Developing a Method for Quantifying Meropenem in Children-Volumetric Adsorptive Microsampling Versus Plasma Sampling
Ramadan et al.
The finding, in our words
Volumetric absorptive microsampling of whole blood did not provide a reliable basis for calculating meropenem plasma concentrations in critically ill children, so a validated low volume plasma method was required for paediatric therapeutic drug monitoring.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
The validated LC-MS/MS method showed similar pharmacokinetic profiles for albendazole and its metabolites across plasma, whole blood, dried blood spots and Mitra microsamples from hookworm-infected adolescents, supporting microsampling for paediatric pharmacokinetic studies. Mitra extraction proved more robust than dried blood spots during validation and is recommended for future albendazole pharmacokinetic work, despite higher albendazole sulfone concentrations observed in both microsampling devices compared with wet matrices.
The study developed and validated a rapid LC-MS/MS method for quantifying cefazolin in capillary whole blood collected via VAMS, plasma, and plasma ultrafiltrate, showing robust performance across matrices and successful application in a pediatric pilot cohort for therapeutic drug monitoring.
This study validated a method for quantifying fluconazole using the Mitra device, demonstrating sufficient accuracy and precision for therapeutic drug monitoring in paediatric patients.
VAMS finger-prick sampling showed moderate agreement with conventional venous sampling for clofazimine, with a systematic 13% lower concentration that can be corrected, and was more cost-effective by about 4.45 USD per sample, supporting its use for routine therapeutic drug monitoring in MDR-TB.
The study validated a VAMS-based LC-MS/MS method for measuring sirolimus levels, showing it was clinically equivalent to the standard whole blood method and suitable for therapeutic drug monitoring in paediatric transplant patients, supporting the use of decentralised microsampling for this purpose.