2014 · Scandinavian journal of clinical and laboratory investigation · paywalled
Quantification of valproic acid in dried blood spots
Pohanka et al.
The finding, in our words
The validated LC-MS method for valproic acid in dried blood spots showed imprecision below 9% CV and accuracy within ±14% across the clinically relevant range of 10 to 1200 μmol/L, with haematocrit effects manageable between 30 and 60%, supporting its potential for home-based therapeutic drug monitoring of this antiepileptic medication.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
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A review of dried blood microsampling for tyrosine kinase inhibitor monitoring, covering the analytical and clinical requirements for moving oral cancer-drug TDM out of hospital.
Clinical validation for tacrolimus and mycophenolic acid monitoring showed that while volumetric absorptive microsampling met analytical criteria after concentration correction, conventional dried blood spots achieved superior adherence to strict clinical criteria, sample quality, and cost efficiency without significant haematocrit bias.