2022 · Frontiers in genetics · open access
Dermody et al.
Urine-based liquid biopsy detecting trans-renal cell-free tumor DNA provides a non-invasive alternative to blood sampling, enabling frequent home self-collection and mail-in monitoring of cancer biomarker kinetics.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
2021
In first-void urine collected with Colli-Pee, the extraction method influenced HPV and human DNA yield more than the collected volume did: standardising processing matters at least as much as standardising volume.
Téblick et al., Molecules · source ↗
2017
Urine trans-renal DNA and plasma circulating tumour DNA showed concordant dynamics that paralleled clinical course in a metastatic colorectal cancer patient treated with an ALK inhibitor. Urine-based detection of the CAD-ALK rearrangement anticipated radiological confirmation of disease progression, demonstrating that self-collected urine can non-invasively monitor tumour evolution and emerging resistance mutations during therapy.
Siravegna et al., Annals of oncology : official journal of the European Society for Medical Oncology (paywalled) · source ↗
2026
The study found that testing for ASCL1/LHX8 DNA methylation in at-home collected first-void urine can detect most cervical cancers and high-grade precancers, supporting a fully molecular screening pathway without a clinical visit.
Van Keer et al., Communications medicine · source ↗
2026
The authors developed an integrated sequencing workflow that simultaneously profiles copy number aberrations and a three-gene methylation panel from home-collected urine cell-free DNA, achieving high diagnostic accuracy for both primary and recurrent bladder cancer in a cohort of 89 participants, which supports the feasibility of decentralised cancer detection from self-collected urine samples.
Beijert et al., JCO precision oncology (paywalled) · source ↗
2026
An eight-millilitre sample of first-morning urine self-collected without prostatic massage yields reproducible microbial profiles using PathoChip microarray. The workflow identified Streptococcaceae enrichment in higher-grade prostate cancer, supporting its potential for decentralised, non-invasive screening, though larger validation cohorts are needed.
Mello-Grand et al., The journal of liquid biopsy (paywalled) · source ↗