2017 · Journal of pharmaceutical and biomedical analysis · paywalled
Volumetric adsorptive microsampling-liquid chromatography tandem mass spectrometry assay for the simultaneous quantification of four antibiotics in human blood: Method development, validation and comparison with dried blood spot
Barco et al.
The finding, in our words
A VAMS-LC-MS/MS method was developed and validated for measuring four antibiotics in 10 microlitres of human blood, showing that VAMS provided accurate quantification unaffected by haematocrit, unlike dried blood spots. The method was applied to paediatric patient samples, supporting its use for therapeutic drug monitoring in children.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
This review summarises liquid chromatography with tandem mass spectrometry assays using dried blood spots and volumetric absorptive microsampling for quantifying antimicrobial drugs in children, highlighting that VAMS reduces haematocrit bias and offers a viable alternative to traditional plasma sampling for therapeutic drug monitoring.
Moorthy et al., Therapeutic drug monitoring (paywalled) · source ↗
The study validated an LC-MS/MS method for eight antiepileptic drugs and two metabolites in dried blood spot and VAMS formats, with satisfactory analytical performance and stability, and was the first to include the oxcarbazepine metabolite DHCB. In 80 paired patient samples, microsampling concentrations showed promising correlation with plasma, supporting decentralised therapeutic drug monitoring of antiepileptic treatment.
Cobo-Golpe et al., Journal of analytical toxicology · source ↗
The study developed and validated a rapid LC-MS/MS method for quantifying cefazolin in capillary whole blood collected via VAMS, plasma, and plasma ultrafiltrate, showing robust performance across matrices and successful application in a pediatric pilot cohort for therapeutic drug monitoring.
Kocur et al., Clinica chimica acta; international journal of clinical chemistry (paywalled) · source ↗
A validated LC-MS method quantified multiple antibiotics from a single volumetric absorptive microsample, with stability up to 90 days for most analytes and minimal haematocrit effect except vancomycin, enabling pharmacokinetic and pharmacodynamic studies in decentralised settings.
Takyi-Williams et al., Bioanalysis (paywalled) · source ↗
This narrative review evaluates microsampling devices for therapeutic drug monitoring, concluding that techniques such as volumetric absorptive microsampling and dried blood spots offer reliable, less invasive alternatives to venous sampling when paired with high-sensitivity mass spectrometry, which supports implementation in routine clinical practice.