2019 · Pharmacology research & perspectives · open access
A pharmacokinetic study of radiprodil oral suspension in healthy adults comparing conventional venous blood sampling with two microsampling techniques
Sciberras et al.
The finding, in our words
In ten healthy volunteers, radiprodil pharmacokinetics measured by Aqua-Cap™ Drummond microsampling closely matched conventional venous blood draws, whereas Mitra™ microsampling gave marginally lower exposure values. Both microsampling methods fell within the accepted bioequivalence range, indicating they could enable patient-centric therapeutic drug monitoring and future paediatric decentralised trials.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
In 55 patients, four approaches to convert dried capillary blood concentrations to plasma equivalents were evaluated. All methods except haematocrit-based conversion yielded acceptable analytical and clinical agreement for paracetamol and metabolites, supporting the reliability of capillary microsampling for decentralised therapeutic drug monitoring.
Boffel et al., The AAPS journal (paywalled) · source ↗
The study validated a VAMS-based LC-MS/MS method for measuring sirolimus levels, showing it was clinically equivalent to the standard whole blood method and suitable for therapeutic drug monitoring in paediatric transplant patients, supporting the use of decentralised microsampling for this purpose.
Kocur et al., Pharmacological reports : PR · source ↗
A study of 50 paediatric renal transplant recipients found that a validated VAMS LC-MS/MS method for tacrolimus showed high correlation with the reference method over 0.5–60 ng/mL, with minimal haematocrit effect.
Two feasibility studies assessed low-volume blood sampling for therapeutic drug monitoring. In patients receiving an anti-A therapeutic, drug levels were measured from finger-prick whole blood collected with Neoteryx Mitra and from capillary plasma collected with TASSO OnDemand, and compared with venipuncture samples. The work outlines practical considerations for adopting these patient-centric microsampling methods in decentralised trials and clinical care.
Williams et al., Bioanalysis (paywalled) · source ↗
Capillary blood sampling using volumetric absorptive microsampling demonstrated non-significant differences in cannabidiol concentrations compared to venous blood and plasma in pediatric patients treated with Epidiolex. The method requires 30 µL of sample, achieves linear quantification between 1 and 800 µg/L, and ensures analyte stability on VAMS devices for up to four weeks at room temperature.