Comparison between Urine and Cervical Samples for HPV DNA Detection and Typing in Young Women in Colombia

The study validated the Allplex HPV28 assay for use with first-void urine samples collected using a Colli-Pee device, finding good agreement with a reference method and that it works without pre-centrifugation. This provides a reliable, non-invasive option for HPV screening and vaccine monitoring, which is important for increasing participation in decentralised settings.

Optimization and analytical validation of the Allplex HPV28 genotyping assay for use in first-void urine samples — Bell et al., Journal of clinical microbiology · source ↗

• colli-pee
• first-void
• sti
• hpv
• urine
• validation
• genotyping

This meta-analysis found that HPV testing using self-collected vaginal and urine samples showed sensitivities of 88.6% and 81% for detecting cervical precancer. Using a standardised device for first-void urine increased sensitivity to 86.6%, supporting decentralised patient-centric screening, though data on specificity and specific commercial devices were not consistently reported.

Diagnostic Performance of HPV Testing Using Self-Collected Urine and Vaginal Samples for Detecting Cervical Precancer or Worse: A Meta-Analysis — Hsiao et al., The journal of obstetrics and gynaecology research (paywalled) · source ↗

• urine
• first-void
• self-collection
• validation
• hpv
• sti

A comparison of human papillomavirus detection in first-void urine and cervicovaginal samples from Colombian women showed moderate prevalence but weak concordance between the two methods. Although urine-based screening offers a non-invasive alternative, its limited diagnostic performance in this study highlights the ongoing need to optimise collection and processing strategies for decentralised screening.

HPV detection in first void urine and cervicovaginal samples: comparative study and analysis of associated factors in women from tunja, colombia — Neita et al., Preventive medicine reports · source ↗

• first-void
• sti
• hpv
• urine
• genotyping

This meta-analysis found that self-collected urine samples for HPV testing had lower sensitivity for detecting high-grade lesions compared to physician-collected cervical specimens. The use of a first-void collection device such as Colli-Pee was associated with marginally higher sensitivity than general urine sampling.

Accuracy of HPV Testing Using Self-collected Urine Compared With Physician-collected Cervical Specimen for HSIL or Worse — Chen et al., Journal of lower genital tract disease (paywalled) · source ↗

• urine
• first-void
• colli-pee
• self-collection
• validation
• hpv
• sti

Vaginal self-sampling achieved higher pooled sensitivity and specificity than urine self-sampling for detecting high-risk HPV, making it the preferred option, while urine self-sampling remains a useful non-invasive choice for under-screened populations.

Diagnostic Accuracy of Urine and Vaginal Self-Sampling for Detection of High-Risk Human Papillomavirus: A Systematic Review and Meta-Analysis — Rakhat & Aimagambetova, Viruses · source ↗

• first-void
• sti
• self-collection
• hpv
• urine
• validation