The Library
1530 papers on microsampling and monitoring, each with a finding paraphrased to our standard and labelled in one vocabulary. Every entry links to a legitimate copy; nothing is copied from an abstract.
Papers 301–400 of 1530, newest first.
2025
Self-collection of menstrual blood using the M-strip was feasible and highly acceptable to women, and hr-HPV DNA results from menstrual blood showed 100% concordance with direct cervical smears, supporting its potential use in decentralised cervical screening.
HPV-DNA testing from self-sampled menstrual blood using M-strip: A proof-of-concept study on feasibility & acceptance of a novel biosampling method — Chandra et al., The Indian journal of medical research
- blood
- self-collection
- acceptability
- hpv
2025
A home-based PrEP follow-up programme using self-collected specimens and remote monitoring was evaluated among predominantly Black and Latino men who have sex with men in South Florida. Only 37.5% elected home-based care, with completion rates falling from 48.3% at first follow-up to 15% by the third, and most returned to clinic care citing discomfort with self-collection and logistical barriers, highlighting that decentralised HIV prevention requires enhanced support to achieve equitable uptake and persistence.
PrEP Beyond the Clinic: Evaluation of a Home-Based PrEP Follow-Up System Among a Cohort of Predominantly Black and Latino Men who Have Sex with Men in South Florida — Butts et al., Journal of acquired immune deficiency syndromes (paywalled)
- blood
- urine
- self-collection
- acceptability
- sti
2025
Focus groups with 48 women from diverse ethnic groups in Northwest England revealed that self-sampling for cervical screening was highly acceptable, particularly because it offered privacy, autonomy, and reduced discomfort. The study indicates that providing a self-sampling option could increase screening uptake among underserved populations, though participants expressed concerns about test accuracy and practical usability.
Acceptability of Self-Sampling for Cervical Screening in Ethnically Diverse Groups in Northwest England: A Focus Group Study — Whitley et al., Health expectations : an international journal of public participation in health care and health policy
- urine
- self-collection
- acceptability
- hpv
2025
Self-scans with a smartphone-based home ultrasound device produced image quality and measurements of follicle count, endometrial thickness and oocyte yield that closely matched in-clinic sonography, with strong correlations and no difference in clinical decisions, supporting remote monitoring of ovarian stimulation.
Monitoring Ovarian Stimulation for Assisted Reproduction With Patient Self-Scans Using a Home Vaginal Ultrasound Device: A Single-Center Interventional, Prospective Study — Shufaro et al., Journal of medical Internet research
- fertility
- rpm
2025
A newborn screening programme using dried blood spots detected classic 21-hydroxylase deficiency in 1 in 17,699 infants, with second-tier LC-MS/MS testing achieving a positive predictive value of 4.3. However, 23% of cases became symptomatic before results were reported, highlighting that timeliness remains a critical challenge for decentralised diagnostics.
Newborn screening for congenital adrenal hyperplasia due to 21 hydroxylase deficiency: the Italian experience 2006-2019 — Baronio et al., Journal of endocrinological investigation (paywalled)
- blood
- dried
- dbs
- pediatric
- hormones
2025
Remote motor assessment achieved a 95 percent completion rate and high caregiver acceptability in children with Canavan disease. Good to excellent inter- and intra-rater reliability demonstrates that rigorous remote assessment protocols can be implemented in decentralised trials for rare pediatric conditions, reducing burden on families.
Feasibility, Acceptability, and Reliability of Remote Motor Assessment in Children With Canavan Disease — Kiefer et al., Pediatric neurology (paywalled)
- pediatric
- dct
- rpm
- digital-biomarker
2025
This retrospective analysis found that trials using local labs had a lower percentage of white participants, while those using virtual visits had a lower percentage of Black participants. Wearables showed no significant demographic impact. These findings demonstrate that different decentralised trial components can have varying effects on participant diversity, which must be considered when designing equitable diagnostic studies.
Examining the Association Between DCT Solutions Use and Participant Diversity in Clinical Trials — Smith & Getz, Therapeutic innovation & regulatory science (paywalled)
- dct
2025
Participants and site personnel viewed the hybrid decentralised trial design favourably, though remote forced vital capacity assessments were more likely to be missed than in-clinic ones, and technological challenges were common.
Participant, site personnel and sponsor perspectives on decentralized trial features in COURAGE-ALS: a randomized clinical trial — Rudnicki et al., Amyotrophic lateral sclerosis & frontotemporal degeneration (paywalled)
- acceptability
- dct
2025
In a Phase 1 crossover study of etrasimod, self-collected blood microsamples yielded pharmacokinetic exposures comparable to conventional venous sampling, both with and without participant practice sessions. Continuous wearable sensors concurrently enabled real-time remote monitoring of safety vital signs and electrocardiograms, demonstrating the viability of hybrid decentralised designs in early-phase clinical trials.
Advancing Early Clinical Trials: The Transformative Potential of Decentralized Designs and Digital Technologies in Phase 1 Clinical Trial — Malhotra et al., Clinical pharmacology and therapeutics
- blood
- capillary
- self-collection
- venous-agreement
- dct
- wearable
- rpm
- digital-biomarker
- multimodal
2025
A fully decentralised trial of 9151 participants using a mobile app for daily voice capture found two machine learning algorithms met pre-specified success criteria for screening viral respiratory illness, with sensitivity increasing as symptoms increased while specificity remained consistent. This demonstrates voice-based digital biomarkers can identify infections remotely and validates bring-your-own-device trial designs.
Longitudinal voice monitoring in a decentralized Bring Your Own Device trial for respiratory illness detection — Santamaria et al., NPJ digital medicine
- dct
- rpm
- digital-biomarker
2025
WELT-I significantly improved sleep efficiency and reduced dysfunctional beliefs about sleep compared with a sham app in a decentralised clinical trial, supporting the feasibility of remote digital therapeutics for insomnia.
Validating the Efficacy of a Mobile Digital Therapeutic for Insomnia (WELT-I): Randomized Controlled Decentralized Clinical Trial — Park et al., Journal of medical Internet research
- dct
- digital-biomarker
2025
A large decentralised trial investigating a wearable device for COVID-19 detection retained 80.4% of participants at six months and 68.5% until completion. Multivariable analysis identified vaccinated pensioners as a high-risk discontinuation group, and targeted telephone calls reduced their dropout rate to 11.4%, showing that personalised retention strategies can improve engagement in remote diagnostic studies.
Increasing Retention in a Large-Scale Decentralized Clinical Trial: Learnings From the COVID-RED Trial — Zwiers et al., Mayo Clinic proceedings. Digital health
- dct
- wearable
- rpm
2025
This literature review maps the regulatory landscape for decentralised clinical trials across the US, EU and China, finding that the US emphasises efficiency and technological integration, the EU prioritises equity and patient engagement, and China focuses on rare diseases with a cautious regulatory approach. It argues that fragmented governance across jurisdictions hampers the full realisation of DCTs and calls for greater international harmonisation.
The status quo of the development of decentralized clinical trials — Chen et al., Frontiers in medicine
- dct
2025
Transgender women in Uganda valued integrated PrEP and STI services that used urine self-collection for therapeutic drug monitoring and infection detection. The convenience of this approach motivated adherence to pre-exposure prophylaxis, while same-day initiation and drug-level feedback supported engagement with care, demonstrating that decentralised, patient-centric models can improve prevention uptake in vulnerable populations.
Integrated PrEP and STI Services for Transgender Women in Uganda: Qualitative Findings from a Randomized Trial — Mujugira et al., AIDS and behavior (paywalled)
- urine
- self-collection
- acceptability
- tdm
- sti
2025
A meta-analysis of 15 studies with 3665 participants showed that urine and vaginal self-sampling for HPV testing achieved pooled sensitivity of 0.88 and specificity of 0.81 for cervical cancer screening, with an area under the curve of 0.92. Vaginal self-sampling outperformed urine sampling for high-risk HPV detection, and both methods demonstrated high sensitivity for identifying CIN2 lesions, indicating their suitability for patient-centric screening.
Accuracy analysis of cervical cancer screening using urine and vaginal self-sampling versus clinician-collected samples: A systematic review and meta-analysis — Li et al., International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (paywalled)
- urine
- self-collection
- validation
- hpv
- sti
2025
Self-collection of urine and vaginal swabs at home for STI testing in a national survey was feasible and broadly acceptable, with vaginal swabs providing higher testing sensitivity than urine.
Home-based self-collection of biological samples, including vaginal swabs: a mixed methods study for Britain's fourth National Survey of Sexual Attitudes and Lifestyles (Natsal-4) — Oeser et al., Sexually transmitted infections
- urine
- self-collection
- acceptability
- sti
2025
Self-collected urine HPV nucleic acid amplification testing shows high pooled sensitivity but modest specificity for detecting HSIL+, supporting its use as a non-invasive decentralised screening option though confirmatory testing may be needed due to lower specificity.
Accuracy of human papillomavirus testing using self-collected urine samples for detecting high-grade squamous intra-epithelial lesion or worse: a diagnostic meta-analysis — Hsiao et al., International journal of gynecological cancer : official journal of the International Gynecological Cancer Society (paywalled)
- urine
- self-collection
- validation
- hpv
- sti
2025
Self-collection of urine, pharyngeal and anal specimens for chlamydia and gonorrhoea testing was highly acceptable among HIV PrEP clients in Vietnam, with 97.9% providing specimens from all three sites and 99.4% willing to repeat the process; cost was the most important factor influencing testing preferences.
Preferences and Acceptability of Testing for Sexually Transmitted Infections in an HIV Pre-Exposure Prophylaxis Clinic in Hanoi, Vietnam — Bui et al., Sexually transmitted diseases (paywalled)
- urine
- self-collection
- acceptability
- sti
2025
This Cochrane review identified 21 studies with over 13 million participants to evaluate decentralised SARS-CoV-2 testing strategies, including home-based saliva self-collection. It applied GRADE and SWiM methods to assess impact on COVID-19 cases, hospitalisations and deaths, establishing an evidence framework for patient-centric diagnostics.
Effectiveness of SARS-CoV-2 testing strategies in reducing COVID-19 cases, hospitalisations, and deaths — Saif-Ur-Rahman et al., The Cochrane database of systematic reviews (paywalled)
- saliva
- self-collection
2025
This paper describes a handheld electrochemical sensor for vitamin C measurement in saliva and urine, showing a linear range from 0.2 to 200 µm and detection limit of 0.03 µm. The device demonstrated satisfactory accuracy and recovery in human samples, suggesting potential for affordable home-based testing of vitamin C status.
A Multi-Channel Handheld Diagnostic Device Based on Green Biomimetic Material for Point-of-Care Testing of Vitamin C in Human Fluids — Fu et al., Advanced healthcare materials (paywalled)
- saliva
- urine
- liquid
- self-collection
- biomarkers
2025
In 20 adults, CRP measured in urine and saliva strongly correlated with serum CRP (Spearman rho 0.886) and was significantly elevated in participants with systemic inflammation compared with controls, suggesting these noninvasive matrices could replace venipuncture for monitoring inflammatory status in remote or at-home settings.
Multimodal Noninvasive Assessment of C-Reactive Protein for Systemic Inflammation in Adults: Cross-Sectional Study — Shim et al., JMIR formative research
- saliva
- urine
- stool
- sweat
- venous-agreement
- acceptability
- biomarkers
2025
Oral sponge saliva RT-PCR achieved 95% sensitivity and 95% specificity compared with nasopharyngeal swabs in 3,488 symptomatic and asymptomatic adults, while buccal swab performance varied with infection history and symptoms. The rapid antigen test showed 66.9% sensitivity overall, increasing to 97% in high viral load samples. Oral sponge collection permits self-sampling without laboratory pre-analytical steps, offering a robust method for decentralised SARS-CoV-2 screening.
Diagnostic accuracy of non-invasive SARS-CoV-2 screening tests: a national prospective analysis — Althaus et al., BMC infectious diseases
- saliva
- self-collection
- validation
- serology
2025
The First to Know Syphilis Self-Test, using self-collected fingerstick capillary blood, demonstrated 93.4% sensitivity and 99.5% specificity against a composite reference standard in a 1,270-subject study. This over-the-counter test enables patient-centric screening at home, which could improve early detection and reduce transmission of syphilis and associated STIs.
Clinical development and performance of the First to Know Syphilis Self-Test for over-the-counter usage: a <i>de novo</i> rapid test for treponemal antibody — Clark et al., Journal of clinical microbiology
- blood
- liquid
- capillary
- self-collection
- validation
- serology
- sti
2025
Among staff in long-term care and retirement homes in Ontario, SARS-CoV-2 seroprevalence rose from 24% in 2021 to 44% in 2022 and was higher in Black, East and Southeast Asian and other racialised groups, lower in higher income neighbourhoods and among those with paid sick leave, indicating socioeconomic disparities that should inform equity rooted public health interventions.
Patterns of SARS-CoV-2 seropositivity among essential workers in long term care and retirement homes in Ontario, Canada: A descriptive cross-sectional study — Fahim et al., PLOS global public health
- blood
- dried
- dbs
- self-collection
- serology
2025
A term newborn died at 4 days; newborn screening by tandem mass spectrometry on a dried blood spot indicated mitochondrial trifunctional protein or long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency, and genetic analysis of the same DBS identified two HADHA variants, confirming the diagnosis; the authors review early neonatal deaths from fatty acid oxidation disorders and discuss limitations of newborn screening for these conditions, highlighting the role of DBS-based screening and post-mortem genetic testing in decentralised diagnostics.
Sudden Death of a Four-Day-Old Newborn Due to Mitochondrial Trifunctional Protein/Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiencies and a Systematic Literature Review of Early Deaths of Neonates with Fatty Acid Oxidation Disorders — Drole Torkar et al., International journal of neonatal screening
- blood
- dried
- dbs
- pediatric
2025
Dried blood spot HPLC accurately identified and quantified all major hemoglobin variants after ambient storage for up to three weeks, correctly diagnosing sickle cell, beta-thalassemia and other hemoglobinopathies compared to conventional whole blood analysis. This supports cost-effective, decentralised screening in remote regions where venous sampling is impractical.
Hemoglobin Variant Analysis and Its Comparison between Conventional High-performance Liquid Chromatography Using Whole Blood versus Dried Blood Spot: High-performance Liquid Chromatography — Jena et al., Indian journal of public health (paywalled)
- blood
- dried
- dbs
- validation
- venous-agreement
- economics
2025
In a prospective study of 126 people who inject drugs, 44 percent completed DBS self-collection and received HCV results; among completers, 7 percent had detectable HCV RNA and all initiated treatment. Completion was higher in those aged 40 or older and in opioid agonist treatment, but lower with stimulant use and previous HCV testing, demonstrating feasibility of peer-supported mail-order screening.
Peer-delivered mail-order self-collection and linkage to treatment for hepatitis C virus infection among users of a harm reduction service in Denmark — Demant et al., The International journal on drug policy (paywalled)
- blood
- dried
- dbs
- self-collection
- serology
2025
Concentrated first-void urine samples detected HPV with 84.6% sensitivity and 97.8% specificity, showing substantial agreement with cervical swabs (Fleiss' kappa 0.796). This noninvasive self-collection method could expand screening coverage and improve patient acceptance in decentralised and resource-limited settings.
Concentrated urine as an alternative to cervical smear samples enabling easy screening of HPV in large populations — Uyar et al., Journal of infection and public health (paywalled)
- urine
- first-void
- self-collection
- validation
- hpv
2025
Non-invasive HPV self-sampling kits such as first-void urine and menstrual blood devices may increase screening participation among non-Western ethnic minority women by addressing cultural beliefs about virginity and body autonomy.
"Well, that Was Pretty Clever!"-Ethnic Minority Women's Views on HPV Self-Sampling Devices for Cervical Cancer Screening: Attitudes to Brushes, First-Void Urine, and Menstrual Blood Devices — Hald et al., Journal of racial and ethnic health disparities
- urine
- first-void
- self-collection
- acceptability
- hpv
- sti
2025
In 41 Black adults with heart failure, elevated xanthine oxidase activity from capillary blood collected with Mitra microsampling associated significantly with dyspnoea severity. This demonstrates that microsampling can capture clinically relevant inflammatory biomarkers linked to symptom burden in underserved populations, supporting its use in decentralised cardiovascular monitoring.
Inflammation markers associated with symptoms and neighborhood deprivation in black adults with heart failure — Butts et al., Heart & lung : the journal of critical care (paywalled)
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- biomarkers
2025
An LC-MS/MS assay using volumetric absorptive microsampling achieved 72.5% to 98.9% accuracy and under 8% precision for measuring circulating endocannabinoids and related lipid mediators. However, drying time significantly altered 2-AG and 2-OG concentrations, and marked differences were observed between whole blood and plasma measurements.
Spotlight on Endocannabinoids in Healthy Individuals Using Volumetric Absorptive Microsampling Combined with LC-MS/MS Analysis — Haroune et al., ACS omega
- blood
- dried
- vams
- neoteryx-mitra
- validation
- haematocrit
- biomarkers
2025
Among 154 volunteers, 85% found HemaSpot HF self-sampling acceptable, but correlation with venous blood for anti-tetanus toxin IgG was moderate (r = 0.73) and sensitivity varied from 70% to 100% depending on the cut-off value, with concentration differences widening at higher IgG levels. The device requires further improvement before it can reliably replace venous puncture for decentralised serological testing.
Feasibility of blood self-sampling with HemaSpot HF for Anti-Clostridium tetani Toxin IgG detection — Kettlitz et al., Scientific reports
- blood
- dried
- dbs
- self-collection
- venous-agreement
- acceptability
- serology
2025
A programmatic architecture for remote decentralised clinical trials in atrial fibrillation successfully enrolled 513 participants across rural and metropolitan settings, with 89 percent retention at 12 months and sustained engagement with a smartphone-based adherence intervention. The approach reached diverse populations including 62 percent women and 44 percent with limited health literacy, demonstrating feasibility of patient-centric remote monitoring for cardiovascular research.
Augmenting Engagement in Decentralized Clinical Trials for Atrial Fibrillation: Development and Implementation of a Programmatic Architecture — Omole et al., JMIR cardio
- dct
- rpm
2025
Home-based ECG and blood pressure monitoring in 3,820 elderly hypertensive patients detected undiagnosed atrial fibrillation in 5.8 per cent over three months. The detection rate was not significantly associated with baseline blood pressure category, measurement frequency, or antihypertensive medication use, indicating that broad screening may be warranted regardless of blood pressure control.
Relationship Between Screening-Detected Atrial Fibrillation and Blood Pressure Levels in Elderly Hypertensive Patients: The OMRON Heart Study — Senoo et al., Thrombosis and haemostasis
- dct
- rpm
- digital-biomarker
2025
Healthy older adults performed similarly on functional capacity tests whether delivered by computer or cloud-based tablet, with only a five per cent speed improvement on the iPad version of one test. This supports the feasibility of migrating digital clinical assessments to remote cloud-based delivery for decentralised trials without compromising validity.
Migration of digital functional capacity assessments from device resident to cloud-based delivery: Development and convergent validity — Harvey et al., Schizophrenia research. Cognition
- dct
- digital-biomarker
2025
The RADIAL proof-of-concept trial delivered investigational medicinal products directly to participants with a 94 percent success rate across six European countries, though drop-off of biological samples was more challenging in the fully remote arm. Key obstacles included regulatory divergence, unclear vendor responsibilities, and unreliable sample collection, showing that decentralised trials need robust logistics, temperature control, and participant training to ensure safety and data integrity.
The Supply of Investigational Medicinal Product and Management of Study Materials for Decentralized Participants-Insights from the Trials@Home RADIAL Proof-of-Concept Trial — Heath et al., Clinical pharmacology and therapeutics
- dct
2025
Targeted proteomic evaluation of a novel finger-prick dried plasma device demonstrated strong quantitative correlation with conventional plasma (R = 0.99) and precision under 10% CV for 80% of quantified peptides across healthy donors. Quantified targets also remained stable during room temperature storage for up to 232 days, supporting its use for decentralised biomarker monitoring.
Quantitative Assessment of a Novel Device Designed for Patient-centric Sampling of Dried Plasma Using Targeted Proteomics — Hober et al., Analytical chemistry
- blood
- dried
- capillary
- self-collection
- validation
- venous-agreement
- dct
- biomarkers
2025
In MSM with HIV, Mycoplasma genitalium infection was common across anatomical sites, especially rectal, and resistance-associated mutations were frequent, limiting azithromycin efficacy while moxifloxacin or minocycline achieved satisfactory cure rates; this supports targeted testing and resistance-guided therapy in decentralised STI care.
Multi-anatomical site prevalence of <i>Mycoplasma genitalium</i> infection, resistance and association with coinfections: a prospective study in MSM with HIV — Wong et al., JAC-antimicrobial resistance
- urine
- self-collection
- sti
2025
This review summarises how emerging HPV detection methods including CRISPR/Cas systems, droplet digital PCR and isothermal amplification, combined with self-collected vaginal swabs and liquid biopsy from urine or blood, could improve screening acceptability and enable point-of-care testing compared with conventional approaches that require invasive sampling and centralised laboratory infrastructure.
Evolving HPV diagnostics: current practice and future frontiers — Shi et al., Frontiers in cellular and infection microbiology
- urine
- self-collection
- validation
- hpv
- sti
- liquid-biopsy
2025
Long-term sleep quality improved significantly during an internet-based intervention for major depressive disorder. Patients with poor sleep initially showed blunted cortisol awakening responses, which normalised as sleep quality improved, demonstrating that self-collected saliva can track biological stress changes in decentralised mental health care.
Sleep quality and the biological stress system during an internet-based intervention for major depressive disorder — Laufer et al., Comprehensive psychoneuroendocrinology
- saliva
- self-collection
- hormones
- cortisol
- dct
2025
Self-collected saliva specimens yielded high-quality results for SARS-CoV-2 PCR and whole-genome sequencing in an occupational screening programme, with variant determination achieved in 67–83 per cent of positive samples. The study shows that PCR cycle threshold cut-offs critically influence sequencing success, supporting decentralised genomic surveillance for respiratory pathogens.
SARS-CoV-2 genomic surveillance using self-collected saliva specimens during occupational testing programs — Schnaubelt et al., Frontiers in public health
- saliva
- self-collection
- serology
2025
Comfort Draw collected adequate capillary blood from the upper arm in 85.5 per cent of attempts for total blood volume and 95.1 per cent for serum volume, with 17 of 19 serum analytes meeting CLIA acceptance criteria against matched venous samples. The procedure scored a mean pain rating of 0.39 out of 10, indicating high patient acceptability, and the device’s simpler design may lower cost for decentralised diagnostics.
Evaluation of a Simplified Upper Arm Device for Vacuum-Assisted Collection of Capillary Blood Specimens — Schaff et al., Diagnostics
- blood
- liquid
- capillary
- validation
- venous-agreement
- acceptability
2025
The study found that dried blood spot sampling showed good agreement with plasma concentrations for vancomycin and creatinine, with most differences within 20%, and patients preferred the finger prick method over venepuncture, supporting its use for decentralised therapeutic drug monitoring.
Clinical validation of an innovative dried whole-blood spot method to quantify simultaneously vancomycin and creatinine in adult patients — Hassanzai et al., The Journal of antimicrobial chemotherapy
- blood
- dried
- dbs
- self-collection
- validation
- venous-agreement
- acceptability
- tdm
- antimicrobials
2025
First-void urine PCR identified Ureaplasma urealyticum in 19% of symptomatic men, alongside other pathogens, confirming that patient-collected urine samples provide valid diagnostic results for STI screening outside traditional clinical settings.
Investigation of mycoplasma and ureaplasma species using a molecular method in male patients suffering from urethritis symptoms: a cross-sectional study in the city of Antalya — Karpuz et al., BMC urology
- urine
- first-void
- sti
2025
Capillary blood collection using volumetric absorptive microsampling demonstrated equivalent quantification of principal colonic polyphenol metabolites compared with matched venous plasma across a six-hour period following barley biscuit consumption. The technique successfully captured the pharmacokinetic profiles over 48 hours, confirming VAMS as a reliable alternative to venepuncture for dietary biomarker monitoring.
Finger-prick blood sampling using volumetric absorptive microsampling (VAMS) method for monitoring the main (poly)phenolic metabolites in human blood after barley biscuit intake — Cortijo-Alfonso et al., Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- venous-agreement
- metabolome
- biomarkers
2025
A fully validated LC-MS method quantifies four direct oral anticoagulants and phenprocoumon from 10 µL capillary blood collected with Neoteryx Mitra VAMS devices. Samples remained stable for seven days at room temperature, showed no significant haematocrit effect, and offers a reliable approach for ambulatory therapeutic drug monitoring.
Development and validation of a quantification method for direct oral anticoagulants from capillary blood using volumetric absorptive microsampling and online SPE-LC-MS — Opitz et al., Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (paywalled)
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- tdm
- haematocrit
2025
VAMS finger-prick sampling showed moderate agreement with conventional venous sampling for clofazimine, with a systematic 13% lower concentration that can be corrected, and was more cost-effective by about 4.45 USD per sample, supporting its use for routine therapeutic drug monitoring in MDR-TB.
Analytical and clinical validation of a volumetric absorptive microsampling (VAMS) - Ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the analysis of Clofazimine in whole blood — Nugraha et al., Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- venous-agreement
- tdm
- antimicrobials
- economics
2025
The study validated Mitra VAMS devices for detecting nerve agent, sulfur mustard and opioid metabolites in dried human blood, achieving sensitivities between 0.05 and 1 ng/mL across analytes with acceptable precision, accuracy and recovery, supporting their use as a simpler alternative to refrigerated sample transport for forensic exposure verification.
Evaluation of dried blood spot sampling for verification of exposure to chemical threat agents — Walker et al., Forensic toxicology
- blood
- dried
- vams
- neoteryx-mitra
- validation
- toxicology
2025
Among 404 Australians at risk of hepatitis C, 91% of those with prior infection selected point-of-care RNA testing, citing rapid results, while 72% of those without prior infection preferred staff-assisted antibody testing. Offering rapid, staff-assisted testing improves uptake among people who inject drugs, those experiencing homelessness and those receiving opioid agonist therapy.
Patient preferences for simplified hepatitis C testing modalities among people at risk of hepatitis C infection in Australia: the SELECT study — Stevens et al., The International journal on drug policy (paywalled)
- blood
- capillary
- dbs
- self-collection
- acceptability
- serology
2025
Among 133 users of HIV self-sampling and self-testing in the Netherlands, the commonest reason for choosing this route was saving time, followed by anonymity and avoiding a GP visit. However, 22% encountered problems, with seven in ten of those struggling to obtain enough blood from a finger prick, showing that while self-testing expands reach, blood collection remains a key usability hurdle for decentralised HIV screening.
Self-sampling and self-testing for HIV at a commercial and community-based test provider in the Netherlands: user preferences and usability — Willemstein et al., BMC health services research
- blood
- capillary
- self-collection
- acceptability
- serology
- sti
2025
Self-sampling of dried blood spots for HIV viral load monitoring proved acceptable among sexual minority men who use stimulants, with 92% returning Tasso-M20 kits and 88% returning HemaSpot HD kits. Participants' device preferences centred on convenience and pain, and they highlighted that clearer instructions, contingency planning, and addressing intersectional stigma are essential for engagement, indicating that patient choice in sampling methods could improve uptake of decentralised diagnostics.
'I was like, this is gonna hurt': Implementing self-sampling of dried blood spots to measure HIV viral load — Chavez et al., PloS one
- blood
- dried
- dbs
- self-collection
- acceptability
- serology
2025
In 50 cancer patients monitored at home with an Apple Watch for 28 days, a method that classified missing step data by gap duration and context produced the most reliable daily step estimates. Daily step counts on days with at least ten hours of wear time predicted time to first clinical event (p=0.068) and identified participants at lower hazard of mortality, with 83.3% accuracy for clinical event prediction, demonstrating that processed consumer wearable data can support remote monitoring in decentralised oncology trials.
Analysis Method of Real-World Digital Biomarkers for Clinical Impact in Cancer Patients — Oakley-Girvan et al., Digital biomarkers
- oncology
- dct
- wearable
- digital-biomarker
- actigraphy
2025
In this decentralised trial of 899 adults with asthma, participants using a digital self-management programme with wearable device integration showed a 4.6-point gain on the Asthma Control Test at 12 months relative to usual care. This provides evidence that remote digital interventions can achieve clinically significant improvements in asthma control without in-person visits.
A Digital Asthma Self-Management Program for Adults: A Randomized Clinical Trial — Silberman et al., JAMA network open
- dct
- wearable
- rpm
- digital-biomarker
2025
A qualitative study of Danish policy stakeholders found that conflicting interests across patient, healthcare, industry and political groups create paradoxical tensions that obstruct efficient implementation of decentralised clinical trials. Resolving these tensions and assigning clear implementation responsibility are necessary for sustainable adoption of decentralised diagnostics.
Exploring implementation challenges of decentralized clinical trials: A qualitative study of policy stakeholder perspectives in Denmark — Hestbjerg et al., Digital health
- dct
2025
In surveys of 141 trial-site staff and 481 individuals, participants showed greater enthusiasm for hybrid and remote decentralised trials than site staff, who worried about burden, trust and security. Participant willingness to use trial technologies decreased with rising perceived burden, underscoring that practical support is vital for adoption in decentralised diagnostics.
Comparison of Participant and Site Perceptions of Decentralized Clinical Trials in the USA — Barge & Floody, Mayo Clinic proceedings. Digital health
- acceptability
- dct
2025
The analysis highlights that leveraging digital health technologies and decentralised clinical trials can improve evidence generation and access in rare disease drug development, offering more efficient and inclusive processes where traditional approaches are limited.
Addressing global regulatory challenges in rare disease drug development — Costa et al., Drug discovery today (paywalled)
- dct
- digital-biomarker
2025
The study found that decentralised trial participants were more representative than conventional trial participants in terms of age, insulin use, smoking status and body mass index, suggesting that decentralised approaches can improve demographic and clinical diversity in trials. This matters because better representativeness enhances the generalisability of trial results to real-world patient populations.
The impact of operational trial approaches on representativeness: Comparison of decentralized clinical trial participants, conventional trial participants, and patients in daily practice — de Jong et al., Drug discovery today (paywalled)
- dct
2025
Participants in the ACTIV-6 decentralised trial viewed remote procedures supported by digital health technologies as acceptable and efficient for organising study activities, communicating with study personnel and managing medications at home, though social media recruitment raised concerns about trust and study legitimacy that future trial designs should address.
Participant experiences in a decentralized clinical trial using digital health technologies: The ACTIV-6 study — Reale et al., Journal of clinical and translational science
- acceptability
- dct
2025
The Cobas Liat CT/NG/MG nucleic acid amplification test achieved 97% specificity for chlamydia, gonorrhoea, and mycoplasma from self-collected urine and vaginal swabs at point-of-care, with sensitivity of at least 92% for most specimen types. Sensitivity was modestly lower for female urine (77–87%), yet the 20-minute turnaround time and ease of use support rapid, decentralised STI screening and reduced empiric treatment.
Sensitivity and specificity of the Cobas Liat CT/NG/MG nucleic acid test in a clinical laboratory setting and point-of-care location — Van Der Pol et al., Journal of clinical microbiology
- urine
- self-collection
- validation
- sti
2025
In an HIV preexposure prophylaxis programme in Hanoi, Vietnam, the prevalence of chlamydia or gonorrhoea was high at 28.9 per cent, with gonorrhoea most common in the pharynx and chlamydia most common in the rectum; urethral testing in asymptomatic individuals had limited value.
Routine testing for chlamydia and gonorrhea in an HIV preexposure prophylaxis program in Hanoi, Vietnam: implications for low- and middle-income countries — Adamson et al., AIDS (paywalled)
- urine
- self-collection
- sti
2025
Self-collected penile-meatal swabs matched urine samples with 98.7% agreement for STI detection in symptomatic Ugandan men, performing equally well even in those with multiple concurrent infections. This validates swabs as a simpler, more practical alternative for decentralised STI screening in low-resource settings.
Self-collected penile-meatal swabs are suitable for the detection of STIs in Ugandan men with high rates of STI coinfections — Melendez et al., Sexually transmitted infections (paywalled)
- urine
- self-collection
- validation
- sti
2025
Self-collected vaginal and urine specimens demonstrated good to substantial agreement with clinician-collected cervical samples for detecting high-risk HPV and other sexually transmitted infections, supporting their use in decentralised screening programmes. The higher STI positivity rate among hrHPV-positive women suggests coinfections may influence cervical disease, warranting further investigation.
Molecular Detection of Human Papillomavirus (HPV) and Other Sexually Transmitted Pathogens in Cervical and Self-Collected Specimens — Giubbi et al., International journal of molecular sciences
- urine
- self-collection
- validation
- hpv
- sti
2025
Higher lifetime trauma exposure in adolescent mothers was associated with higher evening salivary cortisol, and maternal trauma during pregnancy was associated with higher bedtime cortisol in infants, suggesting that self-collected saliva can capture diurnal cortisol patterns relevant to trauma research and decentralised sampling.
A Preliminary Investigation of Associations Between Traumatic Events Experienced During Pregnancy and Salivary Diurnal Cortisol Levels of Brazilian Adolescent Mothers and Infants — Wiley et al., American journal of human biology : the official journal of the Human Biology Council (paywalled)
- saliva
- self-collection
- pediatric
- hormones
- cortisol
2025
Saliva-based RT-PCR for SARS-CoV-2 achieved 100 per cent sensitivity and 97 per cent specificity against nasopharyngeal swabs, while rapid antigen testing on saliva showed comparable performance and detected 97 per cent of infectious cases with cycle threshold values of 30 or below. This supports saliva self-collection as an accurate, practical option for decentralised COVID-19 screening.
Evaluating saliva for SARS-CoV-2 detection: A practical alternative — Sultana et al., Diagnostic microbiology and infectious disease (paywalled)
- saliva
- self-collection
- validation
- serology
2025
Capillary blood sampling showed near-perfect correlation with venous sampling for total PSA across a wide clinical range with negligible bias, and samples remained stable at ambient temperature for up to eight days, supporting feasibility of home self-testing for prostate cancer.
Total Prostate-Specific Antigen (PSA) Testing in Capillary Samples: Proof-of-Principle and Feasibility Study for Home Self-Testing for Prostate Cancer — Sodi et al., The journal of applied laboratory medicine (paywalled)
- blood
- liquid
- capillary
- validation
- venous-agreement
2025
A dried blood spot LC-MS/MS method for voclosporin was analytically validated using volumetric sampling devices, demonstrating strong agreement with whole blood analysis across a 10-600 µg/L range. The method meets ICH M10 guidelines and allows remote therapeutic drug monitoring in kidney transplant recipients.
Dried blood spot LC-MS/MS quantification of voclosporin in renal transplant recipients using volumetric dried blood spot sampling — Metscher et al., Journal of pharmaceutical and biomedical analysis (paywalled)
- blood
- dried
- dbs
- volumetric
- validation
- tdm
- immunosuppressants
2025
Researchers developed an assay to quantify seven cannabinoids and metabolites from 20 µL oral fluid self-collected via a VAMS device, achieving a limit of quantitation of 0.5 ng/mL. In six cannabis consumers, the method successfully quantified Δ9-tetrahydrocannabinol up to 6236 ng/mL, demonstrating the feasibility of low-volume volumetric microsampling for non-invasive toxicology and roadside testing.
Quantitative analysis of cannabinoids and metabolites in oral fluid by volumetric absorptive microsampling combined with UHPLC-HRMS — Thiebot et al., Analytical and bioanalytical chemistry (paywalled)
- saliva
- vams
- neoteryx-mitra
- validation
- doping
- toxicology
2025
In a national surveillance pilot in Georgia, 39.8% of children aged 5-7 years had blood lead levels at or above 3.5 micrograms per decilitre, with predictors including male sex, unpainted housing, urban living in Imereti, and household lead bullet production and spice use in Adjara. The study shows that VAMS is a feasible, less invasive method for accurate lead testing in resource limited settings.
Blood Lead Levels in Children 5 to 7 Years of Age from the Republic of Georgia: A Feasibility Study on Lead Surveillance Using Volumetric Absorptive Microsampling — Rylander et al., Environmental health perspectives
- blood
- dried
- vams
- pediatric
2025
Capillary blood collected by fingerstick or microblade devices produced metabolite profiles that were virtually identical to venous samples when the same biofluid type was compared. This validation study demonstrates that inexpensive microsampling systems can deliver comparable metabolomics data, supporting their use in decentralised diagnostics.
Quantitative comparison of whole blood, plasma and serum metabolomes across different blood collection methods — Zubkowski et al., Metabolomics : Official journal of the Metabolomic Society (paywalled)
- blood
- capillary
- validation
- venous-agreement
- metabolome
2025
In a fully remote decentralised clinical trial of a mobile mental health intervention, 62% of eligible screeners were fraudulent, detected most commonly by duplicate identifiers and VPN or proxy detection, with social media recruitment yielding a higher fraud rate of 85% compared with 26% from survey panels.
Mitigating fraud in a fully decentralized clinical trial of a digital health intervention — Moore et al., Annals of behavioral medicine : a publication of the Society of Behavioral Medicine (paywalled)
- dct
2025
In a French trial of 682 under-screened women, most found HPV self-sampling instructions clear and procedures easy, with around 80% preferring home collection over clinic visits. Urine self-sampling was better tolerated than vaginal self-sampling, suggesting it may improve participation in decentralised cervical cancer screening programmes.
Women's perceptions and preferences toward HPV self-sampling in France: A questionnaire within the French CapU4 Trial — De Pauw et al., Journal of infection and public health (paywalled)
- urine
- self-collection
- acceptability
- hpv
- sti
2025
In 121 women with abnormal cervical cytology, self-collected vaginal samples detected HPV with 77.8% concordance and 75.7% sensitivity compared to clinician-collected cervical samples using the BD Onclarity assay, while spot urine samples stored under optimal conditions (BD Probe Tec container, <72 h at room temperature) achieved only 63.9% concordance and 46.4% sensitivity. This demonstrates that self-collected vaginal sampling is a viable patient-centric approach for decentralised HPV screening, though urine-based testing requires further methodological refinement to improve clinical performance.
The Utility of an Human Papillomavirus Genotype Assay for Cancer Screening in Self-Collected Urine and Vaginal Samples from Japanese Women — Mizuno et al., Gynecologic and obstetric investigation
- urine
- self-collection
- validation
- hpv
- sti
2025
Erythropoietin was unstable in urine stored at room temperature or 37 degrees, with degradation in eight of twelve participants, while serum samples showed greater stability. Recombinant EPO detectability was identical across urine, venous serum and capillary serum collected with the Tasso+ SST device, leading the authors to recommend capillary serum collection for doping control to improve overall detection of erythropoiesis-stimulating agents.
Assessing EPO stability in urine and comparing recombinant EPO detectability in matched urine, venous serum, and capillary serum following a controlled epoetin alfa administration — Miller et al., Drug testing and analysis (paywalled)
- blood
- urine
- capillary
- validation
- venous-agreement
- doping
2025
Endogenous erythropoietin was detectable in 100% of microvolumetric capillary serum samples shipped at ambient temperature, and recombinant erythropoietin remained detectable under varied storage and shipping conditions except extreme heat, indicating that blood microsamples can be shipped without cold chain for ERA testing.
Detecting EPO in Microvolumetric Capillary Serum Shipped at Ambient Temperature for Antidoping Testing — Miller et al., Drug testing and analysis (paywalled)
- blood
- capillary
- validation
- doping
2025
Capillary whole blood collected with RedDrop and Tasso+ devices showed excellent laboratory agreement with venous blood for complete blood count parameters except platelets, indicating that microcapillary sampling is a valid alternative to venepuncture for anti-doping athlete biological passport testing.
Comparison of Microcapillary Blood Sampling Devices for Use in Anti-Doping — Lewis et al., Drug testing and analysis (paywalled)
- blood
- liquid
- capillary
- validation
- venous-agreement
- doping
2025
In this decentralised n-of-1 crossover trial of dapagliflozin in 20 adults with type 2 diabetes, remote collection of urine and capillary blood samples achieved 99.4% and 98.4% delivery success respectively, demonstrating that remote monitoring can reliably track individual albuminuria responses to therapy.
Albuminuria Responses to Dapagliflozin in Patients With Type 2 Diabetes: A Crossover Trial — Beernink et al., JAMA network open
- blood
- urine
- capillary
- self-collection
- dct
2025
In a decentralised phase 1 trial, healthy adults used a clinical trial app to self-collect blood microsamples and vital signs at home, with 65 to 70 per cent successfully providing blood samples and most preferring self-collection over staff collection.
Conducting clinical trials with self-collection of pharmacokinetic samples: Experience from an exploratory, phase 1, open-label trial of centanafadine SR in healthy individuals — Ye et al., Contemporary clinical trials communications
- blood
- self-collection
- acceptability
- dct
- rpm
- multimodal
2025
The study found that while decentralised clinical trials improve accessibility, they introduce complexities that can negatively affect patient engagement and the relationship between staff and participants due to limited interaction frequency and quality.
Adaptation of Clinical Research Staff to Decentralized Clinical Trials and Impacts on the Patient-Centered Experience: Qualitative Interview Study — Gamble et al., Journal of medical Internet research
- acceptability
- dct
2025
A saliva-derived transcriptomic signature using support vector machine learning detected gastric cancer with an AUC of 0.87, sensitivity of 79% and specificity of 70%. Tissue-based gene expression models performed poorly when applied to saliva, indicating that saliva-specific biomarker panels are needed for effective non-invasive gastric cancer screening.
Saliva-derived transcriptomic signature for gastric cancer detection using machine learning and leveraging publicly available datasets — Lopes et al., Scientific reports
- saliva
- self-collection
- biomarkers
- liquid-biopsy
2025
An optimized 4D-lipidomics UHPLC-HRMS protocol using stable isotope internal standards enabled semi-quantitative profiling of 432 unique lipid features from 10 ̢L dried blood spot samples with high analytical reproducibility. The workflow demonstrates the viability of capillary blood microsampling for large-scale, remote population lipidomics and metabolic profiling.
Dried blood spot microsampling: A semi-quantitative 4D-lipidomics approach using ultrahigh-performance liquid chromatography - high-resolution mass spectrometry (UHPLC - HRMS) — Roberts et al., Talanta (paywalled)
- blood
- dried
- dbs
- self-collection
- validation
- metabolome
- biomarkers
2025
Dried blood spot sampling matched venous serum performance for islet autoantibody detection and was considered minimally invasive and convenient by parents and stakeholders, supporting its use for decentralised screening in home or community settings.
Establishing the performance and acceptability of dried blood spot sampling to screen for islet-specific autoantibodies — Faustini et al., Diabetic medicine : a journal of the British Diabetic Association
- blood
- dried
- capillary
- dbs
- self-collection
- validation
- venous-agreement
- acceptability
- pediatric
2025
The method quantified elexacaftor, tezacaftor and ivacaftor across plasma, dried plasma spots and VAMS with good linearity, accuracy and no matrix effect. Plasma and dried plasma spot results were interchangeable, while VAMS gave lower concentrations due to high protein binding and were corrected using the haematocrit to estimate equivalent plasma levels.
A Novel LC-MS/MS Method for the Measurement of Elexacaftor, Tezacaftor and Ivacaftor in Plasma, Dried Plasma Spot (DPS) and Whole Blood in Volumetric Absorptive Microsampling (VAMS) Devices — Pigliasco et al., Pharmaceutics
- blood
- dried
- vams
- neoteryx-mitra
- validation
- tdm
- haematocrit
2025
In a pooled analysis of three screening studies in rural West Bengal involving 80,988 women, high-risk HPV positivity remained stable at around 5% over two decades with no significant difference between self-collected and provider-collected samples, while CIN 2+ detection rates declined significantly from 5.7 per 1000 to 2 per 1000, attributed to improved education, delayed marriage and reduced fertility rather than organised screening or vaccination.
Analysis of time trends of prevalence of high-risk HPV infections, high grade cervical precancer and cervical cancer disease in women from Eastern India over 20 years - Pooled analysis from three studies — Bose et al., Cancer epidemiology (paywalled)
- self-collection
- hpv
2025
In a decentralised trial of 108 pulmonary fibrosis patients, a nine-week digital cognitive behavioural therapy programme reduced GAD-7 anxiety scores by 2.7 points more than treatment as usual (p=0.0006). This shows decentralised digital interventions can deliver clinically significant psychological benefit in chronic respiratory disease, supporting remote patient management.
A digital therapy targeting anxiety in pulmonary fibrosis: A decentralized randomized controlled trial — Solomon et al., Respirology
- dct
- digital-biomarker
2025
In 22 adults, capillary blood collection demonstrated strong correlation with venous sampling for 66 per cent of inflammatory proteins and moderate to strong correlation for 80 per cent overall, supporting its validity for proteomic measurement in decentralised trials.
Comparing Venous vs. Capillary Blood Collection Methods for Proteomic Measurement in Peripheral Blood — Ni Lochlainn et al., Proteomics. Clinical applications
- blood
- capillary
- validation
- venous-agreement
- dct
- biomarkers
2025
The authors outline that FDA supports decentralised clinical trials to boost participation, noting that while they offer convenience for participants, successful implementation requires careful coordination, remote supervision, training, and risk management. This matters because it establishes the regulatory context and operational considerations for deploying patient-centric microsampling and remote monitoring in drug development.
Decentralized Clinical Trials in the Development of Drugs and Biological Products — Robinson & Sacks, Therapeutic innovation & regulatory science
- dct
2025
The authors developed disposable, calibration-free electrochemical aptamer-based sensors for detecting cocaine in human saliva collected via an oral swab workflow, achieving low micromolar sensitivity with results in under five minutes, and found that food and drink residues in saliva can compromise sensor accuracy.
Single-Use Electrochemical Aptamer-Based Sensors for Calibration-Free Measurements in Human Saliva via Dual-Frequency Approaches: Prospects and Challenges — Liu et al., Analytical chemistry (paywalled)
- saliva
- self-collection
- validation
- toxicology
2025
Across perinatal care, wearable sensors and home-monitoring platforms support timely intervention, with remote monitoring linked to a 7 to 11 percent reduction in maternal mortality and preeclampsia incidence. In neonatal care, predictive digital monitoring such as the Heart Rate Observation system reduced mortality in very low-birth-weight infants by approximately 20 percent.
Integrating Artificial Intelligence into Perinatal Care Pathways: A Scoping Review of Reviews of Applications, Outcomes, and Equity — El Arab et al., Nursing reports
- fertility
- wearable
- rpm
2025
During COVID-19, 95% of cancer trial sponsors adopted decentralised elements, with remote laboratory assessments used in 63% of trials, demonstrating that such methods can generate FDA-approvable data. Sponsors reported institutional policies as the main barrier, yet most plan to continue remote monitoring and telemedicine, indicating sustained viability for reducing patient burden.
Adoption of Decentralized Trial Elements in Cancer Clinical Trials Supporting FDA Approvals during COVID-19 — Patel et al., Clinical cancer research : an official journal of the American Association for Cancer Research (paywalled)
- oncology
- dct
2025
The RADIAL proof-of-concept trial demonstrated that a modular, multi-vendor technology package can operationalise decentralised clinical trials, but revealed significant challenges with Bring Your Own Device variability, immature device technologies, and clinical site infrastructure limitations. Investing in participant support infrastructure, automated multichannel notifications, and early cross-functional compliance planning enhanced participant engagement and streamlined governance, reducing burden.
Operationalizing Decentralized Clinical Trials: Technology Insights from the Trials@Home RADIAL Proof-of-Concept Trial — Hanke et al., Clinical pharmacology and therapeutics
- dct
- rpm
2025
DNA methylation levels in self-collected cervicovaginal samples fell two years after treatment in patients who remained free of recurrent cervical cancer. This shows that home-collected urine and cervicovaginal specimens can be used to assess methylation markers for surveillance of cervical cancer recurrence.
Recurrent cervical cancer detection using DNA methylation markers in self-collected samples from home — Schaafsma et al., International journal of cancer
- urine
- self-collection
- hpv
- biomarkers
2025
Self-collected urine and vaginal samples were tested with a new hrHPV PCR assay and compared to cervical samples. Urine showed lower sensitivity but higher specificity than vaginal and cervical samples, while vaginal samples were slightly less sensitive than cervical samples. This supports the use of self-collection for cervical screening, though urine is less sensitive than vaginal or cervical sampling.
Diagnostic accuracy of human papillomavirus testing on self-collected samples among women referred for colposcopy — Yan et al., Scientific reports
- urine
- self-collection
- validation
- hpv
- sti
2025
Self-collected saliva from asymptomatic healthcare workers yielded a cumulative pneumococcal carriage prevalence of 21% over four months, with 11% of samples testing positive by qPCR for piaB; serotypes 19F and 3 were common. This supports saliva as a viable decentralised specimen for respiratory pathogen surveillance.
Detection of Pneumococcal Carriage in Asymptomatic Healthcare Workers — Waghela et al., Open forum infectious diseases
- saliva
- self-collection
2025
Among people who inject drugs, point-of-care HCV testing was preferred over dried blood spot collection and venepuncture because rapid results reduced anxiety. The study shows that for decentralised screening, non-judgemental care and assisted collection are critical acceptability factors, even when self-collection is available.
Acceptability of hepatitis C testing using point-of-care testing and dried blood spot collection among people at risk of hepatitis C infection — Stevens et al., The International journal on drug policy (paywalled)
- blood
- dried
- dbs
- self-collection
- acceptability
- serology
2025
The study compared five microsampling devices, including Mitra tips and Tasso-M20, for detecting 27 steroid esters in dried blood by LC-MS/MS, and found that methanol extraction with Girard's reagent P or T provided the best screening sensitivity with detection limits of 0.05 to 1.0 ng/mL, while methoxyamine derivatization was recommended for confirming boldenone and certain testosterone esters. The Tasso-M20 device produced chromatographic interference with methanol extraction that was only partially resolved by using mixed solvents, at the cost of lower recoveries.
Comparability of different analytical workflows for steroid esters detection in doping control field — Mazzarino et al., Journal of pharmaceutical and biomedical analysis (paywalled)
- blood
- dried
- vams
- dbs
- neoteryx-mitra
- validation
- doping
2025
Over two years, 1,507 participants used in-home capillary blood spot sampling for islet autoantibody screening, with only one reporting collection failure, compared with five failures among 276 venipuncture participants. Blood spot sampling reached younger and regionally based Australians at lower cost and with greater convenience, identifying preclinical type 1 diabetes at expected prevalence and supporting early diagnosis without the barriers of clinic-based venous draws.
Islet Autoantibody Screening Throughout Australia Using In-Home Blood Spot Sampling: 2-Year Outcomes of Type1Screen — Wentworth et al., Diabetes care (paywalled)
- blood
- capillary
- dbs
- self-collection
- venous-agreement
- pediatric
2025
The article outlines the benefits and operational strategies for decentralised clinical trials, emphasising that remote participation improves access and convenience. It argues that making trials participant centric through intentional recruitment and engagement can accelerate scientific discovery and build trust in the research process.
Participants as Partners in Decentralized Clinical Trials — Harris & Cheng, NEJM evidence (paywalled)
- dct
2025
Clinical trial practitioners in China generally understand decentralized clinical trials and are willing to participate, although they lack practical experience and identify technical barriers and data reliability as the main challenges to implementation.
Study on knowledge, practices, and attitudes toward decentralized clinical trials among the clinical trial practitioners in China — Shi et al., Frontiers in medicine
- dct
2025
A smartphone based colourimetric assay that detects a metabolic byproduct of HPV infected cells in urine achieved sensitivity and specificity comparable to nucleic acid detection, offering a low cost, user friendly option for home self screening of HPV.
Smartphone-based urine colourimetric assay for home self-screening of HPV infection — Zhang et al., Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (paywalled)
- urine
- self-collection
- hpv
- sti
2025
Escherichia coli caused 72% of lower urinary tract infections in symptomatic college women, with 95% of cases detectable at ≥10⁴ CFU/mL. Self-diagnosis accuracy reached 72%, suggesting that self-collection and self-assessment could support decentralised screening for urinary and sexually transmitted infections in this population.
Microbiology, chlamydia or gonorrhea incidence, and self-diagnosis accuracy in sexually active college women with lower urinary tract symptoms — Guertler et al., Journal of American college health : J of ACH (paywalled)
- urine
- self-collection
- sti
Read from the corpus on .