The Library
1530 papers on microsampling and monitoring, each with a finding paraphrased to our standard and labelled in one vocabulary. Every entry links to a legitimate copy; nothing is copied from an abstract.
Papers 1101–1200 of 1530, newest first.
2021
The study demonstrates a fully automated workflow for dried blood spot sample handling and extraction that recovers intact SARS-CoV-2 IgG antibodies using a commercial ELISA kit, enabling minimally invasive at-home sampling without third-party involvement.
Fully automated dried blood spot sample handling and extraction for serological testing of SARS-CoV-2 antibodies — Gaugler et al., Drug testing and analysis (paywalled)
- blood
- dried
- dbs
- self-collection
- serology
2021
A bioanalytical method for tacrolimus quantitation from MITRA capillary blood samples met all FDA and EMA validation criteria, showing accuracy and precision across 1–50 ng/mL. Haematocrit and hyperlipidaemia did not affect quantitation, and samples remained stable for up to 96 days, supporting minimally invasive therapeutic drug monitoring from a fingerprick.
Quantitation of Tacrolimus in Human Whole Blood Samples Using the MITRA Microsampling Device — Undre et al., Therapeutic drug monitoring
- blood
- dried
- vams
- neoteryx-mitra
- validation
- tdm
- immunosuppressants
2021
This review summarises liquid chromatography with tandem mass spectrometry assays using dried blood spots and volumetric absorptive microsampling for quantifying antimicrobial drugs in children, highlighting that VAMS reduces haematocrit bias and offers a viable alternative to traditional plasma sampling for therapeutic drug monitoring.
Microsampling Assays for Pharmacokinetic Analysis and Therapeutic Drug Monitoring of Antimicrobial Drugs in Children: A Critical Review — Moorthy et al., Therapeutic drug monitoring (paywalled)
- blood
- dried
- vams
- dbs
- neoteryx-mitra
- validation
- pediatric
- tdm
- antimicrobials
- haematocrit
2021
Near-infrared spectroscopy predicted haematocrit in dried blood spots with a maximal bias of 0.012 L/L and coefficient of variation of 4.5%. The method demonstrated robustness for capillary finger-prick samples and across various storage conditions, filter paper types and spotted volumes, enabling correction of haematocrit-related bias in quantitative analysis and supporting broader use of patient-centric microsampling.
Near-infrared-based hematocrit prediction of dried blood spots: An in-depth evaluation — Delahaye et al., Clinica chimica acta; international journal of clinical chemistry (paywalled)
- blood
- dried
- capillary
- dbs
- validation
- haematocrit
2021
In 1793 participants, self-taken rectal and pharyngeal swabs matched clinician-taken samples for diagnostic accuracy of gonorrhoea and chlamydia detection. The study demonstrated that most infected men who have sex with men would be missed by urogenital testing alone, supporting extragenital self-sampling as a viable component of decentralised STI screening programmes.
Swab-yourself Trial With Economic Monitoring and Testing for Infections Collectively (SYSTEMATIC): Part 1. A Diagnostic Accuracy and Cost-effectiveness Study Comparing Clinician-taken vs Self-taken Rectal and Pharyngeal Samples for the Diagnosis of Gonorrhea and Chlamydia — Wilson et al., Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (paywalled)
- urine
- self-collection
- validation
- economics
- sti
2021
Among women referred for colposcopy after abnormal cytology, self-collected vaginal samples demonstrated comparable diagnostic accuracy to clinician-collected cervical samples for detecting high-risk HPV and cervical intraepithelial neoplasia grade 2 or worse. Self-collected urine samples were markedly less accurate, indicating vaginal but not urine self-sampling is suitable for decentralised HPV screening.
Performance and Diagnostic Accuracy of Human Papillomavirus Testing on Self-Collected Urine and Vaginal Samples in a Referral Population — Cho et al., Cancer research and treatment
- urine
- self-collection
- validation
- hpv
- sti
2021
A quantitative VAMS method for PEth 16:0/18:1 was developed and validated across two laboratories, showing good comparability (average bias −0.4%, 85% of differences within 20%) and reproducibility over one year; this supports reliable decentralised alcohol monitoring using finger‑prick dried blood microsamples.
Quantitation of phosphatidylethanol in dried blood after volumetric absorptive microsampling — Van Uytfanghe et al., Talanta (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- toxicology
2021
Pooled data from ten clinical studies show saliva detects SARS-CoV-2 with 87% sensitivity and 98% specificity. This supports saliva as a viable specimen for non invasive self collection in decentralised screening in workplaces, schools and homes.
Saliva Exhibits High Sensitivity and Specificity for the Detection of SARS-COV-2 — Warsi et al., Diseases
- saliva
- self-collection
- validation
- serology
2021
Among 174 symptomatic emergency room patients, self-collected saliva identified SARS-CoV-2 in 98% of those positive by nasopharyngeal swab, with excellent agreement (kappa 0.96). Saliva detected one additional pneumonia case and showed higher cycle threshold values, confirming its utility for decentralised infectious disease screening.
Self-collected saliva for SARS-CoV-2 detection: A prospective study in the emergency room — Echavarria et al., Journal of medical virology (paywalled)
- saliva
- self-collection
- validation
- serology
2021
Two feasibility studies assessed low-volume blood sampling for therapeutic drug monitoring. In patients receiving an anti-A therapeutic, drug levels were measured from finger-prick whole blood collected with Neoteryx Mitra and from capillary plasma collected with TASSO OnDemand, and compared with venipuncture samples. The work outlines practical considerations for adopting these patient-centric microsampling methods in decentralised trials and clinical care.
Assessment of low volume sampling technologies: utility in nonclinical and clinical studies — Williams et al., Bioanalysis (paywalled)
- blood
- capillary
- vams
- neoteryx-mitra
- validation
- venous-agreement
- tdm
- biologics
2021
Evidence from cross-sectional and clinical trial studies over the past year supports saliva as a viable matrix for SARS-CoV-2 RNA detection, offering a non-invasive, self-collection method that can protect frontline staff and identify infections missed by nasopharyngeal swabs. This positions salivary testing as a key tool for decentralised, patient-centric COVID-19 screening.
One-Year Update on Salivary Diagnostic of COVID-19 — Caixeta et al., Frontiers in public health
- saliva
- self-collection
- validation
- serology
2021
Dried blood spots collected by fingerstick from SARS-CoV-2 convalescent and vaccinated individuals showed strong correlation with paired plasma for antibody binding and neutralisation titres. This supports decentralised serology by enabling self-collection and ambient-temperature mailing and storage, overcoming the cold-chain requirements of venous sampling.
SARS-CoV-2 Antibody Binding and Neutralization in Dried Blood Spot Eluates and Paired Plasma — Itell et al., Microbiology spectrum
- blood
- dried
- dbs
- self-collection
- validation
- venous-agreement
- serology
2021
Self-collected oral fluid achieved only 41.6% sensitivity compared with nasal-oropharyngeal swabs for SARS-CoV-2 detection, with positive agreement falling from 44.6% in the first five days after symptom onset to even lower levels thereafter. This demonstrates that saliva self-collection, while feasible for decentralised testing, lacks the sensitivity required for reliable COVID-19 diagnosis, particularly in later disease stages.
Self-Collected Oral Fluid Saliva Is Insensitive Compared With Nasal-Oropharyngeal Swabs in the Detection of Severe Acute Respiratory Syndrome Coronavirus 2 in Outpatients — Manabe et al., Open forum infectious diseases
- saliva
- self-collection
- validation
2021
The study found that adding dried blood spot collection to measure C-reactive protein was feasible and acceptable among transgender and gender-nonconforming youth aged 9 to 20 attending a clinical service, and that a composite of greater gender-based stress with lower support was associated with higher inflammation, though no individual stress or support subscale reached statistical significance.
Gender Minority Stress, Support, and Inflammation in Transgender and Gender-Nonconforming Youth — McQuillan et al., Transgender health (paywalled)
- blood
- dried
- dbs
- acceptability
- pediatric
2021
Li et al developed an electricity-free chemical heater that maintains stable temperature for isothermal nucleic acid amplification. They demonstrated detection of SARS-CoV-2 in self-collected saliva, creating a low-cost, disposable test that works without power and enables decentralised COVID-19 screening.
Electricity-free chemical heater for isothermal nucleic acid amplification with applications in COVID-19 home testing — Li et al., The Analyst (paywalled)
- saliva
- self-collection
2021
Self-collected saliva tested by CLEIA achieved 98.2% concordance with RT-qPCR for SARS-CoV-2 detection. A two-step screening strategy using initial CLEIA followed by confirmatory RT-qPCR for intermediate results would require secondary testing in 11-21% of samples, providing a scalable decentralised testing approach.
A novel strategy for SARS-CoV-2 mass screening with quantitative antigen testing of saliva: a diagnostic accuracy study — Yokota et al., The Lancet. Microbe
- saliva
- self-collection
- validation
- serology
2021
The HPLC-MS/MS assay on dried capillary blood collected with VAMS was linear, precise and stable, and showed strong agreement with liquid venous tacrolimus measurements, supporting its use for therapeutic drug monitoring in transplant recipients.
Volumetric absorptive microsampling for the quantification of tacrolimus in capillary blood by high performance liquid chromatography-tandem mass spectrometry — Tron et al., Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (paywalled)
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- venous-agreement
- tdm
- immunosuppressants
2021
Dried blood spots collected by finger prick from nursing home residents and staff showed sensitivities of 95.0–97.1% and specificities of 97.1–98.8% against venous blood for SARS-CoV-2 IgG antibodies, demonstrating reliable performance even in elderly people with reduced cutaneous microvasculature. This supports decentralised serosurveillance and post-authorisation vaccine studies because DBS can be obtained remotely and stored at room temperature.
Comparison of Dried Blood Spots and Venous Blood for the Detection of SARS-CoV-2 Antibodies in a Population of Nursing Home Residents — Meyers et al., Microbiology spectrum
- blood
- dried
- capillary
- dbs
- validation
- venous-agreement
- serology
2021
Host cell DNA methylation levels in first-void urine increased with disease severity among HR-HPV positive women, and GHSR and LHX8 methylation discriminated CIN2+ with AUCs of 0.80 and 0.76, respectively, supporting decentralised urine-based triage to improve cervical screening uptake.
Triage of human papillomavirus infected women by methylation analysis in first-void urine — Van Keer et al., Scientific reports
- urine
- first-void
- hpv
- biomarkers
2021
Among 596 participants, self-collected saliva achieved 80.3% sensitivity and 99.4% specificity for SARS-CoV-2 compared with nasopharyngeal swabs. Saliva collected one to five days after symptom onset yielded 85.1% positivity, indicating it can support early diagnosis in low-resource and community settings.
Diagnostic Performance of Self-Collected Saliva Versus Nasopharyngeal Swab for the Molecular Detection of SARS-CoV-2 in the Clinical Setting — Uddin et al., Microbiology spectrum
- saliva
- self-collection
- validation
- serology
2021
Saliva swabs demonstrated 89.5% sensitivity and 100% specificity for influenza detection compared with nasopharyngeal swabs, with 97.6% overall agreement. Median cycle threshold values were significantly higher in saliva (33) than in NP specimens (31), yet saliva swabs remain a feasible specimen type that can be easily self-collected with minimal equipment and discomfort for decentralised influenza testing.
Use of Saliva Swab for Detection of Influenza Virus in Patients Admitted to an Emergency Department — Galar et al., Microbiology spectrum
- saliva
- self-collection
- validation
- serology
2021
The review summarises that dried blood spot analysis and hepatitis C self-test assays have demonstrated diagnostic value for screening in decentralised settings and remote populations, supporting WHO diagnosis targets. This matters for decentralised diagnostics by confirming microsampling methods can be used for infectious disease screening outside clinical facilities.
Hepatitis C Diagnosis: Simplified Solutions, Predictive Barriers, and Future Promises — Shahid et al., Diagnostics
- blood
- dried
- dbs
- self-collection
- serology
2021
Pooled sensitivity of 78% and specificity of 89% for high-risk HPV in first-void urine indicate acceptable diagnostic test accuracy for cervical HPV, supporting its use as a non-invasive decentralised screening option.
Diagnostic Test Accuracy of First-Void Urine Human Papillomaviruses for Presence Cervical HPV in Women: Systematic Review and Meta-Analysis — Bober et al., International journal of environmental research and public health
- urine
- first-void
- validation
- hpv
2021
Capillary blood self-sampling showed near-perfect agreement with venous sampling for SARS-CoV-2 IgG detection, achieving a Cohen's kappa of 0.88. Samples remained stable at room temperature for seven days, and 38 of 39 participants successfully collected adequate volumes, supporting its use for decentralised serological testing.
Self-sampling of capillary blood for SARS-CoV-2 serology — Brown et al., Scientific reports
- blood
- liquid
- dried
- capillary
- dbs
- self-collection
- validation
- venous-agreement
- serology
2021
Self-sampled dried blood spots showed 99.20% sensitivity and 98.65% specificity for SARS-CoV-2 serology compared with venous sampling, and 99.87% of unsupervised home DBS cards were analysable, supporting DBS as a valid tool for large scale serosurveys and surveillance in resource limited settings.
A dried blood spot protocol for high throughput analysis of SARS-CoV-2 serology based on the Roche Elecsys anti-N assay — Beyerl et al., EBioMedicine
- blood
- dried
- dbs
- self-collection
- validation
- venous-agreement
- serology
2021
The paper identified that the Zymo DNA/RNA shield preservative paired with the QIAamp Viral RNA Mini Kit extraction yielded more detectable SARS-CoV-2 RNA from stool than the OMNIgene-GUT kit or storage without preservative. This supports decentralised diagnostics by establishing a validated method for preserving and analysing self-collected stool samples, enabling reliable detection of viral shedding for epidemiology and patient management.
Standardized preservation, extraction and quantification techniques for detection of fecal SARS-CoV-2 RNA — Natarajan et al., Nature communications
- stool
- stabilised
- dna-genotek-omnigene
- validation
- serology
2021
Shotgun metagenomics showed the Copan FLOQSwab in an active drying tube had the best technical and compositional reproducibility among five room temperature methods, outperforming RNALater and OMNIgene-GUT, while LifeGuard and a dry BBL swab allowed unpredictable Escherichia outgrowth; in a further 239-sample evaluation the FLOQSwab-ADT maintained performance across -20 °C, room temperature and 50 °C for four weeks, making it an excellent alternative to existing room temperature stabilisation for stool microbiome diagnostics.
Critical evaluation of faecal microbiome preservation using metagenomic analysis — Pribyl et al., ISME communications
- stool
- stabilised
- dna-genotek-omnigene
- validation
- microbiome
2021
Two dry vaginal self-sampling devices and a first-void urine collector detected over 90% of high-grade cervical lesions (CIN 3+) and all invasive cancers, with sensitivity comparable to clinician-taken smears. Participants found the devices easy to use and self-sampling was well accepted, which could improve uptake of cervical screening.
CoCoss-Trial: Concurrent Comparison of Self-Sampling Devices for HPV-Detection — Ertik et al., International journal of environmental research and public health
- urine
- first-void
- colli-pee
- self-collection
- acceptability
- hpv
- sti
2021
Self-collected saliva and buccal swabs showed only moderate agreement with healthcare worker-collected nasopharyngeal swabs for SARS-CoV-2 detection, with positive percent agreement of 66.7% and 56.7% respectively. This suggests they may be useful for initial screening in decentralised settings, but negative results should be confirmed with standard nasopharyngeal sampling to avoid missing infections.
Validation of self-collected buccal swab and saliva as a diagnostic tool for COVID-19 — Ku et al., International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
- saliva
- self-collection
- validation
- serology
2021
Saliva PCR viral loads were equivalent to nasopharyngeal swab in symptomatic COVID-19 patients, with high agreement and comparable detection sensitivity, supporting saliva as a useful self-collected diagnostic tool.
Equivalent SARS-CoV-2 viral loads by PCR between nasopharyngeal swab and saliva in symptomatic patients — Yokota et al., Scientific reports
- saliva
- self-collection
- validation
- serology
2020
A Danish virtual feasibility study of 55 adults with atopic dermatitis found that remote recruitment and self-collection of DNA samples by mail, combined with weekly smartphone tasks, achieved 96% retention and over 90% task adherence, over a short eight-week study with self-reported outcomes.
High adherence and low dropout rate in a virtual clinical study of atopic dermatitis through weekly reward-based personalized genetic lifestyle reports — Ali et al., PLOS ONE
- dct
- acceptability
- self-collection
- genotyping
2020
In 33 patients, dried blood spots showed high correlation with venipuncture for adalimumab, Pearson ≥0.96, whereas home sampling showed moderate correlation with predicted concentrations, Pearson 0.51.
Monitoring of Adalimumab Concentrations at Home in Patients with Inflammatory Bowel Disease Using Dried Blood Samples — Berends et al., Therapeutic Drug Monitoring (paywalled)
- venous-agreement
- biologics
- blood
- dbs
- tdm
- self-collection
- dried
- capillary
2020
A review contrasting the formats, framing the haematocrit effect, non-uniform spreading and homogeneity limits of DBS as the problems volumetric sampling is designed to solve.
Opportunities and obstacles for microsampling techniques in bioanalysis: special focus on DBS and VAMS — Londhe & Rajadhyaksha, J. Pharmaceutical and Biomedical Analysis (paywalled)
- vams
- blood
- dbs
- haematocrit
- dried
- validation
2020
A direct DUS-versus-VAMS comparison for 13 steroids on the same urine: VAMS gave better precision and recovery and superior one-year room-temperature stability.
Dried urine microsampling coupled to LC-MS/MS for the analysis of unconjugated anabolic-androgenic steroids — Protti et al., Molecules
- vams
- volumetric
- doping
- dried
- steroids
- toxicology
- hormones
- urine
- validation
2020
Urine VAMS quantified doxycycline with 96–106% accuracy and 31-day room-temperature stability, supporting cold-chain-free adherence monitoring.
A validated VAMS-LC-MS/MS method to quantify doxycycline in urine: monitoring malaria-chemoprophylaxis compliance — Penot, Linard & Taudon, J. Analytical Methods in Chemistry
- vams
- tdm
- dried
- antimicrobials
- urine
- validation
2020
Late-night salivary cortisol was a highly sensitive screen, about 97%, for ACTH-dependent Cushing syndrome, but performed poorly for adrenal disease: a validated screening, not confirmatory, test.
Prospective Evaluation of Late-Night Salivary Cortisol and Cortisone in Suspected Cushing Syndrome — Kannankeril et al., J. Endocrine Society
- cortisol
- hormones
- liquid
- validation
- saliva
2020
A multi-institution workshop made the case for a characterised whole-stool reference material so microbiome measurements can be standardised across labs, addressing the absence of defined faecal inputs.
Toward a human whole-stool reference material for metabolomic and metagenomic gut-microbiome measurements — Mandal et al., Metabolomics
- standardised-input
- metabolome
- standards
- microbiome
- metagenomics
- stool
- validation
2020
A study of three children found that the region of stool sampled did not change microbial alpha diversity, while 22 of 176 metabolites varied; homogenising the stool mattered for metabolomics and short room-temperature storage had little effect, which supports simpler home collection protocols within the limits of so small a study.
Impact of sampling regions and storage methods on fecal gut microbiome and metabolome profiles — Liang et al., mSphere
- standardised-input
- metabolome
- microbiome
- pediatric
- stool
- validation
2020
Vaccine-induced HPV antibodies from cervicovaginal secretions were detectable in first-void urine and correlated with serum levels, so one self-collected urine sample can monitor both HPV infection and immunogenicity without a blood draw; the authors see promise for decentralised follow-up after vaccination.
Non-invasive Assessment of Vaccine-Induced HPV Antibodies via First-Void Urine — Pattyn et al., Frontiers in Immunology
- first-void
- sti
- serology
- hpv
- liquid-biopsy
- liquid
- urine
- biomarkers
2020
Self-collected saliva samples provided adequate DNA for genotyping in preterm birth research, though questionnaire data on birth details had limited concordance with prospective records, indicating that while DNA sampling is feasible via post, phenotyping requires more reliable data collection methods for genetic studies.
Postal recruitment for genetic studies of preterm birth: A feasibility study — Keag et al., Wellcome open research
- dct
- dna-genotek-oragene
- self-collection
- liquid
- saliva
- genotyping
2020
Testing 130 healthy adults, researchers found that a caffeine breath test can identify the rs4410790 genotype using saliva collected via the Oragene DNA saliva collection kit. However, breath metrics did not differ for rs762551 or rs5751876 genotypes, and all subjects had the CC genotype at rs2472297.
<sup>13</sup>C-caffeine breath test identifies single nucleotide polymorphisms associated with caffeine metabolism — Ishii et al., Drug metabolism and pharmacokinetics (paywalled)
- saliva
- dna-genotek-oragene
- genotyping
2020
The study found that HIV-1 viral load testing using fingerstick blood collected in BD Microtainer tubes showed high correlation, R² ≥0.980, with standard venous assays, supporting decentralised patient-centric microsampling. The authors note the limitation that testing was performed at a single laboratory site.
Performance evaluation of the Aptima HIV-1 RNA Quant assay on the Panther system using the standard and dilution protocols — Rossetti et al., Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology (paywalled)
- blood
- liquid
- capillary
- bd-microtainer
- venous-agreement
- serology
2020
Using OraGene kits for saliva collection from 210 Portuguese mothers, this study found that the 5-HTTLPR polymorphism moderates environmental effects on maternal sensitivity. While generalisability may be limited by the Portuguese community sample, the work shows that decentralised saliva sampling is viable for gene-environment interaction studies.
Does 5-HTTLPR moderate the effect of the quality of environmental context on maternal sensitivity? Testing the differential susceptibility hypothesis — Baião et al., Psychiatric genetics (paywalled)
- saliva
- dna-genotek-oragene
- genotyping
2020
Using the Oragene DNA self-collection kit, this study found no significant difference in CNTFR genotype frequencies between weightlifters, 56% CC, 32% CT and 12% TT, and controls, 53% CC, 40% CT and 7% TT. However, the CT+TT genotype was associated with higher relative performance, though the cross-sectional design limits causal inference.
Ciliary Neurotrophic Factor Receptor rs41274853 Polymorphism Is Associated With Weightlifting Performance in Japanese Weightlifters — Homma et al., Journal of strength and conditioning research (paywalled)
- saliva
- dna-genotek-oragene
- self-collection
- genotyping
2020
Using a patient-centric saliva microsampling kit, the study found that genetic variants, VKORC1 and CYP2C9, and smoking explained 39.2% of warfarin dose variability in a Qatari population, supporting decentralised sampling for pharmacogenomic profiling.
The effect of genetic and nongenetic factors on warfarin dose variability in Qatari population — Bader et al., The pharmacogenomics journal (paywalled)
- tdm
- dna-genotek-oragene
- self-collection
- saliva
- genotyping
2020
Protein abundances measured by SomaScan were comparable between capillary samples collected with the TAP device and venous samples, and selected ELISA assays showed strong correlation, supporting the use of the TAP device for quantitative protein biomarker analysis in decentralised trials.
Evaluation of a novel blood microsampling device for clinical trial sample collection and protein biomarker analysis — Xing et al., Bioanalysis (paywalled)
- dct
- venous-agreement
- blood
- capillary
- yourbio
- biomarkers
2020
This proof-of-principle study found that baseline salivary DNA methylation, collected using the Oragene DNA kit, predicted childhood obesity three years later. A child at the 75th percentile of NRF1 methylation had a 48% chance of obesity versus 30% at the 25th percentile, showing the value of salivary microsampling for paediatric screening.
Salivary epigenetic biomarkers as predictors of emerging childhood obesity — Rushing et al., BMC medical genetics
- saliva
- dna-genotek-oragene
- pediatric
- genotyping
2020
The study found that the OMNIgene ORAL kit produced different microbiome profiles compared to some alternative oral collection methods, particularly Saccomanno's fixative. This matters for decentralised sampling as it shows the choice of a standardised, stabilised collection method is critical for reliable results in remote studies of the oral microbiome.
Comparison of Oral Microbiota Collected Using Multiple Methods and Recommendations for New Epidemiologic Studies — Yano et al., mSystems
- stabilised
- microbiome
- validation
- saliva
2020
Eighty-four per cent of 148 diverse US adults found self-collection of saliva, oropharyngeal swabs and dried blood spots for SARS-CoV-2 testing acceptable, and 87 per cent were confident their specimens were sufficient for laboratory analysis. The lack of demographic differences in acceptability supports broad feasibility of decentralised diagnostics.
At-home self-collection of saliva, oropharyngeal swabs and dried blood spots for SARS-CoV-2 diagnosis and serology: Post-collection acceptability of specimen collection process and patient confidence in specimens — Valentine-Graves et al., PloS one
- blood
- saliva
- dbs
- self-collection
- acceptability
- serology
2020
Microbiome profiles remained stable in OMNIgene GUT for 21 days at room temperature and metabolite abundance relationships were preserved, though absolute abundances varied slightly. This supports using a single stool collection procedure with OMNIgene GUT to obtain both microbiome and metabolome data for decentralised diagnostics.
Changes in microbiome and metabolomic profiles of fecal samples stored with stabilizing solution at room temperature: a pilot study — Lim et al., Scientific reports
- stool
- stabilised
- dna-genotek-omnigene
- microbiome
- metabolome
2020
This study validated a method using volumetric absorptive microsampling (VAMS) for therapeutic drug monitoring of antidepressants in whole blood and oral fluid. The method showed good extraction yield (84%), precision (relative standard deviation under 15%), and stability (over 85% after three months), with results agreeing well with conventional sampling. By enabling self-collection at home, VAMS simplifies sampling, improves analyte stability, and reduces costs, making decentralised monitoring of antidepressant treatment feasible.
Whole blood and oral fluid microsampling for the monitoring of patients under treatment with antidepressant drugs — Marasca et al., Journal of pharmaceutical and biomedical analysis (paywalled)
- blood
- saliva
- vams
- self-collection
- validation
- tdm
2020
Fingerprick blood collected with Neoteryx Mitra devices showed minimal bias compared to venous sampling for tacrolimus (-5.6%) and creatinine (-6.5%) in renal transplant patients. This validated method could enable home-based therapeutic drug monitoring and kidney function testing, reducing the need for hospital visits.
Assessment of tacrolimus and creatinine concentration collected using Mitra microsampling devices — Marshall et al., Annals of clinical biochemistry (paywalled)
- blood
- capillary
- vams
- neoteryx-mitra
- validation
- venous-agreement
- tdm
- immunosuppressants
2020
The authors developed and validated a VAMS method for quantifying immunosuppressants from venous whole blood using LC-MS/MS with a novel UniSpray ionisation probe. This supports patient-centric microsampling for transplant recipients requiring therapeutic drug monitoring.
Volumetric Absorptive Microsampling (VAMS) for assaying immunosuppressants from venous whole blood by LC-MS/MS using a novel atmospheric pressure ionization probe (UniSpray™) — Paniagua-González et al., Journal of pharmaceutical and biomedical analysis (paywalled)
- blood
- vams
- validation
- tdm
- immunosuppressants
2020
Dried blood spots collected serially from 763 female adolescent and young adult cancer survivors for up to 18 months revealed that anti-Müllerian hormone trajectories vary markedly by treatment gonadotoxicity and age at diagnosis. This establishes patient-centric microsampling as a viable method for longitudinal fertility assessment in decentralised oncology follow-up care.
Modeling Variation in the Reproductive Lifespan of Female Adolescent and Young Adult Cancer Survivors Using AMH — Su et al., The Journal of clinical endocrinology and metabolism (paywalled)
- blood
- dried
- dbs
- fertility
- hormones
2020
Finger-stick dried blood spots from 191 young women yielded anti-Müllerian hormone concentrations in the normal range (mean 5.66 ng/mL) and were deemed acceptable, with 81 per cent comfortable with collection and 88 per cent willing to repeat it. This supports feasibility of decentralised reproductive health studies, though validation against gold-standard measures remains necessary.
A pilot study for exploring blood spot anti-mullerian hormone for population-based adolescent reproductive health research — Hall et al., Frontiers in women's health (paywalled)
- blood
- dried
- capillary
- dbs
- acceptability
- fertility
- hormones
2020
Over half of emergency department patients offered the choice elected to self-collect their own stool sample for faecal occult blood testing, and every self-collected specimen was adequate for analysis. Younger patients were significantly more likely to choose self-collection, suggesting that offering this option could enhance patient autonomy while maintaining diagnostic quality in decentralised care settings.
"Your Finger or Mine?"-Patient Preferences in the Collection of Fecal Occult Blood Testing in the Emergency Department — Freeman et al., Military medicine (paywalled)
- stool
- self-collection
- acceptability
2020
Home dried blood spot monitoring for maple syrup urine disease raised the proportion of leucine concentrations meeting therapeutic targets by 35 per cent. More frequent self-sampling at home was associated with better biochemical control in newborns and fewer hospital visits, showing that patient-centric microsampling can improve management of inherited metabolic disorders.
The utility of dried blood spot monitoring of branched-chain amino acids for maple syrup urine disease: A retrospective chart review study — Kaur et al., Clinica chimica acta; international journal of clinical chemistry (paywalled)
- blood
- dried
- dbs
- self-collection
- pediatric
2020
A targeted NGS panel using dried blood spots achieved 100% concordance with Sanger sequencing in detecting pathogenic variants across 32 samples, with average coverage of 596X. This validates microsampling for decentralised newborn screening programmes, enabling accurate genetic diagnosis from minimally invasive specimens.
A targeted gene capture next-generation sequencing panel for genetic screening of newborns — Peng et al., JPMA. The Journal of the Pakistan Medical Association (paywalled)
- blood
- dried
- dbs
- validation
- pediatric
- genotyping
2020
Home-collected dried blood spots from 143 infants aged 8-14 months revealed wide variation in total cholesterol (4.1 mmol/L, range 2.3-6.6) and glycated haemoglobin (4.9%, range 3.7-6.0). Infant cholesterol correlated with macronutrient intake and maternal cholesterol, supporting decentralised paediatric screening.
Infant cholesterol and glycated haemoglobin concentrations vary widely-Associations with breastfeeding, infant diet and maternal biomarkers — Øyri et al., Acta paediatrica (paywalled)
- blood
- dried
- dbs
- self-collection
- pediatric
- biomarkers
2020
Urine samples produced lower cycle threshold values than urethral swabs for Chlamydia trachomatis and Neisseria gonorrhoeae positives, but the two methods yielded highly consistent results with only four discordant findings among 100 male outpatients. This validates clinician-collected swabs as an alternative to first-void urine on the cobas 4800 platform, which could aid decentralised diagnostics where urine collection is impractical.
Clinician-collected urethra swab: A good alternative sample type using cobas 4800 system for Chlamydia trachomatis and Neisseria gonorrhoeae in men — Wang et al., Journal of clinical laboratory analysis
- urine
- first-void
- validation
- sti
2020
In fifteen men consuming a controlled salt intake, second-void urine provided more reliable estimates of 24-hour urinary sodium excretion than first-void urine, with the sodium-to-potassium ratio in first-day second-void samples showing significant correlation with measured 24-hour output. This suggests spot second-void sampling could replace cumbersome 24-hour collections for sodium intake assessment in decentralised nutrition monitoring.
Development of objective indicators for quantitative analysis of sodium intake: the sodium to potassium ratio of second-void urine is correlated with 24-hour urinary sodium excretion — Kim et al., Nutrition research and practice
- urine
- first-void
- validation
2020
The study found that while participants generally viewed body fluid testing as useful for knowing their health status, cultural and religious concerns created ambivalence about sampling, particularly for blood and semen. Ensuring privacy, confidentiality and ongoing counselling helped address these barriers, supporting the design of more acceptable decentralised sampling programmes.
Perceptions on the collection of body fluids for research on persistence of Ebola virus: A qualitative study — Kutalek et al., PLoS neglected tropical diseases
- blood
- self-collection
- acceptability
2020
The study found only fair agreement between self-collected urine and vaginal samples for HPV DNA detection, with an overall agreement of 64.04% and a kappa value of 0.29. This suggests that urine self-sampling may not be a reliable substitute for vaginal self-sampling in this high-prevalence population for HPV screening.
Comparison of two self-sampling methods for human papillomavirus (HPV) DNA testing among women with high prevalence rates — Kuriakose et al., Journal of medical virology (paywalled)
- urine
- self-collection
- validation
- hpv
- sti
2020
Saliva shows potential as a patient-friendly alternative to nasopharyngeal swabs for COVID-19 diagnosis, with comparable sensitivity and specificity in RT-PCR testing. Its self-collection capability supports decentralised, patient-centric testing strategies during pandemics.
Saliva as a Biological Sample for COVID-19 Diagnosis? — Kafle & Sapkota, Kathmandu University medical journal (paywalled)
- saliva
- self-collection
- validation
- acceptability
- serology
2020
A community-based participatory research study across five American Indian communities showed that a home-based salivary cortisol collection protocol achieved high participant compliance, with 91% providing at least one usable sample and 79% providing four, and that deviations from timing were not robustly associated with cortisol indices, indicating that such decentralised protocols can yield valid hormone data.
Assessment of feasibility and outcomes of a salivary cortisol collection protocol in five American Indian communities — Walls et al., Stress (paywalled)
- saliva
- self-collection
- cortisol
2020
During urban reactive case detection for malaria in Lusaka, dried blood spot sampling was deployed for parasite genetic analysis alongside rapid diagnostic tests. However, high infection complexity and small sample numbers constrained the ability to discern transmission pathways from the genetic data.
The use of spatial and genetic tools to assess Plasmodium falciparum transmission in Lusaka, Zambia between 2011 and 2015 — Bridges et al., Malaria journal
- blood
- dried
- dbs
- serology
- genotyping
2020
Dried blood spots yield accurate HBV-DNA quantification comparable to plasma, with a limit of quantification of 400 IU/mL. The DNA remains stable in dried spots at room temperature for one month, offering a practical solution for remote hepatitis B monitoring in resource-limited settings to guide treatment and prevent mother-to-child transmission.
Combined use of dried blood spot and rapid molecular systems: A robust solution to monitor hepatitis B virus infection with potential for resource-limited countries — Bargain et al., Journal of virological methods (paywalled)
- blood
- dried
- dbs
- validation
- venous-agreement
- serology
2020
The study found that stimulant users were less likely to complete an at-home dried blood spot collection protocol than other drug users, but it is feasible to conduct decentralised studies with this population. This matters because it supports the use of patient-centric microsampling in high-risk groups for infectious disease monitoring, despite adherence challenges.
Stimulant Use and Study Protocol Completion: Assessing the Ability of Men Who Have Sex with Men to Collect Dried Blood Spots for Laboratory Measurement of HIV Viral Load — Teran et al., Archives of sexual behavior (paywalled)
- blood
- dried
- dbs
- self-collection
- serology
2020
This mixed-method study demonstrated that 97% of parents successfully collected dried blood spot samples from their children, with 72% reporting the process was easy and 80% preferring home collection. The results suggest that decentralised self-sampling for therapeutic drug monitoring is feasible and can reduce stress for families managing paediatric epilepsy.
Parents' perspectives on dried blood spot self-sampling from children with epilepsy: A mixed-method study — Linder et al., Acta paediatrica (paywalled)
- blood
- dried
- dbs
- self-collection
- acceptability
- pediatric
- tdm
2020
The study validated dried blood spot cards for detecting rabies virus antibodies in 99 human pre- and post-vaccination samples, finding strong correlation between DBS and serum with the gold-standard FAVNt (R = 0.88) and acceptable sensitivity and specificity with both FAVNt and Platelia-II ELISA, supporting their use for rabies serology in remote areas where venipuncture is impractical.
Dried blood spot cards: A reliable sampling method to detect human antibodies against rabies virus — Doornekamp et al., PLoS neglected tropical diseases
- blood
- dried
- dbs
- validation
- venous-agreement
- serology
2020
The study developed and validated an LC-MS/MS method to measure selumetinib in whole blood collected via VAMS, showing the approach is reliable and stable under various conditions. This supports decentralised therapeutic drug monitoring, particularly in paediatric populations where less invasive sampling is beneficial.
Novel LC-MS/MS method for the determination of selumetinib (AZD6244) in whole blood collected with volumetric absorptive microsampling — Voggu et al., Bioanalysis (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- pediatric
- tdm
2020
Self-collected salivary cortisol, measured at three daily time points in cocaine-abstinent outpatients, showed elevated morning levels and area-under-the-curve values that correlated positively with craving and negatively with verbal memory performance. This pilot study suggests home-based cortisol monitoring could help track relapse risk and cognitive impairment in substance-use disorders.
Salivary Cortisol Levels Are Associated with Craving and Cognitive Performance in Cocaine-Abstinent Subjects: A Pilot Study — Sampedro-Piquero et al., Brain sciences
- saliva
- self-collection
- hormones
- cortisol
2020
Self-collected saliva samples taken six times daily across three weekdays from 49 Chinese undergraduates showed that higher trait resilience is associated with a stronger cortisol awakening response and steeper diurnal decline. The protocol, which objectively monitored compliance, supports the feasibility of intensive decentralised sampling for stress-axis biomarker research.
Biomarking Trait Resilience With Salivary Cortisol in Chinese Undergraduates — Lai et al., Frontiers in psychology
- saliva
- self-collection
- hormones
- cortisol
2020
Saliva cortisol levels were 30% higher overall in toddlers receiving at-home childcare compared with centre-based care, although both groups displayed typical circadian rhythms. Home-based, patient-centric microsampling of saliva is feasible in paediatric populations, and these findings show that caregiving context must be accounted for when interpreting decentralised cortisol results.
Toddlers' diurnal cortisol levels affected by out-of-home, center-based childcare and at-home, guardian-supervised childcare: comparison between different caregiving contexts — Tervahartiala et al., European child & adolescent psychiatry
- saliva
- self-collection
- pediatric
- hormones
- cortisol
2020
The authors developed and validated high-sensitivity LC-MS/MS methods for tranexamic acid quantification in human whole blood, using either liquid samples or dried samples on volumetric absorptive microsampling devices. The methods performed excellently across clinically relevant concentrations, showed stability for up to one month at +50°C, and were validated with clinical samples, supporting decentralised therapeutic drug monitoring of this antifibrinolytic.
Tranexamic acid quantification in human whole blood using liquid samples or volumetric absorptive microsampling devices — Lamy et al., Bioanalysis (paywalled)
- blood
- liquid
- dried
- vams
- neoteryx-mitra
- validation
- tdm
2020
A head-to-head comparison of three commercial assays on self-collected vaginal swabs and first-void urine from 300 women showed Aptima MG achieved 100% sensitivity for Mycoplasma genitalium on both specimen types, while ResistancePlus MG sensitivity fell to 83.3% on urine versus 100% on swabs, and Seeplex STD6 ACE performed poorly on both. This demonstrates that for decentralised STI diagnostics, both assay choice and specimen type profoundly affect accuracy, with vaginal swabs proving more reliable than urine for two of the three tests.
Comparison of Assays for the Diagnosis of Mycoplasma genitalium and Macrolide Resistance Mutations in Self-Collected Vaginal Swabs and Urine — Chernesky et al., Sexually transmitted diseases (paywalled)
- urine
- first-void
- self-collection
- sti
2020
A VAMS method for measuring gamma-hydroxybutyric acid in blood was fully validated, showing linearity from 0.5 to 200 μg/ml and a lower limit of quantitation of 0.5 μg/ml. The method compared well with conventional plasma analysis in a patient receiving GHB therapy, suggesting microsampling could support decentralised therapeutic drug monitoring for this compound.
Development and validation of volumetric absorptive microsampling coupled with UHPLC-MS/MS for the analysis of gamma-hydroxybutyric acid in human blood — Mohamed et al., Biomedical chromatography : BMC (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
2020
The hemaPEN device demonstrated acceptable volumetric accuracy and precision for collecting dried blood spots in vitro, with performance unaffected by user training, while observed haematocrit-dependent bias was attributed to the extraction process rather than the device itself.
<i>In vitro</i> testing of the hemaPEN microsampling device for the quantification of acetaminophen in human blood — Sen et al., Bioanalysis (paywalled)
- blood
- dried
- dbs
- volumetric
- validation
- haematocrit
2020
Vibration during maximal cycling increased salivary cortisol by 83% compared with no vibration, while testosterone did not differ, reducing the testosterone/cortisol ratio. This demonstrates that saliva can detect exercise modality effects on stress hormones, which could inform remote monitoring of training load or rehabilitation if self-collection methods were validated.
Salivary endocrine response following a maximal incremental cycling protocol with local vibration — Jemni et al., PloS one
- saliva
- hormones
- cortisol
- biomarkers
2020
Among 196 women providing first-void urine, bacterial vaginosis correlated with Gardnerella biofilms on vaginal cells (88–90% of cases) and inversely with Lactobacillus biofilms. This confirms bacterial growth form as a diagnostic marker for vaginal dysbiosis, though no association was found with UTI symptoms, HIV status, or discharge.
Growth Forms of <i>Gardnerella</i> spp. and <i>Lactobacillus</i> spp. on Vaginal Cells — Jung et al., Frontiers in cellular and infection microbiology
- urine
- first-void
- microbiome
2020
In a randomised trial of 260 women undergoing natural cycle frozen embryo transfer, home-based ovulation monitoring using urine LH tests provided greater feelings of empowerment and treatment discretion compared with hospital monitoring, despite similar increases in anxiety and sadness across both pathways.
Home- or hospital-based monitoring to time frozen embryo transfer in the natural cycle? Patient-reported outcomes and experiences from the Antarctica-2 randomised controlled trial — Zaat et al., Human reproduction
- urine
- self-collection
- acceptability
- fertility
- hormones
- dct
2020
The magnitude of the cortisol awakening response, measured from self-collected saliva at home, positively predicted performance on an attention-switching task later the same day in healthy young adults. The association held only when sampling occurred within eight minutes of waking, demonstrating that precise electronic timing verification is essential for valid decentralised saliva-based cognitive biomarker studies.
The cortisol awakening response predicts a same-day index of executive function in healthy young adults — Law et al., International journal of psychophysiology : official journal of the International Organization of Psychophysiology (paywalled)
- saliva
- self-collection
- hormones
- cortisol
2020
An LC-MS/MS assay for testosterone, androstenedione and 17-hydroxyprogesterone using Mitra microsampling devices achieved mean recoveries of 102%, 98% and 97% respectively, with limits of quantification of 1–4 nmol/L. This analytical validation demonstrates that volumetric absorptive microsampling can deliver reliable reproductive hormone measurements, supporting its use in decentralised diagnostics.
Quantification of testosterone, androstenedione and 17-hydroxyprogesterone in whole blood collected using Mitra microsampling devices — Marshall et al., Annals of clinical biochemistry (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- venous-agreement
- fertility
- hormones
2020
Capillary blood collected by VAMS gave cannabidiol concentrations that agreed strongly with venous plasma (R² 0.93) in five paediatric and young adult patients with Dravet syndrome. This validates VAMS as a less invasive method for therapeutic drug monitoring of cannabidiol, enabling personalised therapy in refractory epilepsy within decentralised settings.
A Volumetric Absorptive Microsampling Technique to Monitor Cannabidiol Levels in Epilepsy Patients — Dubois et al., Frontiers in pharmacology
- blood
- dried
- capillary
- vams
- venous-agreement
- pediatric
- tdm
2020
Among 603 women in Zambia, home self-collection of genital and urine specimens for schistosomiasis diagnosis proved highly acceptable: more than 96% were willing to repeat each sample type, and 90% preferred home-based to clinic-based collection, chiefly for privacy and convenience. This supports decentralised, patient-centric screening strategies for female genital schistosomiasis in endemic settings.
Acceptability and feasibility of genital self-sampling for the diagnosis of female genital schistosomiasis: a cross-sectional study in Zambia — Rutty Phiri et al., Wellcome open research
- urine
- self-collection
- acceptability
2020
Acutely concussed youth studied at home showed longer sleep latency and greater fatigue than controls, with altered overnight cortisol dynamics and lower bedtime melatonin; these home-based saliva and actigraphy measures highlight decentralised endpoints for acute concussion care.
Sleep and stress in the acute phase of concussion in youth — Maerlender et al., Sports medicine and health science
- saliva
- liquid
- self-collection
- pediatric
- hormones
- cortisol
- actigraphy
- multimodal
2020
AstraZeneca's two case studies showed that reduced pharmacokinetic sampling schedules and composite plasma and dried-blood profiles in patient-centric trials maintained outcomes while lowering burden. This validates decentralised therapeutic drug monitoring and haematocrit modelling, but success demands organisational collaboration and accepting that no single device fits all patients.
Giving patients choices: AstraZeneca's evolving approach to patient-centric sampling — Bailey et al., Bioanalysis (paywalled)
- blood
- dried
- dct
- haematocrit
2020
A pilot study of 43 nursing home residents with dementia and chronic pain found that only eight participants could provide adequate saliva samples both before and after a six-week intervention, despite using salivary swabs. The cognitive impairment, difficulty obtaining sufficient sample volume, and cost suggest saliva collection may not be feasible for cortisol monitoring in this population, which has implications for decentralised stress assessment in vulnerable groups.
Using Salivary Cortisol as an Objective Measure of Physiological Stress in People With Dementia and Chronic Pain: A Pilot Feasibility Study — Pu et al., Biological research for nursing (paywalled)
- saliva
- self-collection
- acceptability
- cortisol
2020
The cobas® Plasma Separation Card demonstrated high sensitivity and specificity for HIV viral load from both venous and capillary blood, with misclassification rates under 1% compared with 5.9% for dried blood spots. This enables accurate decentralised HIV monitoring in primary care without requiring plasma centrifugation or cold chain transport.
Accurate HIV viral load measurement in primary health care settings using the cobas® plasma separation card — Vubil et al., PloS one
- blood
- dried
- capillary
- dbs
- validation
- venous-agreement
- serology
2020
First-void urine HPV antibody concentrations were lower than serum but showed strong positive correlations across four HPV types. The VLP-based multiplex ELISA demonstrated moderate to good agreement with the GST-L1 assay, confirming that self-collected first-void urine offers a viable non-invasive alternative for assessing HPV vaccine responses in decentralised studies, though larger investigations are needed to establish routine feasibility.
Comparison of a VLP-based and GST-L1-based multiplex immunoassay to detect vaccine-induced HPV-specific antibodies in first-void urine — Pattyn et al., Journal of medical virology
- urine
- first-void
- validation
- serology
- hpv
2020
The study compared detection rates and concordance of HPV16/18 E6 oncoprotein in urine, self-collected vaginal, and cervical specimens, demonstrating the potential for patient-collected samples to support decentralised cervical cancer screening in low-resource settings.
Detection of HPV E6 oncoprotein from urine via a novel immunochromatographic assay — Oliveira et al., PloS one
- urine
- self-collection
- validation
- hpv
- sti
2020
Among 181 HIV-positive men who have sex with men, four nucleic acid amplification assays showed variable sensitivity for detecting chlamydia and gonorrhea from self-collected rectal and urine specimens, with the ProbeTec GCQ assay significantly less sensitive for rectal gonorrhea. Urine-only screening would have missed more than 80 per cent of infections, underscoring the need for extragenital self-sampling in decentralised sexually transmitted infection diagnostics for this population.
Performance of 4 Molecular Assays for Detection of Chlamydia and Gonorrhea in a Sample of Human Immunodeficiency Virus-Positive Men Who Have Sex With Men — Footman et al., Sexually transmitted diseases (paywalled)
- urine
- self-collection
- validation
- sti
2020
In 385 expectant couples, maternal psychological stress during late pregnancy strengthened the diurnal cortisol linkage between partners when saliva was self-collected at home. This demonstrates that home-based sampling can capture clinically relevant interpersonal physiological dynamics that may influence prenatal and postnatal health.
Maternal psychological stress moderates diurnal cortisol linkage in expectant fathers and mothers during late pregnancy — Braren et al., Psychoneuroendocrinology (paywalled)
- saliva
- self-collection
- hormones
- cortisol
2020
In children with epilepsy in remote African settings, dried blood microsampling enabled therapeutic drug monitoring but showed most patients had subtherapeutic antiepileptic drug concentrations. Volumetric absorptive microsampling gave inexplicably higher results than dried blood spots, and drug levels did not correlate with seizure control.
Dried Blood Microsampling-Based Therapeutic Drug Monitoring of Antiepileptic Drugs in Children With Nodding Syndrome and Epilepsy in Uganda and the Democratic Republic of the Congo — Velghe et al., Therapeutic drug monitoring (paywalled)
- blood
- dried
- vams
- dbs
- neoteryx-mitra
- pediatric
- tdm
2020
Capillary blood collected with Neoteryx Mitra VAMS microsampling devices can quantify IGF-1 by automated chemiluminescent immunoassay after aqueous extraction. The hormone is stable for at least one month at room temperature, and dried blood concentrations match serum after dilution correction, though capillary samples underestimate high serum values, supporting patient-centric, decentralised endocrine monitoring but requiring population-specific reference ranges.
Volumetric Absorptive Microsampling (VAMS) technology for IGF-1 quantification by automated chemiluminescent immunoassay in dried blood — Marchand et al., Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society (paywalled)
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- venous-agreement
- hormones
2020
Birth testing for HIV using dried blood spots proved acceptable in Zambia, with low maternal refusal. Yet centralised laboratory testing created operational challenges: result return varied from 51.6% to 92.1% across sites, and linkage to care for infected infants was incomplete, underscoring the need for point-of-care platforms to accelerate diagnosis and treatment.
Acceptability and feasibility of testing for HIV infection at birth and linkage to care in rural and urban Zambia: a cross-sectional study — Sutcliffe et al., BMC infectious diseases
- blood
- dried
- dbs
- acceptability
- pediatric
- serology
2020
Capillary whole-blood point-of-care RNA testing and fingerstick dried blood spot sampling were feasible and acceptable for hepatitis C screening in high-risk individuals at social-medical harm reduction sites. Detection rates were comparable across both methods, enabling simplified screening and successful linkage to pan-genotypic direct-acting antiviral treatment.
Assessing Molecular Point-of-Care Testing and Dried Blood Spot for Hepatitis C Virus Screening in People Who Inject Drugs — Chevaliez et al., Open forum infectious diseases
- blood
- dried
- capillary
- dbs
- acceptability
- serology
2020
A survey of 39 kidney transplant recipients found that 85% preferred finger prick microsampling over venepuncture and 95% were interested in home self-sampling, highlighting the potential of decentralised blood collection to reduce patient burden and anxiety.
Kidney transplant recipient's perceptions of blood testing through microsampling and venepuncture — Scuderi et al., Bioanalysis (paywalled)
- blood
- dried
- vams
- dbs
- self-collection
- acceptability
2020
The authors developed and validated a volumetric absorptive microsampling assay for vancomycin in whole blood that is suitable for paediatric therapeutic drug monitoring. Vancomycin remained stable in dried VAMS samples for at least 160 days at -78°C, enabling reliable quantification in clinical studies using minimal blood volumes.
A whole blood microsampling assay for vancomycin: development, validation and application for pediatric clinical study — Moorthy et al., Bioanalysis (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- pediatric
- tdm
- antimicrobials
2020
This workshop report provides recommendations on blood sampling sites, bridging study design, and statistical methods for correlation to support the adoption of microsampling in patient-centric drug development. It emphasises the critical need for away-from-clinic sampling techniques to maintain patient safety during the COVID-19 pandemic.
Land O'Lakes Workshop on Microsampling: Enabling Broader Adoption — Wickremsinhe et al., The AAPS journal
- blood
- capillary
- venous-agreement
- acceptability
- dct
- standards
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