Semen inflammatory markers and Chlamydia trachomatis infection in male partners of infertile couples

The study found comparable seropositivity for Chlamydia trachomatis and Toxoplasma gondii among male partners of infertile couples in Odisha, with 28 per cent showing anti-Chlamydia IgA and 28 per cent anti-Toxoplasma IgM antibodies. This demonstrates that first-void urine and seminal fluid can detect relevant infections, supporting their use in decentralised fertility screening programmes.

Seropositivity of <i>Chlamydia trachomatis & Toxoplasma gondii</i> among male partners of infertile couples in Odisha, India: A facility-based exploratory study — Naik et al., The Indian journal of medical research · source ↗

• first-void
• blood
• sti
• serology
• fertility
• urine

In 250 Iranian infertile couples followed for 24 months, detection of Chlamydia trachomatis DNA in first-void urine, semen or serum antibodies did not predict tubal factor infertility, pregnancy rate or outcome. This indicates that patient-collected first-void urine screening for these organisms may have limited clinical utility in fertility assessment.

Relationship between Chlamydia trachomatis and Mycoplasma genitalium infection and pregnancy rate and outcome in Iranian infertile couples — Dehghan Marvast et al., Andrologia (paywalled) · source ↗

• blood
• urine
• first-void
• fertility
• serology
• sti

A cross-sectional survey of 1,087 men who have sex with men in Jiangsu province, China found a syphilis prevalence of 6.3% and chlamydia prevalence of 4.2%, with higher odds among those recruited online and with recent STI diagnosis. The use of first-void urine for nucleic acid amplification testing demonstrates the utility of decentralised sampling for STI screening in high-risk populations.

Prevalence of syphilis and chlamydia trachomatis infection among men who have sex with men in Jiangsu province, China: A cross-sectional survey — Hu et al., Frontiers in public health · source ↗

• first-void
• blood
• sti
• serology
• urine

Among 250 infertile Iranian men, self-collected first-void urine enabled decentralised detection of Chlamydia trachomatis, yet infection status showed no correlation with sperm chromatin condensation or DNA fragmentation. The study validates first-void urine for remote STI screening in fertility assessment, while indicating sperm quality markers are independent of Chlamydia infection.

Effects of Chlamydia trachomatis infection on sperm chromatin condensation and DNA integrity — Dehghan Marvast et al., Andrologia (paywalled) · source ↗

• urine
• first-void
• fertility
• serology
• sti

The study found that IgG seropositivity against Chlamydia trachomatis was significantly higher in infertile women than in pregnant controls (15% versus 0%), but PCR positivity in first-void urine was very low, with only one of 80 samples positive across all three primer sets. The authors concluded that serological screening is more diagnostically useful than first-void urine PCR for identifying chlamydial infection in infertile women in this setting.

Association of Genital Chlamydia trachomatis Infection with Female Infer-tility, Study in a Tertiary Care Hospital in Eastern India — Ghosh et al., The open microbiology journal · source ↗

• urine
• first-void
• fertility
• serology
• sti