2023 · Children · open access
Ciancia et al.
During ACTH stimulation, salivary cortisol correlated only weakly with serum and gave modest accuracy: saliva does not reliably replace serum cortisol for adrenal insufficiency. A concrete limit.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
2026
This study found that salivary 11-dehydrodexamethasone correlates strongly with serum dexamethasone, unlike salivary dexamethasone which shows poor agreement. This validation suggests patients could self-collect saliva samples at home to verify dexamethasone absorption for the overnight suppression test.
The Utility of Salivary 11-Dehydrodexamethasone as a Marker of Dexamethasone Absorption — Marshall et al., The Journal of clinical endocrinology and metabolism (paywalled) · source ↗
2026
This study validated a lateral flow fluorescence assay using quantum dots for saliva and europium nanoparticles for serum to detect cortisol within physiological ranges. The test operates in 15 minutes with a handheld reader, supporting point-of-care and at-home monitoring without a cold chain.
Ultrasensitive de novo Protein Sandwich Lateral flow Fluorescence Assay for Cortisol in Saliva and Serum using Quantum dots and Europium Nanoparticles — Bruno et al., Journal of fluorescence (paywalled) · source ↗
2025
Salivary concentrations of 17OH-progesterone, androstenedione, dehydroepiandrosterone, testosterone and progesterone showed strong positive correlations with serum in both prepubertal and pubertal children with congenital adrenal hyperplasia, supporting saliva as a minimally invasive alternative to venipuncture for diagnosis and therapy monitoring.
[Salivary steroid profile investigation by high performance liquid chromatography-tandem mass spectrometry in children with congenital adrenal hyperplasia] — Tiulpakov et al., Problemy endokrinologii · source ↗
2024
A validated LC-MS/MS assay successfully measured 13 steroid hormones and two synthetic steroids in saliva, requiring only 50 microlitres, or down to 2 to 5 microlitres for nine analytes. This shows saliva's viability for non-invasive, patient-centric microsampling and decentralised monitoring in paediatric, neonatal and adult populations.
An LC-MS/MS assay for simultaneous determination of 13 steroid hormones and two synthetic steroids in saliva: potential utility for paediatric population and beyond — Dahl et al., Scandinavian journal of clinical and laboratory investigation (paywalled) · source ↗
2022
Salivary glucocorticoid concentrations were comparable across Salivette Cortisol, passive drool and SalivaBio collection methods, and remained stable for 72 hours at room temperature and 4 degrees Celsius with no significant degradation after repeated freeze-thaw cycles. In children under six years, the SaliPac pacifier swab was well tolerated and collected sufficient saliva for steroid analysis in under four minutes.
Salivary Steroid Collection in Children Under Conditions Replicating Home Sampling — Tonge et al., The Journal of clinical endocrinology and metabolism (paywalled) · source ↗