New Trend in Toxicological Screening Using Volumetric Absorptive Microsampling (VAMS) and High-Resolution Mass Spectrometry (HR/MS) Combination

This study validated a method for measuring the alcohol biomarker phosphatidylethanol using two volumetric absorptive microsampling devices, finding that the Mitra device met all validation criteria and agreed with venous sampling. The Capitainer device was deemed suitable but showed reduced accuracy at higher concentrations, with a small proportional negative bias compared to venous results.

A validated method for capillary phosphatidylethanol 16:0/18:1 quantification with two different 10-µl volumetric absorptive microsample devices in the same setup — Andreassen et al., Journal of analytical toxicology (paywalled) · source ↗

• vams
• venous-agreement
• neoteryx-mitra
• blood
• dbs
• dried
• toxicology
• capillary
• validation

A VAMS method using Mitra devices for whole blood lead quantification showed no significant difference compared with the centre's routine method, supporting VAMS as a practical alternative for blood lead and other trace element analyses.

Method development for the quantification of lead levels in whole blood sampled on Mitra^® with VAMS^® tips by inductively coupled plasma-MS/MS — Breton et al., Bioanalysis (paywalled) · source ↗

• blood
• dried
• vams
• neoteryx-mitra
• validation
• venous-agreement
• toxicology

Capillary VAMS combined with direct mercury analysis demonstrated strong correlation with venous blood mercury concentrations in adult volunteers, with acceptable accuracy and precision above 1.0 µg/l. Storage in pre-cleaned glass vials following two hours of desiccator drying maintained analyte stability for at least four weeks.

Mercury biomonitoring in German adults using volumetric absorptive microsampling — Koutsimpani-Wagner et al., Environmental monitoring and assessment · source ↗

• blood
• dried
• capillary
• vams
• neoteryx-mitra
• validation
• venous-agreement
• toxicology

Researchers successfully validated an analytical method for measuring creatinine across plasma and volumetric absorptive microsampling devices, demonstrating strong correlation between conventional plasma and dried microsamples. This provides a reliable, patient-centric approach for monitoring kidney function remotely during transplant follow-up.

Surrogate-based LC-MS/MS quantification of endogenous creatinine in plasma, plasma-equivalent dried spots (qDPS), and volumetric absorptive microsampling (VAMS): an ICH M10-compliant bridging study — Kocur et al., European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences (paywalled) · source ↗

• vams
• venous-agreement
• neoteryx-mitra
• blood
• dried
• validation
• biomarkers

In lung and renal transplant recipients, VAMS sampling with LC-MS/MS quantification of mycophenolic acid and tacrolimus showed good linearity and accuracy, and with a haematocrit-adjusted conversion formula achieved clinical agreement in most samples; tacrolimus did not require haematocrit correction. The approach is virtually painless and enables richer sampling for more accurate drug exposure estimates, supporting decentralised therapeutic drug monitoring.

Evaluation of hematocrit-adjusted conversion strategies for mycophenolic acid and tacrolimus monitoring using volumetric absorptive microsampling in lung and renal transplant recipients — Juan et al., Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · source ↗

• blood
• dried
• vams
• neoteryx-mitra
• validation
• venous-agreement
• tdm
• immunosuppressants
• haematocrit