The Library
1530 papers on microsampling and monitoring, each with a finding paraphrased to our standard and labelled in one vocabulary. Every entry links to a legitimate copy; nothing is copied from an abstract.
Papers 201–300 of 757 labelled “validation”, newest first.
2025
First-void urine self-collection achieved almost perfect agreement with clinician-collected cervical samples for high-risk HPV detection (prevalence-adjusted kappa 0.95 for HPV16). The method showed comparable sensitivity and specificity ratios for identifying cervical intraepithelial neoplasia grade two or worse, supporting its use as a decentralised screening alternative.
A United States study of self-collected urine vs clinician-collected cervical sample for HPV and cervical intraepithelial neoplasia grade two or worse detection: Cross-sectional agreement and diagnostic accuracy study — Young et al., Preventive medicine reports
- urine
- first-void
- self-collection
- validation
- hpv
- sti
2025
Urine-based HPV testing demonstrated 74% sensitivity and 52% specificity for detecting CIN2+, with performance improving when first-void collection and PCR-based assays were used. Although less sensitive than clinician-collected cervical samples, urine testing was preferred by over 90% of women, indicating potential as a complementary screening strategy to improve uptake.
- urine
- first-void
- self-collection
- validation
- acceptability
- hpv
- sti
2025
Researchers validated a UHPLC-MS/MS assay for citrinin in capillary blood collected with Neoteryx Mitra VAMS devices, plus feces and urine, achieving quantification limits of 0.05 ng/mL. The study derived human toxicokinetic parameters from 48-hour sample collection after a single oral dose, demonstrating that microsampling enables robust population-level exposure assessment for mycotoxins.
Derivation of Human Toxicokinetic Parameters and Chemical-Specific Adjustment Factor of Citrinin Through a Human Intervention Trial and Hierarchical Bayesian Population Modeling — Visintin et al., Toxins
- blood
- urine
- stool
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- toxicology
2025
The study develops and validates a dried blood microsampling method for oxylipin analysis in newborn blood using UPLC-MS/MS, showing that small-volume, minimally invasive capillary blood collection is feasible and suitable for unstable, low-abundant analytes, enabling practical decentralised sampling in vulnerable populations.
Assessment of dried blood micro-sampling methods for oxylipin analysis in newborn blood using UPLC-MS/MS — Albiach-Delgado et al., Analytica chimica acta (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- pediatric
2025
In 55 patients, four approaches to convert dried capillary blood concentrations to plasma equivalents were evaluated. All methods except haematocrit-based conversion yielded acceptable analytical and clinical agreement for paracetamol and metabolites, supporting the reliability of capillary microsampling for decentralised therapeutic drug monitoring.
Comparative Evaluation of Approaches to Convert Microsampled Capillary Blood Concentrations to Plasma Concentrations: Paracetamol and Metabolites as a Case Study — Boffel et al., The AAPS journal (paywalled)
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- venous-agreement
- dct
- haematocrit
2025
This feasibility study demonstrated that a surrogate matrix solution enables accurate quantitation of a monoclonal antibody from dried blood samples collected via VAMS or Tasso-M20 devices. The method resolves challenges related to daily calibrator preparation and sample dilution for ligand binding assays used in pharmacokinetic studies.
The Use of Surrogate Matrix for Calibrators in the Analysis of Dried Blood Samples - A Feasibility Study — Lee et al., The AAPS journal (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- biologics
2025
All five at-home urine ovulation predictor kits demonstrated high accuracy (92–97%) when compared with blood LH levels, though sensitivity varied widely from 38% to 77% with Clinical Guard the lowest. Patient experience was comparable across kits, though Clinical Guard was slightly less favoured for future use.
Similar accuracy and patient experience with different one-step ovulation predictor kits — Vanderhoff et al., Fertility and sterility (paywalled)
- blood
- urine
- self-collection
- validation
- venous-agreement
- acceptability
- fertility
- hormones
2025
Capillary blood collected with a Tasso+ device showed excellent agreement with venous serum for testosterone, the testosterone/androstenedione ratio, and luteinising hormone in 20 adults tracked over six weeks. The biomarkers remained stable when capillary samples were stored at room temperature, suggesting capillary microsampling could enable decentralised, patient-centric collection for the Athlete Biological Passport without cold-chain logistics.
Is blood blood? Comparing quantitation of endogenous steroids and luteinizing hormone in concurrently collected venous serum and Tasso+ SST capillary serum samples — Goodrum et al., Drug testing and analysis (paywalled)
- blood
- capillary
- validation
- venous-agreement
- hormones
- doping
2025
Capillary finger-stick blood showed excellent comparability with venous samples for 30 of 33 routine chemistry analytes against total allowable error criteria, and met CLIA 2024 proficiency testing limits for all but glucose. This validates capillary sampling as a clinically acceptable alternative for most routine tests, benefiting patients with needle phobia and enabling remote sampling.
Comparison of capillary finger stick and venous blood sampling for 34 routine chemistry analytes: potential for in hospital and remote blood sampling — Doeleman et al., Clinical chemistry and laboratory medicine (paywalled)
- blood
- liquid
- capillary
- validation
- venous-agreement
2024
At-home capillary microsampling carried pharmacokinetic sampling across the Paxlovid phase II/III programme, with fewer than 3% of more than 800 samples unusable, and the resulting data supported the Emergency Use Authorization and subsequent FDA approval: remotely collected samples accepted in a registrational filing.
Patient Centric Microsampling to Support Paxlovid Clinical Development: Bridging and Implementation — Wan et al., Clinical Pharmacology & Therapeutics (paywalled)
- dct
- volumetric
- venous-agreement
- blood
- self-collection
- dried
- capillary
- validation
2024
Head-to-head clinical validation of two VAMS devices for tacrolimus and mycophenolic acid, with roughly 86–88% of samples within ±20% of venous.
Clinical validation of two volumetric absorptive microsampling devices to support home-based therapeutic drug monitoring of immunosuppression — Leino et al., British Journal of Clinical Pharmacology (paywalled)
- vams
- venous-agreement
- acceptability
- neoteryx-mitra
- blood
- tdm
- self-collection
- dried
- immunosuppressants
- validation
2024
DBS achieved 100% sensitivity, 99% specificity and ~97% concordance versus paired serum: the strength of the classic card for ratio/threshold serology.
Using Dried Blood Spots to Quantitatively Detect Anti-SARS-CoV-2 IgG Antibodies by ELISA: A Validation Study — Ylade et al., American J. Tropical Medicine and Hygiene
- blood
- dbs
- dried
- serology
- validation
2024
Confirms urine is the second-most-applied VAMS matrix in forensics, collecting a consistent volume regardless of viscosity and enabling room-temperature storage and shipping.
Volumetric Absorptive Microsampling in Toxicology — Review, Toxics
- vams
- volumetric
- blood
- dried
- toxicology
- urine
- validation
- saliva
2024
An analysis of 88 individuals aged 7 to 18 years found that stimulated saliva collection detected disease-associated microbiome taxa that unstimulated sampling missed. The authors note that sampling protocols must be standardised before results can be compared across decentralised studies.
Saliva sampling method influences oral microbiome composition and taxa associated with oral diseases — Roca et al., PLoS ONE
- microbiome
- pediatric
- liquid
- validation
- saliva
2024
In 91 children and adults, capillary C-peptide taken with the TAP device matched venous sampling with 100% sensitivity and specificity for a clinically relevant level, 200 pmol/L or above, with r = 0.996. 63% preferred it to a needle against 7% who preferred the needle, and same-day bruising was 5.5% versus 34.8% after a venous draw.
Transdermal blood sampling for C-peptide is a minimally invasive, reliable alternative to venous sampling in children and adults with type 1 diabetes — Besser et al., Diabetes Care
- blood
- liquid
- yourbio
- capillary
- pediatric
- venous-agreement
- acceptability
- validation
2024
In at-home and trial settings, a wet capillary device reliably collected a median ~450 µL with a 4.4% failure rate; 88% of adults preferred self-collection over venipuncture, with lower pain.
Feasibility, acceptability and safety of a device for self-collecting capillary blood in clinical trials — Dasari et al., PLOS ONE
- acceptability
- blood
- self-collection
- capillary
- pediatric
- liquid
- validation
2024
An independent VALHUDES evaluation found HPV screening on Colli-Pee first-void urine detected high-grade cervical lesions with sensitivity comparable to clinician-collected cervical samples, reinforcing urine self-sampling for cervical screening.
Clinical Performance of the OncoPredict HPV Screening Assay on Self-Collected Vaginal and Urine Specimens (VALHUDES) — Giubbi et al., J. Medical Virology
- colli-pee
- first-void
- self-collection
- hpv
- liquid
- urine
- validation
2024
In children, stool preserved in OMNIgene-GUT kept its microbial community structure better than unpreserved stool, with alpha and beta diversity similar to direct freezing, which supports the kit for decentralised stool collection from children.
Omnigene-Gut<sup>tm</sup> ensures fecal microbiome stability in the pediatric population — Hoogendijk et al., AMB Express
- dct
- stabilised
- dna-genotek-omnigene
- microbiome
- pediatric
- stool
- validation
2024
Plasma total carbon dioxide concentrations were significantly lower in BD Microtainers compared to standard vacutainers, with reductions driven by low sample volume and transport delays rather than brief air exposure. These findings indicate that microtainers must be filled completely and analysed rapidly to maintain accuracy for this analyte.
Impact of blood volume, air exposure duration, transport duration, and testing delay on plasma total carbon dioxide in simulated open collections using microtainers — Reid et al., Clinical biochemistry (paywalled)
- blood
- liquid
- capillary
- bd-microtainer
- validation
2024
A validated LC-MS/MS assay successfully measured 13 steroid hormones and two synthetic steroids in saliva, requiring only 50 microlitres, or down to 2 to 5 microlitres for nine analytes. This shows saliva's viability for non-invasive, patient-centric microsampling and decentralised monitoring in paediatric, neonatal and adult populations.
An LC-MS/MS assay for simultaneous determination of 13 steroid hormones and two synthetic steroids in saliva: potential utility for paediatric population and beyond — Dahl et al., Scandinavian journal of clinical and laboratory investigation (paywalled)
- cortisol
- self-collection
- steroids
- pediatric
- hormones
- liquid
- validation
- saliva
2024
In 102 patients, Mitra and Capitainer microsamples gave urine albumin-to-creatinine ratios at 102% and 95% of the clinical analyser's, and both stayed within 98% to 103% after three weeks at room temperature, which supports either device for decentralised urine collection.
Patient-Centric Quantitative Microsampling for Accurate Determination of Urine Albumin to Creatinine Ratio (UACR) in a Clinical Setting — Löfgren et al., The journal of applied laboratory medicine (paywalled)
- dct
- volumetric
- neoteryx-mitra
- urine
- validation
- biomarkers
2024
A review of 18 studies found that microsampling techniques, including dried blood spot sampling and volumetric absorptive microsampling, are validated for antipsychotic monitoring. Although most studies have shortcomings limiting generalisability, microsampling is recommended for clozapine and is a promising, virtually painless option to support decentralised, patient-centric care.
Microsampling Techniques Suitable for Therapeutic Drug Monitoring of Antipsychotics — Geers et al., Journal of clinical psychopharmacology (paywalled)
- vams
- blood
- dbs
- tdm
- dried
- validation
2024
The study validated a VAMS-based LC-MS/MS method for measuring sirolimus levels, showing it was clinically equivalent to the standard whole blood method and suitable for therapeutic drug monitoring in paediatric transplant patients, supporting the use of decentralised microsampling for this purpose.
Personalization of pharmacotherapy with sirolimus based on volumetric absorptive microsampling (VAMS) in pediatric renal transplant recipients-from LC-MS/MS method validation to clinical application — Kocur et al., Pharmacological reports : PR
- vams
- venous-agreement
- neoteryx-mitra
- blood
- tdm
- haematocrit
- dried
- capillary
- pediatric
- immunosuppressants
- validation
2024
The study developed and validated LC-MS/MS methods for ciclosporin in whole blood and volumetric absorptive microsampling across 1-2000 ng/mL, meeting international bioanalytical criteria, and confirmed interchangeability with clinical samples and external proficiency testing, supporting decentralised microsampling for therapeutic drug monitoring in children.
A novel approach to therapeutic drug monitoring of Ciclosporin in pediatric renal transplant recipients using volumetric absorptive microsampling (VAMS) - Teaching old dog new tricks — Kocur et al., Clinica chimica acta; international journal of clinical chemistry (paywalled)
- vams
- blood
- tdm
- pediatric
- immunosuppressants
- validation
2024
This study evaluated the repeatability of a point-of-care G6PD test using capillary blood collected via fingerprick and BD Microtainers, finding that modified sample application methods reduced variability in laboratory and field settings.
Field assessment of the operating procedures of a semi-quantitative G6PD Biosensor to improve repeatability of routine testing — Sadhewa et al., PloS one
- blood
- liquid
- capillary
- bd-microtainer
- validation
2024
Patterned DBS cards meter reproducible volumes of dried blood across a range of haematocrits, allowing accurate white blood cell counts by qPCR that match HemoCue measurements. This enables reliable at-home sampling for populations without easy access to clinical facilities.
Hematocrit-Independent Sampling Enables White Blood Cell Counts from Patterned Dried Blood Spot Cards — Tierney et al., Analytical chemistry (paywalled)
- blood
- dbs
- self-collection
- haematocrit
- dried
- validation
2024
This review found saliva comparable to blood and urine for detecting viral genetic material and antibodies, supporting patient-centric monitoring and decentralised surveillance. The authors state that standardised protocols and further validation are required for routine clinical use.
The Emergence of Saliva as a Diagnostic and Prognostic Tool for Viral Infections — Oliveira et al., Viruses
- blood
- self-collection
- serology
- hpv
- urine
- validation
- saliva
- biomarkers
2024
Microsampling enables less invasive, patient-centric self-collection of capillary blood for remote monitoring of metabolites and lipids, overcoming conventional venipuncture constraints. Recent device innovations address dried blood spot limitations, particularly haematocrit and volume variations, expanding decentralised applications in population health, drug discovery and multi-omics research.
Revolutionizing Blood Collection: Innovations, Applications, and the Potential of Microsampling Technologies for Monitoring Metabolites and Lipids — Bossi et al., Metabolites
- multimodal
- blood
- dbs
- metabolome
- self-collection
- haematocrit
- dried
- capillary
- validation
- biomarkers
- multi-omics
2024
A time-resolved fluorescence assay detected HPV16-specific IgG in first-void urine with strong correlation to paired serum across four immunoassays in 225 healthy women, supporting first-void urine as a non-invasive alternative to venous blood for HPV antibody monitoring.
Time-resolved fluorescence (TRF) for total IgG and HPV16-specific antibody detection in first-void urine and serum: A comparative study — Lipovac et al., Journal of virological methods
- urine
- first-void
- validation
- venous-agreement
- serology
- hpv
2024
The paper found that two laboratory assays for the anticoagulants apixaban and rivaroxaban gave markedly different plasma concentrations, and that dried blood volumetric absorptive microsamples taken by patients at home did not agree with plasma results. For decentralised diagnostics this means clinical laboratories must validate their chosen method and always measure haematocrit when using microsamples to ensure accurate anticoagulant monitoring.
Assays for Monitoring Apixaban and Rivaroxaban in Emergency Settings, State-of-the-Art Routine Analysis, and Volumetric Absorptive Microsamples Deliver Discordant Results — Fehér et al., Diagnostics
- blood
- dried
- vams
- validation
- tdm
- haematocrit
2024
The study validated a method for determining 15 trace elements in whole blood collected via VAMS, showing high precision and accuracy with agreement to a liquid sampling method. This supports the use of VAMS for decentralised trace element analysis in clinical and research settings.
A miniaturized sample preparation method for routine elemental determination in whole blood using volumetric absorptive micro-sampling by ICP-QQQ — Schmidt et al., Analytical and bioanalytical chemistry (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- venous-agreement
2024
The study developed and validated a LC-MS/MS method for quantifying Lurasidone using volumetric absorptive microsampling, comparing dried blood and plasma matrices; the method appears precise, accurate and robust, enabling reliable decentralised therapeutic drug monitoring with small-volume dried blood samples.
Development of LC-MS/MS method for quantification of Lurasidone using volumetric absorptive microsampling (VAMS); a comparative study between dried blood and plasma samples — Rajadhyaksha & Londhe, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (paywalled)
- blood
- dried
- vams
- validation
- tdm
2024
This systematic review of 67 studies involving 34,739 kidney disease patients found dried blood microsampling was mainly used for immunosuppressant therapeutic drug monitoring and kidney function assessment. The approach offered cost savings, was preferred by patients for home self-collection, and provides a patient-centric opportunity to upscale longitudinal sampling and reduce participation bias in decentralised kidney disease research.
A Systematic Literature Review on the Use of Dried Biofluid Microsampling in Patients With Kidney Disease — Lamond et al., Journal of clinical laboratory analysis
- blood
- dried
- capillary
- self-collection
- validation
- acceptability
- tdm
- immunosuppressants
- economics
2024
A four-item questionnaire for menstrual phase identification, validated against progesterone in dried blood spots, achieved 92.1 per cent accuracy with less restrictive scoring, substantially better than self-reported onset of menses alone (60.2 per cent). This tool could enable accurate phase determination in decentralised research and low-resource settings without intensive clinical assessment.
Menstrual Phase Identification Questionnaire (MPIQ): Development and validation of a cross-sectional survey to identify follicular and luteal phases — Allen et al., Experimental and clinical psychopharmacology (paywalled)
- blood
- dried
- dbs
- validation
- fertility
- hormones
2024
Self-collected urine samples matched clinician-collected cervical samples in detecting all seven CIN3 lesions among hrHPV-positive women when extended HPV typing was used, showing 82% concordance for hrHPV detection. This indicates urine self-collection could serve as a patient-centric, decentralised screening option for cervical precancer without compromising diagnostic yield.
Performance of urine samples compared to cervical samples for detection of precancer lesions among HPV-positive women attending colposcopy clinic in Mexico City — Meneses-León et al., Cancer causes & control : CCC
- urine
- self-collection
- validation
- hpv
- sti
2024
Self-collected urine samples detected high-risk HPV DNA in 25.5 per cent of women and 8 per cent of men by qPCR, while oral gargle samples detected HPV in 7 per cent of women and 5 per cent of men. With good diagnostic accuracy against Pap smear, qPCR on self-collected specimens offers a viable decentralised approach to HPV screening in remote populations.
Evaluating different samples & techniques for hr-HPV DNA genotyping to improve the efficiency of risk profiling for oral & cervical cancers in Sikkim, India — Gupta et al., The Indian journal of medical research
- saliva
- urine
- self-collection
- validation
- genotyping
- hpv
- sti
2024
SalivaDirect offers a simpler, faster RNA extraction protocol for SARS-CoV-2 detection from self-collected saliva samples, demonstrating good diagnostic performance and enabling large-scale testing in resource-limited settings without trained healthcare professionals.
SalivaDirect: an alternative to a conventional RNA extraction protocol for molecular detection of SARS-CoV-2 in a clinical setting — Uddin et al., Microbiology spectrum
- saliva
- self-collection
- validation
- serology
2024
The review found dried blood spot sampling correlates strongly with plasma for HIV-1 viral load and offers simplified collection, transport and storage without cold-chain. This could expand access to monitoring in resource-limited settings and improve clinical outcomes through earlier detection of treatment failure.
Revolutionizing HIV-1 Viral Load Monitoring in India: The Potential of Dried Blood Spot Analysis for Expanding Access and Improving Care — Chandane Tak et al., Healthcare
- blood
- dried
- dbs
- validation
- venous-agreement
- serology
2024
First-void urine IgG remained stable for at least 14 days at room temperature when stored with conservation medium. Amicon filtration with Melon Gel purification enriched HPV16-specific IgG that correlated strongly with serum levels, supporting non-invasive disease monitoring and vaccine impact assessment.
Stability, enrichment, and quantification of total and HPV16-specific IgG present in first-void urine — Téblick et al., Scientific reports
- urine
- first-void
- validation
- serology
- hpv
2024
Microsampling with Mitra® devices correlated strongly with venous plasma for capecitabine therapeutic drug monitoring (r=0.97), but yielded consistently lower concentrations. Patients preferred this method and reported minimal pain, suggesting it is suitable for patient-centric oncology drug monitoring in decentralised settings.
Comparison of capecitabine concentrations determined by microsampling versus plasma concentrations for therapeutic drug monitoring: a pilot study — Shafiei et al., The Journal of pharmacy and pharmacology (paywalled)
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- venous-agreement
- acceptability
- tdm
- oncology
2024
The authors validated a VAMS method for ivermectin therapeutic drug monitoring in whole blood, achieving a lower limit of quantification of 1 ng/mL and a linear range of 1–150 ng/mL. By eliminating haematocrit effects that limit dried blood spots, the method supports accurate decentralised sampling for antiparasitic therapy.
Development and validation of ivermectin quantification method in volumetric absorptive microsampling using liquid chromatography-tandem mass spectrometry — Harahap et al., Heliyon
- blood
- dried
- vams
- neoteryx-mitra
- validation
- tdm
- antimicrobials
2024
An LC-MS/MS method for warfarin in VAMS samples was validated to FDA 2022 standards, showing linearity from 5–500 ng/mL. Analysis of 25 patients on warfarin therapy yielded concentrations of 6.05–431.39 ng/mL, confirming that self-collected VAMS can reliably support anticoagulation monitoring in decentralised settings.
Determination of warfarin in volumetric absorptive microsampling by liquid chromatography-tandem mass spectrometry — Harahap et al., Heliyon
- blood
- dried
- vams
- neoteryx-mitra
- validation
- tdm
2024
The study developed and validated an ICP-MS/MS method for trace elements in whole blood collected on VAMS and found that most targeted elements gave accurate and reproducible results compared with a reference method, indicating that VAMS could become an alternative to venipuncture for blood sampling in trace elements analysis.
Validation of Mitra<sup>®</sup> VAMS<sup>®</sup> as a blood collection technique for trace elements analysis using ICP-MS/MS — Breton et al., Bioanalysis (paywalled)
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- venous-agreement
2024
The authors validated a UPLC-PDA assay for ceftazidime in 10 microlitre dried blood spots collected with the Capitainer device from neonatal patients, achieving accuracy of 90.1 to 104.8 per cent and precision within 11.7 per cent coefficient of variation across a quantification range of 0.5 to 200 micrograms per millilitre, and confirmed the method worked on clinical neonatal samples. This supports microsampling-based therapeutic drug monitoring of an antimicrobial in a vulnerable population where conventional venous blood draws are difficult.
Development and validation of a UPLC-PDA method for quantifying ceftazidime in dried blood spots — Lv et al., Journal of pharmaceutical and biomedical analysis (paywalled)
- blood
- dried
- capillary
- dbs
- validation
- pediatric
- tdm
- antimicrobials
2024
An analytical method using Capitainer B devices collecting 10 microlitres of capillary blood was successfully validated for the quantitative determination of 25 PFAS using UHPLC-MS/MS. The method demonstrated high recovery above 80% and met precision and accuracy criteria across the validated range of 2 to 100 ng/mL.
Development and validation of the UHPLC-MS/MS method for the quantitative determination of 25 PFAS in dried blood spots — Galletto et al., Analytical and bioanalytical chemistry
- blood
- dried
- capillary
- dbs
- qdbs
- validation
- toxicology
2024
Plasma separation cards showed high specificity (99.3%) but moderate sensitivity (87.5%) against EDTA-plasma for HIV-1 viral load monitoring at a 1,000 copies/ml threshold in a South African cohort. Despite favourable usability among healthcare workers, laboratory-reported technical difficulties must be addressed to enable reliable decentralised scale-up in resource-constrained settings.
Assessment of the performance of the plasma separation card for HIV-1 viral load monitoring in South Africa — Chimoyi et al., Journal of clinical microbiology
- blood
- dried
- capillary
- validation
- venous-agreement
- acceptability
- pediatric
- serology
2024
A dried urine spot method for measuring 14 amino acids was validated using filter paper and mass spectrometry, offering a stable alternative to liquid urine that supports patient self-collection and remote analysis.
Dried urine spot (DUS) applied for sampling prior to the accurate HILIC-MS/MS determination of 14 amino acids — Meikopoulos et al., Talanta (paywalled)
- urine
- dried
- validation
- dct
2024
The study developed a curcumin-embedded paper sensor for bilirubin detection in saliva, coupled with an IoT-enabled hand-held reader. Clinical testing in 18 jaundiced infants demonstrated good correlation with reference methods for both salivary and blood bilirubin, indicating utility for decentralised neonatal jaundice monitoring.
Spicy Recipe for At-Home Diagnostics: Smart Salivary Sensors for Point-of-Care Diagnosis of Jaundice — Golmohammadi et al., ACS sensors (paywalled)
- saliva
- self-collection
- validation
- pediatric
2024
In confirmed COVID-19 patients, direct RT-PCR on self-collected raw saliva detected all cases (100% sensitivity) with 94.3% concordance to nasopharyngeal swabs. Guanidine-based and guanidine-free inactivators reduced sensitivity to 65.9% and 82.9% respectively. Raw saliva offers a reliable patient-centric alternative for decentralised SARS-CoV-2 testing without sample treatment.
Diagnostic accuracy of direct reverse transcription-polymerase chain reaction using guanidine-based and guanidine-free inactivators for SARS-CoV-2 detection in saliva samples — Katsuno et al., Journal of virological methods (paywalled)
- saliva
- self-collection
- validation
- serology
2024
Microsampling enables home-based specimen collection for drug development and clinical trials, reducing patient burden and expanding enrolment diversity, but requires bridging studies to ensure data comparability with conventional methods and faces analytical challenges that LC-MS strategies aim to address.
Enhancing drug development and clinical studies with patient-centric sampling using microsampling techniques: Opportunities, challenges, and insights into liquid chromatography-mass spectrometry strategies — Chen et al., Journal of mass spectrometry : JMS (paywalled)
- validation
- dct
- standards
2024
Urinary HPV testing offers comparable detection to cervical samples and high patient acceptability, making it a viable noninvasive option for decentralised cervical cancer screening and vaccine surveillance. However, the absence of standardised protocols for sample collection and processing currently limits its widespread clinical adoption.
A review of urinary HPV testing for cervical cancer management and HPV vaccine surveillance: rationale, strategies, and limitations — Cheng et al., European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (paywalled)
- urine
- self-collection
- validation
- acceptability
- hpv
- sti
2024
The review found that saliva and nasal samples generally have lower sensitivity than nasopharyngeal samples for detecting SARS-CoV-2, though performance varies with operator expertise and collection protocol; this supports careful selection of sampling site and method to optimise accuracy in decentralised diagnostics.
The effect of sample site and collection procedure on identification of SARS-CoV-2 infection — Davenport et al., The Cochrane database of systematic reviews
- saliva
- self-collection
- validation
2024
The authors demonstrated that saliva is a viable specimen for SARS-CoV-2 detection and developed an open-source, extraction-free RT-PCR protocol (SalivaDirect) that uses readily available reagents. This approach, which gained FDA Emergency Use Authorisation and scaled to over 200 laboratories performing more than 6.5 million tests, establishes a decentralised model that reduces logistical barriers and enables frequent, self-collected testing for pandemic response.
Scalable solutions for global health: the SalivaDirect model — Wyllie et al., Frontiers in cellular and infection microbiology
- saliva
- self-collection
- validation
- serology
2024
Folate vitamer stability in dried blood microsamples was strongly dependent on temperature and time, with levels remaining within 85 to 115 per cent of baseline at -20°C and 4°C for up to two weeks in both VAMS and DBS, but only lasting three days at room temperature in VAMS and failing at 37°C. The authors conclude that decentralised sampling for folate status monitoring is feasible if transport temperature and duration are controlled, though pretreatment with stabilising agents and desiccant use offered only partial improvement at ambient temperature.
Is the stability of folates in dried blood microsamples sufficient to perform home-sampling studies? — Heughebaert & Stove, The Analyst (paywalled)
- blood
- dried
- vams
- dbs
- neoteryx-mitra
- self-collection
- validation
- biomarkers
2024
The study developed and validated LC-MS/MS methods for ganciclovir in serum, dried serum spots, and VAMS-Mitra devices. In 80 pediatric renal transplant recipients, VAMS showed interchangeability with serum samples while extending stability to at least 49 days at room temperature, making decentralised therapeutic drug monitoring more feasible for transplant patients.
Assessment of Dried Serum Spots (DSS) and Volumetric-Absorptive Microsampling (VAMS) Techniques in Therapeutic Drug Monitoring of (Val)Ganciclovir-Comparative Study in Analytical and Clinical Practice — Kocur et al., International journal of molecular sciences
- blood
- dried
- vams
- neoteryx-mitra
- validation
- pediatric
- tdm
- antimicrobials
2024
The Tasso+ device, which uses a vacuum to collect capillary blood from the upper arm, gathered an average of 536 microlitres of whole blood from 47 men who have sex with men using PrEP, with 91% of samples sufficient for HIV testing and 89% for syphilis testing. Acceptability was high, with 87% expressing a positive attitude and 77% willing to use the device again for home self-sampling.
Using an Innovative Method for Self-Collection of Capillary Blood for HIV and Syphilis Testing Among Men Who Have Sex With Men Who Use Pre-exposure Prophylaxis in the Netherlands; Limburg4zero — Goense et al., Sexually transmitted diseases (paywalled)
- blood
- liquid
- capillary
- self-collection
- validation
- acceptability
- serology
- sti
2024
Capillary blood collection using liquid and dried microsampling devices yielded pharmacokinetic profiles comparable to venous sampling for two monoclonal antibodies and a small molecule, whereas haematocrit correction was necessary for dried formats and bridging was ineffective for hydroxychloroquine. The findings demonstrate the bioanalytical feasibility and patient acceptability of remote microsampling tools for pharmacokinetic evaluations in decentralised clinical trials.
Evaluation of Patient-Centric Sample Collection Technologies for Pharmacokinetic Assessment of Large and Small Molecules — Mandlekar et al., Clinical pharmacology and therapeutics (paywalled)
- blood
- liquid
- dried
- capillary
- neoteryx-mitra
- validation
- venous-agreement
- acceptability
- tdm
- biologics
- dct
- haematocrit
2024
Low volume sampling devices showed good concordance with venous serum for measuring the pharmacodynamic biomarker sMAdCAM-1, but dried blood samples required substantial dilution to overcome buffer interference, which was mitigated by using a highly sensitive Simoa assay. The study demonstrates that while these devices have potential for decentralised clinical trials, careful validation is needed to address site-specific biases and assay sensitivity limitations.
Evaluation of low volume sampling devices for a pharmacodynamic biomarker analysis: Challenges and solutions — Yang et al., Journal of pharmaceutical and biomedical analysis (paywalled)
- blood
- liquid
- dried
- neoteryx-mitra
- validation
- venous-agreement
- dct
- biomarkers
2024
Self-collected dried blood spots analysed on the Roche Elecsys platform gave quantitative anti-spike antibody results that agreed closely with paired venous samples, with sensitivity 96.63% and specificity 97.81% and a conversion formula across 0.018 to 250 U/mL, enabling accurate tracking of titre changes in longitudinal cohorts after vaccination.
A Dried Blood Spot protocol for high-throughput quantitative analysis of SARS-CoV-2 RBD serology based on the Roche Elecsys system — Castelletti et al., Microbiology spectrum
- blood
- dried
- dbs
- self-collection
- validation
- venous-agreement
- serology
2024
Steroid hormones in dried blood spots remained within 15% of baseline for up to 14 days at 37C, and for up to 6 months at -20C, 4C and room temperature, with specific exceptions for androstenedione, 17-OHP, cortisone and cortisol. These findings support the use of DBS for decentralised hormone monitoring by defining storage limits that preserve analyte integrity during transit and storage.
Stability of steroid hormones in dried blood spots (DBS) — Olthof et al., Clinical chemistry and laboratory medicine (paywalled)
- blood
- dried
- dbs
- self-collection
- validation
- hormones
2024
First-void urine testing detected HPV with 87% sensitivity and 89% specificity, and participants reported feeling comfortable with this self-collection method. This approach could improve uptake of cervical cancer screening in decentralised settings.
The Impact of Urine-Sample HPV Testing on the Effectiveness of Screening for Cervical Cancer: An Umbrella Review — Miazga et al., Cancers
- urine
- first-void
- self-collection
- validation
- acceptability
- hpv
2024
A validated LC-MS method quantified multiple antibiotics from a single volumetric absorptive microsample, with stability up to 90 days for most analytes and minimal haematocrit effect except vancomycin, enabling pharmacokinetic and pharmacodynamic studies in decentralised settings.
Bioanalysis of six antibiotics from volumetric microsamples: a new tool for precision dosing in critically ill children — Takyi-Williams et al., Bioanalysis (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- pediatric
- tdm
- antimicrobials
- haematocrit
2024
The study validated an LC-HRMS method for measuring breast cancer drugs in plasma, urine, VAMS and oral fluid, showing that all matrices except oral fluid for certain drugs can support decentralised therapeutic drug monitoring. VAMS and oral fluid faced practical challenges in collection due to patient conditions, but the method enables patient-centric monitoring with dried blood and other self-collected samples.
Towards clinical adherence monitoring of oral endocrine breast cancer therapies by LC-HRMS-method development, validation, comparison of four sample matrices, and proof of concept — Jacobs et al., Analytical and bioanalytical chemistry
- blood
- saliva
- urine
- dried
- vams
- neoteryx-mitra
- validation
- tdm
- oncology
2024
The authors validated an LC-HRMS/MS assay for steroids and thyroid hormones in 30 microlitres of capillary blood collected with Neoteryx Mitra VAMS devices, demonstrating storage stability of over 28 days frozen and 14 days at room temperature. Using authentic samples from 50 healthy active adults, the method showed adequate sensitivity to detect the reduced hormone concentrations seen in relative energy deficiency in sport, supporting self-collected VAMS as a practical tool for regular hormone monitoring in athletes.
Development of an LC-HRMS/MS Method for Quantifying Steroids and Thyroid Hormones in Capillary Blood: A Potential Tool for Assessing Relative Energy Deficiency in Sport (RED-S) — Tuma et al., Metabolites
- blood
- dried
- vams
- neoteryx-mitra
- validation
- hormones
2024
This study found that dried blood spot samples stored at room temperature for four years correlated highly with serum measurements for testosterone and androstenedione, indicating that hematocrit adjustment may be unnecessary for serial monitoring in home-based self-sampling.
Dried blood spot sampling of testosterone microdosing in healthy females — Desai et al., The Journal of steroid biochemistry and molecular biology (paywalled)
- blood
- dried
- capillary
- dbs
- self-collection
- validation
- venous-agreement
- fertility
- hormones
- haematocrit
2024
An on-line SPE-LC-MS method using 10 microlitre capillary blood samples collected on VAMS tips achieved lower limits of quantitation of 0.03 micromolar for methotrexate and 7-OH-MTX and 0.05 micromolar for DAMPA, with acceptable accuracy and precision. A plasma-to-whole-blood correlation factor of 0.46 was observed, supporting low-volume pediatric drug monitoring.
Development and validation of a bioanalytical method for the quantification of methotrexate from serum and capillary blood using volumetric absorptive microsampling (VAMS) and on-line solid phase extraction (SPE) LC-MS — Opitz et al., Journal of chromatography. A (paywalled)
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- pediatric
- tdm
- oncology
2024
The study validated a VAMS-based method for measuring cenobamate in capillary blood, showing high precision accuracy and stability at room temperature for up to 15 days. Cenobamate levels in VAMS samples agreed with those in venous plasma, supporting its use in decentralised therapeutic drug monitoring for epilepsy patients.
A VAMS-based LC-MS/MS method for precise cenobamate quantification in epilepsy (patients) — Pigliasco et al., Epilepsia open
- blood
- dried
- vams
- validation
- venous-agreement
- tdm
2024
An LC-MS/MS method for seven antiepileptic drugs was validated using dried blood and dried plasma spots, showing acceptable precision and accuracy. Samples remained stable for seven days at ambient temperature and 40°C, with good correlation to wet plasma concentrations, supporting decentralised therapeutic drug monitoring with self-collection and room-temperature transport.
Simultaneous monitoring of seven antiepileptic drugs by dried blood spot and dried plasma spot sampling: method validation and clinical application of a LC-MS/MS-based technique — Cao et al., Journal of pharmaceutical and biomedical analysis (paywalled)
- blood
- dried
- dbs
- validation
- venous-agreement
- tdm
2024
Self-collected saliva without additives showed comparable diagnostic performance to nasopharyngeal swabs for SARS-CoV-2 detection, with 87.6% sensitivity and 99.6% specificity. The sample remained stable for 72 hours and was deemed acceptable by both patients and staff, supporting its use in decentralised, patient-centric screening programmes.
Diagnostic performance, stability, and acceptability of self-collected saliva without additives for SARS-CoV-2 molecular diagnosis — Marín-Echeverri et al., European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (paywalled)
- saliva
- self-collection
- validation
- acceptability
- serology
2024
A validated high-throughput LC-MS/MS assay for piperaquine from dried blood spots achieved 54-72% recovery with <9% relative standard deviation and a quantification limit of 3 ng/mL, enabling detection for 4-8 weeks post-dose. The method showed minimal haematocrit interference and is suitable for therapeutic drug monitoring of antimalarial treatment in resource-limited settings and pediatric populations.
A high-throughput LC-MS/MS assay for piperaquine from dried blood spots: Improving malaria treatment in resource-limited settings — Blessborn et al., Journal of mass spectrometry and advances in the clinical lab
- blood
- dried
- capillary
- dbs
- validation
- tdm
- antimicrobials
- haematocrit
2024
This pilot study of 15 subjects demonstrated that dried fecal spots on quantitative DBS devices yielded bile acid profiles equivalent to frozen samples after four months of ambient storage and shipping. This validates a decentralised stool microsampling method that could enable patient home testing and expand screening in rural or resource-limited settings.
Repurposing dried blood spot device technology to examine bile acid profiles in human dried fecal spot samples — Engevik et al., American journal of physiology. Gastrointestinal and liver physiology (paywalled)
- stool
- dried
- qdbs
- self-collection
- validation
- metabolome
2024
The OncoPredict HPV Quantitative Typing assay achieved clinical sensitivity ratios of 0.99 for urine and 1.00 for vaginal self-samples versus clinician-collected cervical samples for detecting CIN2+, and after cut-off optimisation showed similar accuracy on self-collected and cervical specimens, supporting decentralised cervical screening through urine self-collection with Colli-Pee.
Clinical accuracy of OncoPredict HPV Quantitative Typing (QT) assay on self-samples — Latsuzbaia et al., Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology (paywalled)
- urine
- first-void
- colli-pee
- self-collection
- validation
- hpv
- sti
2024
Self-collected first-void urine using the Colli-Pee device detected high-risk HPV with 96.7 per cent concordance compared with clinician-collected cervical swabs in 240 women, with a Cohen's kappa of 0.87, indicating strong agreement and supporting urine self-collection as an acceptable approach for HPV screening.
Comparable detection of HPV using real-time PCR in paired cervical samples and concentrated first-stream urine collected with Colli-Pee device — Nilyanimit et al., Diagnostic microbiology and infectious disease
- urine
- first-void
- colli-pee
- self-collection
- validation
- hpv
2024
This review of 2022 to 2023 work surveys dried blood microsampling for targeted and untargeted metabolomic and lipidomic profiling, finding the approach viable across paediatric research, therapeutic drug monitoring, metabolite screening, biomarker discovery, sports supervision, clinical disorder studies and forensic toxicology. The authors note that dried blood spots and VAMS dominate the published literature over other volumetric formats, and argue that harmonising analytical methods would accelerate wider clinical adoption of microsampling as an alternative to conventional plasma or serum profiling.
Targeted and untargeted metabolomics and lipidomics in dried blood microsampling: Recent applications and perspectives — Couacault et al., Analytical science advances
- blood
- dried
- vams
- dbs
- validation
- pediatric
- tdm
- toxicology
- metabolome
- biomarkers
2024
This review of remote HbA1c testing via capillary blood microsampling finds that both dried and liquid formats can produce results comparable to venous sampling when collection, stability and extraction are properly validated. It matters because self-collected microsamples could enable decentralised diabetes monitoring and telemedicine, but heterogeneity in study designs and methods must be resolved before reliable implementation.
Remote HbA<sub>1c</sub> testing via microsampling: fit for purpose? — Verougstraete et al., Clinical chemistry and laboratory medicine (paywalled)
- blood
- liquid
- dried
- capillary
- self-collection
- validation
- venous-agreement
- acceptability
2024
The authors validated a dried blood spot method for simultaneous measurement of vancomycin and creatinine with a 5.2-minute run time, demonstrating linear ranges suitable for therapeutic drug monitoring. This supports home-based sampling to reduce the burden of clinic visits for patients requiring vancomycin monitoring.
Dried blood spot analysis for the quantification of vancomycin and creatinine using liquid chromatography - tandem mass spectrometry: Method development and validation — Bahmany et al., Clinica chimica acta; international journal of clinical chemistry (paywalled)
- blood
- dried
- dbs
- validation
- tdm
- antimicrobials
2024
The Xpert CT/NG assay showed high specificity and moderate-to-high sensitivity for chlamydia and gonorrhoea in urine and rectal specimens, though pharyngeal sensitivity was lower. High acceptability among men who have sex with men and rapid turnaround support its use for decentralised STI screening with immediate treatment initiation.
Clinic-based evaluation of the dual Xpert CT/NG assay on the GeneXpert System for screening for extragenital chlamydial and gonococcal infections amongst men who have sex with men — Cordioli et al., BMC infectious diseases
- urine
- first-void
- validation
- acceptability
- sti
2024
This study validated a method for measuring six oral anticancer drugs and their metabolites in 10 μL dried whole blood collected by VAMS. The method remained stable for 14 days at room temperature during shipping and up to nine months when frozen, supporting its use for decentralised therapeutic drug monitoring and reducing the need for clinic visits.
Analytical Validation of a Volumetric Absorptive Microsampling Method for Therapeutic Drug Monitoring of the Oral Targeted Anticancer Agents, Abiraterone, Alectinib, Cabozantinib, Imatinib, Olaparib, and Sunitinib, and Metabolites — Meertens et al., Therapeutic drug monitoring (paywalled)
- blood
- dried
- vams
- validation
- tdm
- oncology
2024
The study developed a one-pot duplex RT-LAMP assay for saliva that detects SARS-CoV-2 down to 100 copies per microlitre within 30 minutes without RNA extraction, using human 18S ribosomal RNA as an internal amplification control. In 30 clinical saliva samples the assay achieved 95 per cent sensitivity, 100 per cent specificity and 96 per cent accuracy, supporting reliable at-home and point-of-care molecular diagnostics.
Development of an integrated sample amplification control for salivary point-of-care pathogen testing — Sritong et al., Analytica chimica acta (paywalled)
- saliva
- self-collection
- validation
2024
Self-collected saliva for SARS-CoV-2 RT-PCR showed high sensitivity and specificity with an overall agreement of 84% compared with nasopharyngeal swabs, supporting its use as a viable diagnostic option where laboratory facilities are limited.
MOLECULAR DETECTION PROTOCOL OF SARS-COV-2 THROUGH SELF-COLLECTED SALIVA SPECIMENS VERSUS NASOPHARYNGEAL SWABS — Abderezak et al., African journal of infectious diseases
- saliva
- self-collection
- validation
- pediatric
- serology
2024
Self-collected unpreserved saliva samples gave SARS-CoV-2 detection that was only slightly less accurate than nasopharyngeal swabs, offering a more convenient patient-centric alternative for COVID-19 surveillance and potentially increasing testing in decentralised settings.
Evaluation of Self-collected Saliva Samples Without Viral Transport Media for SARS-CoV-2 Testing via RT-PCR and Comparison of Amplicon Sequences Against Commonly Used Primers in Diagnostic Assays — Ramos et al., Military medicine (paywalled)
- saliva
- liquid
- self-collection
- validation
- serology
2024
Self-collected saliva samples for SARS-CoV-2 testing yielded higher viral loads than nasal or urine specimens and showed moderate agreement (kappa 0.52) with nasal swabs. A colourimetric LAMP assay achieved 90% concordance with RT-PCR, offering a rapid alternative deployable in clinics, workplaces, and homes for decentralised surveillance.
Evaluation of self-collected nasal, urine, and saliva samples for molecular detection of SARS-CoV-2 using an EUA approved RT-PCR assay and a laboratory developed LAMP SARS-CoV-2 test — Purcell-Wiltz et al., Immunity, inflammation and disease
- saliva
- urine
- self-collection
- validation
- serology
2024
Three freeze-thaw cycles, Virkon disinfectant, and air drying on Mitra microsamplers for two hours each inactivated Trypanosoma cruzi in spiked blood, while FTA C cards failed. These validated methods permit safe removal of infectious samples from containment facilities for storage and analysis, supporting decentralised diagnostics.
Validation of Trypanosoma cruzi inactivation techniques for laboratory use — MacLean et al., PloS one
- blood
- dried
- vams
- neoteryx-mitra
- validation
- serology
2024
Dried blood microsamplers (Mitra) and dried blood spots maintained metabolite stability comparable to plasma at minus 80 degrees Celsius, and both dried formats remained stable at minus 20 degrees Celsius while plasma showed reduced stability. At refrigerated temperature, Mitra microsampler profiles were more stable than plasma or dried blood spots, particularly for lipids, suggesting capillary blood microsampling could support sample collection outside clinical settings where ultra-cold storage is unavailable.
Effects of storage temperature and time on metabolite profiles measured in dried blood spots, dried blood microsamplers, and plasma — Petrick et al., The Science of the total environment (paywalled)
- blood
- dried
- capillary
- vams
- dbs
- neoteryx-mitra
- validation
- metabolome
2024
Filtered protein precipitation was the most effective extraction method for 75 per- and polyfluoroalkyl substances from dried blood spots collected with a capillary microsampler, recovering 72 analytes within 70–130% with limits of detection from 0.05 to 0.34 ng/mL. The method detected 16 PFAS in self-collected human samples, demonstrating feasibility for large-scale biomonitoring studies using minimally invasive sampling.
Validating blood microsampling for per- and polyfluoroalkyl substances quantification in whole blood — Partington et al., Journal of chromatography. A (paywalled)
- blood
- dried
- capillary
- dbs
- validation
- toxicology
2024
A graphene lab-on-a-chip device achieved high accuracy and precision for multiplex renal biomarker testing in serum and saliva, with sensitivities ranging from 89.0 to 99.7 per cent. Untrained volunteers produced results comparable to trained chemists, suggesting the device is suitable for patient-centric at-home diagnostics and could improve access to chronic kidney disease monitoring.
Noninvasive and Multiplex Self-Test of Kidney Disease Biomarkers with Graphene-Based Lab-on-a-Chip (G-LOC): Toward Digital Diagnostics in the Hands of Patients — Diforti et al., Analytical chemistry (paywalled)
- saliva
- self-collection
- validation
- acceptability
- biomarkers
2024
Capillary dried blood spots collected during professional triathlon competitions detected endogenous erythropoietin in all 111 athletes using Tasso-M20 devices, even when matching urine samples were negative. Mitra VAMS devices also sensitively detected recombinant EPO micro-doses and the EPO c.577del variant, confirming that microsampling provides a viable complementary matrix for decentralised doping analysis.
Dried blood spots for erythropoietin analysis: Detection of micro-doses, EPO c.577del variant and comparison with in-competition matching urine samples — Heiland et al., Drug testing and analysis (paywalled)
- blood
- dried
- capillary
- vams
- dbs
- neoteryx-mitra
- validation
- doping
2024
In young elite footballers with regular cycles, salivary progesterone correlated strongly with capillary blood concentrations, offering a non‑invasive way to track ovarian function. A luteal‑phase saliva progesterone threshold of 50 pg/ml and a 1.5‑fold rise over follicular baseline showed good accuracy for confirming ovulation against serum criteria.
The use of saliva and blood progesterone to profile the menstrual cycles of youth professional football players — Ferrer et al., Frontiers in sports and active living
- blood
- saliva
- capillary
- validation
- fertility
- hormones
2024
This literature review found that DNA methylation markers on self-collected urine or cervicovaginal swabs detected cervical intraepithelial neoplasia as well as cytology. The combination could improve screening uptake and reduce loss to follow-up, particularly in low- and middle-income countries, though more evidence is needed to identify the most efficacious methylation tests.
The current state of DNA methylation biomarkers in self-collected liquid biopsies for the early detection of cervical cancer: a literature review — Sumiec et al., Infectious agents and cancer
- urine
- self-collection
- validation
- hpv
- sti
- biomarkers
- liquid-biopsy
2024
Fifty-eight matched capillary and venous blood samples collected under official doping control conditions demonstrated excellent laboratory agreement for complete blood count parameters (except platelets) after temperature-monitored air shipment. This validates micro capillary collection as a virtually painless, athlete-friendly alternative to venipuncture for the Athlete Biological Passport, supporting its use in decentralised diagnostics.
Application of micro capillary blood sampling in an anti-doping setting — Lewis et al., Drug testing and analysis (paywalled)
- blood
- capillary
- validation
- venous-agreement
- doping
2024
The authors validated an LC-MS/MS method for quantifying 18 endogenous steroids and metabolites in 30 μL dried blood VAMS samples from 20 healthy volunteers. Steroids remained stable for up to 100 days across storage temperatures from room temperature to -80 °C and through three freeze-thaw cycles, suggesting VAMS is reliable for doping control and clinical hormone monitoring outside traditional settings.
LC-MS/MS measurement of endogenous steroid hormones and phase II metabolites in blood volumetric absorptive microsampling (VAMS) for doping control purposes — Ponzetto et al., Clinica chimica acta; international journal of clinical chemistry (paywalled)
- blood
- dried
- vams
- validation
- hormones
- doping
- toxicology
2024
Self-collected dried blood spots showed high specificity and acceptable sensitivity for detecting islet antibodies compared to serum samples, and participants preferred this method over venous blood draw for its ease and reduced pain.
Feasibility and Validity of In-Home Self-Collected Capillary Blood Spot Screening for Type 1 Diabetes Risk — Sing et al., Diabetes technology & therapeutics (paywalled)
- blood
- capillary
- dbs
- self-collection
- validation
- venous-agreement
- acceptability
2024
In 30 adult solid organ transplant recipients, capillary blood self-collected using the Tasso+ device showed 91% concordance with venous samples for detecting CMV DNAemia above the limit of detection, with excellent quantitative correlation (Spearman R² = 0.99). Most participants preferred self-collection over venipuncture, suggesting the device could enable decentralised viral monitoring, though sensitivity was lower (95% at 308 IU/mL).
Evaluation of the Tasso+ blood self-collection device for quantitation of plasma cytomegalovirus (CMV) DNAemia in adult solid organ transplant recipients (SOTr) — Phan et al., Microbiology spectrum
- blood
- liquid
- capillary
- self-collection
- validation
- venous-agreement
- acceptability
- serology
2024
Older adults achieved 98% adherence when self-collecting dried blood spots at home for inflammatory markers, with 97% of samples yielding valid results. Test-retest reliability was good (ICCs 0.70–0.76) and correlation with venous blood was strong (r=0.60–0.99), demonstrating that remote capillary sampling is a feasible and valid method for decentralised assessment of inflammation in older adults.
Remote dried blood spot collection for inflammatory markers in older adults is feasible, reliable, and valid — Reed et al., Brain, behavior, and immunity (paywalled)
- blood
- dried
- dbs
- self-collection
- validation
- venous-agreement
- acceptability
- biomarkers
2024
A systematic review of 70 studies found that 94.7% of accuracy studies reported comparable sensitivity and specificity between self-sampling and clinician collection for HPV detection, with patient acceptability ranging from 84.2% to 100% for devices including Colli-Pee. This evidence endorses decentralised cervical screening to improve uptake.
Comparison of diagnostic accuracy and acceptability of self-sampling devices for human Papillomavirus detection: A systematic review — Aimagambetova et al., Preventive medicine reports
- urine
- first-void
- colli-pee
- self-collection
- validation
- acceptability
- hpv
2024
The novel lateral flow assay demonstrated excellent clinical sensitivity and specificity for detecting Neisseria gonorrhoeae in first-void urine and vaginal swabs, meeting the target product profile for a rapid point-of-care test. This decentralised diagnostic tool could optimise clinical management and reduce unnecessary antibiotic use in primary care settings lacking laboratory infrastructure.
Novel lateral flow assay for point-of-care detection of Neisseria gonorrhoeae infection in syndromic management settings: a cross-sectional performance evaluation — Peters et al., Lancet
- urine
- first-void
- validation
- sti
2023
A study of 50 paediatric renal transplant recipients found that a validated VAMS LC-MS/MS method for tacrolimus showed high correlation with the reference method over 0.5–60 ng/mL, with minimal haematocrit effect.
Therapeutic Drug Monitoring of Tacrolimus Based on VAMS in Renal Transplant Pediatric Recipients — LC-MS/MS Method, Hematocrit Effect, and Clinical Application — Kocur et al., Pharmaceutics
- vams
- neoteryx-mitra
- blood
- tdm
- haematocrit
- dried
- capillary
- pediatric
- immunosuppressants
- validation
2023
VAMS microsampling found no significant difference from venous blood for tacrolimus in paediatric patients; samples were stable for 14 days, with average difference between paired at-home samples of 0.12 ± 0.94 ng/mL.
VAMS and parallel-reaction-monitoring mass spectrometry for tacrolimus trough measurements at home in paediatric heart-transplant patients — Zhao et al., J. Mass Spectrometry and Advances in the Clinical Lab
- vams
- venous-agreement
- acceptability
- blood
- dbs
- tdm
- self-collection
- dried
- capillary
- pediatric
- immunosuppressants
- validation
2023
A structured review: many VAMS assays are analytically validated and can substitute for venous sampling for well-characterised analytes, though clinical-validation depth varies.
Analytical and Clinical Validation of Assays for VAMS of Drugs in Different Blood Matrices: A Literature Review — Nugraha et al., Molecules
- vams
- venous-agreement
- blood
- tdm
- dried
- immunosuppressants
- validation
2023
VAMS matched serum for the kinase inhibitors nilotinib, cabozantinib, dabrafenib and ruxolitinib, r 0.94–0.97, with serum reliably predictable for the first three, and 93% of at-home samples were collected correctly: at-home VAMS shown feasible for routine cancer-drug monitoring.
Clinical validation and feasibility of VAMS for monitoring of nilotinib, cabozantinib, dabrafenib, trametinib and ruxolitinib — Zimmermann et al., J. Pharmaceutical and Biomedical Analysis (paywalled)
- vams
- venous-agreement
- acceptability
- blood
- tdm
- self-collection
- haematocrit
- dried
- oncology
- capillary
- validation
Read from the corpus on .