2021 · International journal of environmental research and public health · open access
CoCoss-Trial: Concurrent Comparison of Self-Sampling Devices for HPV-Detection
Ertik et al.
The finding, in our words
Two dry vaginal self-sampling devices and a first-void urine collector detected over 90% of high-grade cervical lesions (CIN 3+) and all invasive cancers, with sensitivity comparable to clinician-taken smears. Participants found the devices easy to use and self-sampling was well accepted, which could improve uptake of cervical screening.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
This randomised sub-study found return rates of 10.4% for Colli-Pee, 10.1% for FLOQSwabs and 7.4% for Evalyn-Brush. All devices yielded sufficient DNA with low invalid rates, but the authors noted the study was limited by low overall participation.
Hempel et al., Archives of gynecology and obstetrics · source ↗
For decentralised testing, a study found dry vaginal self-samples using Copan FLOQSwabs stored up to two weeks at room temperature maintain DNA quality. However, first-void urine collected with the Colli-Pee device may be less sensitive for HPV detection, showing lower positivity and higher cycle threshold values, median Ct 30 versus 27 for other samples.
Chu et al., BJOG : an international journal of obstetrics and gynaecology · source ↗
In 498 women living with HIV, self-collected first-void urine and vaginal samples showed 78% high-risk HPV prevalence and good genotype concordance, kappa 0.64-0.78. Participants preferred the Colli-Pee device over the Evalyn Brush, supporting decentralised, patient-centric screening feasibility.
Madsen et al., Journal of medical virology · source ↗
Urine self-sampling for HPV showed non-inferior specificity to cervical samples, 85.19%, and found 96% of high-grade lesions. While acceptable, a survey of 1382 participants found 41.6% preferred conventional screening, showing the importance of offering choice in a decentralised, patient-centric programme.
Davies et al., The British journal of general practice : the journal of the Royal College of General Practitioners · source ↗
First-void urine collected with the Colli-pee device detected high-grade cervical precancer with 90.3% sensitivity, substantially better than the 73.4% sensitivity of standard-pot urine, and was acceptable to colposcopy attendees. The device achieved 92% relative sensitivity compared with clinician-collected cervical samples, showing promise for decentralised HPV screening.
Davies et al., BJOG : an international journal of obstetrics and gynaecology (paywalled) · source ↗