A review of recent advances in microsampling techniques of biological fluids for therapeutic drug monitoring
Tey & See
The finding, in our words
The review finds that volumetric absorptive microsampling addresses the haematocrit bias inherent in dried blood spots, making it suitable for therapeutic drug monitoring, but emphasises that each microsampling technique presents distinct analytical and logistical challenges that must be weighed for decentralised deployment.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
This narrative review evaluates microsampling devices for therapeutic drug monitoring, concluding that techniques such as volumetric absorptive microsampling and dried blood spots offer reliable, less invasive alternatives to venous sampling when paired with high-sensitivity mass spectrometry, which supports implementation in routine clinical practice.
The review evaluates microsampling techniques including dried matrix spots, volumetric absorptive microsampling and capillary microsampling for SARS-CoV-2 bioanalytical applications, outlining their respective advantages and disadvantages to guide researchers and clinicians in pandemic-related diagnostics.
Protti et al., Journal of pharmaceutical and biomedical analysis · source ↗
Confirms urine is the second-most-applied VAMS matrix in forensics, collecting a consistent volume regardless of viscosity and enabling room-temperature storage and shipping.
This systematic review of 67 studies involving 34,739 kidney disease patients found dried blood microsampling was mainly used for immunosuppressant therapeutic drug monitoring and kidney function assessment. The approach offered cost savings, was preferred by patients for home self-collection, and provides a patient-centric opportunity to upscale longitudinal sampling and reduce participation bias in decentralised kidney disease research.
Lamond et al., Journal of clinical laboratory analysis · source ↗
In AML and CLL, 91% of VAMS venetoclax results fell within 20% of plasma after individualised haematocrit correction; in home sampling, 18 of 21 patients self-sampled independently and 76% of returned samples were analysable, which shows home microsampling is workable, though the authors ask for multicentre validation.
Levens et al., Clinical Pharmacokinetics (paywalled) · source ↗