2017 · Journal of pharmaceutical and biomedical analysis · paywalled
Volumetric absorptive microsampling (VAMS) as an alternative to conventional dried blood spots in the quantification of miltefosine in dried blood samples
Kip et al.
The finding, in our words
An LC-MS/MS method for miltefosine quantification using VAMS was successfully validated, showing good accuracy within ±10.8% and precision below 11.9%. Although VAMS reduced haematocrit-induced bias compared to traditional dried blood spots, recovery still declined at higher haematocrit levels.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
The study developed and validated a rapid LC-MS/MS method for quantifying cefazolin in capillary whole blood collected via VAMS, plasma, and plasma ultrafiltrate, showing robust performance across matrices and successful application in a pediatric pilot cohort for therapeutic drug monitoring.
Kocur et al., Clinica chimica acta; international journal of clinical chemistry (paywalled) · source ↗
The authors validated a VAMS method for ivermectin therapeutic drug monitoring in whole blood, achieving a lower limit of quantification of 1 ng/mL and a linear range of 1–150 ng/mL. By eliminating haematocrit effects that limit dried blood spots, the method supports accurate decentralised sampling for antiparasitic therapy.
A validated LC-MS method quantified multiple antibiotics from a single volumetric absorptive microsample, with stability up to 90 days for most analytes and minimal haematocrit effect except vancomycin, enabling pharmacokinetic and pharmacodynamic studies in decentralised settings.
Takyi-Williams et al., Bioanalysis (paywalled) · source ↗
The study developed and validated an LC-MS/MS method for moxidectin and showed that capillary Mitra® microsampling in Strongyloides-infected adults yielded pharmacokinetic profiles in close agreement with venous sampling, with identical time to maximal concentration of 4.0 hours and similar maximal concentrations of 83.9–88.5 ng/mL. This demonstrates the method and device are suitable for therapeutic drug monitoring of anthelmintics in decentralised field settings.
Hofmann et al., Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (paywalled) · source ↗
This review summarises liquid chromatography with tandem mass spectrometry assays using dried blood spots and volumetric absorptive microsampling for quantifying antimicrobial drugs in children, highlighting that VAMS reduces haematocrit bias and offers a viable alternative to traditional plasma sampling for therapeutic drug monitoring.
Moorthy et al., Therapeutic drug monitoring (paywalled) · source ↗