The Library
1530 papers on microsampling and monitoring, each with a finding paraphrased to our standard and labelled in one vocabulary. Every entry links to a legitimate copy; nothing is copied from an abstract.
Papers 1201–1300 of 1530, newest first.
2020
Home-collected saliva samples revealed that patients with central serous chorioretinopathy exhibit a higher cortisol awakening response and altered diurnal trajectories of salivary cortisol and α-amylase compared with controls. This demonstrates that self-sampling can capture chronobiological biomarker differences associated with stress-related eye disease, supporting decentralised collection for ophthalmic and neuroendocrine research.
Diurnal trajectories of salivary cortisol and α-amylase and psychological profiles in patients with central serous chorioretinopathy — Scarinci et al., Chronobiology international (paywalled)
- saliva
- self-collection
- hormones
- cortisol
- biomarkers
2020
The study found reasonable agreement between finger-prick dried blood spot CRP measurements and venous reference assays in 100 rheumatoid arthritis patients, particularly at low to mid-range CRP values, and showed that weekly self-collected DBS CRP monitoring improved flare detection specificity to 72.7% compared with 54.5% for minimal sampling, supporting decentralised microsampling for remote arthritis management.
Assessment of a dried blood spot C-reactive protein method to identify disease flares in rheumatoid arthritis patients — D'Cruz et al., Scientific reports
- blood
- dried
- dbs
- self-collection
- validation
- venous-agreement
- rpm
- multimodal
2020
Capiau et al. developed and validated a VAMS method for cobalt quantitation in whole blood from metal-on-metal prosthesis patients. The method proved accurate (bias ≤4%) and precise (RSD ≤5%), was unaffected by haematocrit, and showed a 0.99 correlation to liquid venous samples; 87% of results satisfied Royal College of Pathologists of Australasia criteria, enabling home-based monitoring of implant wear.
Development, validation and application of an inductively coupled plasma - mass spectrometry method to determine cobalt in metal-on-metal prosthesis patients using volumetric absorptive microsampling — Capiau et al., Talanta (paywalled)
- blood
- dried
- vams
- validation
- venous-agreement
- toxicology
2020
Saliva presents a viable diagnostic alternative to nasopharyngeal and oropharyngeal swabs for SARS-CoV-2 detection by rRT-PCR. Its use facilitates patient self-collection, minimises healthcare worker exposure, and offers a cost-effective approach for widespread testing.
Saliva as a Potential Diagnostic Specimen for COVID-19 Testing — Harikrishnan, The Journal of craniofacial surgery (paywalled)
- saliva
- self-collection
- validation
- serology
2020
In patients undergoing upfront MRI and image-guided biopsy, adding MDx-2 RNA biomarker scores and embedded clinical variables to PI-RADS-v2 improved prediction of high-grade prostate cancer compared with PI-RADS-v2 alone (AUC 0.80 vs 0.67), though the two combined models did not differ significantly, suggesting that biomarkers and clinical predictors in MDx-2 require reassessment in this diagnostic pathway.
Independent Evaluation of the Respective Predictive Values for High-Grade Prostate Cancer of Clinical Information and RNA Biomarkers after Upfront MRI and Image-Guided Biopsies — Roumiguié et al., Cancers
- urine
- first-void
- biomarkers
2020
Volumetric absorptive microsampling provides accurate quantification of 16 anti-epileptic drugs within two days of collection, showing less than ten percent deviation from conventional serum sampling and no haematocrit effect across the clinical range. This supports home-based therapeutic drug monitoring for epilepsy patients, though temperature-sensitive drugs require careful storage.
Therapeutic drug monitoring of anti-epileptic drugs - a clinical verification of volumetric absorptive micro sampling — Canisius et al., Clinical chemistry and laboratory medicine (paywalled)
- blood
- vams
- validation
- venous-agreement
- tdm
- haematocrit
2020
The study reports a colorimetric assay using plasmonic gold nanostructures that change colour in saliva to detect hyperglycaemia, with a dipstick prototype developed for home testing. This non-invasive method could support large-scale diabetic screening and monitoring, overcoming bio-matrix interference issues that typically affect saliva-based glucose detection.
Colorimetric Nanoplasmonics to Spot Hyperglycemia From Saliva — Donati et al., Frontiers in bioengineering and biotechnology
- saliva
- self-collection
2020
Stock solutions including OMNIgene-Gut maintained stable gut microbial profiles in stool for up to two months at room temperature, supporting their use over freezing for decentralised gut microbiome analysis.
Performance comparison of fecal preservative and stock solutions for gut microbiome storage at room temperature — Park et al., Journal of microbiology (paywalled)
- stool
- stabilised
- dna-genotek-omnigene
- microbiome
2020
A VAMS method for 14 antidepressants, antipsychotics and active metabolites was validated on HPLC-MS and conversion factors from capillary blood to plasma were derived from 49 patient samples using Passing-Bablok and Bland-Altman analysis, enabling routine therapeutic drug monitoring.
Validation and clinical application of a volumetric absorptive microsampling method for 14 psychiatric drugs — Stern et al., Bioanalysis (paywalled)
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- tdm
2020
The study developed and validated a LC-HRMS method for intact IGF-I from VAMS dried blood according to World Anti-Doping Agency requirements and showed agreement with serum measurements, supporting decentralised sampling for antidoping testing.
Use of capillary dried blood for quantification of intact IGF-I by LC-HRMS for antidoping analysis — Mongongu et al., Bioanalysis (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- venous-agreement
- doping
2020
The study found that pooling self-collected urine, pharyngeal and rectal specimens for chlamydia and gonorrhoea testing on GeneXpert near the point of care reduced sensitivity to around 90 per cent compared with individual specimen testing, missing nine infections across 388 participants, but pooling remained feasible and could save time and cost when screening at-risk populations.
Reduced sensitivity from pooled urine, pharyngeal and rectal specimens when using a molecular assay for the detection of chlamydia and gonorrhoea near the point of care — Badman et al., Sexual health (paywalled)
- urine
- self-collection
- validation
- sti
2020
HPV DNA was detected significantly more often in first-void urine from patients with urothelial carcinoma than from controls, indicating an association between HPV infection and bladder cancer.
Is There any Association between Urothelial Carcinoma of the Bladder and Human Papillomavirus? A Case-Control Study — Sarier et al., Urologia internationalis (paywalled)
- urine
- first-void
- hpv
2020
A multiplex LC-MS/MS method for dried plasma spots was fully validated for accuracy, precision, selectivity and sensitivity across seven antipsychotics, with limits of quantification ranging from 0.12 to 5.70 µg/L; this enables convenient therapeutic drug monitoring from a simple dried sample.
Multiplexed therapeutic drug monitoring of antipsychotics in dried plasma spots by LC-MS/MS — Ruggiero et al., Journal of separation science (paywalled)
- blood
- dried
- validation
- tdm
2020
Capillary blood sampling using volumetric absorptive microsampling demonstrated non-significant differences in cannabidiol concentrations compared to venous blood and plasma in pediatric patients treated with Epidiolex. The method requires 30 µL of sample, achieves linear quantification between 1 and 800 µg/L, and ensures analyte stability on VAMS devices for up to four weeks at room temperature.
Cannabidiol Determination on Peripheral Capillary Blood Using a Microsampling Method and Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry with On-Line Sample Preparation — Pigliasco et al., Molecules
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- venous-agreement
- pediatric
- tdm
2020
Capillary volumetric dried blood microsampling with hemaPEN provides a patient friendly way to obtain multiple identical samples for LC-MS/MS analysis of CNS drugs and metabolites, with satisfactory validation metrics and practical advantages for storage and extraction, enabling decentralised therapeutic drug monitoring.
Assessment of capillary volumetric blood microsampling for the analysis of central nervous system drugs and metabolites — Protti et al., The Analyst (paywalled)
- blood
- dried
- capillary
- volumetric
- tdm
2020
In 401 COVID-19 patients, self-collected oropharyngeal and mid-turbinate swabs detected 75.1% of infections and saliva detected 74.3%, both inferior to the 82.8% sensitivity of healthcare worker-collected swabs. However, combining both self-collected samples yielded 86.5% sensitivity with 100% specificity, indicating self-collection can be a useful tool for decentralised SARS-CoV-2 screening despite lower individual test sensitivity.
The accuracy of healthcare worker versus self collected (2-in-1) Oropharyngeal and Bilateral Mid-Turbinate (OPMT) swabs and saliva samples for SARS-CoV-2 — Tan et al., PloS one
- saliva
- self-collection
- validation
- serology
2020
The Mitra microsampling device showed high clinical concordance with venous blood for tacrolimus (89%) and cyclosporin A (98%) monitoring, with inter- and intra-precision within 11.5% CV and samples stable for up to 7 days at room temperature. Transplant patients preferred collecting capillary samples at home for their immunosuppressant monitoring, supporting decentralised TDM.
Volumetric Microsampling of Capillary Blood Spot vs Whole Blood Sampling for Therapeutic Drug Monitoring of Tacrolimus and Cyclosporin A: Accuracy and Patient Satisfaction — Mbughuni et al., The journal of applied laboratory medicine (paywalled)
- blood
- capillary
- vams
- volumetric
- neoteryx-mitra
- validation
- venous-agreement
- acceptability
- tdm
- immunosuppressants
2020
The authors validated an automated DNA extraction method for stool microbiome analysis and found that seven stabilising solutions, including OMNIgene•GUT, RNAlater and AquaStool, preserved microbiome composition as well as snap-freezing. OMNIgene•GUT maintained sample integrity for two years at -80°C. This supports decentralised stool collection for microbiome studies by enabling ambient stabilisation and delayed laboratory processing.
Method Validation for Extraction of DNA from Human Stool Samples for Downstream Microbiome Analysis — Neuberger-Castillo et al., Biopreservation and biobanking (paywalled)
- stool
- stabilised
- dna-genotek-omnigene
- validation
- microbiome
2020
The authors developed two simple methods to calculate haematocrit from VAMS samples using potassium content, one with aqueous extraction and one with organic extraction, both designed to integrate with existing VAMS assays so that whole-blood results can be converted to serum or plasma values and compared with therapeutic intervals.
Hematocrit prediction in volumetric absorptive microsamples — Capiau & Stove, Journal of pharmaceutical and biomedical analysis (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- haematocrit
2020
The study validated a VAMS-based bioanalytical method using the Tasso OnDemand device for the drug gefapixant and demonstrated a mathematical bridging relationship with standard plasma assays, supporting its use in decentralised clinical trials.
Clinical application of volumetric absorptive microsampling to the gefapixant development program — Roadcap et al., Bioanalysis (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- venous-agreement
- tdm
2020
Women using a home-based, app-connected urine ovulation test achieved pregnancy in 25.4% of first cycles versus 14.7% for those not using tests (p<0.001), with a cumulative two-cycle rate of 40.8% versus 30.0% (p=0.026). This shows that decentralised hormone self-sampling can significantly improve conception rates while reducing intercourse frequency through better cycle timing.
Increased Likelihood of Pregnancy Using an App-Connected Ovulation Test System: A Randomized Controlled Trial — Johnson et al., Journal of women's health
- urine
- self-collection
- fertility
- hormones
- dct
2020
This review highlights how low-volume, minimally invasive microsampling of matrices such as dried capillary blood, interstitial fluid and saliva can enable untargeted metabolomics and longitudinal exposome studies in children, with the potential for home self-collection to improve convenience and parental support.
Minimally Invasive Biospecimen Collection for Exposome Research in Children's Health — Petrick et al., Current environmental health reports (paywalled)
- blood
- saliva
- interstitial-fluid
- dried
- capillary
- self-collection
- validation
- venous-agreement
- pediatric
- metabolome
2020
Dried blood spot sampling using HemaSpot or Whatman903 cards demonstrated high analytical sensitivity for hepatitis B surface antigen, core antibody and hepatitis C antibody when compared with serum, with ratios ranging from 17.6:1 to 38.9:1. HemaSpot achieved 92.3% sensitivity and 100% specificity for HBsAg detection, maintained 80% detection efficacy after one month of storage, and showed no significant degradation after two weeks at ambient temperature, confirming its suitability for decentralised hepatitis screening in resource-limited settings.
Evaluation of the efficiency of dried blood spot-based measurement of hepatitis B and hepatitis C virus seromarkers — Yamamoto et al., Scientific reports
- blood
- dried
- dbs
- validation
- venous-agreement
- serology
2020
Pooled testing of pharyngeal, anorectal and urine samples detected most Chlamydia trachomatis and Neisseria gonorrhoeae infections in men who have sex with men, missing only one chlamydia-positive urine specimen, and yielded less PCR inhibition than single-site testing. Two self-collected anorectal swabs were inadequately sampled, indicating that pooling can streamline decentralised STI screening but self-collection quality must be assured.
Take three, test one: a cross-sectional study to evaluate the molecular detection of <i>Chlamydia trachomatis</i> and <i>Neisseria gonorrhoeae</i> in pooled pharyngeal, anorectal and urine samples versus single-site testing among men who have sex with men in Belgium — De Baetselier et al., Acta clinica Belgica (paywalled)
- urine
- self-collection
- validation
- sti
2020
The review evaluates microsampling techniques including dried matrix spots, volumetric absorptive microsampling and capillary microsampling for SARS-CoV-2 bioanalytical applications, outlining their respective advantages and disadvantages to guide researchers and clinicians in pandemic-related diagnostics.
Quantitative microsampling for bioanalytical applications related to the SARS-CoV-2 pandemic: Usefulness, benefits and pitfalls — Protti et al., Journal of pharmaceutical and biomedical analysis
- blood
- dried
- vams
- validation
2020
Dried urine spot and volumetric absorptive microsampling methods were validated for quantifying six corticosteroids in 30 μl urine, showing good linearity, extraction yields exceeding 81 percent, and precision within 15 percent relative standard deviation. Analytes remained stable for seven days at room temperature, indicating urine microsampling is viable for remote antidoping control and could support decentralised steroid monitoring.
Microsampling and LC-MS/MS for antidoping testing of glucocorticoids in urine — Protti et al., Bioanalysis (paywalled)
- urine
- dried
- vams
- validation
- hormones
- steroids
- doping
- toxicology
2020
A GC-MS/MS method for anabolic steroids in VAMS dried blood from finger pricking demonstrated good precision, accuracy and stability, with results agreeing with serum specimens. In a testosterone gel administration trial, dried blood total testosterone identified transdermal micro-dosing, with concentrations rising up to ten times baseline at nine hours post-application, supporting decentralised doping screening.
Determination of anabolic steroids in dried blood using microsampling and gas chromatography-tandem mass spectrometry: Application to a testosterone gel administration study — Chang et al., Journal of chromatography. A (paywalled)
- blood
- dried
- vams
- validation
- venous-agreement
- hormones
- doping
2020
Capillary microsampling using the Neoteryx Mitra device predicted tacrolimus AUC with high accuracy and precision compared with venous sampling in renal transplant recipients, with 85% of estimates within ±11.9% error. Patients could self-sample accurately at home, enabling patient-centred therapeutic drug monitoring without extended hospital stays.
Tacrolimus Area Under the Concentration Versus Time Curve Monitoring, Using Home-Based Volumetric Absorptive Capillary Microsampling — Gustavsen et al., Therapeutic drug monitoring (paywalled)
- blood
- capillary
- vams
- neoteryx-mitra
- self-collection
- validation
- venous-agreement
- tdm
- immunosuppressants
2020
In adult kidney transplant patients, adding DBS home sampling to usual care did not reduce outpatient visits or per-visit costs versus usual care alone, though most patients were willing to use DBS if it cut hospital attendances; logistical optimisation of mailing and timely analysis is required to realise travel and cost benefits.
Effects, costs and implementation of monitoring kidney transplant patients' tacrolimus levels with dried blood spot sampling: A randomized controlled hybrid implementation trial — Veenhof et al., British journal of clinical pharmacology
- blood
- dried
- dbs
- self-collection
- acceptability
- tdm
- immunosuppressants
- dct
- economics
2020
The study developed and validated a VAMS-based method for measuring cefepime in small volumes of paediatric blood with high accuracy and precision, enabling less invasive therapeutic drug monitoring in children. This advances decentralised, patient-centric sampling by allowing reliable pharmacokinetic studies without repeated venous draws.
Development and validation of a volumetric absorptive microsampling- liquid chromatography mass spectrometry method for the analysis of cefepime in human whole blood: Application to pediatric pharmacokinetic study — Moorthy et al., Journal of pharmaceutical and biomedical analysis (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- pediatric
- tdm
- antimicrobials
2020
The review highlights that volumetric absorptive microsampling enables easy, minimally invasive home sampling with room temperature storage and fixed volume accuracy, making it a viable alternative for clinical trials and therapeutic drug monitoring during the COVID-19 pandemic.
Volumetric Absorptive Microsampling as a Sampling Alternative in Clinical Trials and Therapeutic Drug Monitoring During the COVID-19 Pandemic: A Review — Harahap et al., Drug design, development and therapy
- blood
- dried
- vams
- neoteryx-mitra
- validation
- tdm
- dct
- haematocrit
2020
Nearly four in five women (79 per cent) had positive feelings about urine-based HPV testing, and more than three-quarters (78 per cent) preferred urine self-collection to cervico-vaginal sampling, with preference varying by race and ethnicity. Sixteen per cent worried about correct cervico-vaginal collection. Urine self-collection is highly acceptable across diverse United States populations and offers a decentralised approach that could improve cervical cancer screening coverage.
Racial and Ethnic Differences in Acceptability of Urine and Cervico-Vaginal Sample Self-Collection for HPV-Based Cervical Cancer Screening — Rohner et al., Journal of women's health (paywalled)
- urine
- self-collection
- acceptability
- hpv
- sti
2020
HbA1c measured from self-collected HemaSpot dried blood spots showed strong linear agreement with venous blood and was stable over time. With high patient acceptance, this supports remote diabetes monitoring for people in decentralised care models.
HbA<sub>1c</sub> determination from HemaSpot™ blood collection devices: comparison of home prepared dried blood spots with standard venous blood analysis — Hall et al., Diabetic medicine : a journal of the British Diabetic Association
- blood
- dried
- dbs
- self-collection
- validation
- venous-agreement
- acceptability
2020
The study validated a VAMS method for cocaine and metabolites in blood and plasma, achieving good extraction yield, precision and accuracy with analyte stability exceeding two months at room temperature. Results from VAMS correlated well with conventional fluid samples, supporting its use for decentralised forensic and toxicological monitoring without venepuncture or cold chain.
Blood and Plasma Volumetric Absorptive Microsampling (VAMS) Coupled to LC-MS/MS for the Forensic Assessment of Cocaine Consumption — Mandrioli et al., Molecules
- blood
- dried
- vams
- neoteryx-mitra
- validation
- doping
- toxicology
2020
In youth aged 8–16 years, first-waking saliva cortisol, IL-6 and IL-1β collected at home associate with prior-night actigraphy sleep metrics. Sleep quality confounds interpretation of salivary stress and immune biomarkers in decentralised paediatric microsampling, so protocols must account for it.
Bidirectional relationships between sleep and biomarkers of stress and immunity in youth — LaVoy et al., International journal of psychophysiology : official journal of the International Organization of Psychophysiology (paywalled)
- saliva
- self-collection
- pediatric
- cortisol
- biomarkers
- actigraphy
- multimodal
2019
The reference systematic review and meta-analysis of needle-fear prevalence across children and adults: the quantified basis for why a proportion of any population will not present for a venous draw.
The fear of needles: A systematic review and meta-analysis — McLenon & Rogers, Journal of Advanced Nursing (paywalled)
- acceptability
- pediatric
2019
A clinical validation showing dried blood samples can support infliximab concentration monitoring in inflammatory bowel disease.
Dried blood samples can support monitoring of infliximab concentrations in patients with inflammatory bowel disease: A clinical validation — Berends et al., British Journal of Clinical Pharmacology
- venous-agreement
- biologics
- blood
- dbs
- tdm
- self-collection
- dried
- validation
2019
Imaging shows analytes distribute non-uniformly within a single spot, one central, one peripheral, so where a sub-punch is taken can change the answer.
Analysis of the heterogeneous distribution of amiloride and propranolol in dried blood spot by UHPLC-FLD and MALDI-imaging — Uribe et al., Molecules
- blood
- dbs
- tdm
- haematocrit
- dried
- validation
2019
The consensus guideline defining the analytical- and clinical-validation requirements for dried-blood TDM: the standardisation reference for implementing a dried assay clinically.
Official IATDMCT Guideline: Development and Validation of Dried Blood Spot-Based Methods for Therapeutic Drug Monitoring — Capiau et al., Therapeutic Drug Monitoring (paywalled)
- blood
- dbs
- tdm
- standards
- haematocrit
- dried
- validation
2019
This study found that dried urine metabolite patterns followed serum concentrations. It shows excellent agreement for the 4-spot method versus 24-hour collections and dried versus liquid urine, with intraclass correlation coefficients greater than 0.95.
Evaluating urinary estrogen and progesterone metabolites using dried filter-paper samples and GC-MS/MS — Newman et al., BMC Chemistry
- dried
- steroids
- fertility
- hormones
- liquid
- urine
- validation
2019
Stool stabilised in OMNIgene·GUT then frozen produced 16S and shotgun profiles statistically indistinguishable from fresh-frozen aliquots, supporting stabilised collection where freezing is impractical.
Gut microbiome comparability of fresh-frozen versus stabilised-frozen samples by 16S and shotgun metagenomics — Ilett et al., Scientific Reports
- stool
- stabilised
- dna-genotek-omnigene
- microbiome
- metagenomics
- validation
2019
At-home first-void urine self-collection with Colli-Pee was feasible, well accepted, and gave chlamydia/gonorrhoea detection comparable to routine clinic-based urine, supporting home first-void sampling for populations needing frequent STI testing.
Evaluation of Colli-Pee first-void urine self-sampling at home versus clinic-based collection for sexually transmitted infections in MSM — De Baetselier et al., BMJ Open
- colli-pee
- acceptability
- first-void
- sti
- self-collection
- liquid
- urine
2019
An analysis of self-collected stool samples from 1,674 adults aged 18 to 74 found that migration and environmental factors shape the gut microbiome, with lower bacterial diversity linked to obesity. While this cross-sectional design limits causal inference, it shows the viability of decentralised sample collection for large-scale epidemiological studies.
Gut microbiome composition in the Hispanic Community Health Study/Study of Latinos is shaped by geographic relocation, environmental factors, and obesity — Kaplan et al., Genome biology
- stool
- self-collection
- microbiome
2019
Comparing matched samples from four individuals, this study found that blood-derived DNA yielded a higher percentage of aligned reads and mean read depth than saliva or buccal samples, p<0.05. While limited by a small sample size, these results suggest decentralised saliva or buccal sampling may be less reliable for whole-genome sequencing.
Impact of DNA source on genetic variant detection from human whole-genome sequencing data — Trost et al., Journal of medical genetics
- blood
- saliva
- genotyping
2019
This study compared four stool collection methods for infant gut microbiome analysis via post and found that the OMNIgene•GUT kit showed the closest agreement with the frozen standard compared to swabs or plain tubes. The findings suggest that stabilised collection offers a viable decentralised solution for parents to sample infant stool at home with minimal DNA degradation.
Gut microbiome analysis by post: Evaluation of the optimal method to collect stool samples from infants within a national cohort study — Williams et al., PloS one
- stool
- stabilised
- dna-genotek-omnigene
- self-collection
- validation
- pediatric
- microbiome
2019
In women with HPV, first-void urine collected with the Colli-Pee device had higher HPV DNA concentrations than urine collected with a standard cup, although this advantage disappeared at high HPV DNA loads. Timing of collection (morning versus later) did not affect HPV DNA copies.
Human papillomavirus detection in urine: Effect of a first-void urine collection device and timing of collection — Pattyn et al., Journal of virological methods (paywalled)
- urine
- first-void
- colli-pee
- self-collection
- validation
- hpv
- sti
2019
Volumetric absorptive capillary microsampling gave reliable tacrolimus measurements throughout the dose interval in renal transplant recipients, with mean biases of -3.1% for mailed samples and -4.2% for direct delivery versus venous blood. Dried microsamples remained stable for one month at ambient temperature, enabling home-based therapeutic drug monitoring with postal shipment.
Tacrolimus Can Be Reliably Measured With Volumetric Absorptive Capillary Microsampling Throughout the Dose Interval in Renal Transplant Recipients — Vethe et al., Therapeutic drug monitoring (paywalled)
- blood
- dried
- capillary
- vams
- validation
- venous-agreement
- tdm
- immunosuppressants
2019
Capillary citrate specimens from finger-stick correlated strongly with laboratory INR (r=0.97) and showed equivalence to venous sampling, with 89% of results within 0.5 INR units of agreement. This method avoids venepuncture trauma in paediatric patients while maintaining diagnostic accuracy for anticoagulation monitoring.
Use of a capillary specimen in the laboratory to verify a point-of-care international normalized ratio: Avoidance of a venipuncture in a pediatric setting — Williams, International journal of laboratory hematology (paywalled)
- blood
- capillary
- validation
- venous-agreement
- pediatric
2019
In a prospective preconception cohort, participants correctly collected 82% of expected female urine samples and 59% of male samples on investigator-identified days, with high agreement between participants and expert reviewers on fertile window timing. This demonstrates that intensively scheduled, biologically triggered, at-home urine collection can be successfully targeted to the periconceptional window and completed in longitudinal research.
Compliance with daily, home-based collection of urinary biospecimens in a prospective, preconception cohort — Cox et al., Environmental epidemiology
- urine
- self-collection
- fertility
2019
Saliva self-collection at home and during clinical procedures yielded cortisol data from 326 children, revealing genetic variants in stress-response pathways that may identify paediatric patients at risk of adverse reactions to painful procedures, supporting tailored interventions in decentralised settings.
Genetic Variants and the Cortisol Response in Children: An Exploratory Study — Ersig et al., Biological research for nursing (paywalled)
- saliva
- self-collection
- pediatric
- cortisol
- genotyping
2019
This study shows wide variation across existing CT load quantification methods and demonstrates that normalising CT load to human cell load is inappropriate because molecular techniques cannot exclude inflammatory cells, supporting the need for standardisation in decentralised STI diagnostics.
Standardisation is necessary in urogenital and extragenital <i>Chlamydia trachomatis</i> bacterial load determination by quantitative PCR: a review of literature and retrospective study — Dirks et al., Sexually transmitted infections (paywalled)
- urine
- self-collection
- validation
- sti
2019
Noviplex dried plasma spot cards yielded neurofilament light chain measurements equivalent to standard plasma in healthy controls and ALS patients, while dried blood spot eluates gave different absolute values but still discriminated between the two groups. The results support remote dried blood microsampling as a practical alternative to venous sampling for neurodegeneration biomarkers in ALS.
Theme 7 Pre-clinical therapeutic strategies — Lombardi et al., Amyotrophic lateral sclerosis & frontotemporal degeneration (paywalled)
- blood
- dried
- dbs
- self-collection
- validation
- venous-agreement
- biomarkers
2019
OMNIgene SPUTUM treated sputum specimens stored and transported at ambient temperature for up to 29 days yielded GeneXpert MTB/RIF results comparable to cold chain samples, with very good inter test agreement (kappa 0.97) and 99% overall agreement, supporting decentralised testing without cold chain.
Comparative study of OMNIgene®•SPUTUM reagent versus cold-chain for the transportation of sputum samples to GeneXpert®MTB/RIF testing sites in Malawi — Alemayehu et al., BMC infectious diseases
- stabilised
2019
Dried blood spot viral load quantification using the Biocentric method correlated with plasma testing (r=0.67–0.82) and delivered comparable diagnostic accuracy at the 1000 copies/mL threshold across three collection methods. This validates patient-centric microsampling for decentralised HIV monitoring in resource-limited settings.
Field Suitability and Diagnostic Accuracy of the Biocentric Open Real-Time PCR Platform for Dried Blood Spot-Based HIV Viral Load Quantification in Eswatini — Kerschberger et al., Journal of acquired immune deficiency syndromes
- blood
- dried
- capillary
- dbs
- validation
- venous-agreement
- serology
2019
A systematic review of dried blood spot sampling for tacrolimus monitoring across adult and paediatric organ transplant recipients demonstrated that reported analytical bias compared with venous sampling fell within acceptable limits across the majority of studies. This supports dried blood microsampling as an accurate approach for decentralised therapeutic drug monitoring.
Predictability of Capillary Blood Spot Toward Venous Whole Blood Sampling for Therapeutic Drug Monitoring of Tacrolimus in Solid Organ Transplant Recipients — Gallant et al., European journal of drug metabolism and pharmacokinetics (paywalled)
- blood
- dried
- capillary
- dbs
- validation
- venous-agreement
- pediatric
- tdm
- immunosuppressants
2019
Molecular tests that use urine or self-collected swabs may make STI screening more acceptable to patients, which could increase testing opportunities and enable faster, more accurate diagnosis and treatment of gonorrhoea, chlamydia, trichomoniasis, and Mycoplasma genitalium infection.
STI update: Testing, treatment, and emerging threats — Hlatshwayo et al., Cleveland Clinic journal of medicine (paywalled)
- urine
- self-collection
- acceptability
- sti
2019
Male fire and emergency service workers showed a lower cortisol awakening response and post-awakening cortisol levels the day after a night on-call with a call, likely due to noise, exertion and stress during callouts. This supports the use of decentralised saliva sampling to assess real-world physiological stress responses in working populations.
Salivary cortisol profiles of on-call from home fire and emergency service personnel — Hall et al., Stress (paywalled)
- saliva
- self-collection
- hormones
- cortisol
- actigraphy
- multimodal
2019
Isoelectric focusing from dried blood spot and capillary samples yields results identical to serum for transferrin glycosylation, with stable storage at -20 degrees Celsius for more than six months, enabling reliable diagnosis and therapy control of congenital disorders of glycosylation and supporting home self-collection for follow-up.
Transferrin glycosylation analysis from dried blood spot cards and capillary blood samples — Wolking et al., Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (paywalled)
- blood
- dried
- capillary
- dbs
- self-collection
- validation
- pediatric
2019
A social skills intervention programme delivered in child care centres produced a significant interaction with time of day for diurnal cortisol secretion in preschool children (p = 0.04), with the intervention group showing more typical decreasing cortisol patterns throughout the day. This demonstrates that saliva-based cortisol monitoring in decentralised settings can detect clinically meaningful changes in stress physiology among paediatric populations.
Impact of a social skills program on children's stress: A cluster randomized trial — Larose et al., Psychoneuroendocrinology (paywalled)
- saliva
- pediatric
- cortisol
2019
Treating first-void urine with Aptima Transfer Solution increased HPV mRNA positivity from about 21-28% to 34-46%, with good overall agreement (81.1%, kappa 0.63) compared with cervical samples; however, cervical specimens detected more HPV in women with abnormal cytology or histopathology, indicating that urine may be less sensitive in this subgroup.
Treatment of first-void urine with Aptima Transfer Solution increases detection of high-risk HPV E6/E7 mRNA — Arias et al., Journal of virological methods (paywalled)
- urine
- first-void
- validation
- hpv
- sti
2019
The assay quantifies salivary progesterone with a 5.5 min run time, LLOQ 20 pmol/L, CV and bias <11%, and mean recovery 91%, and it was applied to profile progesterone across the menstrual cycle and during the luteal phase in women, enabling high-throughput, home-based hormone monitoring.
A novel high-throughput assay for the measurement of salivary progesterone by liquid chromatography tandem mass spectrometry — Schiffer et al., Annals of clinical biochemistry (paywalled)
- saliva
- liquid
- validation
- fertility
- hormones
2019
Among 800 pregnant women in Vietnam, self-collection of urine or vaginal swabs for chlamydia, gonorrhoea and trichomonas screening proved highly acceptable and feasible, with chlamydia prevalence of 6.0%. This supports patient-centric decentralised STI screening in antenatal care, particularly in settings without established programmes.
Acceptability and feasibility of sexually transmissible infection screening among pregnant women in Hanoi, Vietnam — Nguyen et al., Sexual health (paywalled)
- urine
- self-collection
- acceptability
- sti
2019
In 152 low-income pregnant women, saliva self-collected at home by passive drool showed that higher mindfulness and social support correlated with lower perceived stress reactivity, yet the cortisol awakening response did not differ. This demonstrates that home saliva sampling is feasible for stress biomarker assessment in pregnancy, but psychological interventions may affect subjective stress ratings more than physiological cortisol levels.
The influence of mindfulness and social support on stress reactivity during pregnancy — Sanchez Hernandez et al., Stress and health : journal of the International Society for the Investigation of Stress (paywalled)
- saliva
- self-collection
- hormones
- cortisol
2019
Adverse childhood family environments were associated with lower resting blood pressure in women but not men, and home-collected saliva samples showed women had lower total cortisol output than men. This supports the use of self-collected saliva for investigating stress biomarkers in patient-centric cardiovascular research.
Associations between adverse childhood family environments and blood pressure differ between men and women — Schreier et al., PloS one
- saliva
- self-collection
- hormones
- cortisol
2019
In Shenzhen sexual and reproductive health clinics, 10.3% of attendees tested positive for Chlamydia trachomatis by NAAT on self-collected urine, with similar prevalence in men and women; younger age, prior never testing and co-infection with Neisseria gonorrhoeae were independent risk factors, indicating the need for comprehensive CT screening and treatment programmes.
Chlamydia trachomatis infection among patients attending sexual and reproductive health clinics: A cross-sectional study in Bao'an District, Shenzhen, China — Yan et al., PloS one
- urine
- self-collection
- sti
2019
Parents of hospitalised children had lower morning saliva cortisol levels on the ward than when self-sampling at home four weeks later, while postawakening cortisol and cortisol awakening response did not differ between settings. This demonstrates that self-collected saliva can capture setting-specific differences in stress biomarkers, supporting decentralised studies of caregiver wellbeing.
The cortisol response in parents staying with a sick child at hospital — Angelhoff et al., Nursing open
- saliva
- self-collection
- pediatric
- hormones
- cortisol
2019
First-void urine PCR showed strong correlations between Ureaplasma urealyticum and most bacterial vaginosis-associated bacteria in men with non-gonococcal urethritis. This indicates first-void urine can identify organisms potentially involved in male urethral inflammation, supporting its use for decentralised STI screening.
Detection of ureaplasmas and bacterial vaginosis associated bacteria and their association with non-gonococcal urethritis in men — Frølund et al., PloS one
- urine
- first-void
- sti
2019
The authors developed and validated an LC-MS/MS assay for THC, CBD and CBN from 20 µL VAMS blood samples with linear calibration curves and inter-day accuracies of 94.4 to 107 per cent, then applied it to a pediatric pharmacokinetic study, demonstrating that patient-centric microsampling can support decentralised therapeutic drug monitoring of cannabinoids in children.
A patient-centric liquid chromatography-tandem mass spectrometry microsampling assay for analysis of cannabinoids in human whole blood: Application to pediatric pharmacokinetic study — Moorthy et al., Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- pediatric
- tdm
2019
This review found that oral fluid and dried blood spot microsampling can detect hepatitis B virus serological and DNA markers with variable sensitivity ranging from 13 to 100 percent depending on collection method, study population, and assay used. These decentralised sampling approaches could increase access to hepatitis B screening in remote areas and high-risk groups.
Applicability of Oral Fluid and Dried Blood Spot for Hepatitis B Virus Diagnosis — Villar et al., Canadian journal of gastroenterology & hepatology
- blood
- saliva
- dried
- dbs
- validation
- serology
2019
Self-collected first-void urine and vaginal swabs performed at home showed high prevalence and perfect clinic concordance for Mycoplasma genitalium, Chlamydia trachomatis and Neisseria gonorrhoeae, enabling accurate decentralised STI testing.
Mycoplasma genitalium, Chlamydia trachomatis, and Neisseria gonorrhoeae Detected With Aptima Assays Performed on Self-Obtained Vaginal Swabs and Urine Collected at Home and in a Clinic — Chernesky et al., Sexually transmitted diseases (paywalled)
- urine
- first-void
- self-collection
- sti
2019
HPLC-MS/MS methods for midazolam and 1-OH midazolam in wet whole blood and dried blood collected on VAMS were developed and validated, meeting international guideline criteria; a strong correlation between wet and dry concentrations was observed, indicating VAMS is suitable for paediatric clinical studies.
Validation of methods for determining pediatric midazolam using wet whole blood and volumetric absorptive microsampling — Abu-Rabie et al., Bioanalysis (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- venous-agreement
- pediatric
- tdm
2019
Matched fingerstick capillary blood samples showed near-perfect agreement with venipuncture across anti-müllerian hormone, estradiol, FSH, LH, prolactin, testosterone, TSH and free T4, with correlations of 0.99–1.00 and minimal bias, supporting interchangeable use and enabling virtually painless at-home testing for fertility hormone assessment.
Concordance of Fingerstick and Venipuncture Sampling for Fertility Hormones — Burke et al., Obstetrics and gynecology (paywalled)
- blood
- capillary
- validation
- venous-agreement
- fertility
- hormones
2019
Evaluation of the cobas® TV/MG assay showed 100% sensitivity and at least 99.2% specificity for detecting Trichomonas vaginalis in urine and vaginal swabs. Self-collected vaginal swabs performed equivalently to clinician-collected samples, confirming the test supports decentralised, patient-centric STI screening.
<i>Trichomonas vaginalis</i> Detection in Female Specimens with cobas<sup>®</sup> TV/MG for use on the cobas<sup>®</sup> 6800/8800 Systems — Marlowe et al., European journal of microbiology & immunology
- urine
- self-collection
- validation
- sti
2019
In a fixed-sequence two-period Phase I study of 16 healthy volunteers taking sitagliptin, dried blood spot samples collected at home and digital adherence data captured via an electronic pill bottle were feasible and acceptable to participants. This supports patient-centric microsampling and remote monitoring for decentralised clinical trials, though the authors noted areas needing improvement.
Leveraging Digital Health Technologies and Outpatient Sampling in Clinical Drug Development: A Phase I Exploratory Study — Dockendorf et al., Clinical pharmacology and therapeutics
- blood
- dried
- dbs
- self-collection
- acceptability
- dct
2019
Volumetric absorptive microsampling (VAMS) using the Neoteryx Mitra device was validated for mitotane therapeutic drug monitoring across 1–50 mg/L, with acceptable haematocrit bias and one-week stability at room temperature. However, comparison with venous plasma showed poor correlation, suggesting home-based VAMS is of limited clinical value for mitotane unless a method-specific target range is established.
A method for the minimally invasive drug monitoring of mitotane by means of volumetric absorptive microsampling for a home-based therapeutic drug monitoring — Friedl et al., Analytical and bioanalytical chemistry (paywalled)
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- venous-agreement
- tdm
- oncology
2019
The prototype recombinase polymerase amplification assay detected chlamydia in urine and self-collected vulvovaginal swabs with sensitivity of at least 94.3% and specificity of 99.7–100%, and gonorrhoeae in urine with 100% sensitivity and specificity, delivering results in 15 minutes. This rapid, accurate performance comparable to standard NAATs suggests potential for decentralised STI screening to improve treatment and reduce transmission.
Diagnostic accuracy of a prototype rapid chlamydia and gonorrhoea recombinase polymerase amplification assay: a multicentre cross-sectional preclinical evaluation — Harding-Esch et al., Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
- urine
- self-collection
- validation
- sti
2019
The Colli-Pee device achieved very good to almost perfect agreement with clinic collected urine for chlamydia, gonorrhoea and mycoplasma testing, and participants found it feasible and convenient for home sampling, supporting its use for frequent STI screening in at-risk groups.
Evaluation of the 'Colli-Pee', a first-void urine collection device for self-sampling at home for the detection of sexually transmitted infections, versus a routine clinic-based urine collection in a one-to-one comparison study design: efficacy and acceptability among MSM in Belgium — De Baetselier et al., BMJ open
- urine
- first-void
- colli-pee
- self-collection
- acceptability
- sti
2019
The study developed and validated two LC-MS/MS methods for quantifying paracetamol in dried blood and dried cerebrospinal fluid using VAMS, showing acceptable precision and accuracy, limited haematocrit influence, and stability under various storage conditions, thus proving the utility of VAMS for CSF microsampling.
Volumetric absorptive microsampling as an alternative sampling strategy for the determination of paracetamol in blood and cerebrospinal fluid — Delahaye et al., Analytical and bioanalytical chemistry (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- haematocrit
2019
A web-based application that grades dried blood spot quality from smartphone photographs agreed with laboratory technicians in 90% of trained and 87% of untrained collections, raising usable sample rates for therapeutic drug monitoring from 80% to 96% in trained settings and from 42% to 88% in untrained settings. Patients rated the app as acceptable and completed the check in under two minutes, suggesting it could reduce sample rejection in decentralised settings.
Performance of a web-based application measuring spot quality in dried blood spot sampling — Veenhof et al., Clinical chemistry and laboratory medicine (paywalled)
- blood
- dried
- dbs
- self-collection
- acceptability
- tdm
2019
In this pilot study, a home-based urinary PDG test achieved 100% specificity and 85-88% sensitivity for confirming ovulation against serum progesterone. With half of participants finding the test easy to use, the results support further development of decentralised fertility monitoring, though a larger trial is needed for definitive validation.
Pilot observational prospective cohort study on the use of a novel home-based urinary pregnanediol 3-glucuronide (PDG) test to confirm ovulation when used as adjunct to fertility awareness methods (FAMs) stage 1 — Leiva et al., BMJ open
- urine
- self-collection
- acceptability
- fertility
- hormones
2019
Among gay and bisexual men, urine-based STI self-sampling was reported as easy by 99% of participants and rectal swab self-collection by 90%. Nearly all trusted their rapid HIV self-test results, with 94% reading them within the recommended 20-40 minute window, indicating high acceptability and reliability of home-based diagnostic testing for this population.
Gay and bisexual men's experiences using self-testing kits for HIV and rectal and urethral bacterial sexually transmitted infections: Lessons learned from a study with home-based testing — John et al., International journal of sexual health : official journal of the World Association for Sexual Health (paywalled)
- urine
- self-collection
- acceptability
- sti
2019
Guardian-collected capillary dried blood spots were feasible for home monitoring of lamotrigine, and for carbamazepine and valproic acid when conversion factors were applied, with only 4 of 190 comparisons risking a conflicting dose decision and negligible risk of patient harm. Levetiracetam DBS showed high variability against plasma and is recommended only for checking nonadherence, not for dose adjustment.
Dried Blood Spot Self-Sampling by Guardians of Children With Epilepsy Is Feasible: Comparison With Plasma for Multiple Antiepileptic Drugs — Linder et al., Therapeutic drug monitoring (paywalled)
- blood
- liquid
- dried
- capillary
- dbs
- self-collection
- validation
- venous-agreement
- pediatric
- tdm
2019
Users of an internet-based STI testing kit programme reported high satisfaction and many were repeat users. Both men and women preferred genital self-collected swabs to urine specimens, indicating strong patient acceptance of decentralised screening and demand for broader home-testing options.
An Analysis of User Survey Data for an Internet Program for Testing for Sexually Transmitted Infections, I Want the Kit, in Maryland and Washington, DC — Hogenson et al., Sexually transmitted diseases (paywalled)
- urine
- self-collection
- acceptability
- sti
2019
Human adenoviruses are frequently detected and isolated from first-void urine in patients with urethritis and can continue to be shed at high levels for up to 12 days after symptoms resolve, indicating prolonged viral excretion that matters for decentralised diagnostics.
Infectious human adenoviruses are shed in urine even after disappearance of urethral symptoms — Hanaoka et al., PloS one
- urine
- first-void
- serology
- sti
2019
In Ghana STI clinics, first-void urine NAAT showed that painful urination and urethral discharge were significantly associated with gonorrhoea, helping target testing and public health measures.
Risk factors associated with gonorrhea and chlamydia transmission in selected health facilities in Ghana — Dela et al., BMC infectious diseases
- urine
- first-void
- sti
2019
Microsampling with the Neoteryx Mitra device showed acceptable linearity and precision for cyclosporine A, everolimus, sirolimus and tacrolimus, and agreed closely with conventional venous extraction by Deming regression, supporting its use for decentralised immunosuppressant therapeutic drug monitoring.
Feasibility of Immunosuppressant Drug Monitoring by a Microsampling Device — Gruzdys et al., The journal of applied laboratory medicine (paywalled)
- blood
- vams
- neoteryx-mitra
- validation
- venous-agreement
- tdm
- immunosuppressants
2019
A urine progesterone self-test using a 5 μg/mL threshold confirmed ovulation in 82% of cycles, compared with 59% when a 7 μg/mL threshold was used. This pilot study shows that home-based urine testing can reliably detect luteal phase progesterone rise, supporting decentralised fertility monitoring.
Pilot Evaluation of a New Urine Progesterone Test to Confirm Ovulation in Women Using a Fertility Monitor — Bouchard et al., Frontiers in public health
- urine
- self-collection
- fertility
- hormones
2019
In ten healthy volunteers, radiprodil pharmacokinetics measured by Aqua-Cap™ Drummond microsampling closely matched conventional venous blood draws, whereas Mitra™ microsampling gave marginally lower exposure values. Both microsampling methods fell within the accepted bioequivalence range, indicating they could enable patient-centric therapeutic drug monitoring and future paediatric decentralised trials.
A pharmacokinetic study of radiprodil oral suspension in healthy adults comparing conventional venous blood sampling with two microsampling techniques — Sciberras et al., Pharmacology research & perspectives
- blood
- capillary
- vams
- neoteryx-mitra
- validation
- venous-agreement
- pediatric
2019
Mid-stream urine samples were significantly more accurate than first-void urine for point-of-care dipstick, microscopy and culture tests in diagnosing urinary tract infection in general practice, with error rates of 16% versus 23% for culture. A delay in analysis of up to four hours did not reduce test accuracy, which supports practical implementation in decentralised settings.
Sampling of urine for diagnosing urinary tract infection in general practice - First-void or mid-stream urine? — Pernille et al., Scandinavian journal of primary health care
- urine
- first-void
- validation
2019
Remote self-collected dried blood samples were more likely to be graded Good quality than in-clinic samples, with roughly 1.5 times higher odds of a Good grade, though response rates were lower for remote sampling.
Feasibility of Patient-Centric Remote Dried <i>Blood Sampling: The</i> Prediction, Risk, and Evaluation of Major Adverse Cardiac Events (PRE-MACE) Study — Fuller et al., Biodemography and social biology (paywalled)
- blood
- dried
- self-collection
- acceptability
2019
Subcutaneous testosterone undecanoate injection was equally acceptable to intramuscular injection despite causing more pain at 24 hours, with most men preferring the intramuscular route. Pharmacokinetic analysis using dried blood spots showed a later peak concentration after subcutaneous injection, but no clinically meaningful differences in overall exposure, suggesting subcutaneous administration is a viable alternative without dose adjustment.
Pharmacokinetics and Acceptability of Subcutaneous Injection of Testosterone Undecanoate — Turner et al., Journal of the Endocrine Society (paywalled)
- blood
- dried
- dbs
- acceptability
- hormones
- tdm
2019
In extremely preterm-born children, salivary cortisol and DHEA at age 6 correlated inversely with early postnatal growth measures and positively with systolic blood pressure, and DHEA was higher than in term-born children, suggesting perinatal programming of cardiometabolic risk.
Adrenal function links to early postnatal growth and blood pressure at age 6 in children born extremely preterm — Watterberg et al., Pediatric research
- saliva
- self-collection
- pediatric
- hormones
- cortisol
2019
Finger prick dried blood spots correlated strongly with venous whole blood for poly- and perfluoroalkyl substances, achieving Spearman coefficients between 0.72 and 0.97. The method requires only 30 μL of blood, enabling decentralised biomonitoring of environmental toxins with minimal burden.
Dried blood spots for reliable biomonitoring of poly- and perfluoroalkyl substances (PFASs) — Poothong et al., The Science of the total environment (paywalled)
- blood
- dried
- dbs
- validation
- venous-agreement
- toxicology
2019
This study demonstrates for the first time that HPV vaccine antibodies can be detected in first-void urine from young women, with levels correlating strongly to serum (Spearman r 0.64–0.88). This non-invasive approach could support large-scale epidemiological studies and vaccine monitoring, reducing the need for venous blood draws, though further optimisation and validation is needed.
First-void urine as a non-invasive liquid biopsy source to detect vaccine-induced human papillomavirus antibodies originating from cervicovaginal secretions — Van Keer et al., Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology (paywalled)
- urine
- first-void
- validation
- venous-agreement
- serology
- hpv
2019
VAMS capillary blood showed strong agreement with venous serum for measuring anti-influenza antibodies and remained stable for three weeks at room temperature. When volunteers performed finger-stick sampling at home, their results were highly consistent with on-site collection by study personnel.
Application of volumetric absorptive microsampling (VAMS) to measure multidimensional anti-influenza IgG antibodies by the mPlex-Flu assay — Wang et al., Journal of clinical and translational science
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- self-collection
- validation
- venous-agreement
- serology
2019
Non-tobacco users who attended six-hour e-cigarette events showed up to 13-fold increases in urinary cotinine and significant rises in salivary cotinine, both peaking four hours after exposure, with acrolein metabolites also increasing but tobacco-specific nitrosamines unchanged. The multi-timepoint collection of urine including first-void specimens and saliva demonstrates how exposure biomarkers can be tracked through biological samples collected outside a clinic setting.
A biomonitoring assessment of secondhand exposures to electronic cigarette emissions — Johnson et al., International journal of hygiene and environmental health (paywalled)
- saliva
- urine
- first-void
- toxicology
- biomarkers
2019
Mycoplasma genitalium infection persisted for a median of 143 days after syndromic treatment, with 62% of men harbouring macrolide resistance mutations. The findings highlight that first-void urine testing is needed to detect persistent infection and guide appropriate antibiotic therapy in decentralised sexual health settings.
Long Duration of Asymptomatic Mycoplasma genitalium Infection After Syndromic Treatment for Nongonococcal Urethritis — Romano et al., Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (paywalled)
- urine
- first-void
- sti
2019
The VAMS assay quantifies voriconazole and voriconazole N-oxide with linear calibration from 10.0 to 10,000 ng/mL and intra- and inter-day accuracy within 87-102%, enabling accurate and precise therapeutic drug monitoring from a small fixed volume of dried blood.
Development and validation of a volumetric absorptive microsampling assay for analysis of voriconazole and voriconazole N-oxide in human whole blood — Moorthy et al., Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- tdm
- antimicrobials
2019
Women showed elevated evening saliva cortisol and flattened diurnal variation with higher aircraft noise exposure, whereas morning cortisol and all measures in men were unchanged. These findings from self-collected samples demonstrate saliva can serve as a decentralised biomarker for environmentally driven hormonal dysregulation in large cohorts.
Saliva cortisol in relation to aircraft noise exposure: pooled-analysis results from seven European countries — Baudin et al., Environmental health : a global access science source
- saliva
- self-collection
- hormones
- cortisol
2019
Fingerprick dried blood spots showed analytical agreement with whole blood for sirolimus and everolimus in transplant patients, but only 77.3% and 61.5% of samples fell within the pre-defined 15% clinical relevance limit, missing the 80% target for both drugs. This suggests the method cannot yet replace conventional sampling for immunosuppressant monitoring without accepting less stringent clinical criteria, which constrains its use in decentralised diagnostics.
Clinical application of a dried blood spot assay for sirolimus and everolimus in transplant patients — Veenhof et al., Clinical chemistry and laboratory medicine (paywalled)
- blood
- dried
- dbs
- self-collection
- validation
- venous-agreement
- tdm
- immunosuppressants
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