Remote Fingerstick Blood Collection for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Testing

The study found very strong correlation between venous blood collection and capillary VAMS using Mitra devices for detecting SARS-CoV-2 spike antibodies, with samples remaining stable at room temperature for several months. This enables reliable at-home, patient-centric serological testing for large-scale community surveillance and vaccine studies.

Validation of at-home blood sampling for large scale, cost effective serological analysis for anti-viral antibody responses — Mayer et al., Journal of immunological methods (paywalled) · source ↗

• blood
• dried
• capillary
• vams
• neoteryx-mitra
• self-collection
• validation
• venous-agreement
• serology

VAMS capillary blood showed strong agreement with venous serum for measuring anti-influenza antibodies and remained stable for three weeks at room temperature. When volunteers performed finger-stick sampling at home, their results were highly consistent with on-site collection by study personnel.

Application of volumetric absorptive microsampling (VAMS) to measure multidimensional anti-influenza IgG antibodies by the mPlex-Flu assay — Wang et al., Journal of clinical and translational science · source ↗

• blood
• dried
• capillary
• vams
• neoteryx-mitra
• self-collection
• validation
• venous-agreement
• serology

Capillary samples collected using dried blood spots and Mitra microsamplers showed strong agreement with venous plasma for quantifying IgG antibodies against most vaccine-preventable diseases. Sensitivity was high for the majority of pathogens, though the study noted that antibody stability declined at room temperature over time, favouring cold storage for longer durations.

Comparison of capillary microsampling and venous blood for multi-pathogen serosurveillance — Ombati et al., Scientific reports (paywalled) · source ↗

• blood
• dried
• capillary
• vams
• dbs
• neoteryx-mitra
• validation
• venous-agreement
• serology

In participants 11 months after SARS-CoV-2 infection, the nano-immunoassay achieved 98.33% sensitivity and 97.62% specificity on venous serum. When combined with dried capillary microsampling, sensitivity was 95.05% with Mitra, 61.11% with repurposed glucose strips and 83.16% with HemaXis (91.49% after automated extraction), with no loss of specificity, supporting home-based sampling for serology.

Clinical sensitivity and specificity of a high-throughput microfluidic nano-immunoassay combined with capillary blood microsampling for the identification of anti-SARS-CoV-2 Spike IgG serostatus — Michielin et al., PloS one · source ↗

• blood
• dried
• capillary
• vams
• neoteryx-mitra
• validation
• venous-agreement
• serology

Clinical validation for tacrolimus and mycophenolic acid monitoring showed that while volumetric absorptive microsampling met analytical criteria after concentration correction, conventional dried blood spots achieved superior adherence to strict clinical criteria, sample quality, and cost efficiency without significant haematocrit bias.

Comparison of conventional dried blood spots and volumetric absorptive microsampling for tacrolimus and mycophenolic acid determination — Paniagua-González et al., Journal of pharmaceutical and biomedical analysis (paywalled) · source ↗

• blood
• dried
• capillary
• vams
• dbs
• neoteryx-mitra
• self-collection
• validation
• venous-agreement
• tdm
• immunosuppressants
• economics
• haematocrit