The Library
1530 papers on microsampling and monitoring, each with a finding paraphrased to our standard and labelled in one vocabulary. Every entry links to a legitimate copy; nothing is copied from an abstract.
Papers 701–734 of 734 labelled “self-collection”, newest first.
2016
In a cross-sectional study across public health testing sites, Chlamydia prevalence was 5.3% in women, 3.2% in heterosexual men and 3.5% in MSM, with the highest rates in women and heterosexual men aged 18-24; most positive cases were asymptomatic. The findings support routine Chlamydia testing for women under 30 and heterosexual men under 25 in HIV testing settings, to detect asymptomatic infection.
Prevalence of Chlamydia trachomatis infection in women, heterosexual men and MSM visiting HIV counselling institutions in North Rhine-Westphalia, Germany - should Chlamydia testing be scaled up? — Lallemand et al., BMC infectious diseases
- urine
- self-collection
- sti
2016
Urine self-samples showed good agreement with cervical samples for HPV DNA detection (κ=0.65) and viral load correlation (ρ=0.676), with stronger correlation in severe lesions. This supports urine sampling as a valid alternative for decentralised follow-up of HPV intervention trials and screening programmes, enabling home-based monitoring without clinic visits.
Long-Term Follow-up of HPV Infection Using Urine and Cervical Quantitative HPV DNA Testing — Vorsters et al., International journal of molecular sciences
- urine
- self-collection
- validation
- hpv
- sti
2016
Internet-using men who have sex with men returned 82% of mailed at-home dried blood spot HIV test kits, but black non-Hispanic men had roughly half the odds of returning a kit compared with white men. The study shows strong willingness to use decentralised HIV testing while flagging equity gaps that could limit access for minority groups.
Factors Associated with Returning At-Home Specimen Collection Kits for HIV Testing among Internet-Using Men Who Have Sex with Men — Ricca et al., Journal of the International Association of Providers of AIDS Care (paywalled)
- blood
- dried
- dbs
- self-collection
- acceptability
- serology
2016
Among 780 sub-Saharan African migrants attending community outreach sessions in Antwerp, 18.2% underwent HIV testing via oral fluid self-sampling, with 78.9% collecting their results (56.3% via a secure website). Acceptance was higher among women and in church settings with engaged community leaders, demonstrating that decentralised, patient-centric screening can overcome cultural barriers and reach underserved populations who avoid blood draws.
Acceptability of a Community-Based Outreach HIV-Testing Intervention Using Oral Fluid Collection Devices and Web-Based HIV Test Result Collection Among Sub-Saharan African Migrants: A Mixed-Method Study — Loos et al., JMIR public health and surveillance
- saliva
- self-collection
- acceptability
- serology
- sti
2016
In patients coinfected with Chlamydia trachomatis and Neisseria gonorrhoeae, median time to clearance after treatment was 7 days for RNA and 6 days for DNA, with 95 per cent clearing RNA by day 13 and DNA by day 14; the authors recommend performing a test of cure at least 14 days after starting treatment, as a positive result shortly after is likely a blip rather than treatment failure or reinfection.
Time to clearance of Chlamydia trachomatis RNA and DNA after treatment in patients coinfected with Neisseria gonorrhoeae - a prospective cohort study — Wind et al., BMC infectious diseases
- urine
- self-collection
- sti
2016
Young female cancer survivors aged 18 to 44 can successfully self-collect dried blood spot samples at home, with 91% submitting specimens adequate for AMH assay. This demonstrates feasibility of patient-centric, decentralised monitoring of ovarian reserve in geographically dispersed populations, though generalisability may be limited to highly educated, higher-income groups.
Self-collected dried blood spots as a tool for measuring ovarian reserve in young female cancer survivors — Roberts et al., Human reproduction (paywalled)
- blood
- dried
- dbs
- self-collection
- acceptability
- fertility
- hormones
2016
In a prospective cohort of patients with anogenital gonorrhoea, self-collected urine samples tested with modern RNA-based and DNA-based NAATs showed 100% clearance after treatment, with median time to clearance of 2 days (range 1–7 days for RNA-based and 1–15 days for DNA-based NAAT). The authors recommend performing test-of-cure at least 7 days after therapy for RNA-based NAATs and 14 days for DNA-based NAATs, while considering isolated positive blips and possible reinfection when interpreting results.
Test of Cure for Anogenital Gonorrhoea Using Modern RNA-Based and DNA-Based Nucleic Acid Amplification Tests: A Prospective Cohort Study — Wind et al., Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (paywalled)
- urine
- self-collection
- sti
2015
The study identified a mutation in the amelogenin gene from saliva samples collected using self-collection kits, which showed a statistically significant correlation with high caries experience in children. These results suggest that non-invasive genetic screening from saliva could facilitate early risk assessment for dental caries.
Association of Amelogenin with High Caries Experience in Indian Children — Saha et al., The Journal of clinical pediatric dentistry (paywalled)
- saliva
- dna-genotek-oracollect
- self-collection
- pediatric
- genotyping
2015
Capillary dried blood spots collected at home by pediatric transplant patients and mailed to the laboratory gave tacrolimus and sirolimus results that were clinically comparable to venous whole blood, with small negative biases within acceptable limits, enabling remote therapeutic drug monitoring.
Tacrolimus and sirolimus in capillary dried blood spots allows for remote monitoring — Dickerson et al., Pediatric transplantation (paywalled)
- blood
- dried
- capillary
- dbs
- self-collection
- venous-agreement
- pediatric
- tdm
- immunosuppressants
2015
Screening both partners increased detection of positive couples compared with screening only one partner; routine urine screening of the female partner may substantially underestimate prevalence within the couple, leaving many infected couples undiagnosed.
Discordant prevalence of Chlamydia trachomatis in asymptomatic couples screened by two screening approaches — Corbeto et al., International journal of STD & AIDS (paywalled)
- urine
- first-void
- self-collection
- sti
2015
In healthy adults, use of LifeWave Energy Enhancer patches was associated with higher salivary cortisol at midday and mid afternoon compared with placebo, while energy visual analogue scale scores fell in the placebo group but not in the active group.
Effects of energy enhancer patches on cortisol production, peripheral circulation, and psychological measures: a pilot study — Connor et al., Advances in mind-body medicine (paywalled)
- saliva
- self-collection
- cortisol
2015
Urine microsampling for HPV DNA shows high correlation with cervical infections and enables home self-collection, which simplifies follow-up in vaccine efficacy trials. Establishing standardised sampling guidelines could overcome current variability and support decentralised, patient-centric monitoring of viral endpoints.
The use of urine in the follow-up of HPV vaccine trials — Vorsters et al., Human vaccines & immunotherapeutics
- urine
- self-collection
- hpv
- sti
2015
In a population-based study of 566 women in Puerto Rico, self-collection of anal, cervical, and oral specimens for HPV testing achieved an 83.4% response rate with high acceptability: over 98% of participants understood the methods and more than 50% felt comfortable with them. This demonstrates the feasibility of decentralised, patient-centric HPV surveillance using self-collection, supporting wider implementation of remote STI screening programmes.
Methods in HPV Surveillance: Experiences from a Population-Based Study of HPV Infection among Women in the San Juan Metropolitan Area of Puerto Rico — Ortiz et al., Puerto Rico health sciences journal (paywalled)
- self-collection
- acceptability
- hpv
2015
Urine-based laboratory testing was the most preferred HPV screening modality among Zambian women. However, only 39.7% would choose it over visual inspection when service delivery conditions were less favourable, showing that patient acceptance of decentralised screening depends strongly on implementation factors such as examiner characteristics and waiting times.
Preference for human papillomavirus-based cervical cancer screening: results of a choice-based conjoint study in Zambia — Chamot et al., Journal of lower genital tract disease (paywalled)
- urine
- self-collection
- acceptability
- hpv
- sti
2015
A service evaluation of the Gen-Probe APTIMA test at a UK sexual health clinic found Trichomonas vaginalis prevalence of 1.4% in men and 3.6% in women. Asymptomatic men provided self-collected first-void urine and asymptomatic women self-collected vulvovaginal specimens, and the study concluded that targeted screening of high-risk asymptomatic groups is more cost-effective than universal screening, supporting decentralised STI testing strategies.
A service evaluation of the Gen-Probe APTIMA nucleic acid amplification test for Trichomonas vaginalis: should it change whom we screen for infection? — Hathorn et al., Sexually transmitted infections (paywalled)
- urine
- first-void
- self-collection
- sti
2015
In healthy adults self-collecting saliva at home, cortisol did not increase for up to ten minutes after awakening. Delays of five to fifteen minutes before the first sample overestimated the cortisol awakening response and shifted its peak earlier, demonstrating that strict timing adherence is essential for accurate measurement in decentralised settings.
Detailed time course of the cortisol awakening response in healthy participants — Smyth et al., Psychoneuroendocrinology (paywalled)
- saliva
- self-collection
- hormones
- cortisol
2015
Dried capillary blood spot screening correctly identified 95.5% of relatives with multiple islet autoantibodies and 98.6% of those without, and 60% of participants favoured initial home fingerstick screening with clinic visits only if autoantibodies were found.
Use of Dried Capillary Blood Sampling for Islet Autoantibody Screening in Relatives: A Feasibility Study — Bingley et al., Diabetes technology & therapeutics (paywalled)
- blood
- dried
- capillary
- dbs
- self-collection
- venous-agreement
- acceptability
2015
Self-collected urine samples from 2034 tribal girls aged 9-25 years showed 12.9% HPV prevalence, rising to 19.2% among 18-25-year-olds. High-risk types comprised 65% of infections, with HPV16 accounting for 54%. This supports urine-based self-collection as a feasible tool for decentralised HPV screening in underserved populations.
Higher prevalence of human papillomavirus infection in adolescent and young adult girls belonging to different Indian tribes with varied socio-sexual lifestyle — Sharma et al., PloS one
- urine
- self-collection
- pediatric
- hpv
- sti
2015
Self-collected dried blood spots gave HbA1c measurements that agreed closely with venous blood when samples were stored at room temperature for up to seven days, showing low intra-assay variation and clinically acceptable prediction intervals. The method offers a viable alternative for diabetes monitoring in remote or home-bound populations where traditional venepuncture is unavailable.
The use of dried blood spot sampling for the measurement of HbA1c: a cross-sectional study — Mastronardi et al., BMC clinical pathology
- blood
- dried
- capillary
- dbs
- self-collection
- validation
- venous-agreement
2015
A home-based urine HPV self-sampling study invited 5000 French women who had not attended cervical screening for three years; 771 samples were returned and 687 were analysed. High-risk HPV was detected in 29 women, and follow-up screening identified three cases of high-grade cervical intraepithelial neoplasia, showing that urine testing can reach underscreened populations and detect clinically significant disease.
Home-based urinary HPV DNA testing in women who do not attend cervical cancer screening clinics — Ducancelle et al., The Journal of infection (paywalled)
- urine
- self-collection
- hpv
- sti
2015
Salivary cortisol concentrations were unchanged after storage at -18 °C, -4 °C, 4 °C or room temperature for 72 h, and after simulated postal transport with a freezing element, when compared with samples kept continuously at -80 °C. This confirms that enzyme immunoassay of self-collected saliva is robust for home-sampling and postal delivery in decentralised studies.
The effect of storage conditions on salivary cortisol concentrations using an enzyme immunoassay — Nalla et al., Scandinavian journal of clinical and laboratory investigation (paywalled)
- saliva
- self-collection
- validation
- hormones
- cortisol
2015
Dried blood spots from finger-pricks, collected either in clinic or by families at home, showed wide fluctuations in methotrexate levels in 17 of 48 children with juvenile arthritis or dermatomyositis, indicating nonadherence. Younger age and oral administration predicted poorer adherence, while subcutaneous dosing gave higher drug concentrations, proving that decentralised therapeutic drug monitoring is feasible in paediatric patients.
Methotrexate polyglutamates as a potential marker of adherence to long-term therapy in children with juvenile idiopathic arthritis and juvenile dermatomyositis: an observational, cross-sectional study — Hawwa et al., Arthritis research & therapy
- blood
- dried
- dbs
- self-collection
- pediatric
- tdm
- immunosuppressants
2014
Mailed at-home stool self-collection was feasible: ~20% of those approached enrolled and ~80% of those returned a usable specimen: workable, but recruitment depends on active, well-timed follow-up.
Feasibility of self-collection of fecal specimens by randomly sampled women for gut-microbiome studies — Feigelson et al., BMC Research Notes
- self-collection
- microbiome
- stool
- urine
- validation
2014
This study validated self-collected stool and saliva for microbiome profiling, finding that microbial species and gene abundances were highly concordant across different preservation methods including freezing, ethanol, and RNAlater. These results support the feasibility of decentralised sampling for functional gut microbiota research.
Relating the metatranscriptome and metagenome of the human gut — Franzosa et al., Proceedings of the National Academy of Sciences of the United States of America (paywalled)
- multimodal
- self-collection
- microbiome
- stool
- validation
- saliva
- multi-omics
2014
A US survey of 3,400 adults aged 62 to 90 collected up to 15 biomeasures at home, including saliva, dried blood spots and urine, with Salivette and Oragene among the devices used, which shows that several patient-centric sampling methods can run together in home-based research.
Continuity and innovation in the data collection protocols of the second Wave of the National Social Life, Health, and Aging Project — Jaszczak et al., The journals of gerontology. Series B, Psychological sciences and social sciences (paywalled)
- actigraphy
- multimodal
- blood
- dbs
- cortisol
- dna-genotek-oragene
- self-collection
- dried
- bd-microtainer
- hormones
- liquid
- urine
- saliva
- biomarkers
- genotyping
2014
Dried blood spot microsampling provides a patient-centric alternative to venous sampling for therapeutic drug monitoring, with advantages of home self-collection, small sample volumes suitable for children, and analyte stability, though accuracy is affected by haematocrit and requires patient correlation studies to validate clinical equivalence.
Therapeutic drug monitoring by dried blood spot: progress to date and future directions — Wilhelm et al., Clinical pharmacokinetics
- blood
- dried
- dbs
- self-collection
- validation
- venous-agreement
- pediatric
- tdm
- haematocrit
2014
Self-collected urine showed substantial agreement with self-collected vaginal samples for HPV DNA detection among 63 pregnant women, with a kappa of 77.3%. Urine may therefore serve as a reliable sample for HPV testing in pregnancy, supporting decentralised screening without a clinician-collected specimen.
Comparison of urine and self-collected vaginal samples for detecting human papillomavirus DNA in pregnant women — Franciscatto et al., International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (paywalled)
- urine
- self-collection
- hpv
- sti
2014
The validated LC-MS method for valproic acid in dried blood spots showed imprecision below 9% CV and accuracy within ±14% across the clinically relevant range of 10 to 1200 μmol/L, with haematocrit effects manageable between 30 and 60%, supporting its potential for home-based therapeutic drug monitoring of this antiepileptic medication.
Quantification of valproic acid in dried blood spots — Pohanka et al., Scandinavian journal of clinical and laboratory investigation (paywalled)
- blood
- dried
- dbs
- self-collection
- validation
- tdm
- haematocrit
2014
Finger‑prick dried blood spots gave almost identical nandrolone and testosterone concentrations to venous samples. Home self‑collection for 21 days was well tolerated, showing that microsampling supports decentralised therapeutic drug monitoring without clinic visits, venesection or frozen storage.
Pharmacokinetic-pharmacodynamic study of subcutaneous injection of depot nandrolone decanoate using dried blood spots sampling coupled with ultrapressure liquid chromatography tandem mass spectrometry assays — Singh et al., The Journal of clinical endocrinology and metabolism (paywalled)
- blood
- dried
- capillary
- dbs
- self-collection
- venous-agreement
- hormones
- tdm
2014
First-void urine self-collection detected bacterial vaginosis with sensitivity comparable to vaginal swabs when analysed by quantitative PCR for seven key vaginal bacteria. This supports decentralised screening for BV and sexually transmitted infections using patient-collected samples.
Characterization of the vaginal microflora in health and disease — Datcu, Danish medical journal (paywalled)
- urine
- first-void
- self-collection
- microbiome
- sti
2014
Urine-based HPV DNA testing demonstrated 76% agreement with cervical sampling, correctly identifying 100% of uninfected but only 65% of infected women in a high-risk population. All 12 discrepant pairs were urine-negative/cervix-positive, confirming that self-collected urine is substantially less sensitive than cervical sampling for HPV screening.
Urine-based human papillomavirus DNA testing as a screening tool for cervical cancer in high-risk women — Mendez et al., International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (paywalled)
- urine
- self-collection
- validation
- hpv
- sti
2014
First-void urine specimens yielded accurate bacterial vaginosis diagnosis by qPCR for Megasphaera type 1 and Prevotella spp, with sensitivity and specificity matching vaginal swabs. This supports decentralised screening through non-invasive self-collection, removing the need for clinician-collected vaginal samples.
Bacterial vaginosis diagnosed by analysis of first-void-urine specimens — Datcu et al., Journal of clinical microbiology (paywalled)
- urine
- first-void
- self-collection
- validation
- sti
2014
In 230 women, HPV detection in self-collected urine showed 90 per cent agreement with cervical sampling (κ=0.80), with 97 per cent concordance for high-risk types. High viral load in urine correlated with cytological abnormalities, suggesting urine self-sampling could enable decentralised cervical cancer screening with good accuracy.
Interest of human papillomavirus DNA quantification and genotyping in paired cervical and urine samples to detect cervical lesions — Ducancelle et al., Archives of gynecology and obstetrics (paywalled)
- urine
- self-collection
- genotyping
- hpv
- sti
2014
Self-collected saliva revealed that perceived stress at home, but not at work, was associated with a lower cortisol awakening response and flatter diurnal slope, an effect seen only in women. This demonstrates that home-based saliva sampling can detect stress-related hypothalamic-pituitary-adrenal axis changes, supporting its use in remote stress monitoring and highlighting sex-specific responses.
Diurnal salivary cortisol in relation to perceived stress at home and at work in healthy men and women — Sjörs et al., Biological psychology (paywalled)
- saliva
- self-collection
- hormones
- cortisol
Read from the corpus on .