Placental human papillomavirus infections and adverse pregnancy outcomes
Værnesbranden et al.
The finding, in our words
In pregnant women, first-void urine collected at midgestation detected HPV in 38%, with high-risk genotypes and high viral loads associated with placental HPV infection at delivery (prevalence 3%). No increased risk of adverse pregnancy outcomes was observed with placental HPV. This demonstrates urine-based HPV screening can identify placental infection risk non-invasively.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
DNA methylation markers in first-void urine effectively detect high-grade cervical lesions in HPV-positive women, with results similar to clinician-collected samples in those over 30. This enables reliable cervical cancer screening using self-collected urine, reducing the need for invasive follow-up procedures in decentralised settings.
A comparison of human papillomavirus detection in first-void urine and cervicovaginal samples from Colombian women showed moderate prevalence but weak concordance between the two methods. Although urine-based screening offers a non-invasive alternative, its limited diagnostic performance in this study highlights the ongoing need to optimise collection and processing strategies for decentralised screening.
A study of 100 Brazilian women with high-grade cervical lesions found excellent concordance for high-risk HPV detection between clinician-collected samples and patient-centric, self-collected vaginal or first-void urine samples. Self-sampling was preferred for comfort, though the study's single-centre setting may limit generalisability.
The study validated the Allplex HPV28 assay for use with first-void urine samples collected using a Colli-Pee device, finding good agreement with a reference method and that it works without pre-centrifugation. This provides a reliable, non-invasive option for HPV screening and vaccine monitoring, which is important for increasing participation in decentralised settings.
First-void urine identified merely 15.8% of HPV types in circumcised men with genital warts, the lowest detection rate of six sampling methods. Combining wart biopsy with swabs from four genital anatomical sites achieved 98.9% detection, demonstrating that multi-site collection is necessary for accurate decentralised HPV screening in this population.