2020 · Annals of clinical biochemistry · paywalled
Quantification of testosterone, androstenedione and 17-hydroxyprogesterone in whole blood collected using Mitra microsampling devices
Marshall et al.
The finding, in our words
An LC-MS/MS assay for testosterone, androstenedione and 17-hydroxyprogesterone using Mitra microsampling devices achieved mean recoveries of 102%, 98% and 97% respectively, with limits of quantification of 1–4 nmol/L. This analytical validation demonstrates that volumetric absorptive microsampling can deliver reliable reproductive hormone measurements, supporting its use in decentralised diagnostics.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
A liquid chromatography-tandem mass spectrometry method was successfully validated for measuring androstenedione, 17α-hydroxyprogesterone, and 11-ketotestosterone in dried blood samples collected via volumetric absorptive microsampling. The dried samples remained stable at room temperature for up to a week and after postal transit, and plasma concentrations could be reliably estimated from the microsamples when adjusting for haematocrit.
Capillary blood collected with Neoteryx Mitra VAMS microsampling devices can quantify IGF-1 by automated chemiluminescent immunoassay after aqueous extraction. The hormone is stable for at least one month at room temperature, and dried blood concentrations match serum after dilution correction, though capillary samples underestimate high serum values, supporting patient-centric, decentralised endocrine monitoring but requiring population-specific reference ranges.
Marchand et al., Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society (paywalled) · source ↗
The study developed and validated a LC-HRMS method for intact IGF-I from VAMS dried blood according to World Anti-Doping Agency requirements and showed agreement with serum measurements, supporting decentralised sampling for antidoping testing.
Mongongu et al., Bioanalysis (paywalled) · source ↗
The study developed and validated an LC-MS/MS method for quantitating estetrol from 10–20 µL whole blood collected on volumetric absorptive microsampling devices, demonstrating selectivity, trueness, precision, accuracy and stability without derivatisation, and confirmed performance in murine pharmacokinetic studies; this enables reliable, low-volume microsampling for decentralised pharmacokinetic applications.
Nys et al., Journal of pharmaceutical and biomedical analysis (paywalled) · source ↗
Researchers successfully validated an analytical method for measuring creatinine across plasma and volumetric absorptive microsampling devices, demonstrating strong correlation between conventional plasma and dried microsamples. This provides a reliable, patient-centric approach for monitoring kidney function remotely during transplant follow-up.
Kocur et al., European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences (paywalled) · source ↗