Sensitivity and specificity of the Cobas Liat CT/NG/MG nucleic acid test in a clinical laboratory setting and point-of-care location

Midstream urine self-collection demonstrated adequate sensitivity for Chlamydia trachomatis screening in asymptomatic patients, although it was less sensitive than vaginal swabs in women, and the study confirmed that nucleic acids in neat urine remain stable for up to seven days when stored at 4°C.

The potential use of midstream urine samples for diagnosing Chlamydia/Gonorrhoea NAAT in male and female patients, and the pre-analytical storage conditions in neat urine specimens — Ilardo et al., The new microbiologica (paywalled) · source ↗

• sti
• self-collection
• liquid
• urine
• validation

This study found strong agreement between self-collected urine samples tested with the INDICAID HPV assay and clinician-collected swabs tested with the BD Onclarity assay for detecting high-risk HPV. The results suggest that urine-based self-collection offers a reliable alternative for cervical cancer screening, potentially improving access for women who face barriers to standard care.

Agreement between INDICAID™ HPV (human papillomavirus) Urine Test and BD Onclarity™ HPV Assay in detection of high-risk HPV in self-collected urine samples — Yung et al., Journal of gynecologic oncology (paywalled) · source ↗

• sti
• self-collection
• hpv
• liquid
• urine
• validation

Self-collected urine samples matched clinician-collected cervical samples in detecting all seven CIN3 lesions among hrHPV-positive women when extended HPV typing was used, showing 82% concordance for hrHPV detection. This indicates urine self-collection could serve as a patient-centric, decentralised screening option for cervical precancer without compromising diagnostic yield.

Performance of urine samples compared to cervical samples for detection of precancer lesions among HPV-positive women attending colposcopy clinic in Mexico City — Meneses-León et al., Cancer causes & control : CCC · source ↗

• sti
• self-collection
• hpv
• liquid
• urine
• validation

Urine self-sampling for HPV detection showed good agreement with clinician-collected cervical samples (Kappa 0.72) under optimised conditions of 40 mM EDTA preservative, storage at 25°C, and processing within 72 hours. With a cost of USD 1.10 and high acceptability among women and healthcare workers, this method offers a practical decentralised screening approach for resource-limited settings.

Performance of an affordable urine self-sampling method for human papillomavirus detection in Mexican women — Hernández-López et al., PloS one · source ↗

• acceptability
• economics
• sti
• self-collection
• hpv
• liquid
• urine
• validation

In women with HPV, first-void urine collected with the Colli-Pee device had higher HPV DNA concentrations than urine collected with a standard cup, although this advantage disappeared at high HPV DNA loads. Timing of collection (morning versus later) did not affect HPV DNA copies.

Human papillomavirus detection in urine: Effect of a first-void urine collection device and timing of collection — Pattyn et al., Journal of virological methods (paywalled) · source ↗

• colli-pee
• first-void
• sti
• self-collection
• hpv
• liquid
• urine
• validation