The potential use of midstream urine samples for diagnosing Chlamydia/Gonorrhoea NAAT in male and female patients, and the pre-analytical storage conditions in neat urine specimens

This study found strong agreement between self-collected urine samples tested with the INDICAID HPV assay and clinician-collected swabs tested with the BD Onclarity assay for detecting high-risk HPV. The results suggest that urine-based self-collection offers a reliable alternative for cervical cancer screening, potentially improving access for women who face barriers to standard care.

Agreement between INDICAID™ HPV (human papillomavirus) Urine Test and BD Onclarity™ HPV Assay in detection of high-risk HPV in self-collected urine samples — Yung et al., Journal of gynecologic oncology (paywalled) · source ↗

• sti
• self-collection
• hpv
• liquid
• urine
• validation

The Cobas Liat CT/NG/MG nucleic acid amplification test achieved 97% specificity for chlamydia, gonorrhoea, and mycoplasma from self-collected urine and vaginal swabs at point-of-care, with sensitivity of at least 92% for most specimen types. Sensitivity was modestly lower for female urine (77–87%), yet the 20-minute turnaround time and ease of use support rapid, decentralised STI screening and reduced empiric treatment.

Sensitivity and specificity of the Cobas Liat CT/NG/MG nucleic acid test in a clinical laboratory setting and point-of-care location — Van Der Pol et al., Journal of clinical microbiology · source ↗

• sti
• self-collection
• liquid
• urine
• validation

Self-collected urine samples matched clinician-collected cervical samples in detecting all seven CIN3 lesions among hrHPV-positive women when extended HPV typing was used, showing 82% concordance for hrHPV detection. This indicates urine self-collection could serve as a patient-centric, decentralised screening option for cervical precancer without compromising diagnostic yield.

Performance of urine samples compared to cervical samples for detection of precancer lesions among HPV-positive women attending colposcopy clinic in Mexico City — Meneses-León et al., Cancer causes & control : CCC · source ↗

• sti
• self-collection
• hpv
• liquid
• urine
• validation

Urine self-sampling for HPV detection showed good agreement with clinician-collected cervical samples (Kappa 0.72) under optimised conditions of 40 mM EDTA preservative, storage at 25°C, and processing within 72 hours. With a cost of USD 1.10 and high acceptability among women and healthcare workers, this method offers a practical decentralised screening approach for resource-limited settings.

Performance of an affordable urine self-sampling method for human papillomavirus detection in Mexican women — Hernández-López et al., PloS one · source ↗

• acceptability
• economics
• sti
• self-collection
• hpv
• liquid
• urine
• validation

In women with HPV, first-void urine collected with the Colli-Pee device had higher HPV DNA concentrations than urine collected with a standard cup, although this advantage disappeared at high HPV DNA loads. Timing of collection (morning versus later) did not affect HPV DNA copies.

Human papillomavirus detection in urine: Effect of a first-void urine collection device and timing of collection — Pattyn et al., Journal of virological methods (paywalled) · source ↗

• colli-pee
• first-void
• sti
• self-collection
• hpv
• liquid
• urine
• validation