Urine human papillomavirus testing for cervical screening in a UK general screening population: a diagnostic test accuracy study

This randomised sub-study found return rates of 10.4% for Colli-Pee, 10.1% for FLOQSwabs and 7.4% for Evalyn-Brush. All devices yielded sufficient DNA with low invalid rates, but the authors noted the study was limited by low overall participation.

Comparison of three different hpv self-sampling tools - a subanalysis of the prospective, randomized hannover self-collection study — Hempel et al., Archives of gynecology and obstetrics · source ↗

• urine
• first-void
• colli-pee
• self-collection
• acceptability
• hpv
• sti

In 498 women living with HIV, self-collected first-void urine and vaginal samples showed 78% high-risk HPV prevalence and good genotype concordance, kappa 0.64-0.78. Participants preferred the Colli-Pee device over the Evalyn Brush, supporting decentralised, patient-centric screening feasibility.

Feasibility of First-Void Urinary and Vaginal Self-Sampling for High-Risk Human Papillomavirus Testing Among Women Living With Human Immunodeficiency Virus in Guinea-Bissau-A Multicenter Cross-Sectional Study — Madsen et al., Journal of medical virology · source ↗

• colli-pee
• acceptability
• first-void
• sti
• self-collection
• hpv
• urine

First-void urine collected with the Colli-pee device detected high-grade cervical precancer with 90.3% sensitivity, substantially better than the 73.4% sensitivity of standard-pot urine, and was acceptable to colposcopy attendees. The device achieved 92% relative sensitivity compared with clinician-collected cervical samples, showing promise for decentralised HPV screening.

Urine high-risk human papillomavirus testing as an alternative to routine cervical screening: A comparative diagnostic accuracy study of two urine collection devices using a randomised study design trial — Davies et al., BJOG : an international journal of obstetrics and gynaecology (paywalled) · source ↗

• urine
• first-void
• colli-pee
• self-collection
• acceptability
• hpv
• sti

Among 515 women, 93% believed HPV self-sampling could improve screening uptake and 95% found instructions clear and felt confident, yet 41% still preferred clinician collection and 9-19% found it unpleasant. This shows urine-based screening with Colli-Pee is well accepted but not universally preferred, a crucial insight for patient-centric decentralised programmes.

Cervical cancer screening using HPV tests on self-samples: attitudes and preferences of women participating in the VALHUDES study — De Pauw et al., Archives of public health = Archives belges de sante publique · source ↗

• urine
• first-void
• colli-pee
• self-collection
• acceptability
• hpv
• sti

Two dry vaginal self-sampling devices and a first-void urine collector detected over 90% of high-grade cervical lesions (CIN 3+) and all invasive cancers, with sensitivity comparable to clinician-taken smears. Participants found the devices easy to use and self-sampling was well accepted, which could improve uptake of cervical screening.

CoCoss-Trial: Concurrent Comparison of Self-Sampling Devices for HPV-Detection — Ertik et al., International journal of environmental research and public health · source ↗

• colli-pee
• acceptability
• first-void
• sti
• self-collection
• dried
• hpv
• urine