The Library
1530 papers on microsampling and monitoring, each with a finding paraphrased to our standard and labelled in one vocabulary. Every entry links to a legitimate copy; nothing is copied from an abstract.
Papers 801–900 of 1530, newest first.
2023
In women referred to colposcopy, self-collected urine and vaginal samples showed substantial to near-perfect concordance with clinician-collected cervical samples for detecting high-risk HPV (k=0.715 and k=0.898 respectively). This supports using patient-centric self-sampling to expand cervical cancer screening coverage and aligns with WHO elimination targets.
Accuracy of Human Papillomavirus (HPV) Testing on Urine and Vaginal Self-Samples Compared to Clinician-Collected Cervical Sample in Women Referred to Colposcopy — Martinelli et al., Viruses
- urine
- self-collection
- validation
- hpv
- sti
2023
Deprez et al. validated LC‑MS/MS methods for four immunosuppressants and creatinine from a single 10 μL quantitative dried blood spot. With biases under 10 % and CVs below 8 %, the approach enables accurate patient‑centric therapeutic drug monitoring from capillary blood at home, mitigating the haematocrit effect through volumetric collection.
Liquid chromatography-tandem mass spectrometry for therapeutic drug monitoring of immunosuppressants and creatinine from a single dried blood spot using the Capitainer® qDBS device — Deprez et al., Analytica chimica acta (paywalled)
- blood
- dried
- capillary
- qdbs
- volumetric
- validation
- tdm
- immunosuppressants
- haematocrit
2023
First-void urine is established as a reliable self-collected specimen for human papillomavirus screening, triage, and post-vaccination surveillance. The use of specialised collection devices and advanced molecular assays supports the integration of non-invasive sampling into routine cervical cancer prevention strategies.
Testing for Human Papillomaviruses in Urine, Blood, and Oral Specimens: an Update for the Laboratory — Poljak et al., Journal of clinical microbiology
- blood
- saliva
- urine
- first-void
- self-collection
- validation
- hpv
- sti
2023
High-performing dried blood spot assays have been developed and validated for measuring environmental exposures to tobacco smoke, trace elements, and several endocrine-disrupting chemicals, confirming the method as a viable minimally invasive alternative to venous sampling for field-based public health screening and paediatric epidemiological studies. Further validation is required for cadmium, arsenic, inorganic mercury, and bisphenol A to expand the panel of reliable decentralised exposure biomarkers.
A state-of-the-science review and guide for measuring environmental exposure biomarkers in dried blood spots — Jacobson et al., Journal of exposure science & environmental epidemiology
- blood
- dried
- dbs
- validation
- pediatric
- biomarkers
2022
A systematic review of 19,704 articles, analysing 45 trials and 117 documents, found wide heterogeneity in decentralised clinical trial designs. The authors caution that there is currently insufficient evidence to confirm which decentralised methods are most effective for trial recruitment, retention, or overall cost.
A systematic review of methods used to conduct decentralised clinical trials — Rogers et al., British Journal of Clinical Pharmacology (paywalled)
- dct
- validation
2022
An IQ Consortium position paper from sponsor scientists positioning patient-centric sampling as the enabling technology for decentralised trials, and stating that a bridging study against conventional sampling “has quickly been established as a regulatory expectation”.
Leveraging patient-centric sampling for clinical drug development and decentralized clinical trials: Promise to reality — Maass et al., Clinical and Translational Science
- blood
- dct
- standards
- self-collection
- validation
2022
A combined patient-preference and cost analysis of an at-home blood sampling device in chronic care, covering both what patients choose and what the shift costs the system.
The societal impact of implementing an at-home blood sampling device for chronic care patients: patient preferences and cost impact — Lingervelder et al., BMC Health Services Research
- economics
- acceptability
- self-collection
- blood
2022
A review of dried blood microsampling for tyrosine kinase inhibitor monitoring, covering the analytical and clinical requirements for moving oral cancer-drug TDM out of hospital.
Therapeutic Drug Monitoring of Tyrosine Kinase Inhibitors Using Dried Blood Microsamples — Verougstraete et al., Frontiers in Oncology
- blood
- dbs
- tdm
- self-collection
- haematocrit
- dried
- oncology
- pediatric
- validation
2022
A single VAMS run quantified two immunosuppressants plus creatinine with minimal haematocrit effect: combined drug-and-organ-function monitoring from one dried tip.
A VAMS UPLC-MS/MS Method for Simultaneous Quantification of Tacrolimus, Mycophenolic Acid and Creatinine in Whole Blood of Renal Transplant Recipients — Wang et al., Pharmaceutics
- vams
- venous-agreement
- acceptability
- blood
- tdm
- haematocrit
- dried
- immunosuppressants
- validation
2022
This review shows that patient-centric Mitra microsampling devices accurately collect fixed blood volumes for immunosuppressant monitoring, reducing haematocrit bias compared to classic dried blood spots. While ideal for paediatric adherence, wider decentralised adoption requires further multicentre validation and cross-laboratory harmonisation to address current analytical and cost limitations.
Volumetric Absorptive Microsampling in Therapeutic Drug Monitoring of Immunosuppressive Drugs — From Sampling and Analytical Issues to Clinical Application — Kocur & Pawiński, Int. J. Molecular Sciences
- vams
- neoteryx-mitra
- blood
- tdm
- haematocrit
- dried
- pediatric
- immunosuppressants
- validation
2022
The paper records that the TAP II devices used for the infant draws were provided by YourBio Health, and that capillary serum was collected from babies as young as two months: the smallest patients sampled, without a heel prick or a venepuncture.
Durability of anti-spike antibodies in infants after maternal COVID-19 vaccination or natural infection — Shook, Edlow et al., JAMA
- blood
- liquid
- yourbio
- capillary
- pediatric
- serology
2022
Patients self-collected upper-arm capillary blood with press-activated devices including TAP II; autoantibody and CRP results agreed with venous at r≥0.98, were rated less painful, and 98.6% got enough blood within two attempts.
Remote self-collection of upper-arm capillary blood for autoantibody analysis in immune-mediated rheumatic diseases — Zarbl et al., RMD Open
- venous-agreement
- acceptability
- blood
- self-collection
- capillary
- liquid
- yourbio
- biomarkers
2022
Capillary self-sampling gave CRP and autoantibody values nearly identical to venous, ICC 0.97–0.998, was less painful, and the upper-arm route drew far higher acceptance and willingness to sample at home.
Accuracy and tolerability of capillary self-sampling for inflammation and autoantibodies in rheumatoid arthritis: a randomized controlled trial — Knitza et al., Arthritis Research & Therapy
- blood
- liquid
- capillary
- self-collection
- venous-agreement
- acceptability
2022
The study established reference intervals for TSH in dried blood spots for both adults and neonates and defined a quantitative relationship between DBS and serum TSH levels. This allows DBS to be used as a viable, patient-centric alternative to venepuncture for thyroid function monitoring, particularly where venous sampling is difficult.
Adult and neonate TSH blood spot reference intervals — Morris et al., Annals of clinical biochemistry (paywalled)
- blood
- dried
- dbs
- validation
- venous-agreement
- pediatric
- hormones
2022
Female firefighters had lower anti-Müllerian hormone levels than matched non-firefighters, suggesting occupational exposures may affect ovarian reserve; this supports the feasibility of using dried blood spots for hormone measurement outside traditional labs.
Anti-Müllerian Hormone Levels among Female Firefighters — Davidson et al., International journal of environmental research and public health
- blood
- dried
- dbs
- fertility
- hormones
2022
A dissolvable wipe with DESS solution captured stool for metagenomics with high species-level agreement to frozen storage, R2 0.96, preserved Shannon diversity and species richness, and performed comparably to a commercial preservation kit, R2 0.98, enabling stable room temperature collection and transport for decentralised sampling.
A Wipe-Based Stool Collection and Preservation Kit for Microbiome Community Profiling — Hua et al., Frontiers in immunology
- stabilised
- self-collection
- microbiome
- stool
- validation
2022
In British Columbia, finger-prick dried blood spots had 97% specificity and 79% sensitivity for SARS-CoV-2 antibodies in unvaccinated groups, rising to 97 to 100% after vaccination, against serum; limited to one jurisdiction, the results support decentralised serosurveillance with self-collected dried blood spots.
Performance of Immunoglobulin G Serology on Finger Prick Capillary Dried Blood Spot Samples to Detect a SARS-CoV-2 Antibody Response — Nikiforuk et al., Microbiology spectrum
- venous-agreement
- blood
- dbs
- dried
- serology
- capillary
- pediatric
2022
The TAP device showed near perfect agreement with venous sampling for anti-Müllerian hormone measurements, with higher accuracy and lower pain compared to ADx card. This validates TAP as a reliable option for patient-led fertility hormone testing at home.
Evaluation of at-home serum anti-Müllerian hormone testing: a head-to-head comparison study — Silliman et al., Reproductive biology and endocrinology : RB&E
- blood
- capillary
- yourbio
- venous-agreement
- acceptability
- fertility
- hormones
2022
Saliva collected using the ORAcollect device demonstrated high specificity and negative predictive value for SARS-CoV-2 detection by RT-PCR, with some positive results suggesting an earlier detection window than nasopharyngeal swabs. Conversely, the evaluated rapid antigen tests showed unacceptably low sensitivity for screening purposes.
Evaluation of Saliva as a Matrix for RT-PCR Analysis and Two Rapid Antigen Tests for the Detection of SARS-CoV-2 — De Meyer et al., Viruses
- serology
- dna-genotek-oracollect
- liquid
- validation
- saliva
2022
A retrospective analysis of laboratory data found that adherence to a home-collected multi-target stool DNA test was 51.3% among Medicaid enrollees, 54.6% in Managed-Medicaid and 38.9% in Fee-For-Service. This shows that navigation-supported stool self-collection is a viable patient-centric option for decentralised screening, though the study was limited by its retrospective design.
Cross-sectional adherence with the multi-target stool DNA test for colorectal cancer screening in a medicaid population — Miller-Wilson et al., Preventive medicine reports
- stool
- self-collection
- colorectal
2022
The study demonstrated that a decentralised healthcare model using self-collected blood in stool tests achieved high adherence and early detection rates for colorectal cancer. It also showed a favourable cost-benefit ratio compared to the standard costs of treating advanced disease.
"CUIDARAS " : A Nominal and Personalized Health Care Model. Effectiveness of a Massive Screening for Colorectal Cancer Detection at Community level — Marin et al., The Gulf journal of oncology (paywalled)
- stool
- self-collection
- economics
- colorectal
2022
Glyphosate was quantifiable in 99.8% of first-void urine samples from 6848 French adults and children, with higher levels in men and children and lower levels associated with organic food intake and filtered water; occupational exposure was higher in farmers, indicating widespread environmental contamination relevant to decentralised exposure monitoring.
Quantifiable urine glyphosate levels detected in 99% of the French population, with higher values in men, in younger people, and in farmers — Grau et al., Environmental science and pollution research international
- first-void
- toxicology
- pediatric
- urine
2022
Clinical validation for tacrolimus and mycophenolic acid monitoring showed that while volumetric absorptive microsampling met analytical criteria after concentration correction, conventional dried blood spots achieved superior adherence to strict clinical criteria, sample quality, and cost efficiency without significant haematocrit bias.
Comparison of conventional dried blood spots and volumetric absorptive microsampling for tacrolimus and mycophenolic acid determination — Paniagua-González et al., Journal of pharmaceutical and biomedical analysis (paywalled)
- blood
- dried
- capillary
- vams
- dbs
- neoteryx-mitra
- self-collection
- validation
- venous-agreement
- tdm
- immunosuppressants
- economics
- haematocrit
2022
Validated a dried blood spot assay for tacrolimus and mycophenolic acid therapeutic drug monitoring and creatinine-based kidney function in kidney transplant recipients. DBS showed excellent agreement with venous sampling for tacrolimus trough and AUC, adequate agreement for creatinine-based GFR trend monitoring, but suboptimal agreement for mycophenolic acid AUC and inadequate performance for iohexol-based GFR. VAMS was generally inferior. This enables remote, simultaneous immunosuppressant and kidney function monitoring in outpatients, reducing clinic visits.
Volumetric microsampling for simultaneous remote immunosuppressant and kidney function monitoring in outpatient kidney transplant recipients — Zwart et al., British journal of clinical pharmacology
- blood
- dried
- vams
- dbs
- validation
- venous-agreement
- tdm
- immunosuppressants
2022
Home-collected first-void urine testing for high-risk HPV showed sensitivity equivalent to clinician-collected cervical samples for detecting CIN2+ and CIN3, but with marginally lower specificity. This supports urine self-sampling as a viable decentralised screening method to improve coverage among unscreened women.
Analytical and clinical performance of extended HPV genotyping with BD Onclarity HPV Assay in home-collected first-void urine: A diagnostic test accuracy study — Van Keer et al., Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology (paywalled)
- urine
- first-void
- colli-pee
- self-collection
- validation
- hpv
2022
The dried blood spot method via fingerprick showed greater variability than venipuncture for antipsychotic drug concentrations but was feasible in children and adolescents with behavioural problems, and higher risperidone trough concentrations correlated with both increased weight gain and greater effectiveness, enabling definition of a therapeutic window for safer dosing in this population.
[Improving the safety of antipsychotic drugs in children and adolescents by antipsychotic drug concentration measurements using a fingerprick] — Kloosterboer et al., Tijdschrift voor psychiatrie (paywalled)
- blood
- dried
- capillary
- dbs
- validation
- venous-agreement
- pediatric
- tdm
2022
Patients offered the 3-anatomic-site panel (urine, oropharynx and rectum) had higher odds of testing positive for chlamydia and gonorrhoea than those receiving usual care, suggesting that adding patient-collected rectal testing improves detection.
Patient Demographics and the Utilization of a Novel 3-Anatomic-Site Testing Panel Including Rectal Self-Collection as Compared With Usual Care Testing — Horberg et al., Sexually transmitted diseases (paywalled)
- urine
- self-collection
- sti
2022
Among 446 STI clinic attendees in British Columbia, 73% were willing to self-collect urine samples outside clinics, 67% throat swabs and 65% anogenital swabs. Willingness was higher in those aged 35–54 years and lower among heterosexual compared with gay and lesbian participants, suggesting decentralised self-collection is acceptable and could extend STI screening beyond clinical settings.
Attitudes and Preferences Regarding Non-Clinic-Based Self-Collection for Sexually Transmitted Infection Testing Among Clinic Attendees in British Columbia, Canada — Gottschlich et al., Sexually transmitted diseases (paywalled)
- urine
- self-collection
- acceptability
- sti
2022
Urine self-collection was acceptable to participants, but high-risk HPV mRNA detection in urine was less sensitive for high-grade cervical lesions than self- or provider-collected cervical samples. This suggests that while urine sampling may improve participation in decentralised screening programmes, it could miss more disease.
High-Risk Human Papillomavirus Messenger RNA Testing Using Urine, Cervicovaginal Self-Collected and Provider-Collected Cervical Samples Among Women in Mombasa, Kenya — Grabert et al., Sexually transmitted diseases (paywalled)
- urine
- self-collection
- acceptability
- hpv
- sti
2022
The pilot study provided evidence that a dry-stored, self-collected vaginal swab could assist detection of Chlamydia trachomatis when compared with clinician-collected discharge, first-catch urine and blood serology, potentially reducing privacy barriers and removing cold-chain requirements for screening in remote areas.
A pilot clinical validation study of a self-collected vaginal swab device for the detection of <i>chlamydia trachomatis</i> in women — Muljadi et al., Frontiers in bioengineering and biotechnology
- urine
- self-collection
- validation
- sti
2022
Pooled RT-qPCR of self-collected saliva from 824 asymptomatic employees identified two SARS-CoV-2 positives; one positive was detectable only by an amplification trend without a Ct value. A survey of 471 participants revealed that most would accept regular screening only if free or low-cost, supporting pooled saliva testing as a rapid, efficient, and inexpensive method for frequent large-scale decentralised screening.
SARS-CoV-2 RT-qPCR testing of pooled saliva samples: A case study of 824 asymptomatic individuals and a questionnaire survey in Japan — Oba et al., PloS one
- saliva
- self-collection
- acceptability
- serology
2022
A self-collection saliva funnel paired with CRISPR-Cas12a detection achieved 96.86% diagnostic accuracy for SARS-CoV-2 in 578 asymptomatic participants, showing decentralised active case finding is feasible for surveillance in low-resource settings.
COVID-19 active case findings based on self-collected saliva samples with CRISPR-Cas12a detection — Chantaravisoot et al., Experimental biology and medicine (paywalled)
- saliva
- self-collection
- validation
- serology
2022
Self‑collected nasal/oral swabs and saliva showed 77–87 per cent agreement with healthcare worker collection for SARS‑CoV‑2 detection by RT‑PCR, rising to 89 per cent for swabs when viral load was high. This demonstrates that self‑sampling can reliably support early COVID‑19 diagnosis in decentralised settings, reducing burden on healthcare workers.
Diagnostic Performance, Stability, and Usability of Self-Collected Combo Swabs and Saliva for Coronavirus Disease 2019 Diagnosis: A Case-Control Study — Choi et al., Infection & chemotherapy
- saliva
- self-collection
- acceptability
- serology
2022
Patients ranked pregnancy chance as the key facilitator for home-based LH urine testing in frozen embryo transfer cycles, while fear of missing ovulation was their main barrier. Healthcare providers agreed on pregnancy rates but cited laboratory capacity as their primary constraint, highlighting that decentralised fertility monitoring must address both patient confidence and system logistics to succeed.
Facilitators and barriers for home-based monitoring to time frozen embryo transfers in IVF among women and healthcare providers — Zaat et al., Human reproduction open
- urine
- acceptability
- fertility
- hormones
2022
This validation study demonstrated that pooled ddPCR detected SARS-CoV-2 in groups of 34 samples even when the sole positive specimen had a CT value up to 30. The approach can use saliva collected by patients themselves, which lessens risk to staff, and simple heat extraction cuts reagent costs, supporting decentralised screening programmes.
Practical considerations to establish a validated platform for pooled detection of SARS-CoV-2 by droplet digital PCR — Heckel et al., PloS one
- saliva
- self-collection
- validation
- serology
2022
Self-collected saliva and mid-turbinate nasal swabs showed greater than 95 per cent positive agreement with nasopharyngeal swabs for SARS-CoV-2 detection in children when collected within ten days of symptom onset, dropping to 82 per cent for later or asymptomatic cases. This validates less invasive, patient-centric sampling for decentralised diagnostics in pediatric populations.
Comparison of Mid-turbinate Nasal Swabs, Saliva, and Nasopharyngeal Swabs for SARS-CoV-2 Reverse Transcription-Polymerase Chain Reaction Testing in Pediatric Outpatients — Vos et al., Archives of pathology & laboratory medicine (paywalled)
- saliva
- self-collection
- validation
- pediatric
- serology
2022
Thirty-eight patients with rheumatic diseases showed high engagement with twice-daily smartphone symptom reporting (95% completion) and remote dried blood spot collection (84% returned samples, all viable for C-reactive protein analysis). Although symptoms varied considerably, clinically meaningful CRP changes were rare, confirming the feasibility of integrating microsampling with patient-generated health data in decentralised rheumatology research.
Remote sampling of biomarkers of inflammation with linked patient generated health data in patients with rheumatic and musculoskeletal diseases: an Ecological Momentary Assessment feasibility study — Druce et al., BMC musculoskeletal disorders
- blood
- dried
- dbs
- self-collection
- acceptability
- biomarkers
- rpm
- digital-biomarker
- multimodal
2022
The study demonstrates that fully remote clinical trials are feasible, as shown by a successful decentralised trial conducted during the pandemic. This supports the shift towards patient-centric, decentralised diagnostics by reducing the need for in-person visits.
Mental Health Clinical Research Innovations during the COVID-19 Pandemic: The Future Is Now — Ahern & Lenze, The Psychiatric clinics of North America
- dct
2022
Self collected saliva samples showed lower sensitivity (24.4 per cent) than conventional nasopharynx oropharynx swabs for COVID-19 RT-PCR detection, indicating limited utility for decentralised diagnostics without further optimisation.
Conventional Naso-Oropharyngeal Sampling Versus Self-Collected Saliva Samples in COVID-19 Testing — Bidkar et al., Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
- saliva
- self-collection
- validation
2022
Self-collected saliva on cotton showed substantial agreement with nasopharyngeal sampling for detecting SARS-CoV-2, achieving a kappa of 0.79. This supports decentralised screening in resource-limited settings without requiring trained staff.
Alternative SARS-CoV-2 detection protocol from self-collected saliva for mass diagnosis and epidemiological studies in low-incoming regions — de Oliveira et al., Journal of virological methods
- saliva
- self-collection
- validation
- serology
2022
In 1580 paired samples from children aged 3–17 years, saliva self-collection detected SARS-CoV-2 with 84.6% sensitivity compared with nasopharyngeal swabs, and identified eight infections missed by swabs alone. This less invasive approach offers a feasible alternative for decentralised diagnosis of COVID-19 in paediatric populations.
Salivary testing for SARS-CoV-2 in the pediatric population: a diagnostic accuracy study — Hua et al., CMAJ open
- saliva
- self-collection
- validation
- pediatric
- serology
2022
In 45 young adults, pre-pandemic diurnal cortisol output measured from saliva samples predicted the degree of loneliness increase during COVID-19 home confinement, with the relationship moderated by extraversion. This suggests saliva-derived cortisol is a viable biomarker for identifying at-risk individuals in decentralised public health crises monitoring.
Pre-pandemic Psychobiological Features Predict Impact of COVID-19 Confinement on Loneliness — Baliyan et al., Frontiers in psychology
- saliva
- self-collection
- hormones
- cortisol
2022
Self-collected saliva showed moderate sensitivity of 84.8% and high specificity of 98.2% for COVID-19 RT-PCR, with higher accuracy in symptomatic individuals. This supports saliva as a convenient, resource-sparing alternative to nasopharyngeal swabs for decentralised infectious-disease screening.
The diagnostic accuracy of RT-PCR from self-collected saliva versus nasopharyngeal sampling: A systematic review and meta-analysis — Kim et al., Saudi medical journal
- saliva
- self-collection
- validation
- serology
2022
Saliva microsampling by self-collection at home, returned by mail without refrigeration, achieved 95.8% sensitivity and 92.4% specificity for anti-spike IgG at 2-4 weeks after PCR diagnosis, matching serum test performance. This patient-centric approach offers a scalable framework for decentralised SARS-CoV-2 serosurveillance, with multiplex testing for endemic coronaviruses to flag samples needing retest.
Saliva-based SARS-CoV-2 serology using at-home collection kits returned via mail — Campbell et al., Scientific reports
- saliva
- self-collection
- validation
- serology
2022
Capillary blood self-testing using the Hem-Col device demonstrated excellent correlation (r=0.992) and perfect agreement (kappa=1) with venous blood for anti-SARS-CoV-2 antibodies. Feasibility was markedly lower in participants aged 65 or more, who successfully collected the recommended volume in 62.5% of cases versus 86.2% in younger adults, suggesting older people need additional support such as telephone guidance or assistance from family for home-based sampling to be reliable.
Feasibility of home-based ELISA capillary blood self-testing for anti-SARS-CoV-2 antibodies — Baggio et al., Practical laboratory medicine
- blood
- liquid
- capillary
- self-collection
- venous-agreement
- acceptability
- serology
2022
Most of the 16 endothelial and immune activation biomarkers remained stable when stored as dried blood spots at refrigeration temperature for up to three months, and storage at -80°C offered no clear advantage over -20°C for venous plasma aliquots; these practical storage conditions enable host biomarker testing in resource-limited and remote settings.
Practical Methods to Permit the Analysis of Host Biomarkers in Resource-Limited Settings — Chandna et al., The American journal of tropical medicine and hygiene
- blood
- dried
- dbs
- validation
- biomarkers
2022
In an unvaccinated adult cohort in British Columbia, at-home self-collected dried blood spots showed an overall SARS-CoV-2 seropositivity of 2.92%, with higher rates in participants identifying as visible minorities (5.1% vs 2.6%). After adjustment for age and sex, identifying as a visible minority remained the only significant factor associated with antibody detection. This demonstrates the feasibility of decentralised dried blood spot sampling for population serosurveys and highlights inequities that inform public health planning.
Seropositivity of SARS-CoV-2 in an unvaccinated cohort in British Columbia, Canada: a cross-sectional survey with dried blood spot samples — Racey et al., BMJ open
- blood
- dried
- dbs
- self-collection
- serology
2022
The study found comparable seropositivity for Chlamydia trachomatis and Toxoplasma gondii among male partners of infertile couples in Odisha, with 28 per cent showing anti-Chlamydia IgA and 28 per cent anti-Toxoplasma IgM antibodies. This demonstrates that first-void urine and seminal fluid can detect relevant infections, supporting their use in decentralised fertility screening programmes.
Seropositivity of <i>Chlamydia trachomatis & Toxoplasma gondii</i> among male partners of infertile couples in Odisha, India: A facility-based exploratory study — Naik et al., The Indian journal of medical research
- urine
- first-void
- fertility
- serology
- sti
2022
Women with chlamydial infection show reduced microbial diversity in first-void urine, with depletion of Mycoplasmataceae and Ureaplasma parvum and elevated hippurate and lactulose. This demonstrates that urine microbiome and metabolome analysis can reveal infection signatures, supporting decentralised STI screening approaches.
First-Void Urine Microbiome in Women with <i>Chlamydia trachomatis</i> Infection — Gaspari et al., International journal of molecular sciences
- urine
- first-void
- microbiome
- metabolome
- sti
2022
A validated LC-MS/MS assay for furosemide in whole blood collected with volumetric absorptive microsampling (10 µL) showed stability for 161 days when stored dried at -78°C, enabling decentralised therapeutic drug monitoring in neonates and children.
A whole blood microsampling furosemide assay: development, validation and use in a pediatric pharmacokinetic study — Bamat et al., Bioanalysis (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- pediatric
- tdm
2022
The study found that acetylsalicylic acid recovered poorly from VAMS blood samples dried at room temperature, reaching only about 31% of the concentration measured in venous control samples, but humidity-controlled drying raised recovery above 85%. A household vacuum sealer achieved adequate humidity control at home, supporting the feasibility of decentralised, patient-centric blood sampling for acetylsalicylic acid monitoring.
Stability of acetylsalicylic acid in human blood collected using volumetric absorptive microsampling (VAMS) under various drying conditions — Moon et al., Translational and clinical pharmacology
- blood
- dried
- vams
- neoteryx-mitra
- validation
- tdm
- dct
2022
LC-MS/MS assays successfully validated the quantitation of giredestrant in dried whole blood across 1 to 1000 ng/ml using Mitra and Tasso-M20 microsampling devices. Quantitation was unaffected by haematocrit, hyperlipidaemia or anticoagulants, with ambient stability documented for 84 days on Mitra and 28 days on Tasso-M20.
Volumetric absorptive microsampling-LC-MS/MS assays for quantitation of giredestrant in dried human whole blood — Johnson et al., Bioanalysis (paywalled)
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- tdm
- oncology
- haematocrit
2022
Women using a connected urine ovulation test in this home-based randomised trial achieved a live birth rate of 16.4% in the first cycle versus 8.5% in controls (odds ratio 2.12, p=0.001). The result demonstrates that decentralised hormone monitoring improves fertility outcomes, with 78% of all pregnancies ending in live birth.
Increased Chance of Live Birth Following Use of Connected Ovulation Test System: Outcome Results from a Randomized Controlled Trial — Johnson et al., Women's health reports
- urine
- self-collection
- fertility
- hormones
2022
An algorithm using the ratio of area under the curve for daily urinary E3G and PDG, together with a cycle-specific rise in PDG, correctly identified the luteal transition in all 78 cycles and predicted the start of the safe period from day +2 to +6 with a mean of 10.3 safe luteal days. This offers a practical, self-collection based approach to time the menstrual cycle for natural family planning and clinical assessment of ovarian function.
Algorithms with Area under the Curve for Daily Urinary Estrone-3-Glucuronide and Pregnanediol-3-Glucuronide to Signal the Transition to the Luteal Phase — Usala et al., Medicina
- urine
- self-collection
- fertility
- hormones
2022
Direct RT-PCR testing of raw saliva by two assays showed strong agreement with nasopharyngeal swab RT-PCR for SARS-CoV-2 detection in 615 symptomatic and asymptomatic individuals, with 51 of 52 TaqPath-positive saliva samples also positive by a second saliva assay and 49 concordant results against the swab-based reference, supporting saliva self-collection as a scalable, noninvasive alternative for population-scale diagnostic testing.
Clinical Performance of Direct RT-PCR Testing of Raw Saliva for Detection of SARS-CoV-2 in Symptomatic and Asymptomatic Individuals — Castillo-Bravo et al., Microbiology spectrum
- saliva
- liquid
- self-collection
- validation
- serology
2022
Self-collected saliva swabs showed 84.5% agreement with nasopharyngeal RT-PCR within seven days of symptom onset, and almost 500,000 saliva RT-PCR tests were performed on staff in quarantine hotels with a 0.004% positivity rate, supporting frequent, tolerable surveillance testing in high-risk settings.
Surveillance testing using salivary RT-PCR for SARS-CoV-2 in managed quarantine facilities in Australia: A laboratory validation and implementation study — Jenney et al., The Lancet regional health. Western Pacific
- saliva
- self-collection
- validation
- serology
2022
Among three home-use capillary HbA1c tests, only Home Access approached acceptable accuracy with 82% of results within 5% of venous reference values, while CoreMedica and A1cNow+ achieved just 29% and 46% respectively, all falling short of the 90% standard. This demonstrates that most current home-use glycaemic tests lack the accuracy needed for reliable decentralised diabetes monitoring.
Accuracy of Three Commercial Home-Use Hemoglobin A1c Tests — Jacobsen et al., Diabetes technology & therapeutics (paywalled)
- blood
- liquid
- capillary
- self-collection
- validation
- venous-agreement
2022
Neoteryx Mitra sticks and Noviplex cards agreed more closely with venous plasma and gave more repeatable N-glycoprofiling results than dried blood spots, with relative deviance from plasma of 0.092 and 0.069 respectively compared with 0.674 for dried blood spots, and coefficient of variation values of 7.098 per cent and 4.831 per cent against 14.305 per cent for dried blood spots. The findings support these self-sampling devices for decentralised glycoanalysis, though the authors call for larger cohort validation.
Comparison of self-sampling blood collection for N-glycosylation analysis — Cvetko et al., BMC research notes
- blood
- dried
- capillary
- vams
- dbs
- neoteryx-mitra
- validation
- venous-agreement
2022
In a Senegalese validation study of 192 infant samples, the Xpert HIV-1 Qual and m-PIMA HIV 1/2 Detect point-of-care assays showed 100% sensitivity and specificity for HIV-1 detection with both dried blood spots and whole blood, achieving perfect agreement with reference laboratory methods. This supports decentralised early infant diagnosis in resource-limited settings, reducing turnaround time and improving linkage to care.
Validation of the point-of-care (POC) technologies Xpert HIV-1 Qual and m-PIMA HIV 1/2 detect for early diagnosis of HIV-1 and HIV-2 in Senegal — Ndoye et al., The Pan African medical journal
- blood
- dried
- dbs
- validation
- pediatric
- serology
2022
Dried blood spot sampling achieved 99% overall assay accuracy with sensitivities from 87.5% to 100% and specificities above 99.2% across vulnerable remote, occupational and clinical groups, enabling decentralised HCV diagnosis with virtually painless capillary collection.
Feasibility of dried blood spot for hepatitis C diagnosis in vulnerable subjects and people living in remote areas from Brazil — Villar et al., BMC infectious diseases
- blood
- dried
- dbs
- validation
- serology
2022
Non-invasive self-sampling of anal colorectal mucus following defecation provides a patient-acceptable alternative to traditional stool collection for diagnosing colorectal cancer and inflammatory bowel disease. This emerging approach allows reliable measurement of diagnostic biomarkers to improve screening compliance.
Emerging role of colorectal mucus in gastroenterology diagnostics — Nooredinvand & Poullis, World journal of gastroenterology
- self-collection
- acceptability
- colorectal
- biomarkers
2022
Among 1,082 participants, self-collection of saliva and anterior nasal swabs for SARS-CoV-2 testing was highly feasible with near-universal specimen submission, and at least 79% rated the process favourably for ease and comfort. With no clear preference between saliva and nasal swabs, the study supports both as viable options for decentralised infectious disease screening.
Specimen self-collection for SARS-CoV-2 testing: Patient performance and preferences-Atlanta, Georgia, August-October 2020 — O'Laughlin et al., PloS one
- saliva
- self-collection
- acceptability
- serology
2022
Teleconsent was perceived as more convenient than in-person consent with similar security and satisfaction, and achieved faster recruitment and fewer dropouts, supporting its use in decentralised trials.
Participant comprehension and perspectives regarding the convenience, security, and satisfaction with teleconsent compared to in-person consent: A parallel-group pilot study among Danish citizens — Nyholm Gaarskjær et al., Contemporary clinical trials communications
- acceptability
- dct
2022
Self-collected urine NAAT detected a 9.0% prevalence of Chlamydia trachomatis among 8324 clinic attendees in Southern China, with higher rates in men, indicating that urine based self-collection can support STI screening and targeted public health interventions.
High chlamydia infection and its associated factors among patients seeking clinic-based STI services in Southern China: A preliminary cross-sectional study — Wang et al., Frontiers in public health
- urine
- self-collection
- sti
2022
A bean extract-based gargle solution for saliva collection, paired with rapid antigen tests, achieved 97.8 per cent sensitivity and 100 per cent specificity for SARS-CoV-2 in patients within six days of illness, matching the performance of RT-PCR on the same gargle specimens and detecting all asymptomatic cases. The method supports noninvasive self-collected COVID-19 screening as an alternative to nasopharyngeal swabs.
Bean Extract-Based Gargle for Efficient Diagnosis of Active COVID-19 Infection Using Rapid Antigen Tests — Kwon et al., Microbiology spectrum
- saliva
- self-collection
- validation
2022
The SSf-COVID19 kit using self-collected saliva showed high sensitivity and specificity for detecting SARS-CoV-2, making it a reliable option for decentralised diagnostics. This supports the use of patient-centric microsampling in clinical settings where access to phlebotomy or nasopharyngeal swabbing is limited.
Clinical application of the Panbio™ COVID-19 Ag rapid test device and SSf-COVID19 kit for the detection of SARS-CoV-2 infection — Oh et al., BMC research notes
- saliva
- self-collection
- validation
- serology
2022
Paired saliva and nasopharyngeal swab samples from 299 individuals in Nigeria showed 67% positive agreement and 97% negative agreement for SARS-CoV-2 RT-PCR detection, with positive and negative predictive values of 69% and 96% respectively. The findings support drooling saliva as a self-collectable alternative to nasopharyngeal swabs for mass COVID-19 testing, reducing exposure risk and cost while enabling decentralised sampling.
Saliva sample for detection of SARS-CoV-2: A possible alternative for mass testing — Salu et al., PloS one
- saliva
- self-collection
- validation
- serology
2022
Self-collected saliva had lower sensitivity than pharyngeal swabs for COVID-19 RT-PCR and showed only fair agreement, yet it detected additional positive cases and can be used alongside pharyngeal swabs to increase case detection in decentralised settings.
The role of saliva PCR assay in the diagnosis of COVID-19 — Abdollahi et al., Journal of infection in developing countries (paywalled)
- saliva
- self-collection
- validation
- serology
2022
Volumetric Absorptive Microsampling (VAMS) using Neoteryx Mitra devices yields equivalent results to conventional serum samples for aflatoxin B1-lysine analysis when samples are digested with sufficient Pronase at 50 °C. This enables reliable public health exposure assessment from self-collected dried blood samples.
Optimization of Aflatoxin B<sub>1</sub>-Lysine Analysis for Public Health Exposure Studies — Renaud et al., Toxins
- blood
- dried
- vams
- neoteryx-mitra
- validation
- toxicology
2022
The study found that automating sample preparation for tacrolimus testing on VAMS devices reduced operator time and improved workflow consistency without compromising agreement with manual methods. This supports the scalability of decentralised therapeutic drug monitoring using patient-centric microsampling.
Automation of tacrolimus measurement on volumetric absorptive microsampling devices by tandem mass spectrometry — Carling et al., Bioanalysis (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- tdm
- immunosuppressants
2022
The hemaPEN device demonstrated linear measurement of cocaine and metabolites in capillary blood with acceptable precision and accuracy, and analytes remained stable for seven days within the device. While haematocrit affected accuracy, it stayed within acceptable limits, suggesting the device could improve decentralised toxicology screening compared with conventional dried blood spot collection.
Evaluation of hemaPEN<sup>®</sup> sampling device for measurement of cocaine and metabolites in capillary blood by LC-MS/MS — Smidt et al., Bioanalysis (paywalled)
- blood
- dried
- capillary
- validation
- haematocrit
- toxicology
2022
In a large decentralised hypertension trial of 21,104 adults, nearly half used their own home blood pressure monitors for remote monitoring, but 18.7% of identifiable devices lacked validation against standardised protocols despite costing substantially less than validated models. This reveals a critical gap in device quality for decentralised trials relying on patient-owned equipment.
Home blood pressure monitors owned by participants in a large decentralised clinical trial in hypertension: the Treatment In Morning versus Evening (TIME) study — Anbarasan et al., Journal of human hypertension
- dct
- rpm
2022
Citation network and regulatory analysis shows that Internet of Medical Things technologies, particularly telemedicine and remote monitoring across neurology and psychology, are increasingly positioned for adoption in decentralised clinical trials under evolving regulatory frameworks.
Application of Internet of Medical/Health Things to Decentralized Clinical Trials: Development Status and Regulatory Considerations — Sato et al., Frontiers in medicine
- dct
- standards
- rpm
2022
In a rural Ecuadorian community, both urine and vaginal self-sampling for HPV testing were rated as more comfortable, more private, less painful and less difficult than clinician sampling. Vaginal self-sampling was the overall preferred method, suggesting that community training could increase uptake of decentralised cervical cancer screening.
Evaluation of Urine and Vaginal Self-Sampling versus Clinician-Based Sampling for Cervical Cancer Screening: A Field Comparison of the Acceptability of Three Sampling Tests in a Rural Community of Cuenca, Ecuador — Vega Crespo et al., Healthcare
- urine
- self-collection
- acceptability
- hpv
- sti
2022
A national survey of 1,505 US adults found that 34% prioritised testing comfort, preferring saliva over nasal swab, while 20% avoided COVID-19 testing entirely. Offering at-home saliva tests with monetary incentives increased willingness to test among those who initially avoided testing or sought convenience, suggesting that patient-centric design can improve uptake of decentralised diagnostic programmes.
Preferences Toward COVID-19 Diagnostic Testing Features: Results From a National Cross-Sectional Survey — Katare et al., American journal of health promotion : AJHP (paywalled)
- saliva
- self-collection
- acceptability
2022
Salivary glucocorticoid concentrations were comparable across Salivette Cortisol, passive drool and SalivaBio collection methods, and remained stable for 72 hours at room temperature and 4 degrees Celsius with no significant degradation after repeated freeze-thaw cycles. In children under six years, the SaliPac pacifier swab was well tolerated and collected sufficient saliva for steroid analysis in under four minutes.
Salivary Steroid Collection in Children Under Conditions Replicating Home Sampling — Tonge et al., The Journal of clinical endocrinology and metabolism (paywalled)
- saliva
- liquid
- self-collection
- validation
- acceptability
- pediatric
- hormones
- cortisol
2022
Dried blood spot sampling achieved high sensitivity and specificity for SARS-CoV-2 antibody detection with strong correlation to paired serum, enabling virtually painless, decentralised specimen collection in community and remote settings where venepuncture is difficult.
Evaluation of serological assays for SARS-CoV-2 antibody testing from dried blood spots collected from cohorts with prior SARS-CoV-2 infection — Catlett et al., Journal of clinical virology plus
- blood
- dried
- capillary
- dbs
- self-collection
- validation
- venous-agreement
- serology
2022
A capture ELISA on dried blood spot eluates detected SARS-CoV-2 IgG and IgM with 97.9% sensitivity and 99.2% specificity compared with serum, showed strong correlation (r=0.81), and remained stable even when samples were deliberately rendered inadequate or accidentally damaged; all vaccine recipients were seropositive, supporting the use of DBS self-sampling for decentralised seroprevalence studies and post-vaccine response monitoring.
Simple, sensitive, specific self-sampling assay secures SARS-CoV-2 antibody signals in sero-prevalence and post-vaccine studies — Khan et al., Scientific reports
- blood
- dried
- dbs
- self-collection
- validation
- venous-agreement
- serology
2022
The study found that higher urinary levels of certain pesticide metabolites were significantly associated with increased risk of acute lower and upper respiratory infections in children under five, particularly in those older than two years. This supports the use of decentralised urine microsampling for environmental exposure and child health studies.
Urinary Pesticide Residual Levels and Acute Respiratory Infections in Children Under 5 Years of Age: Findings From the Offinso North Farm Health Study — Akyeampong et al., Environmental health insights
- urine
- first-void
- pediatric
- toxicology
2022
In simulations of a chronic weight-management trial, a mixed data-collection strategy where onsite visits for primary endpoints are supplemented by decentralised measurements at intermediate visits yielded unbiased estimates and valid inference at the key time points despite added variability or bias in the decentralised data. This suggests hybrid designs can cut patient burden while safeguarding statistical integrity for main trial outcomes.
Impact of Using A Mixed Data Collection Modality on Statistical Inferences in Decentralized Clinical Trials — Curtis & Qu, Therapeutic innovation & regulatory science
- dct
2022
At a rural Ugandan HIV clinic, most women preferred nurse-led cervical screening to urine HPV self-sampling, yet self-collection proved feasible and detected high HPV prevalence, indicating that decentralised screening programmes must address acceptability through patient-centric education.
The preference of women living with HIV for the HPV self-sampling of urine at a rural HIV clinic in Uganda — Nyabigambo et al., Southern African journal of infectious diseases
- urine
- self-collection
- acceptability
- hpv
- sti
2022
Dried blood spots collected from 272 community participants were successfully analysed for dengue, scrub typhus and leptospirosis IgG, yielding seroprevalences of 7.0%, 4.0% and 5.9% respectively and providing the first evidence of scrub typhus and leptospirosis transmission in Timor-Leste; DBS offers a practical, decentralised approach for integrated serological surveillance with minimal additional fieldwork costs.
Integrated serological surveillance of acute febrile illness in the context of a lymphatic filariasis survey in Timor-Leste: a pilot study using dried blood spots — Arkell et al., Transactions of the Royal Society of Tropical Medicine and Hygiene
- blood
- dried
- dbs
- validation
- serology
2022
First-void urine sampling detected Mycoplasma genitalium in 8% of 493 men with non-gonococcal urethritis at a Hong Kong STI clinic. With antimicrobial-resistance mutations in 63% of isolates, including dual-class resistance in 37%, the results support decentralised screening to guide therapy.
Emergence of antibiotic-resistant Mycoplasma genitalium as the cause of non-gonococcal urethritis in male patients at a sexually transmitted infection clinic — Lee et al., International journal of antimicrobial agents (paywalled)
- urine
- first-void
- sti
2022
The study developed and validated a laboratory technique to accurately quantify tacrolimus and mycophenolic acid from the Neoteryx Mitra device in human whole blood, supporting its use for home-based therapeutic drug monitoring in transplant patients.
Application of a new volumetric microsampling device for quantitative bioanalysis of immunosuppression — Leino et al., Bioanalysis (paywalled)
- blood
- dried
- vams
- tdm
- immunosuppressants
2022
The authors validated an LC-MS and LC-MS/MS method for quantifying axitinib from 10 microlitre capillary blood collected by VAMS, demonstrating within- and between-run precision within 14% CV and accuracy between 81 and 116% against plasma as the gold standard, making the approach suitable for therapeutic drug monitoring in ambulatory and clinical care.
Development and validation of a bioanalytical method for the quantification of axitinib from plasma and capillary blood using volumetric absorptive microsampling (VAMS) and on-line solid phase extraction (SPE) LC-MS — Opitz et al., Journal of pharmaceutical and biomedical analysis (paywalled)
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- venous-agreement
- tdm
- oncology
2022
The study developed and validated a UPLC-MS/MS assay using volumetric absorptive microsampling to measure cyclophosphamide and 4-hydroxycyclophosphamide, achieving lower limits of quantification of 5 ng/mL for cyclophosphamide and 2.5 ng/mL for the metabolite and meeting FDA validation criteria, which supports decentralised therapeutic drug monitoring in oncology.
Development and validation of a UPLC-MS/MS method with volumetric absorptive microsampling to quantitate cyclophosphamide and 4-hydroxycyclophosphamide — Harahap et al., Frontiers in pharmacology
- blood
- dried
- vams
- validation
- tdm
- oncology
2022
The authors validated a quadratic calibration model for automated UV-Vis-based haematocrit prediction from dried blood spots, achieving bias below 0.025 L L-1 and total precision of 2.7%. In therapeutic drug monitoring of tacrolimus, predicted haematocrit values showed good concordance with reference Sysmex measurements, supporting the use of this patient-centric microsampling approach for decentralised immunosuppressant monitoring.
In-depth evaluation of automated non-contact reflectance-based hematocrit prediction of dried blood spots — Boffel et al., The Analyst (paywalled)
- blood
- dried
- dbs
- validation
- tdm
- immunosuppressants
- haematocrit
2022
An end-to-end remote digital protocol using the Current Health wearable and platform achieved rapid deployment and moderate adherence, capturing continuous pulse rate, respiratory rate, SpO2, skin temperature and step count alongside tablet-administered symptom surveys; vital signs remained within normal ranges and symptoms decreased over the 30-day period, demonstrating feasibility and clinical-grade signal quality for decentralised monitoring.
Deployment of an End-to-End Remote, Digitalized Clinical Study Protocol in COVID-19: Process Evaluation — Zahradka et al., JMIR formative research
- dct
- wearable
- rpm
- digital-biomarker
2022
Urine testing for high-risk HPV achieved 86.2% sensitivity for detecting high-grade cervical lesions, slightly below the 94.8% sensitivity of cervical samples, while patient satisfaction was significantly higher with self-collected urine. High agreement for HPV 16/18 genotypes between the two methods supports urine as a viable alternative for decentralised cervical screening.
A comparison of high-risk human papillomavirus DNA detection between urine and cervical sample testing in women with abnormal Pap smears — Punyashthira et al., The journal of obstetrics and gynaecology research (paywalled)
- urine
- self-collection
- acceptability
- hpv
- sti
2022
Female night-shift nurses had significantly lower cortisol awakening response and lower cortisol levels 30 minutes after waking compared with day- and evening-shift nurses, and reported greater stress from inability to complete personal tasks. This suggests shift pattern affects HPA axis activity and may inform risk assessment and support for shift workers.
Cortisol Awakening Response and Stress in Female Nurses on Monthly Shift Rotations: A Longitudinal Study — Lin et al., BioMed research international
- saliva
- self-collection
- hormones
- cortisol
2022
A two‑tier decentralised testing strategy using self‑collected saliva pools detected SARS‑CoV‑2 with higher sensitivity than a commercial IVD RT‑qPCR test and enabled identification of asymptomatic cases at lower cost.
RT-qPCR-based tests for SARS-CoV-2 detection in pooled saliva samples for massive population screening to monitor epidemics — Różański et al., Scientific reports
- saliva
- self-collection
- validation
- economics
- serology
2022
Among 1040 Polish healthcare workers tested before vaccine availability, 25.2% were seropositive for SARS-CoV-2 antibodies using a two-step protocol of capillary blood rapid screening followed by venous confirmation. This demonstrates capillary sampling as a feasible approach for decentralised infectious disease surveillance in occupational health settings.
Healthcare workers highly affected during the COVID-19 epidemic wave in Poland prior to vaccination availability: seroprevalence study — Rosińska et al., Medycyna pracy (paywalled)
- blood
- liquid
- capillary
- serology
2022
Among asymptomatic individuals with gonorrhoea, 71.3% of infections were pharyngeal and 23.1% rectal, with only 4.7% genital. The study evaluated culture recovery from self-collected first-void urine and swabs, demonstrating that decentralised screening must address extragenital sites to enable antimicrobial susceptibility testing.
Neisseria gonorrhoeae culture growth rates from asymptomatic individuals with a positive nucleic acid amplification test — Nadal-Baron et al., Letters in applied microbiology (paywalled)
- urine
- first-void
- serology
- sti
2022
Capillary VAMS combined with direct mercury analysis demonstrated strong correlation with venous blood mercury concentrations in adult volunteers, with acceptable accuracy and precision above 1.0 µg/l. Storage in pre-cleaned glass vials following two hours of desiccator drying maintained analyte stability for at least four weeks.
Mercury biomonitoring in German adults using volumetric absorptive microsampling — Koutsimpani-Wagner et al., Environmental monitoring and assessment
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- venous-agreement
- toxicology
2022
The LC-MS/MS assay for uracil was validated with good accuracy and precision, and uracil concentrations measured in Tasso-SST capillary serum correlated highly with venous plasma (rs 0.910), indicating that capillary microsampling can reliably identify patients with DPD deficiency for safer fluoropyrimidine dosing.
Evaluation of the Tasso-SST® capillary blood microsampling device for the measurement of endogenous uracil levels — Menestrina Dewes et al., Clinical biochemistry (paywalled)
- blood
- liquid
- capillary
- validation
- venous-agreement
- oncology
2022
AI analysis of salivary crystallisation patterns from self-collected saliva predicted delivery dates with high accuracy in a small cohort, offering a virtually painless home monitoring option for pregnant women that could support decentralised antenatal care.
AI Aided Analysis on Saliva Crystallization of Pregnant Women for Accurate Estimation of Delivery Date and Fetal Status — Li et al., IEEE journal of biomedical and health informatics (paywalled)
- saliva
- self-collection
2022
Self-collected dried blood spots enabled a mail-based SARS-CoV-2 serology survey among university affiliates, demonstrating practical feasibility but highlighting challenges in remote recruitment, supply chain constraints, potential sample bias and policy barriers to returning results. Key lessons include the need for clear participant instructions, robust logistics, household data linkage and on-call clinical support to ensure successful decentralised diagnostics.
Optimizing the implementation of a participant-collected, mail-based SARS-CoV-2 serological survey in university-affiliated populations: lessons learned and practical guidance — Cramer et al., BMC public health
- blood
- dried
- dbs
- self-collection
- acceptability
- serology
2022
Finger-prick dried blood spots from 60 individuals provided sufficient sample for chromatographic determination of 20 amino acids, 5 keto acids and 24 fatty acids, with several analytes showing significant gender and age dependencies. This validates home self-collection for metabolic screening as a viable alternative to venous blood draw in decentralised diagnostics.
Dried blood spot as an alternative sample for screening of fatty acid, amino acid, and keto acid metabolism in humans — Laštovičková et al., Biomedical chromatography : BMC (paywalled)
- blood
- dried
- dbs
- self-collection
- validation
- metabolome
2022
In men with urinary symptoms, first-void urine multiplex PCR detected Gardnerella vaginalis in 15.9%, making it the most common pathogen, and it often co-occurred with other agents; including G. vaginalis in panels can increase detection of causes of unexplained urinary or urethral symptoms.
<i>Gardnerella vaginalis</i>: Is it an Underestimated Cause of Urinary Symptoms in Males? — Kılıç et al., Infectious diseases & clinical microbiology
- urine
- first-void
- sti
2022
Among 246 asymptomatic undergraduate students, 12.2% had Trichomonas vaginalis infection when tested by TV in-pouch versus 8.5% by wet preparation, indicating higher sensitivity of the in-pouch method and supporting screening of young people for this common STI.
<i>TRICHOMONAS</i> VAGINALIS INFECTION AMONG ASYMPTOMATIC UNDERGRADUATE STUDENTS IN A PRIVATE UNIVERSITY IN OGUN STATE, NIGERIA — Ajani et al., Annals of Ibadan postgraduate medicine
- urine
- first-void
- sti
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