2015 · The open microbiology journal · open access
Association of Genital Chlamydia trachomatis Infection with Female Infer-tility, Study in a Tertiary Care Hospital in Eastern India
Ghosh et al.
The finding, in our words
The study found that IgG seropositivity against Chlamydia trachomatis was significantly higher in infertile women than in pregnant controls (15% versus 0%), but PCR positivity in first-void urine was very low, with only one of 80 samples positive across all three primer sets. The authors concluded that serological screening is more diagnostically useful than first-void urine PCR for identifying chlamydial infection in infertile women in this setting.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
The study found comparable seropositivity for Chlamydia trachomatis and Toxoplasma gondii among male partners of infertile couples in Odisha, with 28 per cent showing anti-Chlamydia IgA and 28 per cent anti-Toxoplasma IgM antibodies. This demonstrates that first-void urine and seminal fluid can detect relevant infections, supporting their use in decentralised fertility screening programmes.
Among 250 infertile Iranian men, self-collected first-void urine enabled decentralised detection of Chlamydia trachomatis, yet infection status showed no correlation with sperm chromatin condensation or DNA fragmentation. The study validates first-void urine for remote STI screening in fertility assessment, while indicating sperm quality markers are independent of Chlamydia infection.
In 250 Iranian infertile couples followed for 24 months, detection of Chlamydia trachomatis DNA in first-void urine, semen or serum antibodies did not predict tubal factor infertility, pregnancy rate or outcome. This indicates that patient-collected first-void urine screening for these organisms may have limited clinical utility in fertility assessment.
The study of 250 infertile men found that Chlamydia trachomatis infection detected in first-void urine by PCR was associated with lower semen volume, while seminal interleukin levels showed non-significant elevation. This supports the use of patient-centric first-void urine and blood samples for screening sexually transmitted infections in decentralised fertility diagnostics.
First-void urine samples showed significantly higher detection rates of HPV-specific IgG antibodies compared to midstream urine, confirming the necessity of capturing the initial stream. The study found no significant difference between 10 mL and 20 mL collection volumes, indicating flexibility in device specifications for self-collection.