2023 · J. Pharmaceutical and Biomedical Analysis · paywalled
VAMS and dried plasma spot for antifungal triazole agents (voriconazole, posaconazole, isavuconazole) in pediatric patients by LC-MS/MS
Simeoli et al.
The finding, in our words
In children, VAMS and dried plasma spot voriconazole, posaconazole and isavuconazole correlated with fresh plasma, Spearman 0.82–0.94, and stayed stable at room temperature for at least 14 days: refrigeration-free antifungal TDM in paediatrics.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
Volumetric absorptive microsampling of whole blood did not provide a reliable basis for calculating meropenem plasma concentrations in critically ill children, so a validated low volume plasma method was required for paediatric therapeutic drug monitoring.
Ramadan et al., Therapeutic drug monitoring (paywalled) · source ↗
The validated LC-MS/MS method showed similar pharmacokinetic profiles for albendazole and its metabolites across plasma, whole blood, dried blood spots and Mitra microsamples from hookworm-infected adolescents, supporting microsampling for paediatric pharmacokinetic studies. Mitra extraction proved more robust than dried blood spots during validation and is recommended for future albendazole pharmacokinetic work, despite higher albendazole sulfone concentrations observed in both microsampling devices compared with wet matrices.
Schulz et al., Antimicrobial agents and chemotherapy (paywalled) · source ↗
The study validated an LC-MS/MS method for eight antiepileptic drugs and two metabolites in dried blood spot and VAMS formats, with satisfactory analytical performance and stability, and was the first to include the oxcarbazepine metabolite DHCB. In 80 paired patient samples, microsampling concentrations showed promising correlation with plasma, supporting decentralised therapeutic drug monitoring of antiepileptic treatment.
Cobo-Golpe et al., Journal of analytical toxicology · source ↗
The study developed and validated a rapid LC-MS/MS method for quantifying cefazolin in capillary whole blood collected via VAMS, plasma, and plasma ultrafiltrate, showing robust performance across matrices and successful application in a pediatric pilot cohort for therapeutic drug monitoring.
Kocur et al., Clinica chimica acta; international journal of clinical chemistry (paywalled) · source ↗
This study validated a method for quantifying fluconazole using the Mitra device, demonstrating sufficient accuracy and precision for therapeutic drug monitoring in paediatric patients.