The Library
1530 papers on microsampling and monitoring, each with a finding paraphrased to our standard and labelled in one vocabulary. Every entry links to a legitimate copy; nothing is copied from an abstract.
Papers 101–158 of 158 labelled “biomarkers”, newest first.
2023
Room temperature storage of dried blood on VAMS devices caused significant losses in 13 of 21 cytokine analytes after five months compared to storage at 4 °C. Storing devices at 4 °C or colder preserved the majority of tested cytokines, demonstrating that cold storage is essential for reliable longitudinal cytokine profiling in decentralised studies.
Stability of inflammation markers in human blood collected using volumetric absorptive microsampling (VAMS) under typical laboratory storage temperatures — McMahon et al., Cytokine (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- biomarkers
2023
This review surveyed the use of VAMS devices for analysing endogenous metabolites and biomarkers across the full analytical workflow, finding them reliable for biological analysis with improved analyte stability over liquid blood at ambient temperature and a straightforward acquisition model well suited to decentralised diagnostics.
Volumetric Absorptive Microsampling in the Analysis of Endogenous Metabolites — de Sá E Silva et al., Metabolites
- blood
- dried
- vams
- validation
- metabolome
- biomarkers
2023
Profiling EBV DNA methylation in self-collected saliva distinguished nasopharyngeal carcinoma from controls with 90% sensitivity and 100% specificity by capture sequencing; a q-PCR assay targeting one CpG site achieved 78% sensitivity and 100% specificity. The methylation density fell after therapy and rose with recurrence, confirming that decentralised salivary screening can support both diagnosis and disease monitoring.
Saliva biopsy: Detecting the difference of EBV DNA methylation in the diagnosis of nasopharyngeal carcinoma — Zheng et al., International journal of cancer (paywalled)
- saliva
- self-collection
- validation
- oncology
- biomarkers
- liquid-biopsy
2023
Electrochemical aptamer biosensors measured glucose and adenosine monophosphate in undiluted saliva with pico- to nanomolar sensitivity and remained reusable for up to seven days after storage. This noninvasive approach could support point-of-care diagnosis and at-home monitoring without the need for blood draws.
Electrochemical Aptamer-Based Biosensors for Measurements in Undiluted Human Saliva — Nguyen et al., ACS sensors (paywalled)
- saliva
- liquid
- self-collection
- validation
- biomarkers
2023
A prospective study of 1384 individuals developed an 18-small RNA signature (miLung) for lung cancer detection, achieving an area under the curve of 0.86 in discovery and 0.83 in validation cohorts. Diagnostic performance increased with tumour stage, and dried blood spot collection suggests feasibility for home self-collection.
Early Detection of Lung Cancer Using Small RNAs — Sikosek et al., Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer (paywalled)
- blood
- dried
- dbs
- self-collection
- biomarkers
- liquid-biopsy
2023
High-performing dried blood spot assays have been developed and validated for measuring environmental exposures to tobacco smoke, trace elements, and several endocrine-disrupting chemicals, confirming the method as a viable minimally invasive alternative to venous sampling for field-based public health screening and paediatric epidemiological studies. Further validation is required for cadmium, arsenic, inorganic mercury, and bisphenol A to expand the panel of reliable decentralised exposure biomarkers.
A state-of-the-science review and guide for measuring environmental exposure biomarkers in dried blood spots — Jacobson et al., Journal of exposure science & environmental epidemiology
- blood
- dried
- dbs
- validation
- pediatric
- biomarkers
2022
Patients self-collected upper-arm capillary blood with press-activated devices including TAP II; autoantibody and CRP results agreed with venous at r≥0.98, were rated less painful, and 98.6% got enough blood within two attempts.
Remote self-collection of upper-arm capillary blood for autoantibody analysis in immune-mediated rheumatic diseases — Zarbl et al., RMD Open
- venous-agreement
- acceptability
- blood
- self-collection
- capillary
- liquid
- yourbio
- biomarkers
2022
Thirty-eight patients with rheumatic diseases showed high engagement with twice-daily smartphone symptom reporting (95% completion) and remote dried blood spot collection (84% returned samples, all viable for C-reactive protein analysis). Although symptoms varied considerably, clinically meaningful CRP changes were rare, confirming the feasibility of integrating microsampling with patient-generated health data in decentralised rheumatology research.
Remote sampling of biomarkers of inflammation with linked patient generated health data in patients with rheumatic and musculoskeletal diseases: an Ecological Momentary Assessment feasibility study — Druce et al., BMC musculoskeletal disorders
- blood
- dried
- dbs
- self-collection
- acceptability
- biomarkers
- rpm
- digital-biomarker
- multimodal
2022
Most of the 16 endothelial and immune activation biomarkers remained stable when stored as dried blood spots at refrigeration temperature for up to three months, and storage at -80°C offered no clear advantage over -20°C for venous plasma aliquots; these practical storage conditions enable host biomarker testing in resource-limited and remote settings.
Practical Methods to Permit the Analysis of Host Biomarkers in Resource-Limited Settings — Chandna et al., The American journal of tropical medicine and hygiene
- blood
- dried
- dbs
- validation
- biomarkers
2022
Non-invasive self-sampling of anal colorectal mucus following defecation provides a patient-acceptable alternative to traditional stool collection for diagnosing colorectal cancer and inflammatory bowel disease. This emerging approach allows reliable measurement of diagnostic biomarkers to improve screening compliance.
Emerging role of colorectal mucus in gastroenterology diagnostics — Nooredinvand & Poullis, World journal of gastroenterology
- self-collection
- acceptability
- colorectal
- biomarkers
2022
Volumetric absorptive microsampling with mass spectrometry correlated well with reference methods for haemoglobin A1c, but imprecision fell short of clinical quality standards. The platform successfully identified haemoglobin variants, indicating promise for decentralised proteomic testing while requiring precision improvements for routine use.
Evaluation of Volumetric Absorptive Microsampling and Mass Spectrometry Data-Independent Acquisition of Hemoglobin-Related Clinical Markers — Lima et al., Journal of proteome research (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- biomarkers
2022
Salivary cortisol profiles measured from self-collected samples were associated with symptom severity and neurobehavioural impairment after mild traumatic brain injury, suggesting salivary cortisol may be a useful biomarker for characterising biological factors that influence outcomes.
Association between Altered Cortisol Profiles and Neurobehavioral Impairment after Mild Traumatic Brain Injury in College Students — Villegas et al., Journal of neurotrauma (paywalled)
- saliva
- self-collection
- cortisol
- biomarkers
2022
The Tasso SST capillary blood micro-sampling device generated reproducible serum protein measurements, but its concordance with venous samples was analyte-specific: CRP, ferritin, IL-6 and PCT showed strong agreement, while D-dimer, IL-1β and IL-1Ra did not. Self-collection at home with delayed processing led to significant concentration differences for several proteins, underscoring that user proficiency and timely sample handling are critical for decentralised diagnostic applications.
Assessing the use of a micro-sampling device for measuring blood protein levels in healthy subjects and COVID-19 patients — Brandsma et al., PloS one
- blood
- liquid
- capillary
- self-collection
- validation
- venous-agreement
- biomarkers
2021
In first-void urine collected with Colli-Pee, the extraction method influenced HPV and human DNA yield more than the collected volume did: standardising processing matters at least as much as standardising volume.
Impact of Collection Volume and DNA Extraction Method on the Detection of Biomarkers and HPV DNA in First-Void Urine — Téblick et al., Molecules
- colli-pee
- first-void
- self-collection
- hpv
- liquid-biopsy
- liquid
- urine
- biomarkers
2021
Salivary indoxyl sulfate and proteinuria were independent predictors of graft deterioration with an area under the ROC curve of 0.71, supporting their use as non-invasive screening tools in decentralised settings.
Evaluation of Salivary Indoxyl Sulfate with Proteinuria for Predicting Graft Deterioration in Kidney Transplant Recipients — Korytowska et al., Toxins
- saliva
- urine
- self-collection
- biomarkers
2021
In a longitudinal case analysis of repeat sexual trauma, self-collected saliva samples revealed a dysregulated diurnal cortisol profile that tracked with immune suppression and mental health fluctuations. The study highlights the feasibility of incorporating remote self-sampling into sensitive biobehavioural monitoring over time.
The biobehavioral impacts of sexual violence: Findings from an acute repeat survivor of vaginal rape — Anderson et al., Women's health
- saliva
- self-collection
- hormones
- cortisol
- biomarkers
2021
Low-income African American emerging adults showed asymmetrical cortisol and salivary alpha-amylase reactivity to stress that correlated with experiences of racism and interpersonal trauma. Self-collected saliva revealed atypical diurnal cortisol rhythms under daily stress, showing the feasibility of decentralised biomarker monitoring for stress-related health disparities.
Stress response asymmetries in African American emerging adults exposed to chronic social adversity — Wood et al., Stress (paywalled)
- saliva
- self-collection
- hormones
- cortisol
- biomarkers
2021
In a decentralised design, HAE patients collected dried blood spot samples at home during attacks and at clinic visits, with high acceptability and sufficient sample volumes for LC-IM-QToF MS metabolomics, supporting the feasibility of patient-centric microsampling to discover disease activity biomarkers.
HAE patient self-sampling for biomarker establishment — Förster et al., Orphanet journal of rare diseases
- blood
- dried
- dbs
- self-collection
- acceptability
- dct
- biomarkers
2021
Dried blood spot citrulline measurements gave comparable results to plasma for identifying intestinal damage and monitoring mucosal recovery in coeliac disease. This enables remote monitoring of patients at a distance, supporting decentralised care.
Evaluation of the Utility of Amino Acid Citrulline as a Surrogate Metabolomic Biomarker for the Diagnosis of Celiac Disease — Lomash et al., Nutrition and metabolic insights
- blood
- dried
- dbs
- metabolome
- biomarkers
2021
Metabolic phenotyping of dried blood spots showed high analytical reproducibility and detected seasonal differences in household air pollution exposure among rural Chinese women. This demonstrates DBS microsampling is a viable approach for decentralised environmental health research in low-resource settings.
A feasibility study of metabolic phenotyping of dried blood spot specimens in rural Chinese women exposed to household air pollution — Loo et al., Journal of exposure science & environmental epidemiology (paywalled)
- blood
- dried
- dbs
- metabolome
- biomarkers
2021
Home-based dried blood spot sampling from infants showed significant tracking of total cholesterol between 6 and 12 months of age. With 21% of children having elevated cholesterol, this demonstrates that decentralised microsampling can identify those needing early preventive measures.
Cholesterol at ages 6, 12 and 24 months: Tracking and associations with diet and maternal cholesterol in the Infant Cholesterol Study — Øyri et al., Atherosclerosis (paywalled)
- blood
- dried
- dbs
- self-collection
- pediatric
- biomarkers
2021
The study identified differential expression of urine-circulating microRNAs in five Chlamydia trachomatis-positive women with recurrent spontaneous abortion versus controls, with miR-16 showing 4.3-fold upregulation. This supports first-void urine as a viable non-invasive specimen for molecular screening of infection-related reproductive complications in decentralised settings.
Differential expression of urine-circulating micro-RNAs in Chlamydia trachomatis-induced recurrent spontaneous aborters — Ray et al., Microbial pathogenesis (paywalled)
- urine
- first-void
- fertility
- sti
- biomarkers
2021
The study compared VAMS capillary finger prick samples with venous liquid and venous VAMS samples from 50 healthy volunteers for thiamine diphosphate measurement, finding 94 to 100 per cent of results within 20 per cent of their mean across all comparisons with no significant bias. VAMS microsamples also remained stable when sent through regular post without affecting results, supporting their use for decentralised thiamine status assessment in both developed and remote settings.
Volumetric absorptive microsampling (VAMS) as a reliable tool to assess thiamine status in dried blood microsamples: a comparative study — Verstraete & Stove, The American journal of clinical nutrition (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- venous-agreement
- dct
- biomarkers
2021
The authors validated an LC-MS/MS method for measuring thiamine diphosphate in dried blood collected by VAMS, achieving accuracy within 6.5% bias and imprecision below 13% CV. The method was unaffected by haematocrit variation and showed superior stability, with samples remaining stable for one week at 60°C or high humidity and for at least one month at room temperature, enabling thiamine screening without cold chain logistics.
Patient-Centric Assessment of Thiamine Status in Dried Blood Volumetric Absorptive Microsamples Using LC-MS/MS Analysis — Verstraete & Stove, Analytical chemistry (paywalled)
- blood
- dried
- vams
- validation
- haematocrit
- biomarkers
2021
This proof-of-concept study compared VAMS and dried blood spot microsamples with fluid blood for untargeted lipidomic profiling using high-resolution LC-MS/MS, finding that VAMS is a viable option for untargeted lipidomics with the advantage of haematocrit independence over traditional dried blood spots.
Volumetric Absorptive Microsampling of Blood for Untargeted Lipidomics — Marasca et al., Molecules
- blood
- dried
- vams
- dbs
- neoteryx-mitra
- validation
- haematocrit
- biomarkers
2021
Children aged 8 to 14 living in neighbourhoods with higher concentrated poverty showed higher diurnal cortisol output when measured in saliva samples. Otherwise, cortisol output showed little association with other aspects of social disadvantage, suggesting limited support for HPA axis dysregulation as a general mechanism linking socioeconomic inequality to health outcomes in childhood.
Weak and uneven associations of home, neighborhood, and school environments with stress hormone output across multiple timescales — Malanchini et al., Molecular psychiatry (paywalled)
- saliva
- self-collection
- pediatric
- hormones
- cortisol
- biomarkers
2021
Instability of salivary biomarkers after collection and the absence of standardised handling methods are the principal barriers to home-based saliva diagnostics. The review collates preservation strategies for proteins, hormones, and nucleic acids that are essential for reliable decentralised testing.
Stabilization of Salivary Biomarkers — d'Amone et al., ACS biomaterials science & engineering (paywalled)
- saliva
- stabilised
- self-collection
- validation
- biomarkers
2021
Host cell DNA methylation levels in first-void urine increased with disease severity among HR-HPV positive women, and GHSR and LHX8 methylation discriminated CIN2+ with AUCs of 0.80 and 0.76, respectively, supporting decentralised urine-based triage to improve cervical screening uptake.
Triage of human papillomavirus infected women by methylation analysis in first-void urine — Van Keer et al., Scientific reports
- urine
- first-void
- hpv
- biomarkers
2020
Vaccine-induced HPV antibodies from cervicovaginal secretions were detectable in first-void urine and correlated with serum levels, so one self-collected urine sample can monitor both HPV infection and immunogenicity without a blood draw; the authors see promise for decentralised follow-up after vaccination.
Non-invasive Assessment of Vaccine-Induced HPV Antibodies via First-Void Urine — Pattyn et al., Frontiers in Immunology
- first-void
- sti
- serology
- hpv
- liquid-biopsy
- liquid
- urine
- biomarkers
2020
Protein abundances measured by SomaScan were comparable between capillary samples collected with the TAP device and venous samples, and selected ELISA assays showed strong correlation, supporting the use of the TAP device for quantitative protein biomarker analysis in decentralised trials.
Evaluation of a novel blood microsampling device for clinical trial sample collection and protein biomarker analysis — Xing et al., Bioanalysis (paywalled)
- dct
- venous-agreement
- blood
- capillary
- yourbio
- biomarkers
2020
Home-collected dried blood spots from 143 infants aged 8-14 months revealed wide variation in total cholesterol (4.1 mmol/L, range 2.3-6.6) and glycated haemoglobin (4.9%, range 3.7-6.0). Infant cholesterol correlated with macronutrient intake and maternal cholesterol, supporting decentralised paediatric screening.
Infant cholesterol and glycated haemoglobin concentrations vary widely-Associations with breastfeeding, infant diet and maternal biomarkers — Øyri et al., Acta paediatrica (paywalled)
- blood
- dried
- dbs
- self-collection
- pediatric
- biomarkers
2020
Vibration during maximal cycling increased salivary cortisol by 83% compared with no vibration, while testosterone did not differ, reducing the testosterone/cortisol ratio. This demonstrates that saliva can detect exercise modality effects on stress hormones, which could inform remote monitoring of training load or rehabilitation if self-collection methods were validated.
Salivary endocrine response following a maximal incremental cycling protocol with local vibration — Jemni et al., PloS one
- saliva
- hormones
- cortisol
- biomarkers
2020
Home-collected saliva samples revealed that patients with central serous chorioretinopathy exhibit a higher cortisol awakening response and altered diurnal trajectories of salivary cortisol and α-amylase compared with controls. This demonstrates that self-sampling can capture chronobiological biomarker differences associated with stress-related eye disease, supporting decentralised collection for ophthalmic and neuroendocrine research.
Diurnal trajectories of salivary cortisol and α-amylase and psychological profiles in patients with central serous chorioretinopathy — Scarinci et al., Chronobiology international (paywalled)
- saliva
- self-collection
- hormones
- cortisol
- biomarkers
2020
In patients undergoing upfront MRI and image-guided biopsy, adding MDx-2 RNA biomarker scores and embedded clinical variables to PI-RADS-v2 improved prediction of high-grade prostate cancer compared with PI-RADS-v2 alone (AUC 0.80 vs 0.67), though the two combined models did not differ significantly, suggesting that biomarkers and clinical predictors in MDx-2 require reassessment in this diagnostic pathway.
Independent Evaluation of the Respective Predictive Values for High-Grade Prostate Cancer of Clinical Information and RNA Biomarkers after Upfront MRI and Image-Guided Biopsies — Roumiguié et al., Cancers
- urine
- first-void
- biomarkers
2020
In youth aged 8–16 years, first-waking saliva cortisol, IL-6 and IL-1β collected at home associate with prior-night actigraphy sleep metrics. Sleep quality confounds interpretation of salivary stress and immune biomarkers in decentralised paediatric microsampling, so protocols must account for it.
Bidirectional relationships between sleep and biomarkers of stress and immunity in youth — LaVoy et al., International journal of psychophysiology : official journal of the International Organization of Psychophysiology (paywalled)
- saliva
- self-collection
- pediatric
- cortisol
- biomarkers
- actigraphy
- multimodal
2019
Noviplex dried plasma spot cards yielded neurofilament light chain measurements equivalent to standard plasma in healthy controls and ALS patients, while dried blood spot eluates gave different absolute values but still discriminated between the two groups. The results support remote dried blood microsampling as a practical alternative to venous sampling for neurodegeneration biomarkers in ALS.
Theme 7 Pre-clinical therapeutic strategies — Lombardi et al., Amyotrophic lateral sclerosis & frontotemporal degeneration (paywalled)
- blood
- dried
- dbs
- self-collection
- validation
- venous-agreement
- biomarkers
2019
Non-tobacco users who attended six-hour e-cigarette events showed up to 13-fold increases in urinary cotinine and significant rises in salivary cotinine, both peaking four hours after exposure, with acrolein metabolites also increasing but tobacco-specific nitrosamines unchanged. The multi-timepoint collection of urine including first-void specimens and saliva demonstrates how exposure biomarkers can be tracked through biological samples collected outside a clinic setting.
A biomonitoring assessment of secondhand exposures to electronic cigarette emissions — Johnson et al., International journal of hygiene and environmental health (paywalled)
- saliva
- urine
- first-void
- toxicology
- biomarkers
2019
This review summarises evidence that saliva contains proteins, metabolites, DNA alterations and miRNA that may serve as biomarkers for aging and Alzheimer's disease. It matters for decentralised diagnostics because it establishes the scientific rationale for using self-collected saliva in population screening, though it does not present original validation or stability data.
Current State of Saliva Biomarkers for Aging and Alzheimer's Disease — François et al., Current Alzheimer research (paywalled)
- saliva
- self-collection
- validation
- biomarkers
2018
Saliva collected with the Oragene RNA kit contained highly variable amounts of RNA that were predominantly bacterial, with minimal human mRNA present. This limits the immediate utility of salivary transcriptome for disease susceptibility testing in decentralised diagnostics and highlights the need for improved human RNA extraction methods.
Feasibility of the salivary transcriptome as a novel biomarker in determining disease susceptibility — Hidayat et al., Journal of periodontal research (paywalled)
- saliva
- dna-genotek-oragene
- biomarkers
2018
A derivatisation method using 3-nitrophenylhydrazine enabled precise quantitation of 24 carnitines in dried blood spots with intra-day CVs ≤7.8% and inter-day CVs ≤8.8%, and recoveries of 86.9%-109.7%. While all carnitines remained stable after four hours of sunlight, temperature cycling caused concentration changes in several species, which matters for quality control in remote screening programmes for fatty acid oxidation defects.
Isotope-labeling derivatization with 3-nitrophenylhydrazine for LC/multiple-reaction monitoring-mass-spectrometry-based quantitation of carnitines in dried blood spots — Han et al., Analytica chimica acta (paywalled)
- blood
- dried
- dbs
- validation
- biomarkers
2017
Testing 58 IBD patients, 50 IBS patients, and 33 controls found that measuring calprotectin and eosinophil-derived neurotoxin (EDN) in self-collected colorectal mucus distinguishes these groups, P<0.05. This patient-centric, decentralised method successfully monitored disease activity at days 10, 20, and 30, though the authors note EDN performance requires further validation.
Inflammatory bowel disease detection and monitoring by measuring biomarkers in non-invasively collected colorectal mucus — Loktionov et al., Journal of gastroenterology and hepatology (paywalled)
- stool
- self-collection
- colorectal
- biomarkers
2017
The review concludes that first-void urine is a feasible source for molecular biomarkers, such as host and viral gene methylation, to triage high-risk HPV infections, offering a non-invasive and preferred method for women that may improve screening adherence.
First-void urine: A potential biomarker source for triage of high-risk human papillomavirus infected women — Van Keer et al., European journal of obstetrics, gynecology, and reproductive biology (paywalled)
- urine
- first-void
- self-collection
- validation
- hpv
- biomarkers
- liquid-biopsy
2017
A laboratory method study showed that a fluoroplastic porous carrier for dried plasma spots quadruples sample capacity to 70-100 µl and, with antioxidant pretreatment, preserves polyunsaturated fatty acids for up to 35-40 days at room temperature or six months frozen. This enhanced stability and capacity could support decentralised collection and mailing of plasma samples for fatty acid and cholesterol analysis.
[The perspective fluoroplastic porous carrier for conservation and transfer of samples of blood plasma: application of "dry drop" technique with the purpose of detection of individual fatty acids.] — Aripovsky et al., Klinicheskaia laboratornaia diagnostika (paywalled)
- blood
- dried
- dbs
- validation
- biomarkers
2017
A miniaturised stable isotope dilution assay using volumetric absorptive microsampling quantified whole blood 5-methyltetrahydrofolic acid from only 10.8 μL with good precision and reproducibility. The dried samples remained stable for three weeks at -20°C, demonstrating VAMS enables accurate folate status screening with minimal blood volume, which is valuable for population and newborn screening programmes.
Assessing Volumetric Absorptive Microsampling Coupled with Stable Isotope Dilution Assay and Liquid Chromatography-Tandem Mass Spectrometry as Potential Diagnostic Tool for Whole Blood 5-Methyltetrahydrofolic Acid — Kopp & Rychlik, Frontiers in nutrition
- blood
- dried
- vams
- neoteryx-mitra
- validation
- biomarkers
2017
Self-collection of saliva and hair specimens from ethnically diverse breast cancer survivors proved feasible, with samples remaining stable during shipment and storage. Hair cortisol measured by ELISA showed acceptable variability (16% coefficient of variation), supporting decentralised capture of chronic stress biomarkers in oncology cohorts without clinic visits.
Evaluation of cortisol and telomere length measurements in ethnically diverse women with breast cancer using culturally sensitive methods — Ramirez et al., Journal of community genetics
- saliva
- self-collection
- validation
- cortisol
- biomarkers
2017
Aircraft noise exposure flattened the daily cortisol rhythm in 1244 adults, with unchanged morning but higher evening saliva cortisol levels. This shows home-collected saliva can monitor stress-related HPA axis changes linked to cardiovascular disease risk, supporting decentralised biomarker screening.
Effects of aircraft noise exposure on saliva cortisol near airports in France — Lefèvre et al., Occupational and environmental medicine (paywalled)
- saliva
- self-collection
- hormones
- cortisol
- biomarkers
2017
After 15 years of room-temperature storage, dried blood spots showed substantial degradation of polar metabolites with only one remaining statistically significant, whereas 36 lipids remained stable and correlated with matched serum samples. This indicates DBS may be viable for long-term lipid studies but unreliable for polar metabolite analysis in longitudinal decentralised research.
Comparing identified and statistically significant lipids and polar metabolites in 15-year old serum and dried blood spot samples for longitudinal studies — Kyle et al., Rapid communications in mass spectrometry : RCM (paywalled)
- blood
- dried
- dbs
- validation
- metabolome
- biomarkers
2016
This pilot study found that a self-administered anal swabbing technique for collecting colorectal mucus was rated as acceptable by 96% of participants and yielded samples suitable for cytology and protein analysis. The method successfully detected elevated mucin 2 levels in patients with inflammatory bowel disease, indicating its potential for non-invasive screening.
Assessment of cytology and mucin 2 in colorectal mucus collected from patients with inflammatory bowel disease: Results of a pilot trial — Loktionov et al., Journal of gastroenterology and hepatology (paywalled)
- acceptability
- self-collection
- colorectal
- stool
- biomarkers
2016
In healthy women, first-void urinary and plasma green tea catechins correlated weakly to moderately with lipid profiles and glycated haemoglobin. This supports the utility of non-invasive first-void urine collection for evaluating dietary and cardiometabolic biomarkers in decentralized studies.
Elevated plasma and urinary concentrations of green tea catechins associated with improved plasma lipid profile in healthy Japanese women — Takechi et al., Nutrition research (paywalled)
- blood
- urine
- first-void
- biomarkers
2016
Blood phenylalanine concentrations affected peripheral neurotransmitter biomarker concentrations differently in each of nine adults with phenylketonuria. Melatonin increased with tetrahydrobiopterin therapy only when blood phenylalanine fell, indicating that monitoring metabolites in first‑void urine and blood could help optimise individualised treatment.
Evaluation of Tetrahydrobiopterin Therapy with Large Neutral Amino Acid Supplementation in Phenylketonuria: Effects on Potential Peripheral Biomarkers, Melatonin and Dopamine, for Brain Monoamine Neurotransmitters — Yano et al., PloS one
- urine
- first-void
- biomarkers
2015
Retinol measured in dried blood spots showed high agreement with venous plasma (r=0.9724) and remained stable at room temperature for up to 10 weeks when extracted under acidic conditions, enabling simple and reliable assessment of vitamin A status for population studies and large clinical trials.
Robust measurement of vitamin A status in plasma and blood dried on paper — Huang et al., Prostaglandins, leukotrienes, and essential fatty acids (paywalled)
- blood
- dried
- dbs
- validation
- venous-agreement
- biomarkers
2015
First-void urine from autistic children showed significantly elevated kininogen-1 compared with controls, suggesting urine proteomics could yield non-invasive screening markers for autism. The finding supports decentralised diagnostics because urine can be self-collected at home, even in paediatric populations, enabling remote biomarker discovery.
Urine proteome analysis to evaluate protein biomarkers in children with autism — Suganya et al., Clinica chimica acta; international journal of clinical chemistry (paywalled)
- urine
- first-void
- pediatric
- biomarkers
2015
The authors developed and validated a chiral GC-MS method to quantify D-amino acid ratios in 1 mL first-void urine samples. In a study of 40 pregnant women, those with gestational diabetes mellitus showed altered urinary D-amino acid profiles compared to controls, suggesting that minimally invasive urine metabolomics could support decentralised screening for pregnancy-related metabolic disorders.
Optimization and validation of a chiral GC-MS method for the determination of free D-amino acids ratio in human urine: application to a gestational diabetes mellitus study — Lorenzo et al., Journal of pharmaceutical and biomedical analysis (paywalled)
- urine
- first-void
- validation
- metabolome
- biomarkers
2014
The honest counterpoint: many liquid-urine parameters, creatinine, iodine, nitrogen and minerals, remained valid after 12–15 years frozen at −22 °C without preservative.
Long-term urine biobanking: storage stability of clinical-chemical parameters under moderate freezing without preservatives — Remer, Montenegro-Bethancourt & Shi, Clinical Biochemistry (paywalled)
- pediatric
- liquid
- urine
- validation
- biomarkers
2014
A US survey of 3,400 adults aged 62 to 90 collected up to 15 biomeasures at home, including saliva, dried blood spots and urine, with Salivette and Oragene among the devices used, which shows that several patient-centric sampling methods can run together in home-based research.
Continuity and innovation in the data collection protocols of the second Wave of the National Social Life, Health, and Aging Project — Jaszczak et al., The journals of gerontology. Series B, Psychological sciences and social sciences (paywalled)
- actigraphy
- multimodal
- blood
- dbs
- cortisol
- dna-genotek-oragene
- self-collection
- dried
- bd-microtainer
- hormones
- liquid
- urine
- saliva
- biomarkers
- genotyping
2014
European sex- and age-specific reference values for blood lipids in 13,579 children aged 2-11 were established using capillary sampling and a point-of-care analyser. These data support decentralised cardiovascular screening programmes in paediatric populations, showing boys have higher HDL-C but lower total cholesterol and triglycerides than girls.
Blood lipids among young children in Europe: results from the European IDEFICS study — De Henauw et al., International journal of obesity (paywalled)
- blood
- capillary
- pediatric
- biomarkers
2014
Higher vegetable and carbohydrate intake was associated with a lower urinary estrogen DNA adduct ratio in healthy pre‑menopausal women, suggesting dietary factors may modulate a biomarker linked to breast cancer risk.
Associations between Dietary Intake of Fruits and Vegetables in relation to Urinary Estrogen DNA Adduct Ratio — Reding et al., Open journal of preventive medicine (paywalled)
- urine
- first-void
- biomarkers
2014
In a cross-over study of adults with phenylketonuria, adding tryptophan and tyrosine to large neutral amino acid therapy increased urine dopamine but not melatonin metabolite levels, indicating serotonin synthesis remains suppressed by phenylalanine. The protocol demonstrates first-void urine sampling can support therapeutic drug monitoring for metabolic disorders.
Melatonin and dopamine as biomarkers to optimize treatment in phenylketonuria: effects of tryptophan and tyrosine supplementation — Yano et al., The Journal of pediatrics (paywalled)
- urine
- first-void
- hormones
- biomarkers
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