The Library
1823 papers on microsampling and monitoring, each with a finding paraphrased to our standard and labelled in one vocabulary. Every entry links to a legitimate copy; nothing is copied from an abstract.
2 papers labelled “thyroid”, newest first.
2025
ETA guidelines for levothyroxine monotherapy in hypothyroidism
Task-force guideline on optimising levothyroxine monotherapy. After a change of dose it advises measuring free T4 and TSH at six weeks. It attributes the slow response to the long half-life of T4 and the delayed TSH reaction without giving either a number. On dosing routine, taking the tablet with breakfast produced the highest and most variable TSH of three regimens, while an hour before breakfast or at bedtime kept TSH inside the reference interval.
Centanni M, Duntas L, Feldt-Rasmussen U, Koehrle J, Peeters RP, Razvi S, Trimboli P, Virili C, European Thyroid Journal · source ↗
2015
Resting time and diurnal variation: TSH misclassification by time of day
In 20,019 outpatient TSH samples drawn between 07:00 and 15:00, mean TSH fell from 2.76 mIU/L at 07:00-09:00 to 2.22 mIU/L at 13:00-15:00, about 28% across the day, with the steepest decline before 09:00. Against the 4.0 mIU/L upper reference limit, 14.1% of patients were above it at 07:00-08:00 and 7.9% at 14:00-15:00, so 6.2% changed side of the decision limit on sampling time alone. Resting time before sampling had no clinically significant effect on TSH, albumin, calcium or sodium.
Andersen IB, Brasen CL, Christensen H, Noehr-Jensen L, Nielsen DE, Brandslund I, Madsen JS, PLoS One · source ↗
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