2020 · Journal of pharmaceutical and biomedical analysis · paywalled
Development and validation of a volumetric absorptive microsampling- liquid chromatography mass spectrometry method for the analysis of cefepime in human whole blood: Application to pediatric pharmacokinetic study
Moorthy et al.
The finding, in our words
The study developed and validated a VAMS-based method for measuring cefepime in small volumes of paediatric blood with high accuracy and precision, enabling less invasive therapeutic drug monitoring in children. This advances decentralised, patient-centric sampling by allowing reliable pharmacokinetic studies without repeated venous draws.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
The study developed and validated a rapid LC-MS/MS method for quantifying cefazolin in capillary whole blood collected via VAMS, plasma, and plasma ultrafiltrate, showing robust performance across matrices and successful application in a pediatric pilot cohort for therapeutic drug monitoring.
Kocur et al., Clinica chimica acta; international journal of clinical chemistry (paywalled) · source ↗
This study validated a method for quantifying fluconazole using the Mitra device, demonstrating sufficient accuracy and precision for therapeutic drug monitoring in paediatric patients.
The study developed and validated LC-MS/MS methods for ganciclovir in serum, dried serum spots, and VAMS-Mitra devices. In 80 pediatric renal transplant recipients, VAMS showed interchangeability with serum samples while extending stability to at least 49 days at room temperature, making decentralised therapeutic drug monitoring more feasible for transplant patients.
Kocur et al., International journal of molecular sciences · source ↗
A validated LC-MS method quantified multiple antibiotics from a single volumetric absorptive microsample, with stability up to 90 days for most analytes and minimal haematocrit effect except vancomycin, enabling pharmacokinetic and pharmacodynamic studies in decentralised settings.
Takyi-Williams et al., Bioanalysis (paywalled) · source ↗
Volumetric absorptive microsampling of whole blood did not provide a reliable basis for calculating meropenem plasma concentrations in critically ill children, so a validated low volume plasma method was required for paediatric therapeutic drug monitoring.
Ramadan et al., Therapeutic drug monitoring (paywalled) · source ↗