2015 · Analytical Chemistry · paywalled
Leuthold et al.
The foundational quantitative-DBS work: a microfluidic layer meters a controlled 5–10 µL onto a standard card in seconds, targeting the haematocrit problem at source.
A paraphrase to the Library’s standard, never the abstract. The source is one link away and is always the authority.
2024
Microsampling enables less invasive, patient-centric self-collection of capillary blood for remote monitoring of metabolites and lipids, overcoming conventional venipuncture constraints. Recent device innovations address dried blood spot limitations, particularly haematocrit and volume variations, expanding decentralised applications in population health, drug discovery and multi-omics research.
Bossi et al., Metabolites · source ↗
2023
Deprez et al. validated LC‑MS/MS methods for four immunosuppressants and creatinine from a single 10 μL quantitative dried blood spot. With biases under 10 % and CVs below 8 %, the approach enables accurate patient‑centric therapeutic drug monitoring from capillary blood at home, mitigating the haematocrit effect through volumetric collection.
Deprez et al., Analytica chimica acta (paywalled) · source ↗
2023
Self-administered finger-stick blood collection enables routine healthcare assessments without clinic visits, but diagnostic utility depends critically on sample processing and storage. While new materials address haematocrit effects and enable precise low-volume sampling, no single device meets all clinical needs, and plasma separation remains essential for expanding applications.
Baillargeon & Mace, Bioengineering & translational medicine · source ↗
2022
An IQ Consortium position paper from sponsor scientists positioning patient-centric sampling as the enabling technology for decentralised trials, and stating that a bridging study against conventional sampling “has quickly been established as a regulatory expectation”.
Maass et al., Clinical and Translational Science · source ↗
2026
In AML and CLL, 91% of VAMS venetoclax results fell within 20% of plasma after individualised haematocrit correction; in home sampling, 18 of 21 patients self-sampled independently and 76% of returned samples were analysable, which shows home microsampling is workable, though the authors ask for multicentre validation.
Levens et al., Clinical Pharmacokinetics (paywalled) · source ↗