmitted Infection Self-Sampling, and Pre-exposure Prophylaxis for Transgender Women in Uganda: A Randomized Trial — Mujugira et al., Journal of acquired immune deficiency syndromes
- blood
- saliva
- urine
- dbs
- self-collection
- tdm
- dct
- sti
2024
In a 14-day study of youth with neurodevelopmental conditions and chronic pain, multimodal in-home monitoring achieved good accelerometer wear compliance (77% wore devices for at least 7 days) and moderate survey engagement, but adherence to salivary cortisol sampling was low at 28% after excluding protocol violations and dry swabs. Families reported high overall satisfaction and willingness to participate again, highlighting that remote sampling protocols in pediatric populations require iterative tailoring to improve biospecimen collection adherence.
The Living Lab at Home: Feasibility and Acceptability of Multimodal In-Home Data Collection Among Youth Across the Developmental Spectrum — Boerner et al., Journal of developmental and behavioral pediatrics : JDBP
- saliva
- self-collection
- acceptability
- pediatric
- cortisol
- wearable
- actigraphy
- multimodal
2024
In a longitudinal cohort of 1,292 mothers, increased cortisol reactivity to children's distress at 15 months predicted higher harsh parenting at 24 months, and conversely, higher harsh parenting at 15 months predicted increased cortisol reactivity at 24 months. This bidirectional association suggests that salivary cortisol reactivity in early toddlerhood may flag risk for harsh parenting and that parenting stress can further alter maternal stress physiology, which is pertinent to decentralised monitoring of stress biomarkers via saliva.
Within-person bidirectional associations between maternal cortisol reactivity and harsh parenting across infancy and toddlerhood — Ravindran et al., Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (paywalled)
- saliva
- hormones
- cortisol
2024
Four years after vaccination, HPV-16/18 prevalence in schoolgirls fell from 3–6% to under 0.6% for both single-dose and two-dose regimens, with single-dose effectiveness at 90.6% proving non-inferior to the two-dose schedule. This validates first-void urine sampling for community-based vaccine effectiveness monitoring in decentralised screening programmes.
Community intervention of a single-dose or 2-dose regimen of bivalent human papillomavirus vaccine in schoolgirls in Thailand: vaccine effectiveness 2 years and 4 years after vaccination — Jiamsiri et al., Journal of the National Cancer Institute. Monographs
- urine
- first-void
- pediatric
- hpv
2024
In pregnant women, first-void urine collected at midgestation detected HPV in 38%, with high-risk genotypes and high viral loads associated with placental HPV infection at delivery (prevalence 3%). No increased risk of adverse pregnancy outcomes was observed with placental HPV. This demonstrates urine-based HPV screening can identify placental infection risk non-invasively.
Placental human papillomavirus infections and adverse pregnancy outcomes — Værnesbranden et al., Placenta (paywalled)
- urine
- first-void
- genotyping
- hpv
2024
A time-resolved fluorescence assay detected HPV16-specific IgG in first-void urine with strong correlation to paired serum across four immunoassays in 225 healthy women, supporting first-void urine as a non-invasive alternative to venous blood for HPV antibody monitoring.
Time-resolved fluorescence (TRF) for total IgG and HPV16-specific antibody detection in first-void urine and serum: A comparative study — Lipovac et al., Journal of virological methods
- urine
- first-void
- validation
- venous-agreement
- serology
- hpv
2024
The paper found that two laboratory assays for the anticoagulants apixaban and rivaroxaban gave markedly different plasma concentrations, and that dried blood volumetric absorptive microsamples taken by patients at home did not agree with plasma results. For decentralised diagnostics this means clinical laboratories must validate their chosen method and always measure haematocrit when using microsamples to ensure accurate anticoagulant monitoring.
Assays for Monitoring Apixaban and Rivaroxaban in Emergency Settings, State-of-the-Art Routine Analysis, and Volumetric Absorptive Microsamples Deliver Discordant Results — Fehér et al., Diagnostics
- blood
- dried
- vams
- validation
- tdm
- haematocrit
2024
The study validated a method for determining 15 trace elements in whole blood collected via VAMS, showing high precision and accuracy with agreement to a liquid sampling method. This supports the use of VAMS for decentralised trace element analysis in clinical and research settings.
A miniaturized sample preparation method for routine elemental determination in whole blood using volumetric absorptive micro-sampling by ICP-QQQ — Schmidt et al., Analytical and bioanalytical chemistry (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- venous-agreement
2024
The study developed and validated a LC-MS/MS method for quantifying Lurasidone using volumetric absorptive microsampling, comparing dried blood and plasma matrices; the method appears precise, accurate and robust, enabling reliable decentralised therapeutic drug monitoring with small-volume dried blood samples.
Development of LC-MS/MS method for quantification of Lurasidone using volumetric absorptive microsampling (VAMS); a comparative study between dried blood and plasma samples — Rajadhyaksha & Londhe, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (paywalled)
- blood
- dried
- vams
- validation
- tdm
2024
A feasibility study at a Kathmandu maternity hospital showed newborn metabolic screening using dried blood spots achieved 98.8% parental consent, driven primarily by cost-free participation. Despite pandemic-related transport delays to a central Indian laboratory, results were delivered within two weeks, detecting metabolic abnormalities in 13 of 825 infants, with 90% of healthcare providers endorsing routine implementation.
Feasibility of clinical newborn metabolic screening in a high-volume maternity center in Nepal — Khan et al., BMC global and public health
- blood
- dried
- dbs
- acceptability
- pediatric
2024
This systematic review of 67 studies involving 34,739 kidney disease patients found dried blood microsampling was mainly used for immunosuppressant therapeutic drug monitoring and kidney function assessment. The approach offered cost savings, was preferred by patients for home self-collection, and provides a patient-centric opportunity to upscale longitudinal sampling and reduce participation bias in decentralised kidney disease research.
A Systematic Literature Review on the Use of Dried Biofluid Microsampling in Patients With Kidney Disease — Lamond et al., Journal of clinical laboratory analysis
- blood
- dried
- capillary
- self-collection
- validation
- acceptability
- tdm
- immunosuppressants
- economics
2024
Postpartum women with HIV who had low ART drug concentrations reported more challenges with HIV status disclosure, social support, health system interactions and health beliefs compared with those who had continuously high concentrations; integrating objective adherence biomarkers with patient narratives could enable real time interventions to improve ART adherence and maternal infant outcomes.
Antiretroviral therapy adherence among peripartum women with HIV in Kenya: an explanatory mixed methods study using dry blood spot measures and narrative interviews — Hampanda et al., AIDS care (paywalled)
- blood
- dried
- dbs
- acceptability
- tdm
2024
A four-item questionnaire for menstrual phase identification, validated against progesterone in dried blood spots, achieved 92.1 per cent accuracy with less restrictive scoring, substantially better than self-reported onset of menses alone (60.2 per cent). This tool could enable accurate phase determination in decentralised research and low-resource settings without intensive clinical assessment.
Menstrual Phase Identification Questionnaire (MPIQ): Development and validation of a cross-sectional survey to identify follicular and luteal phases — Allen et al., Experimental and clinical psychopharmacology (paywalled)
- blood
- dried
- dbs
- validation
- fertility
- hormones
2024
A scoping review identified twelve studies comparing remote and in-person administration of the ALS Functional Rating Scale-Revised. While correlations between modes were high, the evidence remains insufficient to endorse remote clinician administration for high-quality data in decentralised ALS trials.
Remote-Use Applications of the Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised Clinical Outcome Assessment Tool: A Scoping Review — Bhushan et al., Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research (paywalled)
- dct
- rpm
2024
A survey of 355 clinical research sites found that half had no experience with decentralised trial solutions and only 6.6% had run a fully decentralised trial. Half of respondents viewed decentralised approaches as more burdensome than traditional trials, particularly for clinical procedures requiring staff–patient interaction, indicating that reducing site burden is critical for adoption of decentralised diagnostics.
Quantifying Site Burden to Optimize Protocol Performance — Florez et al., Therapeutic innovation & regulatory science (paywalled)
- dct
2024
A digital decentralised clinical trial platform for long COVID successfully managed e-consent, randomisation, and data capture, but faced significant challenges including recruitment difficulties, imposter participants, and high attrition rates. These findings highlight critical considerations for designing viable remote trials in complex syndromes.
Key considerations for digital decentralised clinical trials from a feasibility study assessing pacing interventions for long COVID — McMullan et al., Scientific reports
- dct
2024
Self-collected urine samples matched clinician-collected cervical samples in detecting all seven CIN3 lesions among hrHPV-positive women when extended HPV typing was used, showing 82% concordance for hrHPV detection. This indicates urine self-collection could serve as a patient-centric, decentralised screening option for cervical precancer without compromising diagnostic yield.
Performance of urine samples compared to cervical samples for detection of precancer lesions among HPV-positive women attending colposcopy clinic in Mexico City — Meneses-León et al., Cancer causes & control : CCC
- urine
- self-collection
- validation
- hpv
- sti
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