The Library
1530 papers on microsampling and monitoring, each with a finding paraphrased to our standard and labelled in one vocabulary. Every entry links to a legitimate copy; nothing is copied from an abstract.
Papers 301–313 of 313 labelled “dbs”, newest first.
2015
Retinol measured in dried blood spots showed high agreement with venous plasma (r=0.9724) and remained stable at room temperature for up to 10 weeks when extracted under acidic conditions, enabling simple and reliable assessment of vitamin A status for population studies and large clinical trials.
Robust measurement of vitamin A status in plasma and blood dried on paper — Huang et al., Prostaglandins, leukotrienes, and essential fatty acids (paywalled)
- blood
- dried
- dbs
- validation
- venous-agreement
- biomarkers
2015
The study validated a commercial ELISA for measuring measles-specific IgG in capillary dried blood spots from children, finding 100% sensitivity and 96.8% specificity against matched venous serum with 92% overall agreement, then applied the method to 1,588 field-collected samples in Mexico and Nicaragua. The procedure was acceptable to surveyors and participants, showing that dried blood spots are a feasible and accurate means of assessing population immunity to measles in low-resource settings.
Use of a commercial ELISA for the detection of measles-specific immunoglobulin G (IgG) in dried blood spots collected from children living in low-resource settings — Colson et al., Journal of medical virology (paywalled)
- blood
- dried
- capillary
- dbs
- validation
- venous-agreement
- acceptability
- pediatric
- serology
2015
Dried capillary blood spot screening correctly identified 95.5% of relatives with multiple islet autoantibodies and 98.6% of those without, and 60% of participants favoured initial home fingerstick screening with clinic visits only if autoantibodies were found.
Use of Dried Capillary Blood Sampling for Islet Autoantibody Screening in Relatives: A Feasibility Study — Bingley et al., Diabetes technology & therapeutics (paywalled)
- blood
- dried
- capillary
- dbs
- self-collection
- venous-agreement
- acceptability
2015
Combining volumetric absorptive microsampling with phospholipid removal plates reduces matrix effects and delivers high sensitivity for dried blood hepcidin quantification. This method establishes a reliable microsampling protocol to quantify this peptide hormone while mitigating haematocrit bias.
Hepcidin determination in dried blood by microfluidic LC-MS/MS: comparison of DBS and volumetric absorptive microsampling for matrix effect and recovery — Houbart et al., Bioanalysis (paywalled)
- blood
- dried
- vams
- dbs
- neoteryx-mitra
- validation
- hormones
- haematocrit
2015
Self-collected dried blood spots gave HbA1c measurements that agreed closely with venous blood when samples were stored at room temperature for up to seven days, showing low intra-assay variation and clinically acceptable prediction intervals. The method offers a viable alternative for diabetes monitoring in remote or home-bound populations where traditional venepuncture is unavailable.
The use of dried blood spot sampling for the measurement of HbA1c: a cross-sectional study — Mastronardi et al., BMC clinical pathology
- blood
- dried
- capillary
- dbs
- self-collection
- validation
- venous-agreement
2015
Dried blood spots from finger-pricks, collected either in clinic or by families at home, showed wide fluctuations in methotrexate levels in 17 of 48 children with juvenile arthritis or dermatomyositis, indicating nonadherence. Younger age and oral administration predicted poorer adherence, while subcutaneous dosing gave higher drug concentrations, proving that decentralised therapeutic drug monitoring is feasible in paediatric patients.
Methotrexate polyglutamates as a potential marker of adherence to long-term therapy in children with juvenile idiopathic arthritis and juvenile dermatomyositis: an observational, cross-sectional study — Hawwa et al., Arthritis research & therapy
- blood
- dried
- dbs
- self-collection
- pediatric
- tdm
- immunosuppressants
2014
A US survey of 3,400 adults aged 62 to 90 collected up to 15 biomeasures at home, including saliva, dried blood spots and urine, with Salivette and Oragene among the devices used, which shows that several patient-centric sampling methods can run together in home-based research.
Continuity and innovation in the data collection protocols of the second Wave of the National Social Life, Health, and Aging Project — Jaszczak et al., The journals of gerontology. Series B, Psychological sciences and social sciences (paywalled)
- actigraphy
- multimodal
- blood
- dbs
- cortisol
- dna-genotek-oragene
- self-collection
- dried
- bd-microtainer
- hormones
- liquid
- urine
- saliva
- biomarkers
- genotyping
2014
Dried blood spot microsampling provides a patient-centric alternative to venous sampling for therapeutic drug monitoring, with advantages of home self-collection, small sample volumes suitable for children, and analyte stability, though accuracy is affected by haematocrit and requires patient correlation studies to validate clinical equivalence.
Therapeutic drug monitoring by dried blood spot: progress to date and future directions — Wilhelm et al., Clinical pharmacokinetics
- blood
- dried
- dbs
- self-collection
- validation
- venous-agreement
- pediatric
- tdm
- haematocrit
2014
The validated LC-MS method for valproic acid in dried blood spots showed imprecision below 9% CV and accuracy within ±14% across the clinically relevant range of 10 to 1200 μmol/L, with haematocrit effects manageable between 30 and 60%, supporting its potential for home-based therapeutic drug monitoring of this antiepileptic medication.
Quantification of valproic acid in dried blood spots — Pohanka et al., Scandinavian journal of clinical and laboratory investigation (paywalled)
- blood
- dried
- dbs
- self-collection
- validation
- tdm
- haematocrit
2014
Finger‑prick dried blood spots gave almost identical nandrolone and testosterone concentrations to venous samples. Home self‑collection for 21 days was well tolerated, showing that microsampling supports decentralised therapeutic drug monitoring without clinic visits, venesection or frozen storage.
Pharmacokinetic-pharmacodynamic study of subcutaneous injection of depot nandrolone decanoate using dried blood spots sampling coupled with ultrapressure liquid chromatography tandem mass spectrometry assays — Singh et al., The Journal of clinical endocrinology and metabolism (paywalled)
- blood
- dried
- capillary
- dbs
- self-collection
- venous-agreement
- hormones
- tdm
2014
Parsons et al. validated a quantitative dried blood spot assay for rifapentine that remained stable for 11 weeks at ambient temperature and showed good agreement with plasma concentrations after haematocrit correction, offering a low-volume sampling approach suitable for therapeutic drug monitoring in international and paediatric tuberculosis trials.
Quantification of rifapentine, a potent antituberculosis drug, from dried blood spot samples using liquid chromatographic-tandem mass spectrometric analysis — Parsons et al., Antimicrobial agents and chemotherapy (paywalled)
- blood
- dried
- dbs
- validation
- venous-agreement
- tdm
- antimicrobials
- haematocrit
2014
The authors developed and validated a sensitive LCMS assay for methotrexate polyglutamates in dried blood spots from finger-prick samples, demonstrating agreement with conventional HPLC-UV analysis of matched red-cell samples in 47 paediatric patients. This enables minimally invasive, parent-collected sampling at home for therapeutic drug monitoring, supporting decentralised clinical studies and care in paediatric rheumatology.
A novel dried blood spot-LCMS method for the quantification of methotrexate polyglutamates as a potential marker for methotrexate use in children — Hawwa et al., PloS one
- blood
- dried
- dbs
- validation
- pediatric
- tdm
- immunosuppressants
2013
The canonical review of the haematocrit effect, decomposing it into recovery bias, matrix effects, spot-size/homogeneity variation and analyte-distribution bias.
Hemato-critical issues in quantitative analysis of dried blood spots: challenges and solutions — De Kesel et al., Bioanalysis (paywalled)
- blood
- dbs
- haematocrit
- dried
- validation
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