The Library
1530 papers on microsampling and monitoring, each with a finding paraphrased to our standard and labelled in one vocabulary. Every entry links to a legitimate copy; nothing is copied from an abstract.
Papers 101–200 of 1530, newest first.
2026
Volumetric microsampling can enable patient-centred therapeutic drug monitoring with high patient preference and acceptable method validation for many drugs, but conversion from capillary to plasma and agreement with venous sampling varies by analyte and requires careful validation.
Volumetric Microsampling for Patient-Centric Therapeutic Drug Monitoring in Clinical Pharmacology: A Scoping Review — Tummala et al., Journal of clinical pharmacology (paywalled)
- volumetric
- venous-agreement
- acceptability
- blood
- tdm
- self-collection
- haematocrit
- dried
- capillary
- validation
2026
In a large study using self-collected capillary blood, current vaping and smoking were independently associated with lower levels of anti-Müllerian hormone, a marker of ovarian reserve. This demonstrates the utility of decentralised capillary sampling for large-scale epidemiological research on reproductive health.
E-cigarette use (vaping) and cigarette smoking are associated with reduced markers of ovarian reserve: a cross-sectional study of 16,087 women — Getreu et al., BMC women's health (paywalled)
- blood
- self-collection
- capillary
- fertility
- hormones
2026
This study demonstrates that a memristor sensor can identify distinct electrical signatures in saliva and urine corresponding to different ovulation phases, suggesting a potential route for noninvasive home fertility monitoring.
A Noninvasive Method for Dynamic Ovulation Monitoring Based on Memristor — Chen et al., ACS omega
- fertility
- hormones
- liquid
- urine
- saliva
2026
Capillary fingerstick sampling showed high correlation and agreement with venous sampling for serum AMH but with proportional bias, so it may improve access to testing yet should not be considered fully interchangeable without further validation.
Comparison of serum anti-Müllerian hormone concentrations measured in capillary fingerstick and venous samples from Korean reproductive-aged women — Lavadia et al., Clinical and experimental reproductive medicine (paywalled)
- blood
- capillary
- validation
- venous-agreement
- acceptability
- fertility
- hormones
2026
Fingerstick capillary sampling showed strong agreement with venous sampling for mycophenolic acid, tacrolimus and cyclosporine A, with acceptable bias and improved agreement for mycophenolic acid after haematocrit correction. This minimally invasive approach may reduce procedural burden and support outpatient or home based therapeutic drug monitoring in children.
Minimally Invasive Therapeutic Drug Monitoring of Immunosuppressants in Children with Kidney Diseases: Validation of Fingerstick Sampling Using LC-MS/MS — Ishii et al., Pharmaceuticals
- venous-agreement
- blood
- tdm
- haematocrit
- capillary
- pediatric
- immunosuppressants
- validation
2026
This study validated a method requiring only 10 microlitres of serum and found high agreement between fingerstick capillary samples and venous serum for monitoring twelve antibiotics. The results suggest capillary serum sampling is a feasible, minimally invasive alternative that avoids the haematocrit effect associated with whole blood microsampling.
Feasibility verification of fingerstick capillary microsampling replacing venipuncture for therapeutic drug monitoring of 12 antibiotics using a rapid LC-MS/MS assay — Chen et al., Talanta (paywalled)
- blood
- liquid
- capillary
- validation
- venous-agreement
- pediatric
- tdm
- antimicrobials
2026
The study developed and validated a reliable HPLC-MS method for quantifying multiple tyrosine kinase inhibitors from VAMS microsamples of capillary blood, showing acceptable accuracy, precision, and 28-day stability at -21°C, with results comparable to venous plasma in 194 samples from patients with solid tumours. This enables therapeutic drug monitoring using microsamples in oncology practice.
HPLC-MS Quantification of Multiple Tyrosine Kinase Inhibitors in Patients with Solid Tumors: Method Validation and Clinical Application — Staudinger et al., Pharmaceutics (paywalled)
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- tdm
- oncology
2026
A validated two-step LC-MS/MS protocol can identify 91 prohibited doping agents from a single dried blood spot collected on either cellulose cards or volumetric absorptive microsampling devices. This demonstrates robust multi-analyte screening from capillary blood, supporting decentralised anti-doping programmes where venous sampling is impractical.
Dried Blood Spots for Doping Purpose-Two-Step Protocol for Analysis of Non-Threshold Substances and Anabolic Steroid Esters From One Spot/Pebble — Stojanovic et al., Biomedical chromatography : BMC (paywalled)
- blood
- dried
- capillary
- vams
- dbs
- validation
- doping
- toxicology
2026
Capillary finger-stick dried blood spots demonstrated strong analytical agreement with venous serum for prostate-specific antigen (R² = 0.987) and remained stable for 31 days across a wide temperature range. This less invasive microsampling approach enables at-home self-collection, supporting decentralised screening and tele-diagnostics for prostate cancer.
Accessible Prostate-Specific Antigen Testing through Finger-Stick Dried Blood Spots and Routine Laboratory Analyzers — van Vugt et al., The journal of applied laboratory medicine (paywalled)
- blood
- dried
- capillary
- dbs
- self-collection
- validation
- venous-agreement
- haematocrit
- biomarkers
2026
In a study of 46 perinatal nicotine users, dried blood spots and saliva were used weekly to measure reproductive hormones, finding that lower postpartum estradiol and greater peripartum declines in oxytocin were associated with increased nicotine craving and use. This demonstrates the feasibility of decentralised microsampling and remote surveys for longitudinal hormone tracking in vulnerable populations.
Exploring hormonal influences on nicotine craving and use across the perinatal period: A prospective longitudinal study — Allen et al., Drug and alcohol dependence reports (paywalled)
- blood
- dbs
- cortisol
- self-collection
- dried
- fertility
- hormones
- saliva
2026
This review highlights that microsampling techniques such as dried blood spots and volumetric absorptive microsampling offer superior alternatives to traditional sampling for the mass spectrometry detection of prohibited substances in anti-doping analysis. It provides guidance on selecting appropriate analytical methods and sample pretreatment strategies to ensure sensitive detection and reliable storage conditions.
Mass Spectrometry-Based Anti-Doping Analysis: A Critical Review of Emerging Analytical and Sample Pretreatment Strategies — Maykar et al., Critical reviews in analytical chemistry (paywalled)
- blood
- urine
- dried
- vams
- dbs
- validation
- doping
- toxicology
2026
The dried urine spot device showed strong agreement with liquid urine across three clinical chemistry analysers and stable performance across temperatures, enabling decentralised ambient collection for albumin-to-creatinine ratio.
Analysis of albumin-to-creatinine ratio on automated analysers using a microsampling card (Capitainer DIP70 card) for the collection of urine — Olausson et al., Clinical chemistry and laboratory medicine (paywalled)
- urine
- dried
- validation
2026
Capillary blood collected with Tasso+ devices demonstrated strong agreement with venous blood for primary Athlete Biological Passport markers (haemoglobin, reticulocytes, OFF-score, ABPS) with correlations ≥0.9, though platelet count showed poor concordance. Despite 44 of 209 samples failing pre-analytical checks mainly due to coagulation, high athlete acceptance and minimal pain support capillary sampling as a less invasive, viable alternative for decentralised anti-doping controls.
Capillary Blood as a Potential New Matrix for the Athlete Biological Passport: A Field-Based Comparison Study — Requena-Tutusaus et al., Medicine and science in sports and exercise (paywalled)
- blood
- liquid
- capillary
- validation
- venous-agreement
- acceptability
- doping
2026
ALAS2 and CA1 mRNA were reliably quantified from venous-cellulose, capillary-cellulose and Tasso-M20 dried blood spots with strong linear agreement (r ≥ 0.96) and no bias for ALAS2. CA1 showed modest proportional bias of 9-22% only when Tasso-M20 was compared with cellulose cards in the rEPO cohort, but no significant differences in relative expression across matrices were observed at any timepoint. These findings support decentralised capillary sampling for longitudinal anti-doping monitoring.
Comparison of Dried Blood Spot Sampling Methods for RNA-Based Biomarker Measurement in Anti-Doping — Bejder et al., Drug testing and analysis
- blood
- dried
- capillary
- dbs
- validation
- venous-agreement
- doping
- biomarkers
2026
In a cohort of 62 participants evaluating home self-collection with the TassoPlus device, 38 returned samples, with 29% excluded due to insufficient plasma volume below 200 ΔL. Although viral load measurements in adequate samples correlated well with conventional testing (r = 0.800), the high failure rate and missed detection in low-volume viremic samples indicate that further technical refinements are necessary before clinical adoption.
Feasibility and reliability of decentralized HIV-1 viral load monitoring on self-sampled blood — Mendes de Leon et al., PloS one
- blood
- liquid
- capillary
- self-collection
- validation
- venous-agreement
- acceptability
- serology
2026
In a feasibility randomised controlled trial with 28 adults aged 65 years, 62% successfully self-collected finger-prick capillary blood samples for influenza antibody and vitamin D measurement. While overall study procedures were acceptable, the capillary sampling method requires refinement before wider deployment in decentralised diagnostics for older adults.
PROTECTIVE-D-a feasibility randomised controlled trial examining the effect of a positive mood intervention and vitamin D supplementation on the immunological responses to influenza vaccination in older adults — Royal et al., Pilot and feasibility studies (paywalled)
- blood
- capillary
- self-collection
- acceptability
- dct
2026
Saliva and dried saliva spot lamotrigine concentrations correlated strongly with plasma (R approximately 0.84 to 0.85), supporting saliva and DSS as needle-free alternatives for therapeutic drug monitoring.
Toward needle-free lamotrigine monitoring: Proof-of-concept for saliva and dried saliva spot analysis by LC-MS/MS - a short communication — Ďurčová et al., Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (paywalled)
- saliva
- dried
- validation
- venous-agreement
- tdm
2026
Among 8007 neonates screened using dried blood spots, the study identified prevalence rates for congenital hypothyroidism (1:2002), congenital adrenal hyperplasia (1:2002) and G6PD deficiency (1:900), with abnormal results confirmed by venous sampling. This demonstrates the practical utility of microsampling for decentralised newborn screening and subsequent clinical management.
Birth Prevalence of Endocrine-Metabolic Disorders Detected by Newborn Screening Test in Pune (India) Population — Narawade et al., Indian journal of clinical biochemistry : IJCB (paywalled)
- blood
- dried
- dbs
- pediatric
- hormones
2026
Menstrual blood offers a noninvasive, patient-centric matrix for detecting endometriosis, cervical cancer, and hormonal disorders through self-collected samples. Wearable in-pad biosensors enabling real-time monitoring and long-term tracking could transform fertility evaluation and early disease detection, though standardisation and large-scale validation remain critical gaps.
Beyond waste: menstrual blood as a powerful diagnostic tool for women's health — Shafiq et al., Annals of medicine and surgery
- blood
- self-collection
- fertility
- hormones
- wearable
- multimodal
2026
In female shift workers, 0.3 mg melatonin reduced climacteric symptoms by 15.8% compared with placebo and improved sleep quality on days off by 35.33%, with no shift interaction; home blood sampling enabled measurement of LH, FSH, estradiol and progesterone.
Low-Dose Melatonin, Climacteric Symptoms and Sleep in Female Shift Workers: A Randomized Controlled Trial — Saraiva et al., Journal of pineal research
- blood
- fertility
- hormones
2026
In a large real-world cohort of pregnancy planners using home urine tests, sensitivity was lower than expected before the expected period, with false negatives of 12.7% at 2 days, 21.4% at 3 days and 46.4% at 4 days before menses; sensitivity rose sharply thereafter to over 99% by 4 days after the expected period, and for any given test day, longer menstrual cycles were associated with higher sensitivity, especially among early testers.
Home pregnancy test sensitivity by test timing and cycle length with real-world use among pregnancy planners who conceived — Sundermann et al., Fertility and sterility (paywalled)
- urine
- self-collection
- fertility
2026
The EpiCom study was co-created with patients, caregivers and healthcare professionals to optimise a decentralised clinical trial framework that reduces participant burden through remote assessments and broader eligibility criteria, highlighting the value of stakeholder collaboration in trial design.
Co-Creation of the EpiCom Clinical Trial: Bringing the Tuberous Sclerosis Complex Patient Community, Healthcare Professionals, and the Pharmaceutical Industry Together — Moore-Ramdin et al., The patient (paywalled)
- dct
2026
A fully remote decentralised clinical trial in Danish adults with type 2 diabetes demonstrated operational feasibility with rapid recruitment, high retention (87 percent), and excellent adherence to continuous glucose monitoring (95 percent achieving ≥70 percent data coverage) and telemedicine visits (97 percent). Activity tracker adherence was poor (12 percent) due to technical issues, but remote safety monitoring was effective with no unexpected adverse events, supporting the viability of remote diabetes management.
Operational and Clinical Insights from a Fully Decentralized Clinical Study Evaluating Protocol Adherence, Participant Satisfaction, and Connected Device Data in Individuals with Type 2 Diabetes on Different Treatment Regimens — Nørgaard et al., Diabetes technology & therapeutics (paywalled)
- dct
- wearable
- rpm
- cgm
- actigraphy
2026
Viloxazine extended release improved ADHD, depression and anxiety symptoms in adults with comorbid conditions during a 14-week decentralised trial. The study demonstrates that remote monitoring via televisit, mobile app and home devices can deliver real-world efficacy and safety data for psychiatric medications.
Viloxazine Extended Release in Adults With Attention-Deficit/Hyperactivity Disorder and Depression and/or Anxiety Symptoms: Results From a Decentralized, Open-Label, Phase 4 Trial — Adler et al., The Journal of clinical psychiatry (paywalled)
- dct
- rpm
2026
A proof-of-concept decentralised trial generated 169 support tickets over 17 months from 90% of sites, with device-related problems accounting for 46% of requests. Most issues were resolved within three days and required two to six exchanges, demonstrating that robust technical support infrastructure is essential for successful remote monitoring and wearable-based trial conduct.
Toward Effective Technology Support in DCTs: Insights from the Trials@Home Proof-of-Concept Trial RADIAL — Weitlaner et al., Journal of medical systems
- dct
- wearable
- rpm
2026
Hybrid decentralized oncology trials are feasible in community hospitals beyond traditional networks, reducing logistical and financial burdens and enabling rapid initiation and patient referrals within three months.
Building HOPE: operationalizing hybrid decentralized oncology clinical trials with community providers beyond traditional healthcare system networks — Morrison et al., The oncologist
- dct
2026
A hybrid decentralised clinical trial using wearable dosing-monitoring and remote adverse-event reporting in healthy adults achieved 100% adherence with only 2% missing data, maintained adverse-event detection sensitivity, and was rated less burdensome than conventional on-site visits. These findings support the feasibility and reliability of participant-centric remote monitoring in early-phase pharmacokinetic studies.
Pioneering a Hybrid Decentralized Clinical Trial in South Korea: Assessing Feasibility, Data Integrity, and Participant Perceptions — Kim et al., Clinical and translational science
- dct
- wearable
- rpm
2026
Low-volume blood collection devices enable frequent, longitudinal sampling at home with reduced invasiveness, thereby improving participant retention in patient-centric studies. This facilitates decentralised biomarker monitoring for tracking disease progression and understanding physiological responses to diet, medication and physical activity.
Low-volume collection devices for longitudinal biomarker monitoring in patient-centric sampling settings — Simon-Guth et al., Bioanalysis (paywalled)
- blood
- self-collection
- validation
- dct
- biomarkers
2026
A female participant using the Tasso+ capillary self-blood collection device developed a gaping lesion at the application site that required surgical treatment and left a permanent scar, highlighting an unexpected safety issue and the need for further safety evaluation of self-administered blood collection systems.
Unexpected scarring following use of capillary self-blood collection device: A case report and discussion of device design — Müller et al., The journal of vascular access
- blood
- capillary
- self-collection
2026
Postnatal women view the six-week check-up as a window of opportunity for cervical screening via urine self-sampling, though some feel it may be too soon after delivery. The study reveals women's health is perceived as neglected compared with infant care, supporting feasibility of a trial to test early postnatal screening uptake.
Investigating the Acceptability of Cervical Screening and Self-Sampling in Postnatal Women at the 6-Week Postnatal Check-Up: A Qualitative Study — Newhouse et al., Health expectations : an international journal of public participation in health care and health policy
- urine
- self-collection
- acceptability
- hpv
2026
A liquid-phase microsampling method using 2.8 µL of whole blood demonstrated strong correlation with conventional venous sampling for immunosuppressant monitoring in renal transplant recipients. This approach enables patient-centric therapeutic drug monitoring, reducing burden and supporting implementation in home-based, paediatric, and telemedicine settings.
Clinical Application of Microvolume LC-MS/MS for Therapeutic Drug Monitoring of Immunosuppressants in Solid-Organ Transplant Recipients — Iwami et al., Journal of clinical medicine
- blood
- liquid
- validation
- venous-agreement
- tdm
- immunosuppressants
- haematocrit
2026
The study identified 48 strengths, 62 weaknesses, 5 opportunities, and 13 threats across eight key trial activities in decentralised clinical trials, highlighting potential advantages like remote participation and challenges such as digital technology barriers and privacy issues.
SWOT analysis of decentralised clinical trials from an ethical, legal, regulatory and operational perspective — Murciano-Gamborino et al., BMC medical ethics
- dct
2026
A nationwide survey of 194 professionals across 140 Japanese hospitals found that geographic and logistical barriers limit access to comprehensive genomic profiling and genotype-matched trials, with over half of eligible patients declining participation due to travel distance; most institutions support telemedicine for consent and results and view DCTs as essential to improve equitable access.
Bridging the distance in precision oncology: a nationwide survey on institutional perspectives toward telemedicine and decentralized trials in Japan — Taniguchi et al., International journal of clinical oncology
- dct
2026
A direct-to-participant, multichannel recruitment strategy enrolled 34,244 older adults into a virtual trial testing an Apple Watch based heart health programme with electrocardiogram and irregular rhythm notification features, achieving broad geographic and gender diversity but under-representing non-White ethnic groups.
Direct-to-Participant Enrollment in a Virtual Trial: Lessons Learned From the Heartline Study — Hills et al., JACC. Advances
- dct
- wearable
- rpm
- digital-biomarker
2026
In people at high risk of nasopharyngeal carcinoma, saliva showed decreased EBV load and increased EBV DNA methylation compared with controls, and a stepwise strategy that adds saliva testing to serum EBV antibodies improved triage efficiency.
Evaluation of Epstein-Barr virus DNA methylation and load in saliva in the management of individuals at high risk of nasopharyngeal carcinoma — Zheng et al., Biomarker research
- saliva
- biomarkers
2026
Statewide mail-based serosurveys using dried blood spot cards showed high spike antibody positivity and rising neutralising antibodies over time, with no differences by socio-demographic factors, supporting the feasibility of decentralised self-sampling for population infection surveillance.
Population-based serosurveys for SARS-CoV-2 transmission 2021-2022, Massachusetts USA — Cramer et al., Vaccine (paywalled)
- blood
- dried
- dbs
- self-collection
- serology
2026
Capillary blood collected by volumetric absorptive microsampling gave a shorter detection window than urine for a stimulant, helping to distinguish recent from earlier use, and more reliable detection of long-acting diuretics that bind red cells. This shows microsampling can improve interpretation in drug-monitoring programmes where urinary data alone may be ambiguous.
Stressing the limits of capillary blood in anti-doping analysis: perspectives on alkylamine-like stimulants and carbonic anhydrase II inhibitors in result management — da Costa Nunes et al., Frontiers in sports and active living
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- doping
- toxicology
2026
In a nationwide survey of 1047 Belgian adults, at-home VAMS achieved a 63% participation-to-analysis completion rate with 16% of samples excluded due to insufficient quality. While dietary intake suggested adequate thiamine consumption, 11% of participants had blood thiamine diphosphate concentrations below the reference threshold, showing the utility of remote microsampling for identifying true nutritional status.
Thiamine status in Belgian adults assessed by volumetric absorptive microsampling: a nation-wide cross-sectional survey — Heughebaert et al., The American journal of clinical nutrition (paywalled)
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- self-collection
- biomarkers
2026
The authors validated VAMS for lumateperone therapeutic drug monitoring and confirmed its stability, which supports decentralised, patient-centric antipsychotic therapy through low-volume blood collection.
Volumetric absorptive microsampling for lumateperone analysis: method validation and stability evaluation — Milandri et al., Analytical and bioanalytical chemistry
- blood
- dried
- vams
- neoteryx-mitra
- validation
- tdm
2026
A triple-channel immunochromatographic system using quantum dots detected influenza A and B and SARS-CoV-2 nucleoproteins in saliva with limits of detection from 0.227 to 0.348 ng/mL. Testing of 15 influenza A patients and 20 healthy controls showed 100% sensitivity and 95.2% specificity, indicating potential for accurate home-based respiratory virus screening.
A multiplexed three-channel detection system for rapid home-based diagnosis of respiratory viruses — Huang et al., Talanta (paywalled)
- saliva
- self-collection
- serology
2026
The authors developed and optimised a dual LC-MS workflow for non-targeted metabolomics from blood microsamples, comprising a 15-minute HILIC-MS method for polar metabolites and an RPLC-MS method for mid- to non-polar compounds. A 20% water/80% methanol extraction with rehydration offered a practical compromise that detected numerous metabolite features across amino acid, acylcarnitine and bile acid pathways, enabling decentralised metabolomic analysis.
RPLC- and HILIC-based non-targeted metabolomics workflow for blood microsamples — Couacault & Witting, Metabolomics : Official journal of the Metabolomic Society
- blood
- dried
- vams
- neoteryx-mitra
- validation
- metabolome
2026
The study found that dried blood microsampling using DBS and VAMS improves the detection of unstable drugs in post-mortem blood compared to conventional tubes, with some substances showing better stability on microsamples. This supports the use of microsampling in forensic settings where sample degradation affects diagnostic accuracy.
Use of blood micro-samples in forensic thanatology — Bertrand-Ndoye et al., Forensic science international (paywalled)
- blood
- dried
- vams
- dbs
- toxicology
2026
Analysis of dried blood spots from 813 newborns demonstrated that extremely preterm infants have markedly elevated corticosterone and 17-hydroxyprogesterone, with the latter showing the strongest inverse correlation with gestational age, indicating these precursors better reflect adrenal immaturity than cortisol alone. This validates DBS as a practical tool for guiding postnatal steroid therapy in preterm infants by helping clinicians distinguish physiological adrenal immaturity from true insufficiency.
Elevation of corticosterone and 17OH progesterone in extremely preterm infants and clinical implications — Kessel et al., Pediatric research
- blood
- dried
- dbs
- pediatric
- hormones
- cortisol
2026
Among 454 postnatal women, 74.4 per cent would be more likely to undergo cervical screening if offered urine self-sampling for HPV at six weeks postnatal, and 54 per cent preferred this method to conventional clinician-taken samples. This indicates high acceptability of patient-collected urine for decentralised HPV screening in the postnatal period, which could improve uptake when integrated into routine postnatal care.
Investigating the acceptability of cervical screening, using conventional clinician-taken cervical samples or urine self-sampling, at 6 weeks postnatal: A cross-sectional questionnaire — Cullimore et al., Journal of medical screening
- urine
- self-collection
- acceptability
- hpv
2026
Salivary HPV DNA testing achieved 91.7% sensitivity and 100% specificity against oropharyngeal swab in patients with oral cavity cancer, demonstrating potential for non-invasive self-collection screening programmes and long-term monitoring of HPV-driven disease.
Application of a Saliva-Based Liquid Biopsy for the Detection of HPV in Patients With Oral Cavity Squamous Cell Carcinoma (OCSCC) — Bulfoni et al., Head & neck
- saliva
- self-collection
- validation
- hpv
- liquid-biopsy
2026
In adults with type 1 diabetes, Dexcom G7 and FreeStyle Libre 3 showed high accuracy during physical activity, whereas the Simplera system was less accurate; this matters for selecting devices in decentralised monitoring.
Performance of three simultaneously used rtCGM systems around a physically active weekend camp in adults with type 1 diabetes: A prospective lab and real-world study — Sanfilippo et al., Diabetes, obesity & metabolism
- blood
- capillary
- wearable
- cgm
- multimodal
2026
The Phase HPV Urine Test detected 14 high-risk HPV types from first-void urine samples, showing 93 per cent concordance with the Roche cobas 4800 reference assay after sequencing adjudication. The test demonstrated high precision, a low limit of detection, and ten-day stability at ambient temperature, supporting non-invasive, self-collected screening to improve access and participation.
Performance of a novel, urine-based test for the detection of cervical human papillomavirus infection — Manjeshwar et al., Journal of clinical microbiology
- urine
- first-void
- self-collection
- validation
- hpv
- sti
2026
This study found that most decentralised clinical trials are still focused on evaluating methods rather than fully implementing them, with digital tools often used to deliver study activities. The work highlights the need for stronger methodological validation, regulatory clarity, and attention to digital equity to advance decentralised diagnostics.
Decentralized clinical trials: A comprehensive analysis of trends, technologies, and global challenges — Kijewski et al., PLOS digital health
- dct
2026
Dried blood spot collection proved feasible during parabolic flight, with seventeen of twenty volunteers successfully providing samples for caffeine pharmacokinetic profiling. The method yielded stable metabolic ratios between ground and weightless conditions, and participants reported high satisfaction, suggesting DBS could support therapeutic drug monitoring in remote or extreme environments such as long-term spaceflight.
Feasibility of dried blood spot collection for caffeine pharmacokinetic studies in microgravity: Insights from parabolic flight campaigns — Derobertmasure et al., British journal of clinical pharmacology
- blood
- dried
- dbs
- self-collection
- acceptability
- tdm
- genotyping
2026
Home spirometry gave slightly lower percent-predicted FEV1 values than office measurements cross-sectionally, but the three-month change in lung function did not differ significantly between settings. This suggests home spirometry can reliably detect treatment effects, supporting its use as an endpoint for decentralised cystic fibrosis trials.
Home Spirometry as a Clinical Trial Endpoint in People with Cystic Fibrosis: Results of the OUTREACH Study — Rosenfeld et al., Annals of the American Thoracic Society (paywalled)
- dct
- rpm
- digital-biomarker
2026
Analysis of six studies revealed that decentralised clinical trial elements enhanced data completeness by enabling direct access to medical records, although this introduced a significant burden for data abstraction. The results suggest that decentralised approaches are not a universal solution but provide specific metrics that can help design fit-for-purpose trials.
Measuring the added benefits of decentralized trial elements (SHASTA): impact on enrollment, demographics, and data completeness through a single sponsor — Yang et al., Scientific reports
- dct
2026
Experts achieved high consensus on recommendations to support decentralised clinical trials in Europe, including training for health care professionals, improving biological sample logistics, and fostering regulatory harmonization. These prioritized solutions aim to overcome barriers to adoption and create more inclusive and efficient research frameworks.
Addressing the Key Challenges of Decentralized Clinical Trials in Europe: Multistakeholder Perspective Delphi Study — Murciano-Gamborino et al., Journal of medical Internet research
- dct
2026
In a retrospective analysis of 444 metabolic disease trials, adoption of decentralised trial elements was not significantly associated with shorter trial duration after adjustment for clinical phase and characteristics. Phase 2 and 3 DCTs showed numerically shorter mean durations, but differences were not statistically significant, suggesting operational complexities may currently offset theoretical efficiency gains.
Association between decentralised clinical trial adoption and trial duration: a retrospective cross-sectional study of metabolic disease trials — Cho & Lee, BMJ open
- dct
2026
In women with abnormal cytology, hrHPV testing and PAX1/ZNF671 methylation were assessed across paired self-collected urine and vaginal samples versus clinician cervical scrapes. Methylation markers showed high area under the ROC curve for CIN3+ and strong correlation with lesion severity, and the optimal PAX1/ZNF671 panel achieved high sensitivity for CIN2+ in cervical samples but lower sensitivity in urine and vaginal samples, indicating cervical samples are optimal for methylation testing while urine and vaginal self-collection may be useful for hrHPV triage.
Comparative performance of hrHPV testing and PAX1/ZNF671 methylation in triaging women with abnormal cytology: a study of paired urine, vaginal and cervical scrape samples — Wang et al., Frontiers in oncology
- urine
- self-collection
- hpv
- sti
2026
The Alinity m STI assay achieved strong agreement with comparator nucleic acid amplification tests across female urogenital specimens, with κ scores of 0.84 to 0.99. Urine and self-collected vaginal swabs showed high positive agreement (≥99.2% and ≥98.0% respectively), validating their reliability for decentralized STI screening.
Evaluation of Alinity m STI Assay for Simultaneous Detection of Chlamydia trachomatis , Neisseria gonorrhoeae , Trichomonas vaginalis , and Mycoplasma genitalium in Female Urogenital Specimens — Gentil et al., Sexually transmitted diseases
- urine
- self-collection
- validation
- sti
2026
A paired-sample study of postnatal cervical screening proved feasible with high attendance and low test inadequacy. Urine self-sampling for HPV showed lower sensitivity (60% at six weeks) than clinician-taken samples, suggesting it may be less reliable in this population.
Comparison of Cervical Screening at 6- and 12-Weeks Postnatal: A Paired-Sample Feasibility Study — Cullimore et al., BJOG : an international journal of obstetrics and gynaecology (paywalled)
- urine
- self-collection
- acceptability
- hpv
- sti
2026
In a multicentre European study the Papilloplex HR-HPV assay showed similar clinical sensitivity for CIN2+ on self collected urine and vaginal swabs compared with clinician taken cervical samples, while clinical specificity was similar for urine but lower for vaginal swabs; cut off optimisation restored specificity for vaginal swabs without compromising sensitivity.
Clinical performance assessment of the Papilloplex HR-HPV assay on self-taken urine and vaginal swab samples: findings from a multicentre European study — Cuschieri et al., Journal of clinical pathology (paywalled)
- urine
- self-collection
- validation
- hpv
- sti
2026
Lower salivary lactoferrin concentrations were independently associated with positive brain amyloid PET imaging and with periodontal disease, suggesting saliva lactoferrin may have value as a non-invasive biomarker in cognitive impairment assessment.
Relationship between salivary lactoferrin level and brain amyloid load in periodontal and non-periodontal subjects — Gil-Montoya et al., Medicina oral, patologia oral y cirugia bucal
- saliva
- biomarkers
2026
The COVID-19 pandemic accelerated adoption of decentralised testing and self-collected saliva specimens, but revealed challenges with variable diagnostic accuracy and lack of internationally standardised processing protocols. Stricter regulatory oversight and robust diagnostic stewardship are needed to balance broad access with clinical performance.
Beyond the laboratory: how COVID-19 reshaped specimen collection, testing workflows, and diagnostic algorithms — Domnich & Pariani, Expert review of molecular diagnostics (paywalled)
- saliva
- self-collection
2026
Among 101 working-age women in Chicago, 70% returned at-home kits for capillary blood and saliva collection, demonstrating that patient-centric microsampling of stress biomarkers (cortisol and CRP) is feasible in diverse urban populations. This supports decentralised diagnostics for population health research.
A feasibility study exploring precarious employment and stress-related health among women — Oddo et al., BMC public health
- blood
- saliva
- capillary
- self-collection
- cortisol
- biomarkers
2026
Capillary whole blood collected and dried on the OneDraw device gave robust PFAS measurements with low limits of quantification, and levels of ten PFAS correlated strongly with matched venous plasma levels in 133 veterans, enabling remote sampling without clinical infrastructure.
Use of a capillary blood collection device to monitor exposure to per- and polyfluoroalkyl substances (PFAS) in Veterans living in proximity to potential sources of environmental contamination — Havens et al., Journal of exposure science & environmental epidemiology (paywalled)
- blood
- dried
- capillary
- validation
- venous-agreement
2026
Capillary blood obtained using an at-home collection device matched venous blood closely in immune cell composition and phenotype. Although shipping affected myeloid cells, T cell numbers, subsets, and phenotypes stayed stable, which supports the practicality of remote immune monitoring.
An at-home blood collection device for remote immune monitoring by high-parameter flow cytometry — Konecny et al., JCI insight
- blood
- liquid
- capillary
- validation
- venous-agreement
2026
The study found that coached dried blood spot collection was feasible for remote biobehavioural assessment of CTRA gene expression among Black women activists, with usable data from 28 of 29 participants at baseline and 27 at follow-up. Within-person increases in activist identity and search for meaning were associated with more favourable CTRA gene expression changes, though mean CTRA did not shift across the group over the two-month period.
The paradox of action: Trajectories in distress, meaning, and gene regulation following self-directed activist engagement among Black women — Geyton & Cole, SSM. Mental health
- blood
- dried
- dbs
- self-collection
- dct
2026
Self-collected dried blood spots from 40 healthy participants arrived intact and yielded good-quality DNA, with most immune and epigenetic biomarkers remaining stable for up to six weeks at room temperature. The study confirms that minimally invasive dried blood and plasma spot sampling is feasible for scalable, longitudinal biomolecular surveillance in occupational health settings.
Dried blood spot-based monitoring of immune and epigenetic biomarkers in occupational exposure studies — De Ryck et al., Journal of exposure science & environmental epidemiology (paywalled)
- blood
- dried
- dbs
- self-collection
- validation
- acceptability
- biomarkers
2026
Finger-stick dried blood spots produce creatinine measurements that correlate strongly with venous plasma (R² = 0.97), with 91% sensitivity and 96% specificity for detecting reduced eGFR. Creatinine stays stable in dried spots for up to one month at refrigerated or frozen temperatures, supporting accurate home-based kidney function screening, patient follow-up, and medication management.
Creatinine measurement from finger stick dried blood spots with a routine chemistry analyzer for estimation of GFR — van Dam et al., Clinical chemistry and laboratory medicine (paywalled)
- blood
- dried
- capillary
- dbs
- self-collection
- validation
- venous-agreement
- haematocrit
2026
Dried blood spot screening of 3210 neonates in an Eastern Indian province found 10.2% had an inherited disorder, most commonly partial biotinidase deficiency (4.5%) and G6PD deficiency (2.7%), with no sex difference except higher 17-OHP in males; the findings justify national newborn screening to reach all communities.
Newborn screening in an Eastern Indian province: prevalence and trends from a burgeoning newborn screening unit — Saharia et al., Journal of tropical pediatrics (paywalled)
- blood
- dried
- dbs
- pediatric
2026
This study demonstrated that a fully remote genome sequencing study using self-collected dried blood spots and buccal swabs is feasible for individuals with Prader-Willi syndrome, with all participants completing the study and reporting the process was easy despite being lengthy. The design successfully returned actionable genetic findings, including those related to blood clot formation, to participants.
Study design with responsible return of results for a fully remote genome sequencing study in individuals with Prader-Willi syndrome — Vrana-Diaz et al., Genetics in medicine open
- blood
- saliva
- dried
- dbs
- self-collection
- acceptability
- dct
- genotyping
2026
This scoping review identified 15 distinct technologies for measuring HbA1c from capillary blood, with point-of-care devices requiring only 2 to 10 µL and delivering results within minutes. However, diagnostic accuracy varied widely between studies and devices, and most evidence comes from high-income countries, indicating gaps in validation for low- and middle-income settings where decentralised screening is most needed.
HbA1c measurement using capillary blood in epidemiological studies: a scoping review of technologies and approaches — Breternitz et al., BMC endocrine disorders (paywalled)
- blood
- dried
- capillary
- dbs
- self-collection
- validation
2026
Home DBS sampling gave testosterone results that agreed well with venous blood in men on intramuscular testosterone undecanoate, but showed falsely high values in those using topical gel, likely from skin contamination. Patients preferred home collection for its convenience, suggesting DBS is viable for decentralised monitoring of injectable testosterone if patients are taught proper technique.
From venipuncture to self-sampling dried blood spots: a shift in monitoring testosterone levels — Olthof et al., Clinical chemistry and laboratory medicine (paywalled)
- blood
- dried
- capillary
- dbs
- self-collection
- validation
- venous-agreement
- acceptability
- fertility
- hormones
- tdm
2026
The TaqPath kit performed well for HIV drug resistance testing from dried blood spots in samples with high viral loads, meeting WHO criteria for sensitivity and mutation detection, but showed reduced sensitivity at lower viral loads below 5000 copies/mL. This supports the use of DBS for decentralised HIV monitoring in resource-limited settings, though caution is needed when viral load is low.
Evaluation of the Applied Biosystems™ TaqPath™ Seq HIV-1 Genotyping Kit for HIV-1 drug resistance testing from dried blood spot specimens — Okafor et al., Journal of virological methods (paywalled)
- blood
- dried
- dbs
- validation
- serology
2026
Among 1242 asymptomatic children in a remote Congolese district, dried blood spot sampling identified 53% as Plasmodium falciparum-positive. No validated artemisinin-resistance mutations were found, but a lumefantrine-susceptibility marker was present in 15% of samples, demonstrating that community-based microsampling can generate actionable resistance surveillance data to guide decentralised malaria treatment strategies.
Prevalence of antimalarial drug resistance markers and factors associated with Plasmodium falciparum infection in asymptomatic children prior to rectal artesunate implementation in Kapolowe Health District, Democratic Republic of the Congo — Luzolo Khote et al., Malaria journal (paywalled)
- blood
- dried
- dbs
- pediatric
- serology
2026
In adults with sterile pyuria, atypical pathogens were detected in 40% of cases, most commonly Chlamydia trachomatis (19%) and Ureaplasma spp. (15%), with risk factors including multiple sexual partners and past pelvic surgery; comprehensive screening of first-void urine for these agents is warranted.
Prevalence of Chlamydia trachomatis, Ureaplasma spp., Mycoplasma hominis and Mycoplasma genitalium in patients with sterile pyuria — Aggarwal et al., Indian journal of medical microbiology (paywalled)
- urine
- first-void
- sti
2026
First-void urine sampling detected 33% prevalence of 28 HPV types in 16-21-year-old Ugandan females. HPV16/18 prevalence was markedly lower among vaccinated participants (1.4%) than unvaccinated (5.6%), though vaccine coverage was suboptimal with inconsistent dosing. This validates patient-centric urine microsampling for decentralised infectious disease surveillance in resource-limited settings.
Human papillomavirus infection and vaccination among young females in rural Uganda — Newton et al., International journal of cancer (paywalled)
- urine
- first-void
- serology
- hpv
2026
The lateral flow assay showed 80.6% sensitivity and 94.2% specificity in first-void urine from asymptomatic men, and 81.8% sensitivity and 98.1% specificity in vaginal swabs from asymptomatic women. Vaginal swab performance met WHO screening criteria for low-resource settings, while urine specificity fell short, indicating the assay is suitable for decentralised STI screening in women but needs improvement for men.
Cross-sectional evaluation of a lateral flow assay for point-of-care detection of <i>Neisseria gonorrhoeae</i> in asymptomatic individuals at primary healthcare facilities in South Africa — Peters et al., Sexually transmitted infections (paywalled)
- urine
- first-void
- validation
- sti
2026
The fluorescence-enhanced catalytic hairpin assembly nanobiosensor detected HPV16 E7 mRNA with high sensitivity and specificity in first-void urine, showing linear performance across clinically relevant concentrations and stability for 45 days, offering a promising tool for decentralised HPV screening programmes.
Fluorescence-Enhanced Catalytic Hairpin Assembly-Driven Nanobiosensor for Ultrasensitive Detection of HPV16 E7 mRNA — Bina et al., Journal of medical virology (paywalled)
- urine
- first-void
- validation
- hpv
2026
The study validated an LC-MS/MS method for eight antiepileptic drugs and two metabolites in dried blood spot and VAMS formats, with satisfactory analytical performance and stability, and was the first to include the oxcarbazepine metabolite DHCB. In 80 paired patient samples, microsampling concentrations showed promising correlation with plasma, supporting decentralised therapeutic drug monitoring of antiepileptic treatment.
Development and application of an LC-MS/MS method for 8 antiepileptic drugs and 2 metabolites using microsampling techniques (DBS and VAMS) — Cobo-Golpe et al., Journal of analytical toxicology
- blood
- dried
- vams
- dbs
- neoteryx-mitra
- validation
- venous-agreement
- tdm
- haematocrit
2026
Untargeted metabolomic profiles from three blood microsampling devices aligned more closely with whole blood than with plasma, and all devices distinguished sex based on amino acids, lipids, and acylcarnitines. This validates that device choice can be tailored to the metabolites of interest for decentralised human biomonitoring.
An LC-MS untargeted metabolomic comparison between three blood microsampling devices, whole blood, and plasma — Avella et al., Metabolomics : Official journal of the Metabolomic Society
- blood
- dried
- vams
- neoteryx-mitra
- validation
- venous-agreement
- metabolome
- biomarkers
2026
This narrative review surveys remote biospecimen collection products for sexual health research, including dried blood spots and volumetric absorptive microsampling, and concludes that successful implementation needs a multidisciplinary, participant-centred team with sufficient time allocated to the complexities of collection procedures and processes.
A Narrative Review of Remote Biospecimen Collection Product and Implementation Considerations for Sexual Health Clinical Research — Horvath et al., AIDS and behavior (paywalled)
- blood
- dried
- vams
- dbs
- self-collection
- validation
- dct
- serology
- sti
2026
A streamlined workflow quantified up to 10,000 protein groups and post-translational modifications from 20 microlitres of dried blood collected by volumetric absorptive microsampling, with mass spectrometry acquisition under two hours. The study established stability profiles and best practices for dried blood proteomics, supporting its feasibility for decentralised precision medicine and disease phenotyping.
Development and Validation of a Streamlined Workflow for Proteomic Analysis of Proteins and Post-translational Modifications from Dried Blood — Foster et al., Journal of proteome research (paywalled)
- blood
- dried
- vams
- validation
- biomarkers
- multi-omics
- multimodal
2026
The authors validated a liquid-liquid extraction LC-MS/MS method that quantifies cannabinoids in only 50 µL of liquid whole blood with lower limits of quantitation from 0.10 to 1.0 ng/mL. This microsampling approach enables roadside collection via finger prick, allowing measurement of THC levels at the time of driving without trained phlebotomists, thus overcoming delays that reduce THC concentrations.
Validation of a microsampling-compatible liquid-liquid extraction method for cannabinoid quantitation in 50 µL of whole blood using liquid chromatography-mass spectrometry — Mohammed et al., Journal of analytical toxicology
- blood
- liquid
- validation
- toxicology
2026
PEth reference values for Belgium were derived from VAMS microsampling of 487 participants in a national survey, showing distinct biomarker distributions between the general population and higher‑alcohol‑consumption subgroups. This validates capillary blood collection as a practical method for decentralised alcohol monitoring and forensic assessment.
Reference values for the alcohol biomarker phosphatidylethanol (PEth) in the Belgian population: Insights from a nationwide microsampling study — Vandenbroucke et al., Drug and alcohol dependence reports
- blood
- dried
- vams
- neoteryx-mitra
- toxicology
- biomarkers
2026
The study developed and validated a rapid LC-MS/MS method for quantifying cefazolin in capillary whole blood collected via VAMS, plasma, and plasma ultrafiltrate, showing robust performance across matrices and successful application in a pediatric pilot cohort for therapeutic drug monitoring.
Rapid, robust LC-MS/MS quantification of cefazolin in whole blood microsamples, plasma, and plasma ultrafiltrate: Analytical method validation and preliminary clinical application in pediatric population — Kocur et al., Clinica chimica acta; international journal of clinical chemistry (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- pediatric
- tdm
- antimicrobials
2026
This study demonstrates that a commercial conductive vial electromembrane extraction device can reliably isolate basic pharmaceuticals from whole blood collected on volumetric absorptive microsampling tips, showing superior reproducibility and reduced matrix effects compared to conventional treatment.
Volumetric absorptive microsampling and conductive vial electromembrane extraction for the analysis of pharmaceuticals in whole blood — Reguli et al., Talanta (paywalled)
- blood
- dried
- vams
- neoteryx-mitra
- validation
- tdm
- haematocrit
2026
In matched clinical samples from rheumatoid arthritis, VAMS and DBS showed strong agreement for methotrexate polyglutamates (slopes 0.95-1.07; bias within -4.21% to 0.36%; SRCC ≥ 0.969), with up to 100% of total MTXPG results within ±20% limits; capillary microsampling agreed closely with whole blood but differed from red blood cells, indicating matrix-specific differences that must be accounted for when interpreting against RBC-based reference values.
Multi-Matrix LC-MS/MS Validation of Methotrexate Polyglutamates: Comparison of VAMS, DBS, and Conventional Blood Sampling in Rheumatoid Arthritis — Kocur et al., International journal of molecular sciences
- blood
- dried
- capillary
- vams
- neoteryx-mitra
- validation
- venous-agreement
- tdm
- immunosuppressants
2026
A UPLC-MS/MS method for linezolid and metabolites in oral fluid and VAMS capillary blood satisfied ICH M10 validation requirements. Linezolid concentrations correlated strongly with venous plasma in both matrices, offering a non‑invasive option for therapeutic drug monitoring, whereas metabolites were systematically underestimated in VAMS and seldom detectable in oral fluid, restricting metabolite measurement.
Simultaneous quantification of linezolid and its metabolites (PNU-142300 and PNU-142586) in oral fluid and capillary blood by UPLC-MS/MS: method validation and clinical application using non-invasive sampling techniques — González-Berdullas et al., Journal of translational medicine (paywalled)
- blood
- saliva
- dried
- capillary
- vams
- validation
- venous-agreement
- tdm
- antimicrobials
- haematocrit
2025
Worked case studies of patient-centric sampling deployed in pharmaceutical drug development: how sponsors have implemented it, rather than whether it is possible.
Case Studies on the Use of Patient-centric Sampling for Clinical Studies in Pharmaceutical Drug Development — Patel et al., The AAPS Journal (paywalled)
- dct
- venous-agreement
- blood
- self-collection
- pediatric
- validation
- biomarkers
2025
A head-to-head pharmacokinetic comparison of conventional venous sampling against patient-centric microsampling: exactly the bridging study regulators now expect before microsampled data supports an endpoint.
A Pharmacokinetic Study of Zavegepant Nasal Spray in Healthy Adults Comparing Conventional Venous Blood Sampling With Patient-Centric Microsampling — Shahin et al., Clinical and Translational Science
- dct
- venous-agreement
- blood
- dried
- capillary
- liquid
- validation
2025
A critical assessment of recent decentralised trial experience, weighing what the model has delivered against what was claimed for it.
Decentralized Clinical Trials in the Era of Real-World Evidence: A Critical Assessment of Recent Experiences — Wang et al., Clinical and Translational Science
- dct
- standards
- digital-biomarker
2025
Patient-centric microsampling of salivary cortisol shows a 12.6 nmol/L cutoff at 60 min post cosyntropin stimulation, 89% accuracy, 85% sensitivity and 90% specificity, for adrenal insufficiency diagnosis, but reproducibility in healthy volunteers was poor.
Utility of Salivary Cortisol and Cortisone in the Diagnostics of Adrenal Insufficiency — Kvam Hellan et al., Journal of Clinical Endocrinology & Metabolism (paywalled)
- cortisol
- hormones
- liquid
- validation
- saliva
2025
A phase 1 trial designed around participant self-collection of pharmacokinetic samples at home, with video training and pre-assembled kits: evidence that the model is a training and logistics package, not only a device.
At-Home Self-Collection of Pharmacokinetic Data: Design and Results From a Phase 1 Open-Label Feasibility Trial — Raoufinia et al., Clinical Pharmacology in Drug Development
- dct
- neoteryx-mitra
- blood
- tdm
- self-collection
- dried
2025
A recommendation paper on extending decentralised elements in trials, covering the conditions under which trial activity, including biological sample collection, may take place away from the investigator site.
Recommendation Paper on Advancing the Use of Decentralised Elements in Clinical Trials — Bond et al., Therapeutic Innovation & Regulatory Science
- dct
- standards
2025
A systematic review found mixed economic evidence for microsampling in therapeutic drug monitoring; one study reported no cost reduction with DBS home-sampling, €688 versus €676, whilst another predicted savings up to 61%. The authors caution that more work is required to assess costs alongside clinical outcomes and optimise logistics for decentralised implementation.
The economic evidence for microsampling to support therapeutic drug monitoring: A systematic review — Carland et al., British Journal of Clinical Pharmacology (paywalled)
- vams
- blood
- economics
- dbs
- tdm
- self-collection
- dried
- antimicrobials
- pediatric
- immunosuppressants
- validation
2025
A review of 39 studies found that dried blood spot and volumetric absorptive microsampling show promising results for therapeutic drug monitoring of oral targeted anticancer drugs. The authors state that external validation remains crucial to confirm reliability, citing haematocrit effects and sample stability as key challenges.
Advancing Therapeutic Drug Monitoring for Oral Targeted Anticancer Drugs: From Hospital-Based Towards Home-Sampling — Meertens et al., Biomedical Chromatography
- vams
- blood
- dbs
- tdm
- self-collection
- haematocrit
- dried
- oncology
- validation
2025
A UK survey of 2,816 healthcare workers found that 74% preferred at-home PCR testing and 52% preferred at-home serological sampling over hospital visits; some reported blood-collection or kit difficulties, and the authors conclude that home sampling is acceptable and workable for keeping participants in long-running studies.
Comparing Participant Experiences of at-Home and Hospital-Based Biological Sampling: Cross-Sectional Insights From the SIREN Study — Lut et al., Health Science Reports
- acceptability
- blood
- self-collection
- serology
- capillary
2025
An evaluation of blood sampling strategies across a large UK healthcare-worker cohort study, covering how sampling approach affected participation.
Evaluating blood sampling strategies within the SIREN study: the experience from a large cohort of healthcare workers in the UK — Hettiarachchi et al., BMC Medical Research Methodology
- dct
- acceptability
- blood
- economics
- self-collection
- capillary
- validation
2025
A multi-targeted procedure covered 237 prohibited substances across 11 WADA classes in dried urine spots, with environmental-stability testing for refrigeration-free transport.
LC-HRMS screening for 11 classes of prohibited substances in dried urine spots for doping control — Mazzarino et al., Analytical and Bioanalytical Chemistry (paywalled)
- neoteryx-mitra
- doping
- dried
- toxicology
- urine
- validation
2025
Testosterone, androstenedione, cortisol and cortisone were measurable from 200 µL saliva, but estradiol fell below quantification and progesterone in under half of samples: only a subset of steroids is reliable in saliva, and not interchangeable with serum.
Non-invasive assessment of free steroid hormones: a high-throughput LC-MS/MS method for salivary steroid quantification — Slettvoll et al., Analytical and Bioanalytical Chemistry
- cortisol
- steroids
- hormones
- liquid
- validation
- saliva
2025
Earlobe capillary microsampling of 100-250 µL found good agreement with venous draws for progesterone, concordance 0.911, and 17β-estradiol, concordance 0.919, across menstrual cycles, showing suitability for decentralised monitoring. However, participant-reported burden was not assessed, and further validation is required in elite athletes.
Larger-volume capillary blood sampling is a valid alternative to assess progesterone and 17β-estradiol for cycle phase identification — Schlie et al., Frontiers in Physiology
- blood
- liquid
- capillary
- hormones
- fertility
- venous-agreement
- validation
2025
A head-to-head of four upper-arm capillary devices, including TAP Micro Select, versus fingerstick and venous: experience and performance varied by device with none clearly superior, while analyte correlations with venous were similar across all.
Comparing capillary blood collection technologies: patient experience, device performance and clinical accuracy — Collier et al., Bioanalysis (paywalled)
- blood
- liquid
- yourbio
- capillary
- venous-agreement
- acceptability
- validation
- bd-microtainer
2025
A vacuum-assisted upper-arm device collected a mean 538 µL and met the volume target in 85.5% of cases; 17 of 19 analytes met CLIA agreement with venous, with pain lower than fingerstick.
Evaluation of a Simplified Upper-Arm Device for Vacuum-Assisted Collection of Capillary Blood — Schaff et al., Diagnostics
- blood
- liquid
- capillary
- venous-agreement
- acceptability
- validation
- bd-microtainer
Read from the corpus on .