The Library
1530 papers on microsampling and monitoring, each with a finding paraphrased to our standard and labelled in one vocabulary. Every entry links to a legitimate copy; nothing is copied from an abstract.
Papers 101–160 of 160 labelled “hpv”, newest first.
2023
First-void urine self-sampling for HPV screening cost £38.57 per complete screen compared with £56.81 for clinician-collected samples, with potential NHS savings of £19.2 million annually if uptake improved among non-attenders. This shows self-sampling is substantially cheaper and could expand screening reach to under-screened women, supporting decentralised diagnostic programmes.
Two self-sampling strategies for HPV primary cervical cancer screening compared with clinician-collected sampling: an economic evaluation — Huntington et al., BMJ open
- urine
- first-void
- self-collection
- economics
- hpv
- sti
2023
In a colposcopy referral population, the Alinity m HR HPV assay showed similar sensitivity for CIN2+ on home-collected first-void urine and vaginal self-samples compared with clinician-collected cervical samples, with comparable specificity for first-void urine and variable specificity across vaginal devices; adjusting signal thresholds improved assay accuracy across all self-sample types.
Clinical Accuracy of Alinity m HR HPV Assay on Self- versus Clinician-Taken Samples Using the VALHUDES Protocol — Latsuzbaia et al., The Journal of molecular diagnostics : JMD (paywalled)
- urine
- first-void
- colli-pee
- self-collection
- validation
- hpv
2023
In women referred to colposcopy, self-collected urine and vaginal samples showed substantial to near-perfect concordance with clinician-collected cervical samples for detecting high-risk HPV (k=0.715 and k=0.898 respectively). This supports using patient-centric self-sampling to expand cervical cancer screening coverage and aligns with WHO elimination targets.
Accuracy of Human Papillomavirus (HPV) Testing on Urine and Vaginal Self-Samples Compared to Clinician-Collected Cervical Sample in Women Referred to Colposcopy — Martinelli et al., Viruses
- urine
- self-collection
- validation
- hpv
- sti
2023
First-void urine is established as a reliable self-collected specimen for human papillomavirus screening, triage, and post-vaccination surveillance. The use of specialised collection devices and advanced molecular assays supports the integration of non-invasive sampling into routine cervical cancer prevention strategies.
Testing for Human Papillomaviruses in Urine, Blood, and Oral Specimens: an Update for the Laboratory — Poljak et al., Journal of clinical microbiology
- blood
- saliva
- urine
- first-void
- self-collection
- validation
- hpv
- sti
2022
Home-collected first-void urine testing for high-risk HPV showed sensitivity equivalent to clinician-collected cervical samples for detecting CIN2+ and CIN3, but with marginally lower specificity. This supports urine self-sampling as a viable decentralised screening method to improve coverage among unscreened women.
Analytical and clinical performance of extended HPV genotyping with BD Onclarity HPV Assay in home-collected first-void urine: A diagnostic test accuracy study — Van Keer et al., Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology (paywalled)
- urine
- first-void
- colli-pee
- self-collection
- validation
- hpv
2022
Urine self-collection was acceptable to participants, but high-risk HPV mRNA detection in urine was less sensitive for high-grade cervical lesions than self- or provider-collected cervical samples. This suggests that while urine sampling may improve participation in decentralised screening programmes, it could miss more disease.
High-Risk Human Papillomavirus Messenger RNA Testing Using Urine, Cervicovaginal Self-Collected and Provider-Collected Cervical Samples Among Women in Mombasa, Kenya — Grabert et al., Sexually transmitted diseases (paywalled)
- urine
- self-collection
- acceptability
- hpv
- sti
2022
In a rural Ecuadorian community, both urine and vaginal self-sampling for HPV testing were rated as more comfortable, more private, less painful and less difficult than clinician sampling. Vaginal self-sampling was the overall preferred method, suggesting that community training could increase uptake of decentralised cervical cancer screening.
Evaluation of Urine and Vaginal Self-Sampling versus Clinician-Based Sampling for Cervical Cancer Screening: A Field Comparison of the Acceptability of Three Sampling Tests in a Rural Community of Cuenca, Ecuador — Vega Crespo et al., Healthcare
- urine
- self-collection
- acceptability
- hpv
- sti
2022
At a rural Ugandan HIV clinic, most women preferred nurse-led cervical screening to urine HPV self-sampling, yet self-collection proved feasible and detected high HPV prevalence, indicating that decentralised screening programmes must address acceptability through patient-centric education.
The preference of women living with HIV for the HPV self-sampling of urine at a rural HIV clinic in Uganda — Nyabigambo et al., Southern African journal of infectious diseases
- urine
- self-collection
- acceptability
- hpv
- sti
2022
Urine testing for high-risk HPV achieved 86.2% sensitivity for detecting high-grade cervical lesions, slightly below the 94.8% sensitivity of cervical samples, while patient satisfaction was significantly higher with self-collected urine. High agreement for HPV 16/18 genotypes between the two methods supports urine as a viable alternative for decentralised cervical screening.
A comparison of high-risk human papillomavirus DNA detection between urine and cervical sample testing in women with abnormal Pap smears — Punyashthira et al., The journal of obstetrics and gynaecology research (paywalled)
- urine
- self-collection
- acceptability
- hpv
- sti
2022
In women with abnormal cervical cytology, self-collected vaginal samples showed substantial agreement with physician-collected samples for HPV detection, particularly for high-risk types 16 and 18. Urine samples yielded moderate agreement but remained effective for high-risk types, suggesting both self-collection methods could support decentralised cervical screening programmes.
Human papillomavirus testing and cytology using physician-collected uterine cervical samples vs. self-collected vaginal samples and urine samples — Terada et al., International journal of clinical oncology (paywalled)
- urine
- self-collection
- validation
- hpv
- sti
2022
Vaginal self-sampling detected HPV with 94.4% sensitivity and 92.1% specificity against clinician collection, while urine self-sampling achieved 88.8% sensitivity and 94.1% specificity. Both methods yielded high negative predictive values, showing that self-sampling can provide accurate HPV screening in rural settings without clinician involvement.
Role of Self-Sampling for Cervical Cancer Screening: Diagnostic Test Properties of Three Tests for the Diagnosis of HPV in Rural Communities of Cuenca, Ecuador — Vega Crespo et al., International journal of environmental research and public health
- urine
- self-collection
- validation
- hpv
- sti
2022
Self-collected urine HPV testing in 195 transpeople showed 19.0% overall HPV positivity, with 79.0% preferring urine tests to provider-collected screening, indicating high acceptability and potential to reach an under-screened group.
HPV screening in the urine of transpeople - A prevalence study — Pils et al., EClinicalMedicine
- urine
- self-collection
- acceptability
- hpv
- sti
2022
Self-collected vaginal and first-void urine samples achieved substantial agreement with clinician-collected cervical samples for HPV detection using the BD Onclarity™ assay, with vaginal samples showing 95.3% overall positive agreement (kappa 0.890) and urine samples 90.6% agreement (kappa 0.776) when no clinical cut-off was applied. This supports decentralised, patient-centric cervical screening programmes.
Evaluation of BD Onclarity™ HPV Assay on Self-Collected Vaginal and First-Void Urine Samples as Compared to Clinician-Collected Cervical Samples: A Pilot Study — Martinelli et al., Diagnostics
- urine
- first-void
- self-collection
- validation
- hpv
- sti
2021
In first-void urine collected with Colli-Pee, the extraction method influenced HPV and human DNA yield more than the collected volume did: standardising processing matters at least as much as standardising volume.
Impact of Collection Volume and DNA Extraction Method on the Detection of Biomarkers and HPV DNA in First-Void Urine — Téblick et al., Molecules
- colli-pee
- first-void
- self-collection
- hpv
- liquid-biopsy
- liquid
- urine
- biomarkers
2021
High-risk HPV testing on first-void urine self-collected with Colli-Pee was about as sensitive, relative sensitivity 0.95, and specific for CIN2+ as clinician-taken cervical samples, supporting standardised first-void urine as a valid screening matrix.
Clinical and analytical evaluation of high-risk HPV testing on Colli-Pee first-void urine using the VALHUDES protocol — Van Keer et al., Gynecologic Oncology (paywalled)
- colli-pee
- first-void
- self-collection
- hpv
- liquid
- urine
- validation
2021
Among 515 women, 93% believed HPV self-sampling could improve screening uptake and 95% found instructions clear and felt confident, yet 41% still preferred clinician collection and 9-19% found it unpleasant. This shows urine-based screening with Colli-Pee is well accepted but not universally preferred, a crucial insight for patient-centric decentralised programmes.
Cervical cancer screening using HPV tests on self-samples: attitudes and preferences of women participating in the VALHUDES study — De Pauw et al., Archives of public health = Archives belges de sante publique
- urine
- first-void
- colli-pee
- self-collection
- acceptability
- hpv
- sti
2021
In women with ASC-US, first-void urine hrHPV testing showed substantial overall concordance with cervical testing (simple concordance 90.8%, Kappa 0.765) and almost perfect concordance for HPV16/18 (98.8%, Kappa 0.840), supporting its use as a decentralised alternative to cervical sampling.
Comparison between Urine and Cervical High-Risk HPV Tests for Japanese Women with ASC-US — Yamazaki et al., Diagnostics
- urine
- first-void
- validation
- hpv
2021
Self-sampled vaginal swabs and urine can identify women with recurrent CIN2+ after treatment for high-grade CIN, with vaginal self-sampling showing high sensitivity and substantial agreement with clinician sampling, while urine shows moderate agreement; this supports home-based follow-up to maximise participation.
Self-sampling for high-risk human papillomavirus as a follow-up alternative after treatment of high-grade cervical intraepithelial neoplasia — Östensson et al., Oncology letters
- urine
- self-collection
- hpv
- sti
2021
Residual pooled rectal/pharyngeal/first-void urine specimens and residual rectal swabs showed 89% and 88% concordance respectively with dedicated anal swabs for HPV DNA detection, with marginally higher positivity rates. This demonstrates that leftover STI test material can reliably be repurposed for HPV prevalence monitoring in men who have sex with men, enabling decentralised public health surveillance without additional patient burden.
Performance of human papillomavirus DNA detection in residual specimens taken for <i>Chlamydia trachomatis</i> and <i>Neisseria gonorrhoeae</i> nucleic acid amplification testing in men who have sex with men — Nugent et al., Sexually transmitted infections (paywalled)
- urine
- first-void
- validation
- hpv
- sti
2021
First-void urine collected via Colli-Pee found no HPV DNA in ocular swabs and no genital-ocular association, refuting autoinoculation in pterygium. Tear VEGF was elevated in pterygium while IL-6, IL-18 and VEGF were raised in dry eye, demonstrating condition-specific cytokine patterns.
Lack of HPV in pterygium with no evidence of autoinoculation and the role of cytokines in pterygium with dry eye — Uthaithammarat et al., Scientific reports
- urine
- first-void
- hpv
2021
Urine self-sampling for HPV detection showed good agreement with clinician-collected cervical samples (Kappa 0.72) under optimised conditions of 40 mM EDTA preservative, storage at 25°C, and processing within 72 hours. With a cost of USD 1.10 and high acceptability among women and healthcare workers, this method offers a practical decentralised screening approach for resource-limited settings.
Performance of an affordable urine self-sampling method for human papillomavirus detection in Mexican women — Hernández-López et al., PloS one
- urine
- self-collection
- validation
- acceptability
- economics
- hpv
- sti
2021
The study found that HPV detection in first-void urine samples was feasible in a decentralised setting, with high rates of type-specific persistence from mid-pregnancy to delivery and clear associations with behavioural risk factors. This supports the use of urine-based microsampling for monitoring sexually transmitted infections during pregnancy in a patient-centric way.
Maternal human papillomavirus infections at mid-pregnancy and delivery in a Scandinavian mother-child cohort study — Værnesbranden et al., International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases (paywalled)
- urine
- first-void
- hpv
- sti
2021
Among women referred for colposcopy after abnormal cytology, self-collected vaginal samples demonstrated comparable diagnostic accuracy to clinician-collected cervical samples for detecting high-risk HPV and cervical intraepithelial neoplasia grade 2 or worse. Self-collected urine samples were markedly less accurate, indicating vaginal but not urine self-sampling is suitable for decentralised HPV screening.
Performance and Diagnostic Accuracy of Human Papillomavirus Testing on Self-Collected Urine and Vaginal Samples in a Referral Population — Cho et al., Cancer research and treatment
- urine
- self-collection
- validation
- hpv
- sti
2021
Host cell DNA methylation levels in first-void urine increased with disease severity among HR-HPV positive women, and GHSR and LHX8 methylation discriminated CIN2+ with AUCs of 0.80 and 0.76, respectively, supporting decentralised urine-based triage to improve cervical screening uptake.
Triage of human papillomavirus infected women by methylation analysis in first-void urine — Van Keer et al., Scientific reports
- urine
- first-void
- hpv
- biomarkers
2021
Pooled sensitivity of 78% and specificity of 89% for high-risk HPV in first-void urine indicate acceptable diagnostic test accuracy for cervical HPV, supporting its use as a non-invasive decentralised screening option.
Diagnostic Test Accuracy of First-Void Urine Human Papillomaviruses for Presence Cervical HPV in Women: Systematic Review and Meta-Analysis — Bober et al., International journal of environmental research and public health
- urine
- first-void
- validation
- hpv
2021
Two dry vaginal self-sampling devices and a first-void urine collector detected over 90% of high-grade cervical lesions (CIN 3+) and all invasive cancers, with sensitivity comparable to clinician-taken smears. Participants found the devices easy to use and self-sampling was well accepted, which could improve uptake of cervical screening.
CoCoss-Trial: Concurrent Comparison of Self-Sampling Devices for HPV-Detection — Ertik et al., International journal of environmental research and public health
- urine
- first-void
- colli-pee
- self-collection
- acceptability
- hpv
- sti
2020
Vaccine-induced HPV antibodies from cervicovaginal secretions were detectable in first-void urine and correlated with serum levels, so one self-collected urine sample can monitor both HPV infection and immunogenicity without a blood draw; the authors see promise for decentralised follow-up after vaccination.
Non-invasive Assessment of Vaccine-Induced HPV Antibodies via First-Void Urine — Pattyn et al., Frontiers in Immunology
- first-void
- sti
- serology
- hpv
- liquid-biopsy
- liquid
- urine
- biomarkers
2020
The study found only fair agreement between self-collected urine and vaginal samples for HPV DNA detection, with an overall agreement of 64.04% and a kappa value of 0.29. This suggests that urine self-sampling may not be a reliable substitute for vaginal self-sampling in this high-prevalence population for HPV screening.
Comparison of two self-sampling methods for human papillomavirus (HPV) DNA testing among women with high prevalence rates — Kuriakose et al., Journal of medical virology (paywalled)
- urine
- self-collection
- validation
- hpv
- sti
2020
First-void urine HPV antibody concentrations were lower than serum but showed strong positive correlations across four HPV types. The VLP-based multiplex ELISA demonstrated moderate to good agreement with the GST-L1 assay, confirming that self-collected first-void urine offers a viable non-invasive alternative for assessing HPV vaccine responses in decentralised studies, though larger investigations are needed to establish routine feasibility.
Comparison of a VLP-based and GST-L1-based multiplex immunoassay to detect vaccine-induced HPV-specific antibodies in first-void urine — Pattyn et al., Journal of medical virology
- urine
- first-void
- validation
- serology
- hpv
2020
The study compared detection rates and concordance of HPV16/18 E6 oncoprotein in urine, self-collected vaginal, and cervical specimens, demonstrating the potential for patient-collected samples to support decentralised cervical cancer screening in low-resource settings.
Detection of HPV E6 oncoprotein from urine via a novel immunochromatographic assay — Oliveira et al., PloS one
- urine
- self-collection
- validation
- hpv
- sti
2020
HPV DNA was detected significantly more often in first-void urine from patients with urothelial carcinoma than from controls, indicating an association between HPV infection and bladder cancer.
Is There any Association between Urothelial Carcinoma of the Bladder and Human Papillomavirus? A Case-Control Study — Sarier et al., Urologia internationalis (paywalled)
- urine
- first-void
- hpv
2020
Nearly four in five women (79 per cent) had positive feelings about urine-based HPV testing, and more than three-quarters (78 per cent) preferred urine self-collection to cervico-vaginal sampling, with preference varying by race and ethnicity. Sixteen per cent worried about correct cervico-vaginal collection. Urine self-collection is highly acceptable across diverse United States populations and offers a decentralised approach that could improve cervical cancer screening coverage.
Racial and Ethnic Differences in Acceptability of Urine and Cervico-Vaginal Sample Self-Collection for HPV-Based Cervical Cancer Screening — Rohner et al., Journal of women's health (paywalled)
- urine
- self-collection
- acceptability
- hpv
- sti
2019
In women with HPV, first-void urine collected with the Colli-Pee device had higher HPV DNA concentrations than urine collected with a standard cup, although this advantage disappeared at high HPV DNA loads. Timing of collection (morning versus later) did not affect HPV DNA copies.
Human papillomavirus detection in urine: Effect of a first-void urine collection device and timing of collection — Pattyn et al., Journal of virological methods (paywalled)
- urine
- first-void
- colli-pee
- self-collection
- validation
- hpv
- sti
2019
Treating first-void urine with Aptima Transfer Solution increased HPV mRNA positivity from about 21-28% to 34-46%, with good overall agreement (81.1%, kappa 0.63) compared with cervical samples; however, cervical specimens detected more HPV in women with abnormal cytology or histopathology, indicating that urine may be less sensitive in this subgroup.
Treatment of first-void urine with Aptima Transfer Solution increases detection of high-risk HPV E6/E7 mRNA — Arias et al., Journal of virological methods (paywalled)
- urine
- first-void
- validation
- hpv
- sti
2019
This study demonstrates for the first time that HPV vaccine antibodies can be detected in first-void urine from young women, with levels correlating strongly to serum (Spearman r 0.64–0.88). This non-invasive approach could support large-scale epidemiological studies and vaccine monitoring, reducing the need for venous blood draws, though further optimisation and validation is needed.
First-void urine as a non-invasive liquid biopsy source to detect vaccine-induced human papillomavirus antibodies originating from cervicovaginal secretions — Van Keer et al., Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology (paywalled)
- urine
- first-void
- validation
- venous-agreement
- serology
- hpv
2018
First-void urine collected with a dedicated device showed good agreement with cervical samples for detecting HPV DNA and viral load, and was strongly preferred by patients over clinician collection, supporting its use for decentralised screening.
Human papillomavirus genotype and viral load agreement between paired first-void urine and clinician-collected cervical samples — Van Keer et al., European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
- urine
- first-void
- colli-pee
- self-collection
- acceptability
- hpv
2018
Urine self-sampling detected high-risk HPV with 51% sensitivity and 96% specificity compared to clinician-collected cervical samples, showing moderate overall agreement but substantial agreement in women aged 40 and older. This indicates urine testing could serve as a viable screening tool in low-resource settings where clinical collection is challenging, particularly for older women.
Randomized controlled trial evaluating the utility of urine HPV DNA for cervical cancer screening in a Pacific Island population — Hernandez et al., Journal of global health reports (paywalled)
- urine
- self-collection
- validation
- hpv
- sti
2018
Urine self-collection detected CIN2/3 with 90.2% sensitivity compared with 93.4% for cervical samples, showing moderate concordance (kappa 0.42) and similar HPV16 detection rates. This validates urine-based HPV screening as a less invasive, patient-centric approach that could expand cervical cancer screening coverage in decentralised healthcare settings.
Detection and genotyping of human papillomavirus virus (HPV): a comparative analysis of clinical performance in cervical and urine samples in Chilean women — Buchegger et al., International journal of clinical and experimental pathology (paywalled)
- urine
- self-collection
- genotyping
- hpv
- sti
2018
First-void urine is suitable for detecting Chlamydia trachomatis and Mycoplasma genitalium by PCR in first-trimester pregnancy, but it is not suitable for HPV detection, for which vaginal or cervical specimens are preferred.
Detection of urinary Chlamydia trachomatis, Mycoplasma genitalium and human papilloma virus in the first trimester of pregnancy by PCR method — Rahimkhani et al., Annals of clinical microbiology and antimicrobials
- urine
- first-void
- serology
- hpv
- sti
2018
Self-collected urine and vaginal swabs were feasible for HPV detection with high agreement between matrices, offering a decentralised alternative for women hesitant to attend cervical screening.
A prospective pilot evaluation of vaginal and urine self-sampling for the Roche cobas 4800 HPV test for cervical cancer screening — Hwang et al., Scientific reports
- urine
- self-collection
- hpv
- sti
2018
Vaginal swabs achieved 86% sensitivity for five STIs (Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, Trichomonas vaginalis and human papillomavirus), substantially exceeding the 63% sensitivity of first-void urine in a prospective cohort of female sex workers. This validation supports adopting self-collected vaginal swabs as the consensus sample type for decentralised STI screening programmes.
Identifying a consensus sample type to test for Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, Trichomonas vaginalis and human papillomavirus — Coorevits et al., Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases (paywalled)
- urine
- first-void
- validation
- hpv
- sti
2017
First-void urine self-collected with the Colli-Pee device detected high-risk HPV with sensitivity for CIN2+ comparable to clinician-taken smears and brush-based self-samples. This supports urine as a viable matrix for decentralised, patient-centric cervical cancer screening.
HPV testing in first-void urine provides sensitivity for CIN2+ detection comparable with a smear taken by a clinician or a brush-based self-sample: cross-sectional data from a triage population — Leeman et al., BJOG : an international journal of obstetrics and gynaecology (paywalled)
- urine
- first-void
- colli-pee
- self-collection
- validation
- hpv
2017
The review concludes that first-void urine is a feasible source for molecular biomarkers, such as host and viral gene methylation, to triage high-risk HPV infections, offering a non-invasive and preferred method for women that may improve screening adherence.
First-void urine: A potential biomarker source for triage of high-risk human papillomavirus infected women — Van Keer et al., European journal of obstetrics, gynecology, and reproductive biology (paywalled)
- urine
- first-void
- self-collection
- validation
- hpv
- biomarkers
- liquid-biopsy
2017
First-void urine testing showed significantly lower overall HPV DNA prevalence in vaccinated male adolescents at 4.1 per cent compared with 10.1 per cent in unvaccinated adolescents, with HPV-16/18 prevalence reduced to zero in the vaccinated group four years after vaccination. The results support bivalent vaccine protective efficacy in men and demonstrate that decentralised HPV screening using self-collected first-void urine is feasible in an adolescent screening context.
Human Papillomavirus (HPV) Prevalence in Male Adolescents 4 Years After HPV-16/18 Vaccination — Lehtinen et al., The Journal of infectious diseases (paywalled)
- urine
- first-void
- pediatric
- hpv
- sti
2017
In a Yap community-based study, 95 per cent of women reported comfort with self-collected urine HPV testing versus 82 per cent with Pap smears, though 42 per cent preferred a clinician to perform the Pap test. This suggests urine self-collection could improve cervical screening access in underserved low-middle income settings where trained personnel are scarce.
Acceptability and feasibility of a community based participatory research project comparing cytology and urine HPV DNA testing for cervical cancer screening in Yap, Federated States of Micronesia — Sy et al., Cancer epidemiology (paywalled)
- urine
- self-collection
- acceptability
- hpv
- sti
2017
First-void urine self-collection detected HPV with 80% sensitivity versus cervical cells when using a multiplex PCR assay, but only 58% with a less sensitive assay, showing that analytical sensitivity determines feasibility of decentralised STI screening. All five high-grade cervical lesions were identified in urine by at least one assay, confirming urine sampling can support HPV vaccine impact monitoring if sensitive methods are employed.
Evaluation of the performance of Human Papillomavirus testing in paired urine and clinician-collected cervical samples among women aged over 30 years in Bhutan — Tshomo et al., Virology journal
- urine
- first-void
- self-collection
- validation
- hpv
- sti
2017
The Cobas 4800 HPV test detected high-grade pre-cancerous cervical lesions in self-collected vaginal samples with the same sensitivity as clinician-taken cervical samples at 92.8 per cent, while urine self-sampling achieved a lower sensitivity of 76.3 per cent, supporting vaginal self-sampling as a viable decentralised alternative to clinic-based cervical screening.
Vaginal and Urine Self-sampling Compared to Cervical Sampling for HPV-testing with the Cobas 4800 HPV Test — Asciutto et al., Anticancer research (paywalled)
- urine
- self-collection
- validation
- hpv
- sti
2016
Urine detected HPV with low sensitivity 41 per cent compared with penile swabs but had high specificity 95 per cent; adding urine to swabs may aid epidemiological or clearance studies though urine alone is not comparable to swabs for diagnosis.
Comparison of urine samples and penile swabs for detection of human papillomavirus in HIV-negative Dutch men — Koene et al., Sexually transmitted infections (paywalled)
- urine
- first-void
- validation
- hpv
- sti
2016
Urine self-samples showed good agreement with cervical samples for HPV DNA detection (κ=0.65) and viral load correlation (ρ=0.676), with stronger correlation in severe lesions. This supports urine sampling as a valid alternative for decentralised follow-up of HPV intervention trials and screening programmes, enabling home-based monitoring without clinic visits.
Long-Term Follow-up of HPV Infection Using Urine and Cervical Quantitative HPV DNA Testing — Vorsters et al., International journal of molecular sciences
- urine
- self-collection
- validation
- hpv
- sti
2016
First-void urine HPV DNA testing showed 64.72% prevalence against 60.00% for cervical samples, with substantial concordance for the four vaccine types. This validates first-void urine as a patient-centric alternative specimen for decentralised cervical screening and HPV vaccination monitoring programmes.
Comparison between Urine and Cervical Samples for HPV DNA Detection and Typing in Young Women in Colombia — Cómbita et al., Cancer prevention research (paywalled)
- urine
- first-void
- validation
- hpv
2015
Urine microsampling for HPV DNA shows high correlation with cervical infections and enables home self-collection, which simplifies follow-up in vaccine efficacy trials. Establishing standardised sampling guidelines could overcome current variability and support decentralised, patient-centric monitoring of viral endpoints.
The use of urine in the follow-up of HPV vaccine trials — Vorsters et al., Human vaccines & immunotherapeutics
- urine
- self-collection
- hpv
- sti
2015
The study found that 10.5% of women in three districts of Tamil Nadu were HPV positive, with HPV16 and HPV6 being the most common types. This supports the use of first-void urine sampling in decentralised, patient-centric screening programmes for HPV in low-resource settings.
A population-based study of the prevalence of HPV in three districts of Tamil Nadu, India — Sureshkumar et al., International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (paywalled)
- urine
- first-void
- serology
- hpv
2015
In a population-based study of 566 women in Puerto Rico, self-collection of anal, cervical, and oral specimens for HPV testing achieved an 83.4% response rate with high acceptability: over 98% of participants understood the methods and more than 50% felt comfortable with them. This demonstrates the feasibility of decentralised, patient-centric HPV surveillance using self-collection, supporting wider implementation of remote STI screening programmes.
Methods in HPV Surveillance: Experiences from a Population-Based Study of HPV Infection among Women in the San Juan Metropolitan Area of Puerto Rico — Ortiz et al., Puerto Rico health sciences journal (paywalled)
- self-collection
- acceptability
- hpv
2015
Urine-based laboratory testing was the most preferred HPV screening modality among Zambian women. However, only 39.7% would choose it over visual inspection when service delivery conditions were less favourable, showing that patient acceptance of decentralised screening depends strongly on implementation factors such as examiner characteristics and waiting times.
Preference for human papillomavirus-based cervical cancer screening: results of a choice-based conjoint study in Zambia — Chamot et al., Journal of lower genital tract disease (paywalled)
- urine
- self-collection
- acceptability
- hpv
- sti
2015
Self-collected urine samples from 2034 tribal girls aged 9-25 years showed 12.9% HPV prevalence, rising to 19.2% among 18-25-year-olds. High-risk types comprised 65% of infections, with HPV16 accounting for 54%. This supports urine-based self-collection as a feasible tool for decentralised HPV screening in underserved populations.
Higher prevalence of human papillomavirus infection in adolescent and young adult girls belonging to different Indian tribes with varied socio-sexual lifestyle — Sharma et al., PloS one
- urine
- self-collection
- pediatric
- hpv
- sti
2015
A home-based urine HPV self-sampling study invited 5000 French women who had not attended cervical screening for three years; 771 samples were returned and 687 were analysed. High-risk HPV was detected in 29 women, and follow-up screening identified three cases of high-grade cervical intraepithelial neoplasia, showing that urine testing can reach underscreened populations and detect clinically significant disease.
Home-based urinary HPV DNA testing in women who do not attend cervical cancer screening clinics — Ducancelle et al., The Journal of infection (paywalled)
- urine
- self-collection
- hpv
- sti
2014
Collecting a first-void sample, not midstream, and combining it immediately with a DNA-conservation buffer markedly improves urinary HPV DNA detection: suboptimal collection otherwise underestimates true prevalence.
Optimization of HPV DNA detection in urine by improving collection, storage, and extraction — Vorsters et al., European J. Clinical Microbiology & Infectious Diseases (paywalled)
- first-void
- hpv
- liquid
- urine
- validation
2014
Self-collected urine showed substantial agreement with self-collected vaginal samples for HPV DNA detection among 63 pregnant women, with a kappa of 77.3%. Urine may therefore serve as a reliable sample for HPV testing in pregnancy, supporting decentralised screening without a clinician-collected specimen.
Comparison of urine and self-collected vaginal samples for detecting human papillomavirus DNA in pregnant women — Franciscatto et al., International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (paywalled)
- urine
- self-collection
- hpv
- sti
2014
Urine-based HPV DNA testing demonstrated 76% agreement with cervical sampling, correctly identifying 100% of uninfected but only 65% of infected women in a high-risk population. All 12 discrepant pairs were urine-negative/cervix-positive, confirming that self-collected urine is substantially less sensitive than cervical sampling for HPV screening.
Urine-based human papillomavirus DNA testing as a screening tool for cervical cancer in high-risk women — Mendez et al., International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (paywalled)
- urine
- self-collection
- validation
- hpv
- sti
2014
In 230 women, HPV detection in self-collected urine showed 90 per cent agreement with cervical sampling (κ=0.80), with 97 per cent concordance for high-risk types. High viral load in urine correlated with cytological abnormalities, suggesting urine self-sampling could enable decentralised cervical cancer screening with good accuracy.
Interest of human papillomavirus DNA quantification and genotyping in paired cervical and urine samples to detect cervical lesions — Ducancelle et al., Archives of gynecology and obstetrics (paywalled)
- urine
- self-collection
- genotyping
- hpv
- sti
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