2016 · Journal of pharmaceutical and biomedical analysis · paywalled
LC-MS/MS and volumetric absorptive microsampling for quantitative bioanalysis of cathinone analogues in dried urine, plasma and oral fluid samples
Mercolini et al.
The finding, in our words
The study developed and validated an LC-MS/MS method using volumetric absorptive microsampling to quantify cathinone analogues in dried urine, plasma and oral fluid, showing satisfactory linearity, precision, recovery, matrix effects, selectivity and stability, and was applied to real samples from users, offering a reliable decentralised sampling strategy for forensic toxicology and sport drug testing.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
Confirms urine is the second-most-applied VAMS matrix in forensics, collecting a consistent volume regardless of viscosity and enabling room-temperature storage and shipping.
This narrative review evaluates microsampling devices for therapeutic drug monitoring, concluding that techniques such as volumetric absorptive microsampling and dried blood spots offer reliable, less invasive alternatives to venous sampling when paired with high-sensitivity mass spectrometry, which supports implementation in routine clinical practice.
This review highlights that microsampling techniques such as dried blood spots and volumetric absorptive microsampling offer superior alternatives to traditional sampling for the mass spectrometry detection of prohibited substances in anti-doping analysis. It provides guidance on selecting appropriate analytical methods and sample pretreatment strategies to ensure sensitive detection and reliable storage conditions.
Maykar et al., Critical reviews in analytical chemistry (paywalled) · source ↗
This review surveyed the use of VAMS devices for analysing endogenous metabolites and biomarkers across the full analytical workflow, finding them reliable for biological analysis with improved analyte stability over liquid blood at ambient temperature and a straightforward acquisition model well suited to decentralised diagnostics.
The analysis indicates that dried blood spots and volumetric absorptive microsampling enable minimally invasive monitoring of prohibited substances, with volumetric absorptive microsampling offering improved quantitative reliability over traditional dried spots.