2024 · Toxics · open access
Review
Confirms urine is the second-most-applied VAMS matrix in forensics, collecting a consistent volume regardless of viscosity and enabling room-temperature storage and shipping.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
2016
The study developed and validated an LC-MS/MS method using volumetric absorptive microsampling to quantify cathinone analogues in dried urine, plasma and oral fluid, showing satisfactory linearity, precision, recovery, matrix effects, selectivity and stability, and was applied to real samples from users, offering a reliable decentralised sampling strategy for forensic toxicology and sport drug testing.
LC-MS/MS and volumetric absorptive microsampling for quantitative bioanalysis of cathinone analogues in dried urine, plasma and oral fluid samples — Mercolini et al., Journal of pharmaceutical and biomedical analysis (paywalled) · source ↗
2026
This review highlights that microsampling techniques such as dried blood spots and volumetric absorptive microsampling offer superior alternatives to traditional sampling for the mass spectrometry detection of prohibited substances in anti-doping analysis. It provides guidance on selecting appropriate analytical methods and sample pretreatment strategies to ensure sensitive detection and reliable storage conditions.
Mass Spectrometry-Based Anti-Doping Analysis: A Critical Review of Emerging Analytical and Sample Pretreatment Strategies — Maykar et al., Critical reviews in analytical chemistry (paywalled) · source ↗
2025
Researchers validated a UHPLC-MS/MS assay for citrinin in capillary blood collected with Neoteryx Mitra VAMS devices, plus feces and urine, achieving quantification limits of 0.05 ng/mL. The study derived human toxicokinetic parameters from 48-hour sample collection after a single oral dose, demonstrating that microsampling enables robust population-level exposure assessment for mycotoxins.
Derivation of Human Toxicokinetic Parameters and Chemical-Specific Adjustment Factor of Citrinin Through a Human Intervention Trial and Hierarchical Bayesian Population Modeling — Visintin et al., Toxins · source ↗
2024
The study validated an LC-HRMS method for measuring breast cancer drugs in plasma, urine, VAMS and oral fluid, showing that all matrices except oral fluid for certain drugs can support decentralised therapeutic drug monitoring. VAMS and oral fluid faced practical challenges in collection due to patient conditions, but the method enables patient-centric monitoring with dried blood and other self-collected samples.
Towards clinical adherence monitoring of oral endocrine breast cancer therapies by LC-HRMS-method development, validation, comparison of four sample matrices, and proof of concept — Jacobs et al., Analytical and bioanalytical chemistry · source ↗
2023
This narrative review evaluates microsampling devices for therapeutic drug monitoring, concluding that techniques such as volumetric absorptive microsampling and dried blood spots offer reliable, less invasive alternatives to venous sampling when paired with high-sensitivity mass spectrometry, which supports implementation in routine clinical practice.
Biological Fluid Microsampling for Therapeutic Drug Monitoring: A Narrative Review — Cafaro et al., Biomedicines · source ↗