Performance of an affordable urine self-sampling method for human papillomavirus detection in Mexican women

Self-sampling for HPV testing using urine and swab devices achieved high DNA detection rates, 92.1-99.7%, and very high participant acceptance, 99.1%, in a primary care population, supporting decentralised screening in low-resource settings.

Population-based self-sampling under primary care conditions - a possible approach for cervical cancer screening in Indonesia (IndoCerCa study) — Wenang et al., Reproductive health · source ↗

• urine
• self-collection
• validation
• acceptability
• hpv
• sti

This study found strong agreement between self-collected urine samples tested with the INDICAID HPV assay and clinician-collected swabs tested with the BD Onclarity assay for detecting high-risk HPV. The results suggest that urine-based self-collection offers a reliable alternative for cervical cancer screening, potentially improving access for women who face barriers to standard care.

Agreement between INDICAID™ HPV (human papillomavirus) Urine Test and BD Onclarity™ HPV Assay in detection of high-risk HPV in self-collected urine samples — Yung et al., Journal of gynecologic oncology (paywalled) · source ↗

• sti
• self-collection
• hpv
• liquid
• urine
• validation

This meta-analysis found that urine self-sampling for HPV detection had significantly lower sensitivity for high-grade lesions compared to vaginal and cervical samples, though specificity remained comparable. Despite the reduced diagnostic accuracy, the non-invasive and acceptable nature of urine sampling supports its use as a decentralised option to improve screening uptake.

A systematic review and meta-analysis of diagnostic accuracy of urine self-sampling for human papillomavirus detection in cervical cancer screening — Nath et al., Journal of medical screening (paywalled) · source ↗

• acceptability
• sti
• self-collection
• hpv
• urine
• validation

Urine-based HPV testing showed broad variability in diagnostic performance, with sensitivity ranging from 44.8 to 98.6 per cent and specificity from 61 to 100 per cent against cervical specimens. High patient acceptability was reported, yet standardisation is needed before this self-collection approach can be approved for decentralised cervical cancer screening.

A Narrative Review of Urine-Based Human Papillomavirus Screening: Performance, Challenges, and Opportunities to Expand Access in the United States — Yang et al., Sexually transmitted diseases (paywalled) · source ↗

• urine
• self-collection
• validation
• acceptability
• hpv
• sti

Urinary HPV testing showed lower sensitivity than cervical sampling for detecting CIN2+ (79% versus 93%) but higher specificity (58% versus 50%), and participants favoured urine self-collection. The authors conclude that while urine sampling may complement screening in resource-limited or culturally conservative settings, its suboptimal performance and absence of standardised protocols preclude its use for general population screening.

Pooled performance of urinary human papillomavirus (HPV) testing for the presence of cervical HPV — Ye et al., Cancer (paywalled) · source ↗

• urine
• self-collection
• validation
• acceptability
• hpv
• sti