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2023 · Clinical biochemistry · paywalled

Validation and application of volumetric absorptive microsampling (VAMS) dried blood method for phenylalanine measurement in patients with phenylketonuria

Gao et al.

The finding, in our words

The study found that VAMS dried blood sampling provides blood phenylalanine measurements highly concordant with venous plasma, with over 88% of results within 20% difference, supporting its use in patient-centric monitoring. This validates a decentralised, microsampling-based approach for therapeutic drug monitoring in phenylketonuria, including in children.

A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.

Read the source ↗DOI 10.1016/j.clinbiochem.2023.03.012PubMed 37001750

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Papers that share these labels

  1. 2024

    The study validated a VAMS-based LC-MS/MS method for measuring sirolimus levels, showing it was clinically equivalent to the standard whole blood method and suitable for therapeutic drug monitoring in paediatric transplant patients, supporting the use of decentralised microsampling for this purpose.

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  2. 2023

    A study of 50 paediatric renal transplant recipients found that a validated VAMS LC-MS/MS method for tacrolimus showed high correlation with the reference method over 0.5–60 ng/mL, with minimal haematocrit effect.

    Therapeutic Drug Monitoring of Tacrolimus Based on VAMS in Renal Transplant Pediatric Recipients — LC-MS/MS Method, Hematocrit Effect, and Clinical Application — Kocur et al., Pharmaceutics · source ↗

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  3. 2023

    Volumetric absorptive microsampling of whole blood did not provide a reliable basis for calculating meropenem plasma concentrations in critically ill children, so a validated low volume plasma method was required for paediatric therapeutic drug monitoring.

    Developing a Method for Quantifying Meropenem in Children-Volumetric Adsorptive Microsampling Versus Plasma Sampling — Ramadan et al., Therapeutic drug monitoring (paywalled) · source ↗

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  4. 2023

    Researchers validated a microsampling method for measuring baricitinib levels in children aged 2–18 years using the Mitra device. The approach showed good agreement with conventional plasma sampling and was well received by clinical sites, suggesting it could support paediatric therapeutic drug monitoring and trial enrolment.

    Microsampling in pediatric studies: pharmacokinetic sampling for baricitinib (Olumiant™) in global pediatric studies — Wickremsinhe et al., Bioanalysis (paywalled) · source ↗

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  5. 2020

    Capillary blood sampling using volumetric absorptive microsampling demonstrated non-significant differences in cannabidiol concentrations compared to venous blood and plasma in pediatric patients treated with Epidiolex. The method requires 30 µL of sample, achieves linear quantification between 1 and 800 µg/L, and ensures analyte stability on VAMS devices for up to four weeks at room temperature.

    Cannabidiol Determination on Peripheral Capillary Blood Using a Microsampling Method and Ultra-High-Performance Liquid Chromatography Tandem Mass Spectrometry with On-Line Sample Preparation — Pigliasco et al., Molecules · source ↗

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