Urine test for <i>EGFR</i> analysis in patients with non-small cell lung cancer
Franovic et al.
The finding, in our words
The paper found that urinary EGFR testing can identify actionable mutations in non-small cell lung cancer patients, offering a non-invasive alternative to tissue biopsy that supports treatment decisions and monitoring. This matters for decentralised diagnostics because urine self-collection enables patient-centric, repeatable sampling outside clinical settings.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
Urine-based liquid biopsy detecting trans-renal cell-free tumor DNA provides a non-invasive alternative to blood sampling, enabling frequent home self-collection and mail-in monitoring of cancer biomarker kinetics.
Urine trans-renal DNA and plasma circulating tumour DNA showed concordant dynamics that paralleled clinical course in a metastatic colorectal cancer patient treated with an ALK inhibitor. Urine-based detection of the CAD-ALK rearrangement anticipated radiological confirmation of disease progression, demonstrating that self-collected urine can non-invasively monitor tumour evolution and emerging resistance mutations during therapy.
Siravegna et al., Annals of oncology : official journal of the European Society for Medical Oncology (paywalled) · source ↗
The authors developed an integrated sequencing workflow that simultaneously profiles copy number aberrations and a three-gene methylation panel from home-collected urine cell-free DNA, achieving high diagnostic accuracy for both primary and recurrent bladder cancer in a cohort of 89 participants, which supports the feasibility of decentralised cancer detection from self-collected urine samples.
Beijert et al., JCO precision oncology (paywalled) · source ↗
An eight-millilitre sample of first-morning urine self-collected without prostatic massage yields reproducible microbial profiles using PathoChip microarray. The workflow identified Streptococcaceae enrichment in higher-grade prostate cancer, supporting its potential for decentralised, non-invasive screening, though larger validation cohorts are needed.
Mello-Grand et al., The journal of liquid biopsy (paywalled) · source ↗
In a Belgian colposcopy referral cohort, a study found that 66.6% of women preferred home-based first-void urine self-sampling over physician-taken samples, and 96.6% found the Colli-Pee UCM FV-5010 device easy to use. This supports patient-centric, decentralised screening, though results are limited to this specific referral population.
Hendrickx et al., Archives of public health = Archives belges de sante publique · source ↗