The Library
1530 papers on microsampling and monitoring, each with a finding paraphrased to our standard and labelled in one vocabulary. Every entry links to a legitimate copy; nothing is copied from an abstract.
Papers 101–200 of 323 labelled “venous-agreement”, newest first.
2025
Over two years, 1,507 participants used in-home capillary blood spot sampling for islet autoantibody screening, with only one reporting collection failure, compared with five failures among 276 venipuncture participants. Blood spot sampling reached younger and regionally based Australians at lower cost and with greater convenience, identifying preclinical type 1 diabetes at expected prevalence and supporting early diagnosis without the barriers of clinic-based venous draws.
Islet Autoantibody Screening Throughout Australia Using In-Home Blood Spot Sampling: 2-Year Outcomes of Type1Screen — Wentworth et al., Diabetes care (paywalled)
- blood
- capillary
- dbs
- self-collection
- venous-agreement
- pediatric
2025
Salivary concentrations of 17OH-progesterone, androstenedione, dehydroepiandrosterone, testosterone and progesterone showed strong positive correlations with serum in both prepubertal and pubertal children with congenital adrenal hyperplasia, supporting saliva as a minimally invasive alternative to venipuncture for diagnosis and therapy monitoring.
[Salivary steroid profile investigation by high performance liquid chromatography-tandem mass spectrometry in children with congenital adrenal hyperplasia] — Tiulpakov et al., Problemy endokrinologii
- blood
- saliva
- venous-agreement
- pediatric
- hormones
2025
In 55 patients, four approaches to convert dried capillary blood concentrations to plasma equivalents were evaluated. All methods except haematocrit-based conversion yielded acceptable analytical and clinical agreement for paracetamol and metabolites, supporting the reliability of capillary microsampling for decentralised therapeutic drug monitoring.
Comparative Evaluation of Approaches to Convert Microsampled Capillary Blood Concentrations to Plasma Concentrations: Paracetamol and Metabolites as a Case Study — Boffel et al., The AAPS journal (paywalled)
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- venous-agreement
- dct
- haematocrit
2025
Capillary volumetric absorptive microsampling showed significant differences in absolute antibiotic concentrations compared to venous plasma, yet it reliably tracked the pharmacokinetic profiles of amoxicillin, metronidazole, and azithromycin over time. The approach was well accepted by both participants and clinicians, indicating its feasibility for less invasive therapeutic drug monitoring in periodontal clinical trials.
A comparison between venous blood sampling and capillary volumetric absorptive microsampling for antibiotics levels monitoring in individuals with and without periodontal disease — Lazaridi et al., Clinical oral investigations
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- venous-agreement
- acceptability
- tdm
- antimicrobials
2025
All five at-home urine ovulation predictor kits demonstrated high accuracy (92–97%) when compared with blood LH levels, though sensitivity varied widely from 38% to 77% with Clinical Guard the lowest. Patient experience was comparable across kits, though Clinical Guard was slightly less favoured for future use.
Similar accuracy and patient experience with different one-step ovulation predictor kits — Vanderhoff et al., Fertility and sterility (paywalled)
- blood
- urine
- self-collection
- validation
- venous-agreement
- acceptability
- fertility
- hormones
2025
Capillary blood collected with a Tasso+ device showed excellent agreement with venous serum for testosterone, the testosterone/androstenedione ratio, and luteinising hormone in 20 adults tracked over six weeks. The biomarkers remained stable when capillary samples were stored at room temperature, suggesting capillary microsampling could enable decentralised, patient-centric collection for the Athlete Biological Passport without cold-chain logistics.
Is blood blood? Comparing quantitation of endogenous steroids and luteinizing hormone in concurrently collected venous serum and Tasso+ SST capillary serum samples — Goodrum et al., Drug testing and analysis (paywalled)
- blood
- capillary
- validation
- venous-agreement
- hormones
- doping
2025
Capillary finger-stick blood showed excellent comparability with venous samples for 30 of 33 routine chemistry analytes against total allowable error criteria, and met CLIA 2024 proficiency testing limits for all but glucose. This validates capillary sampling as a clinically acceptable alternative for most routine tests, benefiting patients with needle phobia and enabling remote sampling.
Comparison of capillary finger stick and venous blood sampling for 34 routine chemistry analytes: potential for in hospital and remote blood sampling — Doeleman et al., Clinical chemistry and laboratory medicine (paywalled)
- blood
- liquid
- capillary
- validation
- venous-agreement
2024
At-home capillary microsampling carried pharmacokinetic sampling across the Paxlovid phase II/III programme, with fewer than 3% of more than 800 samples unusable, and the resulting data supported the Emergency Use Authorization and subsequent FDA approval: remotely collected samples accepted in a registrational filing.
Patient Centric Microsampling to Support Paxlovid Clinical Development: Bridging and Implementation — Wan et al., Clinical Pharmacology & Therapeutics (paywalled)
- dct
- volumetric
- venous-agreement
- blood
- self-collection
- dried
- capillary
- validation
2024
Head-to-head clinical validation of two VAMS devices for tacrolimus and mycophenolic acid, with roughly 86–88% of samples within ±20% of venous.
Clinical validation of two volumetric absorptive microsampling devices to support home-based therapeutic drug monitoring of immunosuppression — Leino et al., British Journal of Clinical Pharmacology (paywalled)
- vams
- venous-agreement
- acceptability
- neoteryx-mitra
- blood
- tdm
- self-collection
- dried
- immunosuppressants
- validation
2024
In 91 children and adults, capillary C-peptide taken with the TAP device matched venous sampling with 100% sensitivity and specificity for a clinically relevant level, 200 pmol/L or above, with r = 0.996. 63% preferred it to a needle against 7% who preferred the needle, and same-day bruising was 5.5% versus 34.8% after a venous draw.
Transdermal blood sampling for C-peptide is a minimally invasive, reliable alternative to venous sampling in children and adults with type 1 diabetes — Besser et al., Diabetes Care
- blood
- liquid
- yourbio
- capillary
- pediatric
- venous-agreement
- acceptability
- validation
2024
A study of 301 adults with epilepsy providing 464 measurements found that patient-centric capillary VAMS microsampling showed good agreement with plasma for seven of 13 antiseizure medicines, such as carbamazepine and levetiracetam. However, systematic differences remained for valproate, primidone, topiramate, and zonisamide, meaning decentralised monitoring is feasible for most but some drugs need further evaluation.
Fingerprick volumetric absorptive microsampling for therapeutic drug monitoring of antiseizure medications: Reliability and real-life feasibility in epilepsy patients — Cancellerini et al., Journal of pharmaceutical and biomedical analysis (paywalled)
- vams
- venous-agreement
- blood
- tdm
- self-collection
- dried
- capillary
2024
The study found excellent agreement between hCG levels measured in remotely collected capillary blood and standard venous samples, with a near-perfect correlation. This demonstrates that remote self-collection is a feasible and acceptable alternative for serial pregnancy monitoring, reducing the need for clinic visits.
Proof-of-concept study: Remote capillary blood collection for hCG analysis in early pregnancy — Joyce et al., European journal of obstetrics, gynecology, and reproductive biology (paywalled)
- venous-agreement
- acceptability
- blood
- self-collection
- capillary
- fertility
- hormones
- liquid
2024
The study validated a VAMS-based LC-MS/MS method for measuring sirolimus levels, showing it was clinically equivalent to the standard whole blood method and suitable for therapeutic drug monitoring in paediatric transplant patients, supporting the use of decentralised microsampling for this purpose.
Personalization of pharmacotherapy with sirolimus based on volumetric absorptive microsampling (VAMS) in pediatric renal transplant recipients-from LC-MS/MS method validation to clinical application — Kocur et al., Pharmacological reports : PR
- vams
- venous-agreement
- neoteryx-mitra
- blood
- tdm
- haematocrit
- dried
- capillary
- pediatric
- immunosuppressants
- validation
2024
A study of 152 women found that HbA1c and reproductive hormone levels from menstrual blood collected via a modified pad highly correlated with venous blood, supporting its use as a decentralised surrogate, though interassay variability was noted.
Concordance of hemoglobin A1c and reproductive hormone levels in menstrual and venous blood — Naseri et al., F&S reports
- blood
- dried
- dbs
- venous-agreement
- fertility
- hormones
2024
Capillary sampling gave TSH and FT4 results that closely matched venous values, with Spearman correlations of 0.99 and 0.97 respectively. This supports using small capillary samples for remote thyroid function testing.
Determination of Capillary Blood TSH and Free Thyroxine Levels Using Digital Immunoassay — Suzuki et al., Journal of the Endocrine Society
- venous-agreement
- blood
- capillary
- hormones
- yourbio
2024
Capillary serum collected with Tasso-SST and Tasso+ devices correlated with venous plasma at r = 0.98 for abrocitinib and its three metabolites, and exposure met bioequivalence criteria; the authors present this as the basis for using Tasso devices in future paediatric studies of abrocitinib.
Patient-centric microsampling for abrocitinib pharmacokinetics: multiple-analytes assay bridging using Tasso device — Tripathy et al., Bioanalysis
- blood
- capillary
- venous-agreement
- pediatric
- tdm
2024
Capillary sampling for carcinoembryonic antigen showed near perfect agreement with venous results and was preferred by most participants, supporting reliable home based collection that could reduce hospital visits.
Feasibility, reliability and satisfaction of (automated) capillary carcinoembryonic antigen measurements for future home-based blood sampling: the prospective CASA-I study — Voigt et al., Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland (paywalled)
- venous-agreement
- acceptability
- blood
- self-collection
- oncology
- colorectal
- capillary
- yourbio
2024
Capillary blood self-collection yielded protein concentrations that matched venipuncture for only a minority of analytes, with 34 of 230 proteins showing acceptable correlation and low variability, while the remainder were more variable; this suggests capillary sampling can support decentralised proteomics for a subset of proteins but may not be universally interchangeable with venipuncture.
Capillary blood self-collection for high-throughput proteomics — El-Sabawi et al., Proteomics
- venous-agreement
- blood
- self-collection
- capillary
- liquid
- biomarkers
2024
Capillary finger prick sampling at home showed close agreement with venous sampling for measuring infliximab, vedolizumab and CRP, with no systematic bias and high patient tolerability and practicality, supporting decentralised monitoring of biologic therapy in IBD.
Clinical Validation of a Capillary Blood Home-Based Self-Sampling Technique for Monitoring of Infliximab, Vedolizumab, and C-Reactive Protein Concentrations in Patients With Inflammatory Bowel Disease — Otten et al., Inflammatory bowel diseases
- blood
- liquid
- capillary
- self-collection
- venous-agreement
- acceptability
- tdm
- biologics
2024
A time-resolved fluorescence assay detected HPV16-specific IgG in first-void urine with strong correlation to paired serum across four immunoassays in 225 healthy women, supporting first-void urine as a non-invasive alternative to venous blood for HPV antibody monitoring.
Time-resolved fluorescence (TRF) for total IgG and HPV16-specific antibody detection in first-void urine and serum: A comparative study — Lipovac et al., Journal of virological methods
- urine
- first-void
- validation
- venous-agreement
- serology
- hpv
2024
The study validated a method for determining 15 trace elements in whole blood collected via VAMS, showing high precision and accuracy with agreement to a liquid sampling method. This supports the use of VAMS for decentralised trace element analysis in clinical and research settings.
A miniaturized sample preparation method for routine elemental determination in whole blood using volumetric absorptive micro-sampling by ICP-QQQ — Schmidt et al., Analytical and bioanalytical chemistry (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- venous-agreement
2024
A short fasting test initiated overnight at home and completed in an outpatient setting diagnosed insulinoma in 11 of 12 patients within 24 hours (91.7% sensitivity). This decentralised approach avoids prolonged inpatient monitoring while maintaining diagnostic accuracy.
Short fasting test as a reliable and effective tool to diagnose insulinoma — Mikovic et al., Endocrine
- blood
- liquid
- capillary
- venous-agreement
- hormones
2024
The review found dried blood spot sampling correlates strongly with plasma for HIV-1 viral load and offers simplified collection, transport and storage without cold-chain. This could expand access to monitoring in resource-limited settings and improve clinical outcomes through earlier detection of treatment failure.
Revolutionizing HIV-1 Viral Load Monitoring in India: The Potential of Dried Blood Spot Analysis for Expanding Access and Improving Care — Chandane Tak et al., Healthcare
- blood
- dried
- dbs
- validation
- venous-agreement
- serology
2024
Microsampling with Mitra® devices correlated strongly with venous plasma for capecitabine therapeutic drug monitoring (r=0.97), but yielded consistently lower concentrations. Patients preferred this method and reported minimal pain, suggesting it is suitable for patient-centric oncology drug monitoring in decentralised settings.
Comparison of capecitabine concentrations determined by microsampling versus plasma concentrations for therapeutic drug monitoring: a pilot study — Shafiei et al., The Journal of pharmacy and pharmacology (paywalled)
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- venous-agreement
- acceptability
- tdm
- oncology
2024
The study developed and validated an ICP-MS/MS method for trace elements in whole blood collected on VAMS and found that most targeted elements gave accurate and reproducible results compared with a reference method, indicating that VAMS could become an alternative to venipuncture for blood sampling in trace elements analysis.
Validation of Mitra<sup>®</sup> VAMS<sup>®</sup> as a blood collection technique for trace elements analysis using ICP-MS/MS — Breton et al., Bioanalysis (paywalled)
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- venous-agreement
2024
Plasma separation cards showed high specificity (99.3%) but moderate sensitivity (87.5%) against EDTA-plasma for HIV-1 viral load monitoring at a 1,000 copies/ml threshold in a South African cohort. Despite favourable usability among healthcare workers, laboratory-reported technical difficulties must be addressed to enable reliable decentralised scale-up in resource-constrained settings.
Assessment of the performance of the plasma separation card for HIV-1 viral load monitoring in South Africa — Chimoyi et al., Journal of clinical microbiology
- blood
- dried
- capillary
- validation
- venous-agreement
- acceptability
- pediatric
- serology
2024
Capillary blood collection using liquid and dried microsampling devices yielded pharmacokinetic profiles comparable to venous sampling for two monoclonal antibodies and a small molecule, whereas haematocrit correction was necessary for dried formats and bridging was ineffective for hydroxychloroquine. The findings demonstrate the bioanalytical feasibility and patient acceptability of remote microsampling tools for pharmacokinetic evaluations in decentralised clinical trials.
Evaluation of Patient-Centric Sample Collection Technologies for Pharmacokinetic Assessment of Large and Small Molecules — Mandlekar et al., Clinical pharmacology and therapeutics (paywalled)
- blood
- liquid
- dried
- capillary
- neoteryx-mitra
- validation
- venous-agreement
- acceptability
- tdm
- biologics
- dct
- haematocrit
2024
Low volume sampling devices showed good concordance with venous serum for measuring the pharmacodynamic biomarker sMAdCAM-1, but dried blood samples required substantial dilution to overcome buffer interference, which was mitigated by using a highly sensitive Simoa assay. The study demonstrates that while these devices have potential for decentralised clinical trials, careful validation is needed to address site-specific biases and assay sensitivity limitations.
Evaluation of low volume sampling devices for a pharmacodynamic biomarker analysis: Challenges and solutions — Yang et al., Journal of pharmaceutical and biomedical analysis (paywalled)
- blood
- liquid
- dried
- neoteryx-mitra
- validation
- venous-agreement
- dct
- biomarkers
2024
Self-collected dried blood spots analysed on the Roche Elecsys platform gave quantitative anti-spike antibody results that agreed closely with paired venous samples, with sensitivity 96.63% and specificity 97.81% and a conversion formula across 0.018 to 250 U/mL, enabling accurate tracking of titre changes in longitudinal cohorts after vaccination.
A Dried Blood Spot protocol for high-throughput quantitative analysis of SARS-CoV-2 RBD serology based on the Roche Elecsys system — Castelletti et al., Microbiology spectrum
- blood
- dried
- dbs
- self-collection
- validation
- venous-agreement
- serology
2024
This study found that dried blood spot samples stored at room temperature for four years correlated highly with serum measurements for testosterone and androstenedione, indicating that hematocrit adjustment may be unnecessary for serial monitoring in home-based self-sampling.
Dried blood spot sampling of testosterone microdosing in healthy females — Desai et al., The Journal of steroid biochemistry and molecular biology (paywalled)
- blood
- dried
- capillary
- dbs
- self-collection
- validation
- venous-agreement
- fertility
- hormones
- haematocrit
2024
The study found that DBS testing showed high specificity for HIV, HBV and HCV and perfect sensitivity for HIV and HBV, but lower sensitivity for syphilis and HCV, with creatinine measurements slightly higher than venous samples. Despite challenges in sample adequacy, DBS was acceptable to participants and could support decentralised STI and renal monitoring in men who have sex with men.
Use of Home-Based Self-Collected Dried Blood Spots to Test for Syphilis, Human Immunodeficiency Virus, Hepatitis C and B Virus Infections and Measuring Creatinine Concentration — Nieuwenburg et al., Sexually transmitted diseases
- blood
- dried
- dbs
- self-collection
- venous-agreement
- acceptability
- serology
- sti
2024
The study validated a VAMS-based method for measuring cenobamate in capillary blood, showing high precision accuracy and stability at room temperature for up to 15 days. Cenobamate levels in VAMS samples agreed with those in venous plasma, supporting its use in decentralised therapeutic drug monitoring for epilepsy patients.
A VAMS-based LC-MS/MS method for precise cenobamate quantification in epilepsy (patients) — Pigliasco et al., Epilepsia open
- blood
- dried
- vams
- validation
- venous-agreement
- tdm
2024
An LC-MS/MS method for seven antiepileptic drugs was validated using dried blood and dried plasma spots, showing acceptable precision and accuracy. Samples remained stable for seven days at ambient temperature and 40°C, with good correlation to wet plasma concentrations, supporting decentralised therapeutic drug monitoring with self-collection and room-temperature transport.
Simultaneous monitoring of seven antiepileptic drugs by dried blood spot and dried plasma spot sampling: method validation and clinical application of a LC-MS/MS-based technique — Cao et al., Journal of pharmaceutical and biomedical analysis (paywalled)
- blood
- dried
- dbs
- validation
- venous-agreement
- tdm
2024
This review of remote HbA1c testing via capillary blood microsampling finds that both dried and liquid formats can produce results comparable to venous sampling when collection, stability and extraction are properly validated. It matters because self-collected microsamples could enable decentralised diabetes monitoring and telemedicine, but heterogeneity in study designs and methods must be resolved before reliable implementation.
Remote HbA<sub>1c</sub> testing via microsampling: fit for purpose? — Verougstraete et al., Clinical chemistry and laboratory medicine (paywalled)
- blood
- liquid
- dried
- capillary
- self-collection
- validation
- venous-agreement
- acceptability
2024
Fifty-eight matched capillary and venous blood samples collected under official doping control conditions demonstrated excellent laboratory agreement for complete blood count parameters (except platelets) after temperature-monitored air shipment. This validates micro capillary collection as a virtually painless, athlete-friendly alternative to venipuncture for the Athlete Biological Passport, supporting its use in decentralised diagnostics.
Application of micro capillary blood sampling in an anti-doping setting — Lewis et al., Drug testing and analysis (paywalled)
- blood
- capillary
- validation
- venous-agreement
- doping
2024
Self-collected dried blood spots showed high specificity and acceptable sensitivity for detecting islet antibodies compared to serum samples, and participants preferred this method over venous blood draw for its ease and reduced pain.
Feasibility and Validity of In-Home Self-Collected Capillary Blood Spot Screening for Type 1 Diabetes Risk — Sing et al., Diabetes technology & therapeutics (paywalled)
- blood
- capillary
- dbs
- self-collection
- validation
- venous-agreement
- acceptability
2024
In 30 adult solid organ transplant recipients, capillary blood self-collected using the Tasso+ device showed 91% concordance with venous samples for detecting CMV DNAemia above the limit of detection, with excellent quantitative correlation (Spearman R² = 0.99). Most participants preferred self-collection over venipuncture, suggesting the device could enable decentralised viral monitoring, though sensitivity was lower (95% at 308 IU/mL).
Evaluation of the Tasso+ blood self-collection device for quantitation of plasma cytomegalovirus (CMV) DNAemia in adult solid organ transplant recipients (SOTr) — Phan et al., Microbiology spectrum
- blood
- liquid
- capillary
- self-collection
- validation
- venous-agreement
- acceptability
- serology
2024
Older adults achieved 98% adherence when self-collecting dried blood spots at home for inflammatory markers, with 97% of samples yielding valid results. Test-retest reliability was good (ICCs 0.70–0.76) and correlation with venous blood was strong (r=0.60–0.99), demonstrating that remote capillary sampling is a feasible and valid method for decentralised assessment of inflammation in older adults.
Remote dried blood spot collection for inflammatory markers in older adults is feasible, reliable, and valid — Reed et al., Brain, behavior, and immunity (paywalled)
- blood
- dried
- dbs
- self-collection
- validation
- venous-agreement
- acceptability
- biomarkers
2023
VAMS microsampling found no significant difference from venous blood for tacrolimus in paediatric patients; samples were stable for 14 days, with average difference between paired at-home samples of 0.12 ± 0.94 ng/mL.
VAMS and parallel-reaction-monitoring mass spectrometry for tacrolimus trough measurements at home in paediatric heart-transplant patients — Zhao et al., J. Mass Spectrometry and Advances in the Clinical Lab
- vams
- venous-agreement
- acceptability
- blood
- dbs
- tdm
- self-collection
- dried
- capillary
- pediatric
- immunosuppressants
- validation
2023
A structured review: many VAMS assays are analytically validated and can substitute for venous sampling for well-characterised analytes, though clinical-validation depth varies.
Analytical and Clinical Validation of Assays for VAMS of Drugs in Different Blood Matrices: A Literature Review — Nugraha et al., Molecules
- vams
- venous-agreement
- blood
- tdm
- dried
- immunosuppressants
- validation
2023
VAMS matched serum for the kinase inhibitors nilotinib, cabozantinib, dabrafenib and ruxolitinib, r 0.94–0.97, with serum reliably predictable for the first three, and 93% of at-home samples were collected correctly: at-home VAMS shown feasible for routine cancer-drug monitoring.
Clinical validation and feasibility of VAMS for monitoring of nilotinib, cabozantinib, dabrafenib, trametinib and ruxolitinib — Zimmermann et al., J. Pharmaceutical and Biomedical Analysis (paywalled)
- vams
- venous-agreement
- acceptability
- blood
- tdm
- self-collection
- haematocrit
- dried
- oncology
- capillary
- validation
2023
Capillary VAMS blood covered more of the metabolome than plasma, capturing intracellular red-cell metabolites, and correlated moderately-to-well with venous, Spearman 0.66; the honest caveats are higher finger-prick replicate variability and a need for −80 °C storage within six hours.
VAMS-based blood capillary sampling for mass-spectrometry-based human metabolomics studies — Volani et al., Metabolites
- vams
- venous-agreement
- blood
- metabolome
- dried
- capillary
- validation
- biomarkers
2023
During ACTH stimulation, salivary cortisol correlated only weakly with serum and gave modest accuracy: saliva does not reliably replace serum cortisol for adrenal insufficiency. A concrete limit.
Reliability of Salivary versus Serum Cortisol for Diagnosing Adrenal Insufficiency in Children — Ciancia et al., Children
- venous-agreement
- blood
- cortisol
- pediatric
- hormones
- liquid
- validation
- saliva
2023
TAP II capillary serum, both professionally collected and self-collected, correlated with venous serum at R > 0.9 for eight analytes including ALT, AST, cholesterol, HDL and triglycerides. Creatinine correlated acceptably but carried a consistent negative bias, and carbon dioxide, potassium and albumin did not reach acceptable agreement: the useful reading is that the panel has to be validated, not the device alone.
Maximizing microsampling: measurement of comprehensive metabolic and lipid panels using a novel capillary blood collection device — Collier et al., The Journal of Applied Laboratory Medicine (paywalled)
- venous-agreement
- blood
- self-collection
- capillary
- bd-microtainer
- liquid
- yourbio
- validation
- biomarkers
2023
Fingerstick blood self-collected into BD Microtainer tubes and posted at ambient temperature for 24 h agreed acceptably with paired serum for 11 of 12 analytes, HbA1c, lipids, creatinine, urea, urate, liver enzymes and total protein, with only AST falling outside limits.
Capillary blood stability and analytical accuracy of 12 analytes stored in Microtainers — Fontaine & Saez, Practical Laboratory Medicine
- blood
- liquid
- capillary
- bd-microtainer
- self-collection
- venous-agreement
- validation
2023
In 28 healthy adults, alectinib concentrations from capillary microsamples were generally similar to venous ones, which supports the method for therapeutic drug monitoring; the study tested a paediatric-friendly suspension, and the authors point to children, for whom venepuncture is difficult, as the intended use.
Relative bioavailability and food effect study of an oral suspension of alectinib in healthy volunteers using venipuncture and capillary microsampling — Liu et al., Clinical and translational science
- blood
- capillary
- venous-agreement
- pediatric
- tdm
- oncology
2023
A study of 50 paediatric renal transplant recipients found that a UHPLC-MS/MS method successfully quantified mycophenolic acid in VAMS microsampling samples over a 0.10-15 µg/mL range. However, converting microsampling results to plasma equivalents using haematocrit-based regression is required for clinical interpretation, supporting patient-centric decentralised monitoring.
Therapeutic drug monitoring of mycophenolic acid (MPA) using volumetric absorptive microsampling (VAMS) in pediatric renal transplant recipients: ultra-high-performance liquid chromatography-tandem mass spectrometry analytical method development, cross-validation, and clinical application — Kocur et al., Pharmacological reports : PR
- vams
- venous-agreement
- blood
- tdm
- haematocrit
- dried
- capillary
- pediatric
- immunosuppressants
- validation
2023
Self-collection of capillary blood using a topper and paediatric tube was successful for most patients under 70 and showed excellent agreement with venous sampling for PSA measurement, supporting its use for decentralised patient monitoring.
Self-sampling of blood using a topper and pediatric tubes; a prospective feasibility study for PSA analysis using 120 prostate cancer patients — van et al., Clinical chemistry and laboratory medicine (paywalled)
- venous-agreement
- blood
- self-collection
- oncology
- capillary
- liquid
2023
In 26 participants, capillary self-collection with Tasso-SST showed no qualitative discrepancies from venous phlebotomy for SARS-CoV-2 antibody results, and quantitative levels correlated strongly, total Ig Spearman rho 0.72 and IgG 0.85; within the limits of so small a study, this supports at-home collection for serosurveillance.
Comparison of capillary blood self-collection using the Tasso-SST device with venous phlebotomy for anti-SARS-CoV-2 antibody measurement — King et al., Journal of immunological methods (paywalled)
- venous-agreement
- blood
- self-collection
- serology
- capillary
- liquid
2023
A study of 37 kidney transplant recipients found Capitainer and Mitra microsampling feasible for decentralised monitoring. Capitainer showed consistent sampling success, 92%-96%, and higher analytical accuracy than Mitra, 52%-88% success. Proportions within ±15% of venous reference for creatinine and haemoglobin were 92%-100% and 93%-100% for Capitainer, versus 79%-96% and 67%-92% for Mitra, despite small cohorts.
Clinical performance of volumetric finger-prick sampling for the monitoring of tacrolimus, creatinine and haemoglobin in kidney transplant recipients — Vethe et al., British journal of clinical pharmacology (paywalled)
- blood
- capillary
- qdbs
- volumetric
- neoteryx-mitra
- self-collection
- validation
- venous-agreement
- tdm
- immunosuppressants
2023
The Tasso+ capillary blood collection device showed substantial to almost perfect concordance with standard venipuncture for measuring abnormal liver function tests including ALT, ALP, AST and total bilirubin, and patient feedback indicated a very favourable experience, supporting its use for more frequent and convenient testing outside the clinic.
Standard Venipuncture vs a Capillary Blood Collection Device for the Prospective Determination of Abnormal Liver Chemistry — Wickremsinhe et al., The journal of applied laboratory medicine (paywalled)
- blood
- capillary
- validation
- venous-agreement
- acceptability
2023
In a 16-donor validation study, prompt centrifugation of serum microsamples maintained analyte stability and preserved clinical chemistry and protein biomarker quality. This demonstrates that remote centrifugation with refrigerated shipping can lessen patient burden and broaden participation in decentralised clinical trials.
Decentralized clinical trial design using blood microsampling technology for serum bioanalysis — Lee et al., Bioanalysis (paywalled)
- blood
- liquid
- validation
- venous-agreement
- dct
- biomarkers
2023
Dried blood spot eluates showed high agreement with serum for SARS-CoV-2 IgG against Spike and Nucleocapsid (r≈0.96; qualitative φ≈0.98–1.0) and remained stable after 6–8 hours of storage, supporting use of capillary DBS for serosurveys and decentralised testing.
Dried blood spot eluates are suitable for testing of SARS-CoV-2 IgG antibodies targeting Spike protein 1 and Nucleocapsid protein — Guttmann et al., Biochemistry and biophysics reports
- blood
- dried
- capillary
- self-collection
- validation
- venous-agreement
- serology
2023
Volumetric absorptive microsampling of whole blood did not provide a reliable basis for calculating meropenem plasma concentrations in critically ill children, so a validated low volume plasma method was required for paediatric therapeutic drug monitoring.
Developing a Method for Quantifying Meropenem in Children-Volumetric Adsorptive Microsampling Versus Plasma Sampling — Ramadan et al., Therapeutic drug monitoring (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- venous-agreement
- pediatric
- tdm
- antimicrobials
2023
Lead can be measured accurately in dried blood spots by ICP-MS only when matrix-matched calibrators are used; aqueous calibrators perform poorly. The three methods evaluated showed strong agreement with whole blood analysis and offer a robust option for decentralised lead screening in children, though the recognised limitations of dried blood spots remain.
Matrix-matched calibrators are necessary for robust and high-quality dried blood spots lead screening assays by inductively coupled plasma-mass spectrometry — Franco et al., Journal of mass spectrometry and advances in the clinical lab
- blood
- dried
- dbs
- validation
- venous-agreement
- pediatric
- toxicology
2023
Capillary finger-stick dried blood spots yielded TSH measurements that agreed strongly with venous plasma (R² 0.988) and correctly identified hypothyroidism and hypothyrotropinemia in most cases. The analyte remained stable for at least four days between -20°C and +30°C, indicating potential for at-home collection in thyroid diagnostics and monitoring.
A Preliminary Analysis of Thyrotropin Measurement from Finger Stick Dried Blood Spot with an Automated High-Throughput Immunoassay Analyzer — Schakelaar et al., Thyroid : official journal of the American Thyroid Association (paywalled)
- blood
- dried
- capillary
- dbs
- self-collection
- validation
- venous-agreement
- hormones
- haematocrit
2023
The study found that serum concentrations of lacosamide and levetiracetam can be accurately estimated from dried capillary blood samples using simple ratio conversion, with high agreement to measured serum levels, supporting their use in decentralised therapeutic drug monitoring. For lamotrigine, the method is acceptable at low to medium concentrations but less reliable at higher levels, indicating a need for cautious interpretation in clinical practice.
Validation of Conversion Factors for Therapeutic Drug Monitoring of Lacosamide, Lamotrigine, and Levetiracetam in Dried Capillary Blood — Hagemann et al., Therapeutic drug monitoring (paywalled)
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- venous-agreement
- tdm
2023
In healthy Chinese adults a single oral dose of padsevonil showed rapid absorption and a favourable safety profile. VAMS dried blood concentrations of padsevonil and its metabolites were generally lower than plasma but were comparable at some time points by Passing‑Bablok regression, indicating that VAMS is promising for therapeutic drug monitoring of this novel antiepileptic drug and warrants further validation.
Pharmacokinetics and safety of Padsevonil in healthy Chinese subjects and comparison of two sampling methods for Padsevonil quantification — Li et al., European review for medical and pharmacological sciences (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- venous-agreement
- tdm
2023
Capillary blood collected in microtubes yielded HbA1c results that agreed closely with venous sampling, while dried blood spots showed markedly poorer agreement. High patient acceptability and willingness to repeat suggest microtubes are a viable option for decentralised diabetes monitoring.
Home monitoring of haemoglobin A<sub>1c</sub> in diabetes: A systematic review and narrative synthesis on accuracy, reliability and patient acceptability — Colley et al., Diabetic medicine : a journal of the British Diabetic Association (paywalled)
- blood
- liquid
- capillary
- dbs
- self-collection
- validation
- venous-agreement
- acceptability
2023
Self-collected capillary blood produces serum creatinine results comparable to venous blood, and the analyte remains stable in unspun capillary samples stored at ambient temperature for three days. This supports the use of capillary microsampling for kidney function monitoring in patient-centric, decentralised settings.
Comparability and Stability of Serum Creatinine Concentration in Capillary and Venous Blood — Woolley et al., British journal of biomedical science
- blood
- liquid
- capillary
- validation
- venous-agreement
2023
In 1070 young adults, dried blood spot eluates correlated strongly with serum for anti-spike IgGAM and total IgG, IgA and IgM; labDBS achieved 82.0% sensitivity and 98.2% specificity and ssDBS 86.1% sensitivity and 96.7% specificity versus serum, with minimal difference between self and investigator collection.
Validation of dried blood spot sampling for detecting SARS-CoV-2 antibodies and total immunoglobulins in a large cohort of asymptomatic young adults — Ferentinos et al., Journal of immunological methods
- blood
- dried
- dbs
- self-collection
- validation
- venous-agreement
- serology
2023
Dried blood spot sampling shows moderate agreement with plasma for therapeutic drug monitoring across evaluated drugs, and home based DBS achieves high yield and adherence with patient preference around three quarters; DBS is a reliable and feasible option for decentralised TDM but needs careful design and evaluation before use.
Reliability and feasibility of home-based dried blood spot in therapeutic drug monitoring: a systematic review and meta-analysis — Xiaoyong et al., European journal of clinical pharmacology (paywalled)
- blood
- dried
- dbs
- self-collection
- validation
- venous-agreement
- acceptability
- tdm
2023
A VAMS method using Mitra devices for whole blood lead quantification showed no significant difference compared with the centre's routine method, supporting VAMS as a practical alternative for blood lead and other trace element analyses.
Method development for the quantification of lead levels in whole blood sampled on Mitra<sup>®</sup> with VAMS<sup>®</sup> tips by inductively coupled plasma-MS/MS — Breton et al., Bioanalysis (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- venous-agreement
- toxicology
2023
Capillary blood collected with the Mitra® device showed correlation with venous samples for paclitaxel therapeutic drug monitoring, but wide confidence intervals suggest the methods may not be interchangeable. While plasma and whole blood concentrations were more closely aligned, the variability raises questions about using self-collected capillary samples for dose individualisation without further validation.
Paclitaxel and Therapeutic Drug Monitoring with Microsampling in Clinical Practice — Radovanovic et al., Pharmaceuticals
- blood
- liquid
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- venous-agreement
- tdm
- oncology
2023
At-home urine oestrone-3-glucuronide measured with the Mira Fertility Tracker during gonadotropin stimulation correlated well with paired serum oestradiol (r = 0.761) and predicted mature oocyte yield to a similar degree, suggesting that patient-centric oestrogen monitoring could reduce reliance on clinic-based venous draws during fertility treatment.
At-home urine estrone-3-glucuronide quantification predicts oocyte retrieval outcomes comparably with serum estradiol — Nakhuda et al., F&S reports
- urine
- first-void
- self-collection
- venous-agreement
- fertility
- hormones
2023
In 102 samples, quantitative TSH by Finecare LFIA showed strong correlation (r approximately 0.93) and excellent agreement (Cohen's kappa 0.85) with the Roche CobasPro reference; using serum, sensitivity was 90.5% and specificity 96.3% for diagnosing thyroid abnormalities, supporting fingerstick and whole-blood use for decentralised TSH testing.
High-sensitive detection and quantitation of thyroid-stimulating hormone (TSH) from capillary/fingerstick and venepuncture whole-blood using fluorescence-based rapid lateral flow immunoassay (LFIA) — Shurbaji et al., Heliyon
- blood
- liquid
- capillary
- validation
- venous-agreement
- hormones
2023
The study demonstrated that qPCR-based epigenetic immune cell counting from capillary dried blood spots agreed with venous blood and conventional flow cytometry in healthy donors, and then identified lymphopenia, neutrophilia and a lowered lymphocyte-to-neutrophil ratio in 103 COVID-19 patients versus 113 healthy controls, with naive B cell frequency tracking disease severity, suggesting that filter-paper blood collection could enable remote immune monitoring in home-isolated patients.
Epigenetic immune monitoring for COVID-19 disease course prognosis — Samans et al., Frontiers in immunology
- blood
- liquid
- dried
- capillary
- validation
- venous-agreement
- serology
2023
In kidney transplant recipients, home capillary blood self-testing of creatinine using a handheld analyser showed good agreement with clinic venous laboratory results, whereas potassium showed poorer agreement; patient self-use of the device was not a significant source of the potassium difference.
Patient Self-Testing of Kidney Function at Home, a Prospective Clinical Feasibility Study in Kidney Transplant Recipients — Murray et al., Kidney international reports
- blood
- liquid
- capillary
- self-collection
- venous-agreement
2023
The Ser-Col dried blood device with automated elution matched plasma gold-standard results for HIV and showed comparable performance to conventional DBS for HBV, HCV and syphilis across 378 miners at remote sites in French Guiana, with full HIV concordance and 87 per cent sensitivity for treponemal antibodies, supporting automated dried blood testing for large-scale infectious disease screening in remote populations.
Automated and combined HIV, HBV, HCV, and syphilis testing among illegal gold miners in French Guiana using a standardized dried blood device — Pisoni et al., Acta tropica (paywalled)
- blood
- dried
- dbs
- validation
- venous-agreement
- serology
- sti
2023
The study found that blood concentrations of padsevonil measured using Mitra devices can reliably predict plasma concentrations with less than 9% mean bias, supporting the use of VAMS as a patient-centric alternative to venous sampling in decentralised trials. This validation strengthens confidence in microsampling for therapeutic drug monitoring where venous draws are impractical.
Clinical Bridging Studies and Modeling Approach for Implementation of a Patient Centric Sampling Technique in Padsevonil Clinical Development — Kramer et al., The AAPS journal (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- venous-agreement
- tdm
- dct
2023
A UHPLC-MS/MS method for measuring Fabry disease biomarkers in dried blood spots was validated using both conventional cards and Capitainer B devices. Capillary blood gave similar results to venous blood across a wide haematocrit range, supporting decentralised screening and longitudinal monitoring of patients.
Mass Spectrometry Analysis of Globotriaosylsphingosine and Its Analogues in Dried Blood Spots — Boutin et al., International journal of molecular sciences
- blood
- dried
- capillary
- dbs
- validation
- venous-agreement
- haematocrit
- biomarkers
2023
Automated dried blood spot analysis achieved clinical and analytical acceptance criteria for tacrolimus, sirolimus, everolimus and cyclosporin A after haematocrit correction. This validates a method that could enable decentralised, patient-centric therapeutic drug monitoring for transplant recipients.
Application of a Fully Automated Dried Blood Spot Method for Therapeutic Drug Monitoring of Immunosuppressants: Another Step Toward Implementation of Dried Blood Spot Analysis — Deprez & Stove, Archives of pathology & laboratory medicine (paywalled)
- blood
- dried
- dbs
- validation
- venous-agreement
- tdm
- immunosuppressants
- haematocrit
2023
In participants 11 months after SARS-CoV-2 infection, the nano-immunoassay achieved 98.33% sensitivity and 97.62% specificity on venous serum. When combined with dried capillary microsampling, sensitivity was 95.05% with Mitra, 61.11% with repurposed glucose strips and 83.16% with HemaXis (91.49% after automated extraction), with no loss of specificity, supporting home-based sampling for serology.
Clinical sensitivity and specificity of a high-throughput microfluidic nano-immunoassay combined with capillary blood microsampling for the identification of anti-SARS-CoV-2 Spike IgG serostatus — Michielin et al., PloS one
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- venous-agreement
- serology
2023
VAMS finger-prick microsampling showed reliable agreement with venous blood sampling for measuring tacrolimus and creatinine after correction for systematic differences, supporting its use in therapeutic drug monitoring. This offers a patient-centric, decentralised alternative to frequent venipunctures in kidney transplant recipients.
Serum Creatinine and Tacrolimus Assessment With VAMS Finger-Prick Microsampling: A Diagnostic Test Study — Scuderi et al., Kidney medicine
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- venous-agreement
- tdm
- immunosuppressants
2023
VAMS capillary samples from 32 liver transplant recipients showed strong agreement with venous blood for everolimus measurement, with a correlation of r squared 0.92 and no proportional or constant bias on Bland Altman analysis. No effect of haematocrit or sampling time was observed, supporting VAMS as a virtually painless decentralised alternative to venous draws for immunosuppressant monitoring in transplant patients.
Volumetric Absorptive Microsampling for the Therapeutic Drug Monitoring of Everolimus in Patients Who Have Undergone Liver Transplant — Yoo et al., Therapeutic drug monitoring (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- venous-agreement
- tdm
- immunosuppressants
- haematocrit
2023
Researchers developed and validated a volumetric absorptive microsampling method for cariprazine therapeutic drug monitoring in psychiatric patients. The approach showed strong agreement with conventional plasma analysis, offering a minimally invasive alternative that could support decentralised monitoring programmes.
Volumetric absorptive microsampling for the therapeutic drug monitoring of psychiatric patients treated with cariprazine — Millán-Santiago et al., Journal of pharmaceutical and biomedical analysis (paywalled)
- blood
- dried
- vams
- validation
- venous-agreement
- tdm
2023
Capillary blood in Hem-Col microtubes showed a relative bias of 1.23% against directly processed venous sampling for CEA, with samples remaining stable for up to four days after withdrawal. Home-based CEA monitoring for colorectal cancer follow-up is feasible with this method, though underfilled tubes flagged by high lithium concentrations yield less reliable results.
Reliable capillary sampling of carcinoembryonic antigen at home: the CASA feasibility study — Voigt et al., Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland (paywalled)
- blood
- liquid
- capillary
- self-collection
- validation
- venous-agreement
- colorectal
2023
Capillary blood self-collection showed acceptable agreement with venous samples for vitamin D, C-reactive protein and alkaline phosphatase even after 36-hour delays, but calcium and phosphate levels were more affected by pre-analytical conditions. This supports decentralised serology and biomarker testing while highlighting analytes that need tighter pre-analytical control.
Concordance in COVID-19 serology, bone mineralization, and inflammatory analytes between venous and self-collected capillary blood samples exposed to various pre-analytical conditions — Hosseini et al., Annals of clinical biochemistry (paywalled)
- blood
- liquid
- capillary
- validation
- venous-agreement
- serology
- biomarkers
2023
The study found that VAMS dried blood sampling provides blood phenylalanine measurements highly concordant with venous plasma, with over 88% of results within 20% difference, supporting its use in patient-centric monitoring. This validates a decentralised, microsampling-based approach for therapeutic drug monitoring in phenylketonuria, including in children.
Validation and application of volumetric absorptive microsampling (VAMS) dried blood method for phenylalanine measurement in patients with phenylketonuria — Gao et al., Clinical biochemistry (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- venous-agreement
2023
The TASSO-M20 device for self-collected capillary blood demonstrated strong agreement with liquid whole blood for phosphatidylethanol (PEth) measurement (r²=0.988) and proved feasible and acceptable during virtual alcohol monitoring, causing less discomfort than finger stick methods. In a single participant tracked over time, PEth levels from the device aligned with urinary ethyl glucuronide and self-reported alcohol consumption.
Validation of the quantification of phosphatidylethanol 16:0/18:1 concentrations in TASSO-M20 devices — Jett et al., Alcohol, clinical & experimental research (paywalled)
- blood
- dried
- capillary
- dbs
- self-collection
- validation
- venous-agreement
- acceptability
2023
Targeted DNA methylation analysis accurately estimated relative and absolute leukocyte subset counts from dried capillary blood collected with Mitra devices, showing strong correlation with conventional venous blood methods (r=0.72–0.97). This enables self-sampling by finger prick, facilitating easier access to leukocyte testing for patients with haematological disorders.
Targeted DNA Methylation Analysis Facilitates Leukocyte Counts in Dried Blood Samples — Hubens et al., Clinical chemistry (paywalled)
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- venous-agreement
- biomarkers
2023
In whole blood spiked with 90 drugs, the VAMS method using the Neoteryx Mitra device confirmed 87 compounds with identification limits below 12.5 ng/mL for 82.2% of drugs and extraction yields of 80.6 to 108.7%. In 15 poisoned patients, 98% of plasma compounds were detected in VAMS with satisfactory concordance (R2 = 0.827), supporting its use for decentralised toxicology screening.
New Trend in Toxicological Screening Using Volumetric Absorptive Microsampling (VAMS) and High-Resolution Mass Spectrometry (HR/MS) Combination — Houzé et al., Molecules
- blood
- dried
- vams
- neoteryx-mitra
- validation
- venous-agreement
- toxicology
2023
Self collected dried blood spots gave equivalent results to venous blood for lipids, HbA1c and C reactive protein, enabling similar classification of cardiovascular risk; self collection had lower response than nurse collection but similar demographic participation.
A randomised study of nurse collected venous blood and self-collected dried blood spots for the assessment of cardiovascular risk factors in the Understanding Society Innovation Panel — Kumari et al., Scientific reports
- blood
- dried
- dbs
- self-collection
- venous-agreement
- acceptability
- biomarkers
2023
In adult kidney transplant patients, fingerprick VAMS and dried blood spot microsampling achieved accurate simultaneous measurement of tacrolimus, mycophenolic acid, and prednisolone compared with venepuncture. The authors noted an overall preference for VAMS over conventional dried blood spots.
Fingerprick Microsampling Methods Can Replace Venepuncture for Simultaneous Therapeutic Drug Monitoring of Tacrolimus, Mycophenolic Acid, and Prednisolone Concentrations in Adult Kidney Transplant Patients — Scuderi et al., Therapeutic drug monitoring (paywalled)
- blood
- dried
- capillary
- vams
- dbs
- neoteryx-mitra
- validation
- venous-agreement
- tdm
- immunosuppressants
2023
Finger-stick capillary blood spotted onto filter paper and dried (DBS) provides C-reactive protein results that correlate excellently with venous plasma (R² = 0.986). The method correctly classified all 25 high cardiovascular-risk patients and 12 of 13 inflammation cases, with analyte stability demonstrated for 31 days, supporting its use for patient-centric at-home sampling in decentralised diagnostics and screening programmes.
Analysis of C-reactive protein from finger stick dried blood spot to predict high risk of cardiovascular disease — Schakelaar et al., Scientific reports
- blood
- dried
- capillary
- dbs
- self-collection
- validation
- venous-agreement
- haematocrit
- biomarkers
2023
The review found that volumetric absorptive microsampling can reliably assay tacrolimus and mycophenolic acid for therapeutic drug monitoring, though correction factors are often required to meet regulatory agreement standards. This supports the use of microsampling for decentralised trials and dose optimisation in transplant recipients.
Volumetric Absorptive Microsampling to Enhance the Therapeutic Drug Monitoring of Tacrolimus and Mycophenolic Acid: A Systematic Review and Critical Assessment — Leino et al., Therapeutic drug monitoring (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- venous-agreement
- tdm
- immunosuppressants
2023
Volumetric dried blood spots from finger-prick correlated strongly with venous serum lithium concentrations (Pearson’s R=0.95, ratio 0.78) in thirty-nine patients. This patient-centric microsampling method could enable home-based therapeutic drug monitoring for bipolar disorder, improving compliance and safety where venous sampling is impractical.
Determination of lithium concentration in capillary blood using volumetric dried blood spots — Wikström et al., Journal of pharmaceutical and biomedical analysis (paywalled)
- blood
- dried
- capillary
- dbs
- volumetric
- self-collection
- venous-agreement
- tdm
2023
Capillary blood yields comparable results to venous blood for common biochemistry and haematology parameters on routine analysers, but performance may degrade if samples are not processed within 24 hours.
Analysis of common biomarkers in capillary blood in routine clinical laboratory. Preanalytical and analytical comparison with venous blood — Maroto-García et al., Diagnosis (paywalled)
- blood
- liquid
- capillary
- validation
- venous-agreement
2023
In healthy adults, capillary blood collected with the Onflow device yielded similar chemistry results to venous blood and was rated more acceptable with lower pain than venepuncture, with high willingness to reuse and positive phlebotomist usability.
Painless Capillary Blood Collection: A Rapid Evaluation of the Onflow Device — Noble et al., Diagnostics
- blood
- liquid
- capillary
- venous-agreement
- acceptability
2022
A single VAMS run quantified two immunosuppressants plus creatinine with minimal haematocrit effect: combined drug-and-organ-function monitoring from one dried tip.
A VAMS UPLC-MS/MS Method for Simultaneous Quantification of Tacrolimus, Mycophenolic Acid and Creatinine in Whole Blood of Renal Transplant Recipients — Wang et al., Pharmaceutics
- vams
- venous-agreement
- acceptability
- blood
- tdm
- haematocrit
- dried
- immunosuppressants
- validation
2022
Patients self-collected upper-arm capillary blood with press-activated devices including TAP II; autoantibody and CRP results agreed with venous at r≥0.98, were rated less painful, and 98.6% got enough blood within two attempts.
Remote self-collection of upper-arm capillary blood for autoantibody analysis in immune-mediated rheumatic diseases — Zarbl et al., RMD Open
- venous-agreement
- acceptability
- blood
- self-collection
- capillary
- liquid
- yourbio
- biomarkers
2022
Capillary self-sampling gave CRP and autoantibody values nearly identical to venous, ICC 0.97–0.998, was less painful, and the upper-arm route drew far higher acceptance and willingness to sample at home.
Accuracy and tolerability of capillary self-sampling for inflammation and autoantibodies in rheumatoid arthritis: a randomized controlled trial — Knitza et al., Arthritis Research & Therapy
- blood
- liquid
- capillary
- self-collection
- venous-agreement
- acceptability
2022
The study established reference intervals for TSH in dried blood spots for both adults and neonates and defined a quantitative relationship between DBS and serum TSH levels. This allows DBS to be used as a viable, patient-centric alternative to venepuncture for thyroid function monitoring, particularly where venous sampling is difficult.
Adult and neonate TSH blood spot reference intervals — Morris et al., Annals of clinical biochemistry (paywalled)
- blood
- dried
- dbs
- validation
- venous-agreement
- pediatric
- hormones
2022
In British Columbia, finger-prick dried blood spots had 97% specificity and 79% sensitivity for SARS-CoV-2 antibodies in unvaccinated groups, rising to 97 to 100% after vaccination, against serum; limited to one jurisdiction, the results support decentralised serosurveillance with self-collected dried blood spots.
Performance of Immunoglobulin G Serology on Finger Prick Capillary Dried Blood Spot Samples to Detect a SARS-CoV-2 Antibody Response — Nikiforuk et al., Microbiology spectrum
- venous-agreement
- blood
- dbs
- dried
- serology
- capillary
- pediatric
2022
The TAP device showed near perfect agreement with venous sampling for anti-Müllerian hormone measurements, with higher accuracy and lower pain compared to ADx card. This validates TAP as a reliable option for patient-led fertility hormone testing at home.
Evaluation of at-home serum anti-Müllerian hormone testing: a head-to-head comparison study — Silliman et al., Reproductive biology and endocrinology : RB&E
- blood
- capillary
- yourbio
- venous-agreement
- acceptability
- fertility
- hormones
2022
Clinical validation for tacrolimus and mycophenolic acid monitoring showed that while volumetric absorptive microsampling met analytical criteria after concentration correction, conventional dried blood spots achieved superior adherence to strict clinical criteria, sample quality, and cost efficiency without significant haematocrit bias.
Comparison of conventional dried blood spots and volumetric absorptive microsampling for tacrolimus and mycophenolic acid determination — Paniagua-González et al., Journal of pharmaceutical and biomedical analysis (paywalled)
- blood
- dried
- capillary
- vams
- dbs
- neoteryx-mitra
- self-collection
- validation
- venous-agreement
- tdm
- immunosuppressants
- economics
- haematocrit
2022
Validated a dried blood spot assay for tacrolimus and mycophenolic acid therapeutic drug monitoring and creatinine-based kidney function in kidney transplant recipients. DBS showed excellent agreement with venous sampling for tacrolimus trough and AUC, adequate agreement for creatinine-based GFR trend monitoring, but suboptimal agreement for mycophenolic acid AUC and inadequate performance for iohexol-based GFR. VAMS was generally inferior. This enables remote, simultaneous immunosuppressant and kidney function monitoring in outpatients, reducing clinic visits.
Volumetric microsampling for simultaneous remote immunosuppressant and kidney function monitoring in outpatient kidney transplant recipients — Zwart et al., British journal of clinical pharmacology
- blood
- dried
- vams
- dbs
- validation
- venous-agreement
- tdm
- immunosuppressants
2022
The dried blood spot method via fingerprick showed greater variability than venipuncture for antipsychotic drug concentrations but was feasible in children and adolescents with behavioural problems, and higher risperidone trough concentrations correlated with both increased weight gain and greater effectiveness, enabling definition of a therapeutic window for safer dosing in this population.
[Improving the safety of antipsychotic drugs in children and adolescents by antipsychotic drug concentration measurements using a fingerprick] — Kloosterboer et al., Tijdschrift voor psychiatrie (paywalled)
- blood
- dried
- capillary
- dbs
- validation
- venous-agreement
- pediatric
- tdm
2022
Capillary blood self-testing using the Hem-Col device demonstrated excellent correlation (r=0.992) and perfect agreement (kappa=1) with venous blood for anti-SARS-CoV-2 antibodies. Feasibility was markedly lower in participants aged 65 or more, who successfully collected the recommended volume in 62.5% of cases versus 86.2% in younger adults, suggesting older people need additional support such as telephone guidance or assistance from family for home-based sampling to be reliable.
Feasibility of home-based ELISA capillary blood self-testing for anti-SARS-CoV-2 antibodies — Baggio et al., Practical laboratory medicine
- blood
- liquid
- capillary
- self-collection
- venous-agreement
- acceptability
- serology
2022
Among three home-use capillary HbA1c tests, only Home Access approached acceptable accuracy with 82% of results within 5% of venous reference values, while CoreMedica and A1cNow+ achieved just 29% and 46% respectively, all falling short of the 90% standard. This demonstrates that most current home-use glycaemic tests lack the accuracy needed for reliable decentralised diabetes monitoring.
Accuracy of Three Commercial Home-Use Hemoglobin A1c Tests — Jacobsen et al., Diabetes technology & therapeutics (paywalled)
- blood
- liquid
- capillary
- self-collection
- validation
- venous-agreement
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