HPV detection in first void urine and cervicovaginal samples: comparative study and analysis of associated factors in women from tunja, colombia

A study of 100 Brazilian women with high-grade cervical lesions found excellent concordance for high-risk HPV detection between clinician-collected samples and patient-centric, self-collected vaginal or first-void urine samples. Self-sampling was preferred for comfort, though the study's single-centre setting may limit generalisability.

Self-sampling for HPV genotyping: a study of vaginal and urine collection in Brazilian women with high-grade lesions — Castanheira et al., Clinics · source ↗

• acceptability
• first-void
• sti
• self-collection
• hpv
• urine
• genotyping

The study validated the Allplex HPV28 assay for use with first-void urine samples collected using a Colli-Pee device, finding good agreement with a reference method and that it works without pre-centrifugation. This provides a reliable, non-invasive option for HPV screening and vaccine monitoring, which is important for increasing participation in decentralised settings.

Optimization and analytical validation of the Allplex HPV28 genotyping assay for use in first-void urine samples — Bell et al., Journal of clinical microbiology · source ↗

• colli-pee
• first-void
• sti
• hpv
• urine
• validation
• genotyping

First-void urine identified merely 15.8% of HPV types in circumcised men with genital warts, the lowest detection rate of six sampling methods. Combining wart biopsy with swabs from four genital anatomical sites achieved 98.9% detection, demonstrating that multi-site collection is necessary for accurate decentralised HPV screening in this population.

Evaluation of the optimal sampling approach for HPV genotyping in circumcised heterosexual men with genital warts — Sarier et al., Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy (paywalled) · source ↗

• urine
• first-void
• genotyping
• hpv
• sti

First-void urine HPV DNA testing showed 64.72% prevalence against 60.00% for cervical samples, with substantial concordance for the four vaccine types. This validates first-void urine as a patient-centric alternative specimen for decentralised cervical screening and HPV vaccination monitoring programmes.

Comparison between Urine and Cervical Samples for HPV DNA Detection and Typing in Young Women in Colombia — Cómbita et al., Cancer prevention research (paywalled) · source ↗

• first-void
• sti
• hpv
• urine
• validation
• genotyping

This meta-analysis found that HPV testing using self-collected vaginal and urine samples showed sensitivities of 88.6% and 81% for detecting cervical precancer. Using a standardised device for first-void urine increased sensitivity to 86.6%, supporting decentralised patient-centric screening, though data on specificity and specific commercial devices were not consistently reported.

Diagnostic Performance of HPV Testing Using Self-Collected Urine and Vaginal Samples for Detecting Cervical Precancer or Worse: A Meta-Analysis — Hsiao et al., The journal of obstetrics and gynaecology research (paywalled) · source ↗

• urine
• first-void
• self-collection
• validation
• hpv
• sti